JPH0119879B2 - - Google Patents
Info
- Publication number
- JPH0119879B2 JPH0119879B2 JP57229619A JP22961982A JPH0119879B2 JP H0119879 B2 JPH0119879 B2 JP H0119879B2 JP 57229619 A JP57229619 A JP 57229619A JP 22961982 A JP22961982 A JP 22961982A JP H0119879 B2 JPH0119879 B2 JP H0119879B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- interleukin
- mrna
- dna
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010002350 Interleukin-2 Proteins 0.000 claims description 74
- 102000000588 Interleukin-2 Human genes 0.000 claims description 72
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- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 description 1
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- 108090001090 Lectins Proteins 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
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- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
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- YVSWPCCVTYEEHG-UHFFFAOYSA-N rhodamine B 5-isothiocyanate Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(N=C=S)C=C1C(O)=O YVSWPCCVTYEEHG-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Priority Applications (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57229619A JPS59140882A (ja) | 1982-12-24 | 1982-12-24 | インターロイキン２活性をもつポリペプチドをコードする遺伝子 |
| EP83101035A EP0091539B2 (en) | 1982-03-31 | 1983-02-03 | Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells |
| DE8383101035T DE3377363D1 (en) | 1982-03-31 | 1983-02-03 | Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells |
| US06/463,496 US4738927A (en) | 1982-03-31 | 1983-02-03 | Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell |
| CA000424401A CA1341562C (en) | 1982-03-31 | 1983-03-24 | Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell |
| AU21472/83A AU556353B2 (en) | 1982-12-15 | 1983-11-17 | Interleukin-2 polypeptide |
| DD25780883A DD218632A5 (de) | 1982-12-15 | 1983-12-12 | Verfahren zur herstellung von interleukin-2 |
| DK577283A DK173788B1 (da) | 1982-12-15 | 1983-12-14 | DNA-fragment, som koder for et polypeptid med interleukin-2-aktivitet, rekombinant DNA omfattende dette DNA-fragment, cellelinie transformeret med det rekombinante DNA og fremgangsmåde til fremstilling af interleukin-2 ved anvendelse af denne cellelinie |
| AT435083A AT392082B (de) | 1982-12-15 | 1983-12-14 | Das polypeptid interleukin-2 kodierendes gen, rekombinante, dieses gen enthaltende dna, diese rekombinante dna aufweisende zellinien und verfahren zur herstellung von interleukin-2 unter verwendung der genannten zellen |
| HU426383A HU197938B (en) | 1982-12-15 | 1983-12-14 | Process for producing gene encoding interleukin-2 polypeptide, recombinant dna carrying the gene, living cell line having the recombinant dna and process for producing interleukin-2 with such cells |
| CA 443333 CA1341633C (en) | 1982-12-15 | 1983-12-15 | Interleukin-2 polypeptides |
| DE8383112661T DE3382383D1 (en) | 1982-12-15 | 1983-12-15 | Interleukin-2-polypeptide. |
| KR1019830005952A KR940002537B1 (ko) | 1982-12-15 | 1983-12-15 | 인터로이킨-2 폴리펩타이드를 코드화하는 dna 서열, 재조합체 dna, 및 인터로이킨-2의 제조방법 |
| EP83112661A EP0118617B1 (en) | 1982-12-15 | 1983-12-15 | Interleukin-2 polypeptides |
| BE0/212058A BE898473A (fr) | 1982-12-15 | 1983-12-15 | Gène codé pour polypeptide d'interleukine-2, ADN recombinant portant ce gène, cellules vivantes contenant l'ADN recombinant et production d'interleukine-2 |
| US07/814,049 US5620868A (en) | 1982-03-31 | 1991-12-26 | Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell |
| US08/096,842 US5399669A (en) | 1982-03-31 | 1993-07-26 | Interleukin-2 polypeptides |
| US08/331,146 US5700913A (en) | 1982-12-15 | 1994-10-28 | Unglycosylated human interleukin-2 polypeptides |
| US08/516,563 US5795769A (en) | 1982-03-31 | 1995-08-18 | Gene encoding interleukin-2 polypeptide, recombinant DNA carrying the gene, a living cell line possessing the recombinant DNA and method for producing interleukin-2 using the cell |
| US08/621,097 US5795777A (en) | 1982-03-31 | 1996-03-22 | Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell |
| US09/769,396 US20010041362A1 (en) | 1982-03-31 | 2001-01-26 | Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57229619A JPS59140882A (ja) | 1982-12-24 | 1982-12-24 | インターロイキン２活性をもつポリペプチドをコードする遺伝子 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63292084A Division JPH0832236B2 (ja) | 1988-11-18 | 1988-11-18 | 組換えヒトインターロイキン２およびその製造法 |
| JP63292085A Division JPH0832237B2 (ja) | 1988-11-18 | 1988-11-18 | ヒトインターロイキン２活性をもつポリペプチドをコードする遺伝子を含有する発現ベクターおよび該ベクターにより形質転換された真核生物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59140882A JPS59140882A (ja) | 1984-08-13 |
| JPH0119879B2 true JPH0119879B2 (es) | 1989-04-13 |
Family
ID=16895021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57229619A Granted JPS59140882A (ja) | 1982-03-31 | 1982-12-24 | インターロイキン２活性をもつポリペプチドをコードする遺伝子 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59140882A (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8303383D0 (en) * | 1983-02-08 | 1983-03-16 | Biogen Nv | Sequences recombinant dna molecules |
| WO1986000334A1 (fr) * | 1984-06-20 | 1986-01-16 | Takeda Chemical Industries, Ltd. | Nouveau transformant et son utilisation |
| WO1986006405A1 (en) * | 1985-05-02 | 1986-11-06 | Takeda Chemical Industries, Ltd. | Novel transformant and its use |
| JP2587609B2 (ja) * | 1984-08-30 | 1997-03-05 | 味の素株式会社 | マウスインターロイキン―２活性を有するポリペプチド及びその製造法 |
| JP2576200B2 (ja) * | 1988-03-09 | 1997-01-29 | 味の素株式会社 | 生理活性タンパク質の製造法 |
-
1982
- 1982-12-24 JP JP57229619A patent/JPS59140882A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59140882A (ja) | 1984-08-13 |
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