JP7602322B2 - 進行型の多発性硬化症を治療するためのグラチラマーデポシステム - Google Patents

進行型の多発性硬化症を治療するためのグラチラマーデポシステム Download PDF

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JP7602322B2
JP7602322B2 JP2019546249A JP2019546249A JP7602322B2 JP 7602322 B2 JP7602322 B2 JP 7602322B2 JP 2019546249 A JP2019546249 A JP 2019546249A JP 2019546249 A JP2019546249 A JP 2019546249A JP 7602322 B2 JP7602322 B2 JP 7602322B2
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depot formulation
certain embodiments
patient
baseline
depot
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JP2020515530A (ja
JP2020515530A5 (enExample
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ダノン，ウリ
キメルマン，ナダヴ ブライヒ
ポッパー，ローラ
マロム，エフド
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マピ ファーマ リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2019546249A 2017-03-26 2018-03-25 進行型の多発性硬化症を治療するためのグラチラマーデポシステム Active JP7602322B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022188123A JP2023022174A (ja) 2017-03-26 2022-11-25 進行型の多発性硬化症を治療するためのグラチラマーデポシステム
JP2024128104A JP7802122B2 (ja) 2017-03-26 2024-08-02 進行型の多発性硬化症を治療するためのグラチラマーデポシステム

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US201762476794P 2017-03-26 2017-03-26
US62/476,794 2017-03-26
PCT/IL2018/050340 WO2018178973A1 (en) 2017-03-26 2018-03-25 Glatiramer depot systems for treating progressive forms of multiple sclerosis

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JP2020515530A JP2020515530A (ja) 2020-05-28
JP2020515530A5 JP2020515530A5 (enExample) 2021-05-06
JP7602322B2 true JP7602322B2 (ja) 2024-12-18

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JP2019546249A Active JP7602322B2 (ja) 2017-03-26 2018-03-25 進行型の多発性硬化症を治療するためのグラチラマーデポシステム
JP2022188123A Pending JP2023022174A (ja) 2017-03-26 2022-11-25 進行型の多発性硬化症を治療するためのグラチラマーデポシステム
JP2024128104A Active JP7802122B2 (ja) 2017-03-26 2024-08-02 進行型の多発性硬化症を治療するためのグラチラマーデポシステム

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JP2024128104A Active JP7802122B2 (ja) 2017-03-26 2024-08-02 進行型の多発性硬化症を治療するためのグラチラマーデポシステム

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US (3) US11167003B2 (enExample)
EP (1) EP3600553B1 (enExample)
JP (3) JP7602322B2 (enExample)
CN (1) CN110382052A (enExample)
AU (1) AU2018242998B2 (enExample)
BR (1) BR112019017724A2 (enExample)
CA (1) CA3050086A1 (enExample)
IL (2) IL316573A (enExample)
MX (1) MX2019010174A (enExample)
WO (1) WO2018178973A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024153882A (ja) * 2017-03-26 2024-10-29 マピ ファーマ リミテッド 進行型の多発性硬化症を治療するためのグラチラマーデポシステム

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
USRE49251E1 (en) * 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
US11471421B2 (en) 2016-08-28 2022-10-18 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN109982712A (zh) 2016-08-31 2019-07-05 Mapi医药公司 包含醋酸格拉替雷的储库系统
AU2021227674A1 (en) * 2020-02-28 2022-07-21 F. Hoffmann-La Roche Ag Methods of treating Primary Progressive Multiple Sclerosis using an inhibitor of Bruton's tyrosine kinase
WO2025150035A1 (en) * 2024-01-11 2025-07-17 Mapi Pharma Ltd. Treatment of primary progressive multiple sclerosis

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