CN109890412B - 修饰的因子h结合蛋白 - Google Patents

修饰的因子h结合蛋白 Download PDF

Info

Publication number
CN109890412B
CN109890412B CN201780060701.6A CN201780060701A CN109890412B CN 109890412 B CN109890412 B CN 109890412B CN 201780060701 A CN201780060701 A CN 201780060701A CN 109890412 B CN109890412 B CN 109890412B
Authority
CN
China
Prior art keywords
gly
ala
lys
leu
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780060701.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN109890412A (zh
Inventor
C·M·唐
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of CN109890412A publication Critical patent/CN109890412A/zh
Application granted granted Critical
Publication of CN109890412B publication Critical patent/CN109890412B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN201780060701.6A 2016-08-31 2017-08-31 修饰的因子h结合蛋白 Active CN109890412B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1614687.0 2016-08-31
GBGB1614687.0A GB201614687D0 (en) 2016-08-31 2016-08-31 fHbp scaffold
PCT/GB2017/052535 WO2018042178A1 (en) 2016-08-31 2017-08-31 Modified factor h binding protein

Publications (2)

Publication Number Publication Date
CN109890412A CN109890412A (zh) 2019-06-14
CN109890412B true CN109890412B (zh) 2025-04-04

Family

ID=57119942

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780060701.6A Active CN109890412B (zh) 2016-08-31 2017-08-31 修饰的因子h结合蛋白

Country Status (12)

Country Link
EP (1) EP3506934A1 (enExample)
JP (1) JP7525093B2 (enExample)
KR (1) KR102643280B1 (enExample)
CN (1) CN109890412B (enExample)
AU (1) AU2017319218B2 (enExample)
BR (1) BR112019003957A2 (enExample)
CA (1) CA3035159A1 (enExample)
GB (2) GB201614687D0 (enExample)
IL (1) IL265078B2 (enExample)
MX (1) MX2019002248A (enExample)
WO (1) WO2018042178A1 (enExample)
ZA (1) ZA201901862B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110903400A (zh) * 2019-11-08 2020-03-24 苏州微超生物科技有限公司 B群脑膜炎球菌fHBP多变体融合蛋白及其制备方法与应用
CN111533792B (zh) 2020-07-07 2020-10-16 康希诺生物股份公司 一种定点突变的载体蛋白及其在制备疫苗中的用途
CN116323680A (zh) * 2020-09-29 2023-06-23 出光兴产株式会社 肽标签和包含其的附加有标签的蛋白
IN202321021121A (enExample) * 2023-03-24 2024-04-19

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006024954A2 (en) * 2004-09-01 2006-03-09 Novartis Vaccines And Diagnostics Srl Domains and epitopes of meningococcal protein nmb1870
CN101356274A (zh) * 2005-11-25 2009-01-28 诺华疫苗和诊断有限公司 脑膜炎球菌nmb1870的嵌合型、杂交和串联多肽
WO2009114485A2 (en) * 2008-03-10 2009-09-17 Children's Hospital & Research Center At Oakland Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use
WO2016083583A1 (en) * 2014-11-28 2016-06-02 Crucell Holland B.V. Meningitis b vaccine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012004275A2 (pt) * 2009-08-27 2016-11-16 Novartis Ag polipeptídios híbridos incluindo sequências meningocócicas de fhbp
GB201015132D0 (en) * 2010-09-10 2010-10-27 Univ Bristol Vaccine composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006024954A2 (en) * 2004-09-01 2006-03-09 Novartis Vaccines And Diagnostics Srl Domains and epitopes of meningococcal protein nmb1870
CN101356274A (zh) * 2005-11-25 2009-01-28 诺华疫苗和诊断有限公司 脑膜炎球菌nmb1870的嵌合型、杂交和串联多肽
WO2009114485A2 (en) * 2008-03-10 2009-09-17 Children's Hospital & Research Center At Oakland Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use
WO2016083583A1 (en) * 2014-11-28 2016-06-02 Crucell Holland B.V. Meningitis b vaccine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Molecular Engineering of Ghfp, the Gonococcal Orthologue of Neisseria meningitidis Factor H Binding Protein;Valentina Rippa等;《Clinical and vaccine immunology》;20150623;第22卷(第7期);第769页摘要-第772页右栏倒数2段、图3、图5 *

Also Published As

Publication number Publication date
IL265078A (enExample) 2019-04-30
IL265078B1 (en) 2023-04-01
GB2568440B (en) 2022-08-17
NZ751995A (en) 2024-03-22
BR112019003957A2 (pt) 2019-06-25
CN109890412A (zh) 2019-06-14
ZA201901862B (en) 2020-09-30
WO2018042178A1 (en) 2018-03-08
MX2019002248A (es) 2019-09-18
AU2017319218A1 (en) 2019-04-18
CA3035159A1 (en) 2018-03-08
GB201903866D0 (en) 2019-05-08
IL265078B2 (en) 2023-08-01
US20220112249A1 (en) 2022-04-14
EP3506934A1 (en) 2019-07-10
JP7525093B2 (ja) 2024-07-30
AU2017319218A2 (en) 2019-05-02
GB201614687D0 (en) 2016-10-12
AU2017319218B2 (en) 2021-10-28
KR102643280B1 (ko) 2024-03-05
GB2568440A (en) 2019-05-15
KR20190064577A (ko) 2019-06-10
JP2019526261A (ja) 2019-09-19

Similar Documents

Publication Publication Date Title
JP5676458B2 (ja) 変異ｈ因子結合タンパク質を含むワクチン組成物
JP7271654B2 (ja) 改変された髄膜炎菌ｆＨｂｐポリペプチド
US20250170232A1 (en) Vaccines for Neisseria Gonorrhoeae
AU2013276083B2 (en) Vaccines for serogroup X meningococcus
CN109890412B (zh) 修饰的因子h结合蛋白
van der Voort et al. Human B-and T-cell responses after immunization with a hexavalent PorA meningococcal outer membrane vesicle vaccine
Perrett et al. Towards an improved serogroup B Neisseria meningitidis vaccine
US12497432B2 (en) Modified factor H binding protein
RU2773464C1 (ru) Модифицированный белок, связывающий фактор н
OA19655A (en) Modified factor H binding protein.
JP2025518168A (ja) 免疫原性組成物
EA046480B1 (ru) МОДИФИЦИРОВАННЫЕ ПОЛИПЕПТИДЫ МЕНИНГОКОККОВОГО fHbp
CN101389643A (zh) 糖模拟肽及其在药物制剂中的用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant