JP7472134B2 - 試料の３次元領域の蛍光信号を検出するための方法および装置 - Google Patents

試料の３次元領域の蛍光信号を検出するための方法および装置 Download PDF

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JP7472134B2
JP7472134B2 JP2021531594A JP2021531594A JP7472134B2 JP 7472134 B2 JP7472134 B2 JP 7472134B2 JP 2021531594 A JP2021531594 A JP 2021531594A JP 2021531594 A JP2021531594 A JP 2021531594A JP 7472134 B2 JP7472134 B2 JP 7472134B2
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カルクブレンナー，トマス
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Carl Zeiss Microscopy GmbH
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/06—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the phase of light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/0075—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 with means for altering, e.g. increasing, the depth of field or depth of focus
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/0006—Arrays
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/12—Fluid-filled or evacuated lenses
    • G02B3/14—Fluid-filled or evacuated lenses of variable focal length
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/30—Polarising elements
    • G02B5/3083—Birefringent or phase retarding elements

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  • General Physics & Mathematics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
JP2021531594A 2018-12-03 2019-12-02 試料の３次元領域の蛍光信号を検出するための方法および装置 Active JP7472134B2 (ja)

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Application Number Priority Date Filing Date Title
DE102018220779.8 2018-12-03
DE102018220779.8A DE102018220779A1 (de) 2018-12-03 2018-12-03 Nachweisverfahren von induzierten Lichtsignalen in einer dreidimensionalen Region einer Probe
PCT/EP2019/083219 WO2020114930A1 (de) 2018-12-03 2019-12-02 Verfahren und vorrichtung zum nachweis von fluoreszenzsignalen in einer dreidimensionalen region einer probe

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JP2022511009A JP2022511009A (ja) 2022-01-28
JPWO2020114930A5 JPWO2020114930A5 (enExample) 2022-12-12
JP7472134B2 true JP7472134B2 (ja) 2024-04-22

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US (1) US20220057329A1 (enExample)
JP (1) JP7472134B2 (enExample)
DE (1) DE102018220779A1 (enExample)
WO (1) WO2020114930A1 (enExample)

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FR3115676B1 (fr) * 2020-10-29 2022-12-16 Keranova Systeme de decoupe d’un tissu oculaire en portions elementaires
CN112584015B (zh) * 2020-12-02 2022-05-17 达闼机器人股份有限公司 物体探测方法、装置、存储介质和电子设备
DE102021123148A1 (de) 2021-09-07 2023-03-09 Carl Zeiss Microscopy Gmbh Verfahren zum auswerten von messdaten eines lichtfeldmikroskops und vorrichtung zur lichtfeldmikroskopie
CN114911036A (zh) * 2022-05-18 2022-08-16 Oppo广东移动通信有限公司 镜头及电子设备
FR3151401A1 (fr) * 2023-07-19 2025-01-24 Universite Grenoble Alpes Dispositif de création d’un champ évanescent

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WO2016152244A1 (ja) 2015-03-25 2016-09-29 コニカミノルタ株式会社 目的生体物質の検出方法および検出システム
JP2017507361A (ja) 2014-02-20 2017-03-16 カール ツァイス マイクロスコピー ゲーエムベーハーＣａｒｌ Ｚｅｉｓｓ Ｍｉｃｒｏｓｃｏｐｙ Ｇｍｂｈ 光シート顕微鏡検査のための方法および装置
US20180149855A1 (en) 2015-04-23 2018-05-31 The University Of British Columbia Multifocal method and apparatus for stabilization of optical systems

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JP2017507361A (ja) 2014-02-20 2017-03-16 カール ツァイス マイクロスコピー ゲーエムベーハーＣａｒｌ Ｚｅｉｓｓ Ｍｉｃｒｏｓｃｏｐｙ Ｇｍｂｈ 光シート顕微鏡検査のための方法および装置
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US20180149855A1 (en) 2015-04-23 2018-05-31 The University Of British Columbia Multifocal method and apparatus for stabilization of optical systems

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WO2020114930A1 (de) 2020-06-11
JP2022511009A (ja) 2022-01-28
DE102018220779A1 (de) 2020-06-04

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