JP7739411B2 - ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法及び晶析装置 - Google Patents

ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法及び晶析装置

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Publication number
JP7739411B2
JP7739411B2 JP2023508903A JP2023508903A JP7739411B2 JP 7739411 B2 JP7739411 B2 JP 7739411B2 JP 2023508903 A JP2023508903 A JP 2023508903A JP 2023508903 A JP2023508903 A JP 2023508903A JP 7739411 B2 JP7739411 B2 JP 7739411B2
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Japan
Prior art keywords
turbidity
reduced coenzyme
crystals
ftu
temperature
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JP2023508903A
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Japanese (ja)
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JPWO2022202215A1 (https=
Inventor
昴 谷崎
直生 大野
貴識 橋本
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Kaneka Corp
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Kaneka Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0063—Control or regulation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D2009/0086—Processes or apparatus therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2023508903A 2021-03-26 2022-03-04 ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法及び晶析装置 Active JP7739411B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021053784 2021-03-26
JP2021053784 2021-03-26
PCT/JP2022/009362 WO2022202215A1 (ja) 2021-03-26 2022-03-04 ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法及び晶析装置

Publications (2)

Publication Number Publication Date
JPWO2022202215A1 JPWO2022202215A1 (https=) 2022-09-29
JP7739411B2 true JP7739411B2 (ja) 2025-09-16

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JP2023508903A Active JP7739411B2 (ja) 2021-03-26 2022-03-04 ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法及び晶析装置

Country Status (5)

Country Link
US (1) US20240166589A1 (https=)
EP (1) EP4317125B1 (https=)
JP (1) JP7739411B2 (https=)
CN (1) CN117062795A (https=)
WO (1) WO2022202215A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024242859A1 (en) 2023-03-30 2025-11-13 Kaneka Corporation Crystal and preparation of reduced coenzyme q10

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006411A1 (fr) 2001-07-13 2003-01-23 Kaneka Corporation Procede de cristallisation d'une coenzyme q10 reduite a partir d'une solution aqueuse
JP2008195650A (ja) 2007-02-13 2008-08-28 Kaneka Corp 還元型補酵素ｑ１０を含有する補酵素ｑ１０粒子の製造方法
WO2012176842A1 (ja) 2011-06-24 2012-12-27 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶
WO2020045571A1 (ja) 2018-08-30 2020-03-05 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
WO2020067275A1 (ja) 2018-09-28 2020-04-02 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
WO2021161807A1 (ja) 2020-02-12 2021-08-19 株式会社カネカ ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3889481B2 (ja) 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
TWI237018B (en) 2001-07-13 2005-08-01 Kaneka Corp Method of producing reduced coenzyme Q10 crystals
JP4170657B2 (ja) 2001-07-13 2008-10-22 株式会社カネカ 還元型補酵素ｑ１０の結晶化法
JP7037531B2 (ja) 2019-10-01 2022-03-16 エスケーシー ソルミックス カンパニー，リミテッド 研磨パッド、その製造方法及びそれを用いた研磨方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006411A1 (fr) 2001-07-13 2003-01-23 Kaneka Corporation Procede de cristallisation d'une coenzyme q10 reduite a partir d'une solution aqueuse
JP2008195650A (ja) 2007-02-13 2008-08-28 Kaneka Corp 還元型補酵素ｑ１０を含有する補酵素ｑ１０粒子の製造方法
WO2012176842A1 (ja) 2011-06-24 2012-12-27 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶
WO2020045571A1 (ja) 2018-08-30 2020-03-05 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
WO2020067275A1 (ja) 2018-09-28 2020-04-02 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
WO2021161807A1 (ja) 2020-02-12 2021-08-19 株式会社カネカ ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶の製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical Engineering Science，2000年，55，p.3759-3770，10.1016/S0009-2509(00)00045-2

Also Published As

Publication number Publication date
US20240166589A1 (en) 2024-05-23
EP4317125A4 (en) 2025-06-11
EP4317125A1 (en) 2024-02-07
JPWO2022202215A1 (https=) 2022-09-29
WO2022202215A1 (ja) 2022-09-29
CN117062795A (zh) 2023-11-14
EP4317125B1 (en) 2026-04-29

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