JP7579840B2 - ヘテロタンデム二環式ペプチド複合体 - Google Patents

ヘテロタンデム二環式ペプチド複合体 Download PDF

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Publication number
JP7579840B2
JP7579840B2 JP2022506048A JP2022506048A JP7579840B2 JP 7579840 B2 JP7579840 B2 JP 7579840B2 JP 2022506048 A JP2022506048 A JP 2022506048A JP 2022506048 A JP2022506048 A JP 2022506048A JP 7579840 B2 JP7579840 B2 JP 7579840B2
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bcy11863
acid
nectin
pharma
acceptable salt
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JP2022544058A5 (enExample
JP2022544058A (ja
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マクドネル ケビン
ウパディヤヤ プニット
ラーデンランタ ジョハンナ
マッド ジェマ
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BicycleTx Ltd
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BicycleTx Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/641—Branched, dendritic or hypercomb peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2022506048A 2019-07-30 2020-07-30 ヘテロタンデム二環式ペプチド複合体 Active JP7579840B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962880191P 2019-07-30 2019-07-30
US62/880,191 2019-07-30
US201962910088P 2019-10-03 2019-10-03
US62/910,088 2019-10-03
US201962931442P 2019-11-06 2019-11-06
US62/931,442 2019-11-06
US202063022667P 2020-05-11 2020-05-11
US63/022,667 2020-05-11
US202063024715P 2020-05-14 2020-05-14
US63/024,715 2020-05-14
PCT/GB2020/051828 WO2021019244A1 (en) 2019-07-30 2020-07-30 Heterotandem bicyclic peptide complex

Publications (3)

Publication Number Publication Date
JP2022544058A JP2022544058A (ja) 2022-10-17
JP2022544058A5 JP2022544058A5 (enExample) 2023-08-07
JP7579840B2 true JP7579840B2 (ja) 2024-11-08

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JP2022506048A Active JP7579840B2 (ja) 2019-07-30 2020-07-30 ヘテロタンデム二環式ペプチド複合体
JP2022505581A Active JP7682852B2 (ja) 2019-07-30 2020-07-30 ＥｐｈＡ２に特異的な二環式ペプチドリガンド
JP2022506077A Active JP7620002B2 (ja) 2019-07-30 2020-07-30 ヘテロタンデム二環式ペプチド複合体
JP2022505570A Active JP7704732B2 (ja) 2019-07-30 2020-07-30 ヘテロタンデム二環式ペプチド複合体
JP2025080947A Pending JP2025122030A (ja) 2019-07-30 2025-05-14 ＥｐｈＡ２に特異的な二環式ペプチドリガンド

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JP2022505581A Active JP7682852B2 (ja) 2019-07-30 2020-07-30 ＥｐｈＡ２に特異的な二環式ペプチドリガンド
JP2022506077A Active JP7620002B2 (ja) 2019-07-30 2020-07-30 ヘテロタンデム二環式ペプチド複合体
JP2022505570A Active JP7704732B2 (ja) 2019-07-30 2020-07-30 ヘテロタンデム二環式ペプチド複合体
JP2025080947A Pending JP2025122030A (ja) 2019-07-30 2025-05-14 ＥｐｈＡ２に特異的な二環式ペプチドリガンド

Country Status (15)

Country Link
US (7) US11312749B2 (enExample)
EP (4) EP4003530A1 (enExample)
JP (5) JP7579840B2 (enExample)
KR (3) KR20220051345A (enExample)
CN (4) CN114555626B (enExample)
AU (3) AU2020322193B2 (enExample)
BR (3) BR112022001532A2 (enExample)
CA (3) CA3148033A1 (enExample)
IL (3) IL290093A (enExample)
MX (3) MX2022001273A (enExample)
MY (2) MY208496A (enExample)
PH (2) PH12022550171A1 (enExample)
SA (2) SA522431587B1 (enExample)
TW (2) TWI860386B (enExample)
WO (4) WO2021019243A1 (enExample)

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CN107148425B (zh) 2014-10-29 2021-08-03 拜斯科阿迪有限公司 对mt1-mmp特异性的双环肽配体
EP3645549A1 (en) 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
CN111902429A (zh) 2018-02-23 2020-11-06 拜斯科技术开发有限公司 多聚体双环肽配体
EP3774851A1 (en) 2018-04-04 2021-02-17 BicycleTX Limited Heterotandem bicyclic peptide complexes
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
US12492224B2 (en) 2018-12-21 2025-12-09 Bicycletx Limited Bicyclic peptide ligands specific for PD-L1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
WO2020225577A1 (en) 2019-05-09 2020-11-12 Bicycletx Limited Bicyclic peptide ligands specific for ox40
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
SMT202500247T1 (it) * 2019-10-03 2025-09-12 Bicycletx Ltd Complessi peptidici eterotandem biciclici
AU2021322934A1 (en) 2020-08-03 2023-03-30 Bicycletx Limited Peptide-based linkers
CA3186504A1 (en) 2020-08-17 2022-02-24 Stephen J. Blakemore Bicycle conjugates specific for nectin-4 and uses thereof
US20250186539A2 (en) * 2021-01-11 2025-06-12 Bicycletx Limited Methods for treating cancer
AU2022328932B2 (en) * 2021-08-17 2026-02-19 Tianjin Conjustar Biologics Co., Ltd. Polypeptide drug conjugate having novel structure and application thereof
MX2024003876A (es) * 2021-09-29 2024-04-19 Conjustar Zhuhai Biologics Co Ltd Conjugado farmaco-polipeptido triciclico y sus aplicaciones.
KR20240100420A (ko) * 2021-11-16 2024-07-01 바이사이클티엑스 리미티드 암을 치료하기 위한 방법
CN116768978A (zh) * 2022-03-11 2023-09-19 上海智肽生物科技有限公司 Nectin-4靶向肽化合物及其药物偶联物
CN121419788A (zh) * 2023-05-04 2026-01-27 坦博公司 用于体内递送有效载荷的基于四嗪的靶向剂
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