JP7525093B2 - 改変ｈ因子結合タンパク質 - Google Patents
改変ｈ因子結合タンパク質 Download PDFInfo
- Publication number
- JP7525093B2 JP7525093B2 JP2019511993A JP2019511993A JP7525093B2 JP 7525093 B2 JP7525093 B2 JP 7525093B2 JP 2019511993 A JP2019511993 A JP 2019511993A JP 2019511993 A JP2019511993 A JP 2019511993A JP 7525093 B2 JP7525093 B2 JP 7525093B2
- Authority
- JP
- Japan
- Prior art keywords
- fhbp
- pora
- modified
- loop
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1614687.0 | 2016-08-31 | ||
| GBGB1614687.0A GB201614687D0 (en) | 2016-08-31 | 2016-08-31 | fHbp scaffold |
| PCT/GB2017/052535 WO2018042178A1 (en) | 2016-08-31 | 2017-08-31 | Modified factor h binding protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526261A JP2019526261A (ja) | 2019-09-19 |
| JP2019526261A5 JP2019526261A5 (enExample) | 2020-10-08 |
| JP7525093B2 true JP7525093B2 (ja) | 2024-07-30 |
Family
ID=57119942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511993A Active JP7525093B2 (ja) | 2016-08-31 | 2017-08-31 | 改変ｈ因子結合タンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12497432B2 (enExample) |
| EP (1) | EP3506934A1 (enExample) |
| JP (1) | JP7525093B2 (enExample) |
| KR (1) | KR102643280B1 (enExample) |
| CN (1) | CN109890412B (enExample) |
| AU (1) | AU2017319218B2 (enExample) |
| BR (1) | BR112019003957A2 (enExample) |
| CA (1) | CA3035159A1 (enExample) |
| GB (2) | GB201614687D0 (enExample) |
| IL (1) | IL265078B2 (enExample) |
| MX (1) | MX420767B (enExample) |
| WO (1) | WO2018042178A1 (enExample) |
| ZA (1) | ZA201901862B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| CN110903400A (zh) * | 2019-11-08 | 2020-03-24 | 苏州微超生物科技有限公司 | B群脑膜炎球菌fHBP多变体融合蛋白及其制备方法与应用 |
| CN111533792B (zh) | 2020-07-07 | 2020-10-16 | 康希诺生物股份公司 | 一种定点突变的载体蛋白及其在制备疫苗中的用途 |
| WO2022071291A1 (ja) * | 2020-09-29 | 2022-04-07 | 出光興産株式会社 | ペプチドタグおよびそれを含むタグ付加タンパク質 |
| IN202321021121A (enExample) * | 2023-03-24 | 2024-04-19 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009517377A (ja) | 2005-11-25 | 2009-04-30 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 髄膜炎菌のｎｍｂ１８７０のキメラ、ハイブリッドおよびタンデムポリペプチド |
| JP2013537884A (ja) | 2010-09-10 | 2013-10-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 髄膜炎菌に対するワクチン |
| WO2016083583A1 (en) | 2014-11-28 | 2016-06-02 | Crucell Holland B.V. | Meningitis b vaccine |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| US7785608B2 (en) * | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| HUE031886T2 (en) * | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| AU2003300841B2 (en) * | 2002-12-10 | 2008-03-20 | Lorantis Ltd. | Stabilized immunogenic HBc chimer particles |
| EP2172213B1 (en) * | 2003-01-30 | 2013-04-03 | Novartis AG | Injectable vaccines against multiple meningococcal serogroups |
| NZ546430A (en) * | 2003-10-02 | 2009-04-30 | Novartis Vaccines & Diagnostic | Liquid vaccines for multiple meningococcal serogroups |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB2414667A (en) * | 2004-06-03 | 2005-12-07 | Isis Innovation | Vaccine compositions of N. meningitidis PorA and FetA antigens |
| CA2574375C (en) * | 2004-07-23 | 2015-03-17 | Chiron Srl | Polypeptides for oligomeric assembly of antigens |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| WO2006081259A2 (en) * | 2005-01-27 | 2006-08-03 | Children's Hospital & Research Center At Oakland | Gna1870-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| EP1925318A1 (en) * | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu |
| CN102356089B (zh) * | 2008-02-21 | 2014-02-19 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽 |
| AU2009223613B2 (en) * | 2008-03-10 | 2014-09-25 | Children's Hospital & Research Center At Oakland | Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use |
| UA99659C2 (uk) * | 2008-05-30 | 2012-09-10 | Дзе Ю.Ес.Ей., Ес Репрезентед Бай Дзе Секретарі Оф Дзе Армі, Он Бехаф Оф Уолтер Рід Армі | Мультивалентна вакцина з нативних везикул зовнішньої мембрани менінгококів, способи її застосування |
| EP2294085A1 (en) * | 2008-06-09 | 2011-03-16 | Novartis AG | Antibodies against neisserial factor h binding protein |
| EP2331562A4 (en) * | 2008-09-03 | 2012-07-04 | Childrens Hosp & Res Ct Oak | PEPTIDES WITH AN EPITOPE OF A DOMAIN OF THE FACTOR H-BINDING PROTEIN AND METHOD OF USE |
| GB0819633D0 (en) * | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
| EP2411048B1 (en) * | 2009-03-24 | 2020-05-06 | GlaxoSmithKline Biologicals SA | Adjuvanting meningococcal factor h binding protein |
| CA2759400A1 (en) * | 2009-04-30 | 2010-11-04 | Children's Hospital & Research Center At Oakland | Chimeric factor h binding proteins (fhbp) and methods of use |
| CN102596240B (zh) * | 2009-08-27 | 2015-02-04 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
| CA2779816A1 (en) * | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| CA2792687A1 (en) * | 2010-03-10 | 2011-09-15 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| TR201802933T4 (tr) * | 2010-03-30 | 2018-03-21 | Childrens Hospital & Res Center At Oakland | Özellikleri değiştirilmiş faktör h bağlama proteinleri (fhbp) ve bunların kullanım yöntemi. |
| WO2011125015A2 (en) * | 2010-04-05 | 2011-10-13 | Bar-Ilan University | Protease-activatable pore-forming polypeptides |
| AU2011268507B2 (en) * | 2010-06-25 | 2014-08-14 | Novartis Ag | Combinations of meningococcal factor H binding proteins |
| AU2011300409B2 (en) * | 2010-09-10 | 2015-03-26 | Wyeth Llc | Non-lipidated variants of Neisseria meningitidis ORF2086 antigens |
| WO2013078223A1 (en) * | 2011-11-23 | 2013-05-30 | Children's Hospital & Research Center Oakland | Anti-factor h binding protein antibodies and methods of use thereof |
| JP2015505309A (ja) * | 2011-12-29 | 2015-02-19 | ノバルティス アーゲー | 髄膜炎菌ｈ因子結合タンパク質のアジュバントされた組み合わせ |
| US10598666B2 (en) * | 2012-03-08 | 2020-03-24 | Glaxosmithkline Biologicals Sa | In vitro potency assay for protein-based meningococcal vaccines |
| SA115360586B1 (ar) * | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| MY198910A (en) * | 2012-03-09 | 2023-10-02 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| AU2013276083B2 (en) * | 2012-06-14 | 2018-04-05 | Institut Pasteur | Vaccines for serogroup X meningococcus |
| GB201215005D0 (en) * | 2012-08-23 | 2012-10-10 | Isis Innovation | Stabilised meningitis vaccine |
| WO2014136064A2 (en) * | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| WO2014140562A1 (en) * | 2013-03-14 | 2014-09-18 | Isis Innovation Limited | Immunogenic composition to neisseria |
| RU2662968C2 (ru) * | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| KR20160127104A (ko) * | 2014-02-28 | 2016-11-02 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 변형된 수막구균 fhbp 폴리펩티드 |
| KR102761870B1 (ko) * | 2014-07-23 | 2025-02-05 | 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 | 인자 h 결합 단백질 변이체 및 이의 사용 방법 |
| WO2016132294A1 (en) * | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| AU2018215585B2 (en) * | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009517377A (ja) | 2005-11-25 | 2009-04-30 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 髄膜炎菌のｎｍｂ１８７０のキメラ、ハイブリッドおよびタンデムポリペプチド |
| JP2013537884A (ja) | 2010-09-10 | 2013-10-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 髄膜炎菌に対するワクチン |
| WO2016083583A1 (en) | 2014-11-28 | 2016-06-02 | Crucell Holland B.V. | Meningitis b vaccine |
Non-Patent Citations (1)
| Title |
|---|
| ＰＬＯＳ Ｐａｔｈｏｇｅｎｓ，Ｖｏｌ．８，Ｉｓｓｕｅ１０，ｅ１０００２９８１ |
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| ZA201901862B (en) | 2020-09-30 |
| KR102643280B1 (ko) | 2024-03-05 |
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| CN109890412A (zh) | 2019-06-14 |
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| GB201903866D0 (en) | 2019-05-08 |
| AU2017319218A1 (en) | 2019-04-18 |
| US12497432B2 (en) | 2025-12-16 |
| CA3035159A1 (en) | 2018-03-08 |
| AU2017319218A2 (en) | 2019-05-02 |
| IL265078A (enExample) | 2019-04-30 |
| IL265078B1 (en) | 2023-04-01 |
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