CN117062795A - FormII型的还原型辅酶Q10结晶或其结晶性固体的制造方法及晶析装置 - Google Patents

FormII型的还原型辅酶Q10结晶或其结晶性固体的制造方法及晶析装置 Download PDF

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Publication number
CN117062795A
CN117062795A CN202280022270.5A CN202280022270A CN117062795A CN 117062795 A CN117062795 A CN 117062795A CN 202280022270 A CN202280022270 A CN 202280022270A CN 117062795 A CN117062795 A CN 117062795A
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CN
China
Prior art keywords
reduced coenzyme
turbidity
crystallization
temperature
ftu
Prior art date
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Pending
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CN202280022270.5A
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English (en)
Chinese (zh)
Inventor
谷崎昂
大野直生
桥本贵识
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Kaneka Corp
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Kaneka Corp
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Publication date
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Publication of CN117062795A publication Critical patent/CN117062795A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0063—Control or regulation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D2009/0086—Processes or apparatus therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202280022270.5A 2021-03-26 2022-03-04 FormII型的还原型辅酶Q10结晶或其结晶性固体的制造方法及晶析装置 Pending CN117062795A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021-053784 2021-03-26
JP2021053784 2021-03-26
PCT/JP2022/009362 WO2022202215A1 (ja) 2021-03-26 2022-03-04 ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法及び晶析装置

Publications (1)

Publication Number Publication Date
CN117062795A true CN117062795A (zh) 2023-11-14

Family

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Family Applications (1)

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CN202280022270.5A Pending CN117062795A (zh) 2021-03-26 2022-03-04 FormII型的还原型辅酶Q10结晶或其结晶性固体的制造方法及晶析装置

Country Status (5)

Country Link
US (1) US20240166589A1 (https=)
EP (1) EP4317125B1 (https=)
JP (1) JP7739411B2 (https=)
CN (1) CN117062795A (https=)
WO (1) WO2022202215A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120858083A (zh) 2023-03-30 2025-10-28 株式会社钟化 还原型辅酶q10结晶及制剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103635452A (zh) * 2011-06-24 2014-03-12 株式会社钟化 稳定性优良的还原型辅酶q10晶体
WO2020045571A1 (ja) * 2018-08-30 2020-03-05 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
WO2020067275A1 (ja) * 2018-09-28 2020-04-02 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3889481B2 (ja) 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
ATE485255T1 (de) * 2001-07-13 2010-11-15 Kaneka Corp Verfahren zum kristallisieren von reduziertem coenzym q10 aus wässriger lösung
TWI237018B (en) 2001-07-13 2005-08-01 Kaneka Corp Method of producing reduced coenzyme Q10 crystals
JP4170657B2 (ja) 2001-07-13 2008-10-22 株式会社カネカ 還元型補酵素ｑ１０の結晶化法
JP5159117B2 (ja) * 2007-02-13 2013-03-06 株式会社カネカ 還元型補酵素ｑ１０を含有する補酵素ｑ１０粒子の製造方法
JP7037531B2 (ja) 2019-10-01 2022-03-16 エスケーシー ソルミックス カンパニー，リミテッド 研磨パッド、その製造方法及びそれを用いた研磨方法
CN115087631B (zh) * 2020-02-12 2024-05-14 株式会社钟化 FormII型的还原型辅酶Q10结晶的制造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103635452A (zh) * 2011-06-24 2014-03-12 株式会社钟化 稳定性优良的还原型辅酶q10晶体
WO2020045571A1 (ja) * 2018-08-30 2020-03-05 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
WO2020067275A1 (ja) * 2018-09-28 2020-04-02 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
M. MOSCOSA-SANTILLAH: "Study of batch crystallization and determination of an alternative temperature-time pro"le by on-line turbidity analysis application to glycine crystallization", CHEMICAL ENGINEERING SCIENCE, vol. 55, no. 18, 15 September 2000 (2000-09-15), pages 3759 - 3770 *
丁绪淮，谈遒编著: "工业结晶", 31 October 1985, 北京：化学工业出版社, pages: 134 - 137 *
作 者 ：（苏）切彼列韦茨基，М.Л，勃鲁茨库斯，Е.В.著；成都工学院化工系无机物工学教研组译: "过磷酸钙生产的物理化学原理", 31 October 1960, 北京：化学工业出版社, pages: 77 - 81 *
熊道陵，陈玉娟，王庚亮编著,: "洗油分离精制应用技术", 31 October 2013, 北京：冶金工业出版社, pages: 146 - 149 *

Also Published As

Publication number Publication date
US20240166589A1 (en) 2024-05-23
JPWO2022202215A1 (https=) 2022-09-29
WO2022202215A1 (ja) 2022-09-29
EP4317125A4 (en) 2025-06-11
EP4317125B1 (en) 2026-04-29
EP4317125A1 (en) 2024-02-07
JP7739411B2 (ja) 2025-09-16

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