JP7684906B2 - ニコチンアミドリボシドを産生する乳酸菌、並びにニコチンアミドモノヌクレオチド及びニコチンアミドリボシドを産生する乳酸菌 - Google Patents

ニコチンアミドリボシドを産生する乳酸菌、並びにニコチンアミドモノヌクレオチド及びニコチンアミドリボシドを産生する乳酸菌 Download PDF

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JP7684906B2
JP7684906B2 JP2021551670A JP2021551670A JP7684906B2 JP 7684906 B2 JP7684906 B2 JP 7684906B2 JP 2021551670 A JP2021551670 A JP 2021551670A JP 2021551670 A JP2021551670 A JP 2021551670A JP 7684906 B2 JP7684906 B2 JP 7684906B2
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fructobacillus
strain
nicotinamide
nicotinamide riboside
lactic acid
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JPWO2021070829A1 (https=
Inventor
信行 吉田
孝治 西川
秀聡 井戸垣
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Shizuoka University NUC
Osaka Soda Co Ltd
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Shizuoka University NUC
Osaka Soda Co Ltd
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N1/205—Bacterial isolates
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
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    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
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    • C12R2001/00—Microorganisms ; Processes using microorganisms
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  • General Health & Medical Sciences (AREA)
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  • Birds (AREA)
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  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2021551670A 2019-10-11 2020-10-06 ニコチンアミドリボシドを産生する乳酸菌、並びにニコチンアミドモノヌクレオチド及びニコチンアミドリボシドを産生する乳酸菌 Active JP7684906B2 (ja)

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JP2025021095A JP2025072615A (ja) 2019-10-11 2025-02-12 ニコチンアミドリボシドを産生する乳酸菌、並びにニコチンアミドモノヌクレオチド及びニコチンアミドリボシドを産生する乳酸菌

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JP2019187501 2019-10-11
JP2019187501 2019-10-11
PCT/JP2020/037902 WO2021070829A1 (ja) 2019-10-11 2020-10-06 ニコチンアミドリボシドを産生する乳酸菌、並びにニコチンアミドモノヌクレオチド及びニコチンアミドリボシドを産生する乳酸菌

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JP2025021095A Pending JP2025072615A (ja) 2019-10-11 2025-02-12 ニコチンアミドリボシドを産生する乳酸菌、並びにニコチンアミドモノヌクレオチド及びニコチンアミドリボシドを産生する乳酸菌

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US (2) US20220340945A1 (https=)
EP (1) EP4059571A4 (https=)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230124883A (ko) * 2020-12-25 2023-08-28 가부시키가이샤 오사카소다 니코틴아미드 모노뉴클레오티드의 제조 방법
TW202317146A (zh) * 2021-07-07 2023-05-01 日商明治控股股份有限公司 口腔環境改善用組合物
CN113736714A (zh) * 2021-10-20 2021-12-03 福建君生益本色生物科技有限公司 嗜酸乳杆菌及其应用
JP7111878B1 (ja) 2021-10-27 2022-08-02 旭化成ファーマ株式会社 ニコチンアミドモノヌクレオチドの製造方法
CN118647360A (zh) * 2021-12-09 2024-09-13 国立大学法人九州大学 胶原蛋白产生促进剂、透明质酸产生促进剂和表皮角质形成细胞活化剂
WO2023175655A1 (ja) * 2022-03-14 2023-09-21 ミライラボバイオサイエンス株式会社 口腔疾患用剤
WO2024048593A1 (ja) * 2022-08-30 2024-03-07 明治ホールディングス株式会社 ニコチンアミドモノヌクレオチド産生向上のための組成物
KR102850602B1 (ko) 2023-01-19 2025-08-26 재단법인 대구경북첨단의료산업진흥재단 골 질환 예방 또는 치료를 위한 신규 유산균 및 이의 배양액
JP2024121821A (ja) * 2023-02-27 2024-09-06 学校法人神戸薬科大学 抗肥満剤、筋力向上剤、脂肪性肝炎改善剤、及び脂質代謝改善剤
JP7799975B2 (ja) * 2023-03-29 2026-01-16 株式会社大阪ソーダ 皮膚バリヤ機能改善剤、及び肌状態改善剤
WO2024225438A1 (ja) 2023-04-28 2024-10-31 明治ホールディングス株式会社 ヨーグルトの製造方法
KR20250156217A (ko) * 2024-04-23 2025-11-03 주식회사 베메스 프럭토바실러스 프럭토서스 prc-1 배양액을 포함하는 항산화, 상처치료, 피부미백 또는 주름개선용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019501638A (ja) 2015-11-13 2019-01-24 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ニコチンアミドリボシドの微生物生産
JP2019513385A (ja) 2016-04-14 2019-05-30 クロマデックス, インコーポレイテッドChromaDex, Inc. ニコチンアミドリボシド、ニコチン酸リボシド、ニコチンアミドモノヌクレオチド、およびニコチノイル化合物誘導体の、乳児用粉ミルクへの使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114626B2 (en) * 2004-02-10 2012-02-14 Trustees Of Dartmouth College Yeast strain and method for using the same to produce nicotinamide riboside
WO2010070836A1 (ja) * 2008-12-18 2010-06-24 メルシャン株式会社 清涼飲料、ぶどう果皮抽出液及びそれらの製造方法
KR101701076B1 (ko) 2012-10-12 2017-01-31 후지필름 가부시키가이샤 액정 표시 장치
WO2015069860A1 (en) * 2013-11-06 2015-05-14 President And Fellows Of Harvard College Biological production of nad precursors and analogs
JP6674312B2 (ja) 2016-04-27 2020-04-01 株式会社東海理化電機製作所 ゲートウェイ装置
JP6997080B2 (ja) 2016-05-19 2022-02-03 三菱商事ライフサイエンス株式会社 β－ＮＭＮ高含有酵母エキス
WO2018034047A1 (ja) * 2016-08-16 2018-02-22 株式会社ゲノム創薬研究所 乳酸菌、該乳酸菌由来の血糖低下剤、糖尿病治療薬、及び飲食品
DE102017103850A1 (de) * 2016-08-24 2018-03-01 Georg Fritzmeier Gmbh & Co. Kg Hautpflegezusammensetzung
CN106755209B (zh) * 2016-12-29 2021-07-23 苏州汉酶生物技术有限公司 一种酶法制备β-烟酰胺单核苷酸的方法
AU2018281511B2 (en) * 2017-06-09 2020-04-16 Sone Farm Co., Ltd. Novel lactic acid bacteria and use thereof
CN107955791B (zh) * 2017-11-20 2021-01-15 江苏美科生物科技有限公司 一种可一步催化得烟酰胺腺嘌呤二核苷酸的菌种及其筛选方法和应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019501638A (ja) 2015-11-13 2019-01-24 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ニコチンアミドリボシドの微生物生産
JP2019513385A (ja) 2016-04-14 2019-05-30 クロマデックス, インコーポレイテッドChromaDex, Inc. ニコチンアミドリボシド、ニコチン酸リボシド、ニコチンアミドモノヌクレオチド、およびニコチノイル化合物誘導体の、乳児用粉ミルクへの使用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Biochem. Biophys. Res. Commun.，1967年，Vol.29, No. 5，p. 635-641
PLOS ONE，2016年，Vol. 11 No. 7: e0159466，p. 1-20
児玉礼次郎，乳酸菌の栄養に関する研究（第1報）乳酸菌の1株No. 353の栄養について（その1），日本農芸化学会誌，1956年，第30巻, 第4号，p. 219-224
児玉礼次郎，乳酸菌の栄養に関する研究（第4報）乳酸菌の一新種Lactobacillus fructosus nov. sp.について，日本農芸化学会誌，1956年，第30巻, 第11号，p. 705-708
浅沼開他，Fructobacillus属乳酸菌の特徴と糖代謝，日本農芸化学会大会講演要旨集，2014年，2A09a05

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