CA3035159A1 - Modified factor h binding protein - Google Patents
Modified factor h binding protein Download PDFInfo
- Publication number
- CA3035159A1 CA3035159A1 CA3035159A CA3035159A CA3035159A1 CA 3035159 A1 CA3035159 A1 CA 3035159A1 CA 3035159 A CA3035159 A CA 3035159A CA 3035159 A CA3035159 A CA 3035159A CA 3035159 A1 CA3035159 A1 CA 3035159A1
- Authority
- CA
- Canada
- Prior art keywords
- fhbp
- modified
- pora
- exogenous peptide
- loop
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710186862 Factor H binding protein Proteins 0.000 title claims abstract description 65
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 150
- 239000000203 mixture Substances 0.000 claims abstract description 33
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 19
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 19
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 19
- 208000015181 infectious disease Diseases 0.000 claims abstract description 12
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 9
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- 238000011282 treatment Methods 0.000 claims abstract description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 58
- 102000004169 proteins and genes Human genes 0.000 claims description 57
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- 239000000427 antigen Substances 0.000 claims description 39
- 102000036639 antigens Human genes 0.000 claims description 39
- 108091007433 antigens Proteins 0.000 claims description 39
- 229960005486 vaccine Drugs 0.000 claims description 33
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- 230000027455 binding Effects 0.000 claims description 15
- 108010060123 Conjugate Vaccines Proteins 0.000 claims description 10
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- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
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- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 206010027202 Meningitis bacterial Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
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- 108700026633 Neisseria meningitidis factor H-binding Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 101150093941 PORA gene Proteins 0.000 description 1
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- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
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- JJZAZDAEVNRFGT-MHLYXQECSA-N furaquinocin I Natural products COC1=C(C)C(=O)c2c3O[C@H](C)[C@](C)([C@H](O)CC=C(/C)C(=O)O)c3c(O)cc2C1=O JJZAZDAEVNRFGT-MHLYXQECSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1614687.0 | 2016-08-31 | ||
| GBGB1614687.0A GB201614687D0 (en) | 2016-08-31 | 2016-08-31 | fHbp scaffold |
| PCT/GB2017/052535 WO2018042178A1 (en) | 2016-08-31 | 2017-08-31 | Modified factor h binding protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3035159A1 true CA3035159A1 (en) | 2018-03-08 |
Family
ID=57119942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3035159A Pending CA3035159A1 (en) | 2016-08-31 | 2017-08-31 | Modified factor h binding protein |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12497432B2 (enExample) |
| EP (1) | EP3506934A1 (enExample) |
| JP (1) | JP7525093B2 (enExample) |
| KR (1) | KR102643280B1 (enExample) |
| CN (1) | CN109890412B (enExample) |
| AU (1) | AU2017319218B2 (enExample) |
| BR (1) | BR112019003957A2 (enExample) |
| CA (1) | CA3035159A1 (enExample) |
| GB (2) | GB201614687D0 (enExample) |
| IL (1) | IL265078B2 (enExample) |
| MX (1) | MX420767B (enExample) |
| WO (1) | WO2018042178A1 (enExample) |
| ZA (1) | ZA201901862B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| CN110903400A (zh) * | 2019-11-08 | 2020-03-24 | 苏州微超生物科技有限公司 | B群脑膜炎球菌fHBP多变体融合蛋白及其制备方法与应用 |
| CN111533792B (zh) | 2020-07-07 | 2020-10-16 | 康希诺生物股份公司 | 一种定点突变的载体蛋白及其在制备疫苗中的用途 |
| CN116323680A (zh) * | 2020-09-29 | 2023-06-23 | 出光兴产株式会社 | 肽标签和包含其的附加有标签的蛋白 |
| IN202321021121A (enExample) * | 2023-03-24 | 2024-04-19 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| US7785608B2 (en) * | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| NZ562998A (en) * | 2002-10-11 | 2008-05-30 | Novartis Vaccines & Diagnostic | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| WO2004053091A2 (en) * | 2002-12-10 | 2004-06-24 | Lorantis Ltd. | STABILIZED IMMUNOGENIC HBc CHIMER PARTICLES |
| PT2172213E (pt) * | 2003-01-30 | 2013-06-03 | Novartis Ag | Vacinas injetáveis contra múltiplos serogrupos meningocócicos |
| NZ546430A (en) * | 2003-10-02 | 2009-04-30 | Novartis Vaccines & Diagnostic | Liquid vaccines for multiple meningococcal serogroups |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB2414667A (en) * | 2004-06-03 | 2005-12-07 | Isis Innovation | Vaccine compositions of N. meningitidis PorA and FetA antigens |
| WO2006011060A2 (en) * | 2004-07-23 | 2006-02-02 | Chiron Srl | Polypeptides for oligomeric assembly of antigens |
| GB0419408D0 (en) | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| EP2682126B1 (en) * | 2005-01-27 | 2016-11-23 | Children's Hospital & Research Center at Oakland | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| EP1925318A1 (en) * | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu |
| WO2009104097A2 (en) * | 2008-02-21 | 2009-08-27 | Novartis Ag | Meningococcal fhbp polypeptides |
| ES2557282T3 (es) * | 2008-03-10 | 2016-01-25 | Children's Hospital & Research Center At Oakland | Proteínas quiméricas de unión al factor H (fHBP) que contienen un dominio B heterólogo, y métodos de uso |
| RU2477145C2 (ru) * | 2008-05-30 | 2013-03-10 | ДЗЕ Ю.Эс.Эй., ЭС РЕПРЕЗЕНТЕД БАЙ ДЗЕ СЕКРЕТАРИ ОФ ДЗЕ АРМИ, ОН БЕХАФ ОФ УОЛТЕР РИД АРМИ | Мультивалентная вакцина из нативных везикул наружной мембраны менингококков, способы ее получения и применения |
| WO2009150531A1 (en) * | 2008-06-09 | 2009-12-17 | Novartis Ag | Antibodies against neisserial factor h binding protein |
| WO2010028096A2 (en) * | 2008-09-03 | 2010-03-11 | Children's Hospital & Research Center At Oakland | Peptides presenting an epitope of an a domain of factor h binding protein and methods of use |
| GB0819633D0 (en) * | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
| CN104548082A (zh) * | 2009-03-24 | 2015-04-29 | 诺华股份有限公司 | 为脑膜炎球菌因子h结合蛋白添加佐剂 |
| CA2759400A1 (en) * | 2009-04-30 | 2010-11-04 | Children's Hospital & Research Center At Oakland | Chimeric factor h binding proteins (fhbp) and methods of use |
| EP2470204B1 (en) * | 2009-08-27 | 2015-12-16 | GlaxoSmithKline Biologicals SA | Hybrid polypeptides including meningococcal fhbp sequences |
| CA2779816A1 (en) * | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| CN102869378A (zh) * | 2010-03-10 | 2013-01-09 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
| EP4036104B1 (en) * | 2010-03-30 | 2024-02-21 | Children's Hospital & Research Center at Oakland | Factor h binding proteins (fhbp) with altered properties and methods of use thereof |
| EP2556085A2 (en) * | 2010-04-05 | 2013-02-13 | Bar-Ilan University | Protease-activatable pore-forming polypeptides |
| EP2585106A1 (en) * | 2010-06-25 | 2013-05-01 | Novartis AG | Combinations of meningococcal factor h binding proteins |
| MY166172A (en) * | 2010-09-10 | 2018-06-07 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
| WO2013078223A1 (en) * | 2011-11-23 | 2013-05-30 | Children's Hospital & Research Center Oakland | Anti-factor h binding protein antibodies and methods of use thereof |
| JP2015505309A (ja) * | 2011-12-29 | 2015-02-19 | ノバルティス アーゲー | 髄膜炎菌ｈ因子結合タンパク質のアジュバントされた組み合わせ |
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| BR112014031386A2 (pt) * | 2012-06-14 | 2017-08-01 | Pasteur Institut | vacinas para meningococos do sorogrupo x |
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| EA034954B1 (ru) * | 2014-02-28 | 2020-04-10 | Глаксосмитклайн Байолоджикалс Са | МОДИФИЦИРОВАННЫЕ МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHbp |
| EP3172224B1 (en) * | 2014-07-23 | 2022-06-29 | Children's Hospital & Research Center at Oakland | Factor h binding protein variants and methods of use thereof |
| US20170326220A1 (en) | 2014-11-28 | 2017-11-16 | Janssen Vaccines & Prevention B.V. | Meningitis b vaccine |
| KR20170103009A (ko) * | 2015-02-19 | 2017-09-12 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| JP7010961B2 (ja) * | 2017-01-31 | 2022-02-10 | ファイザー・インク | 髄膜炎菌組成物およびその方法 |
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| CN109890412A (zh) | 2019-06-14 |
| US12497432B2 (en) | 2025-12-16 |
| ZA201901862B (en) | 2020-09-30 |
| GB201614687D0 (en) | 2016-10-12 |
| IL265078A (enExample) | 2019-04-30 |
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| EP3506934A1 (en) | 2019-07-10 |
| AU2017319218A2 (en) | 2019-05-02 |
| NZ751995A (en) | 2024-03-22 |
| KR20190064577A (ko) | 2019-06-10 |
| IL265078B2 (en) | 2023-08-01 |
| CN109890412B (zh) | 2025-04-04 |
| GB2568440B (en) | 2022-08-17 |
| GB2568440A (en) | 2019-05-15 |
| AU2017319218B2 (en) | 2021-10-28 |
| KR102643280B1 (ko) | 2024-03-05 |
| WO2018042178A1 (en) | 2018-03-08 |
| JP2019526261A (ja) | 2019-09-19 |
| US20220112249A1 (en) | 2022-04-14 |
| MX2019002248A (es) | 2019-09-18 |
| JP7525093B2 (ja) | 2024-07-30 |
| AU2017319218A1 (en) | 2019-04-18 |
| GB201903866D0 (en) | 2019-05-08 |
| MX420767B (es) | 2025-02-10 |
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