AU2002213157A1 - System and method for high numeric aperture imaging systems - Google Patents

System and method for high numeric aperture imaging systems

Info

Publication number
AU2002213157A1
AU2002213157A1 AU2002213157A AU1315702A AU2002213157A1 AU 2002213157 A1 AU2002213157 A1 AU 2002213157A1 AU 2002213157 A AU2002213157 A AU 2002213157A AU 1315702 A AU1315702 A AU 1315702A AU 2002213157 A1 AU2002213157 A1 AU 2002213157A1
Authority
AU
Australia
Prior art keywords
imaging systems
aperture imaging
numeric aperture
high numeric
systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002213157A
Inventor
David A. Basiji
William E Ortyn
David J. Perry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amnis LLC
Original Assignee
Amnis LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amnis LLC filed Critical Amnis LLC
Publication of AU2002213157A1 publication Critical patent/AU2002213157A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10—Beam splitting or combining systems
    • G02B27/1086—Beam splitting or combining systems operating by diffraction only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/031—Multipass arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/0012—Optical design, e.g. procedures, algorithms, optimisation routines
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10—Beam splitting or combining systems
    • G02B27/12—Beam splitting or combining systems operating by refraction only
    • G02B27/126—The splitting element being a prism or prismatic array, including systems based on total internal reflection
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
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    • G02B27/10—Beam splitting or combining systems
    • G02B27/14—Beam splitting or combining systems operating by reflection only
    • G02B27/144—Beam splitting or combining systems operating by reflection only using partially transparent surfaces without spectral selectivity
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
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    • G02B27/10—Beam splitting or combining systems
    • G02B27/14—Beam splitting or combining systems operating by reflection only
    • G02B27/145—Beam splitting or combining systems operating by reflection only having sequential partially reflecting surfaces
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/28—Systems for automatic generation of focusing signals
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/95—Computational photography systems, e.g. light-field imaging systems
    • H04N23/958—Computational photography systems, e.g. light-field imaging systems for extended depth of field imaging
    • H04N23/959—Computational photography systems, e.g. light-field imaging systems for extended depth of field imaging by adjusting depth of field during image capture, e.g. maximising or setting range based on scene characteristics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
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    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0294—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/144—Imaging characterised by its optical setup
    • G01N2015/1443—Auxiliary imaging
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1452—Adjustment of focus; Alignment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle with colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1477—Multiparameters
    • G01N2015/1479—Using diffuse illumination or excitation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/052—Tubular type; cavity type; multireflective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/058—Flat flow cell
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/60—Control of cameras or camera modules
    • H04N23/67—Focus control based on electronic image sensor signals
    • H04N23/673—Focus control based on electronic image sensor signals based on contrast or high frequency components of image signals, e.g. hill climbing method

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Signal Processing (AREA)
  • Multimedia (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Theoretical Computer Science (AREA)
  • Computing Systems (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Lenses (AREA)
AU2002213157A 2000-10-12 2001-10-12 System and method for high numeric aperture imaging systems Abandoned AU2002213157A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24012500P 2000-10-12 2000-10-12
US60240125 2000-10-12
PCT/US2001/031930 WO2002031583A1 (en) 2000-10-12 2001-10-12 System and method for high numeric aperture imaging systems

Publications (1)

Publication Number Publication Date
AU2002213157A1 true AU2002213157A1 (en) 2002-04-22

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AU2002213157A Abandoned AU2002213157A1 (en) 2000-10-12 2001-10-12 System and method for high numeric aperture imaging systems
AU2001297843A Abandoned AU2001297843A1 (en) 2000-10-12 2001-10-12 Imaging and analyzing parameters of small moving objects such as cells

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AU2001297843A Abandoned AU2001297843A1 (en) 2000-10-12 2001-10-12 Imaging and analyzing parameters of small moving objects such as cells

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US (4) US7009651B2 (en)
AU (2) AU2002213157A1 (en)
WO (1) WO2002031583A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7009651B2 (en) 2000-10-12 2006-03-07 Amnis Corporation System and method for high numeric aperture imaging systems
US6995810B2 (en) * 2000-11-30 2006-02-07 Texas Instruments Incorporated Method and system for automated convergence and focus verification of projected images
US6677999B2 (en) * 2001-07-09 2004-01-13 Hewlett-Packard Development Company, L.P. Non-polarizing LCD shutter
US7280207B2 (en) 2001-07-25 2007-10-09 Applera Corporation Time-delay integration in a flow cytometry system
US20070182844A1 (en) * 2003-03-09 2007-08-09 Latia Imaging Pty Ltd Optical system for producing differently focused images
JP2005065064A (en) * 2003-08-19 2005-03-10 Olympus Corp Electronic imaging apparatus
US20090034071A1 (en) * 2007-07-31 2009-02-05 Dean Jennings Method for partitioning and incoherently summing a coherent beam
US8237850B2 (en) * 2007-08-27 2012-08-07 Sanyo Electric Co., Ltd. Electronic camera that adjusts the distance from an optical lens to an imaging surface
US8526754B2 (en) * 2009-05-28 2013-09-03 Aptina Imaging Corporation System for enhancing depth of field with digital image processing
EP3217178A3 (en) 2010-11-12 2017-11-22 incellDX, Inc. Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells
ES2953897T3 (en) 2012-05-02 2023-11-16 Leica Biosystems Imaging Inc Real-time focus in line scan imaging
US9746412B2 (en) 2012-05-30 2017-08-29 Iris International, Inc. Flow cytometer
EP2861956B1 (en) * 2012-05-30 2024-01-24 Iris International, Inc. Flow cytometer
US9584730B2 (en) * 2014-02-03 2017-02-28 Cognex Corporation Apparatus, systems, and methods for a multi-position image sensor
CN104318879A (en) * 2014-10-20 2015-01-28 京东方科技集团股份有限公司 Display device and display device failure analysis system and method
BR112018005822A2 (en) 2015-09-24 2018-10-09 Leica Biosystems Imaging Inc real-time focus in line scan imaging
US10427038B2 (en) * 2016-01-21 2019-10-01 Toccata Gaming International, Llc Game console incorporating beam-splitter display and real world objects
US11307430B2 (en) * 2016-06-07 2022-04-19 Karl Storz Se & Co. Kg Optical device and method for providing improved depth of field and resolution modes
US10324300B2 (en) * 2016-06-07 2019-06-18 Karl Storz Se & Co. Kg Endoscope and imaging arrangement providing depth of field
KR102585276B1 (en) 2017-03-31 2023-10-05 라이프 테크놀로지스 코포레이션 Devices, systems, and methods for imaging flow cytometry
JP6997549B2 (en) * 2017-07-11 2022-01-17 アークレイ株式会社 Analytical instrument and focusing method
US10473903B2 (en) 2017-12-28 2019-11-12 Waymo Llc Single optic for low light and high light level imaging
CN116088083A (en) * 2018-11-02 2023-05-09 元平台技术有限公司 Compact polarization-based multipass optical architecture
DE102018220779A1 (en) * 2018-12-03 2020-06-04 Carl Zeiss Microscopy Gmbh Detection method of induced light signals in a three-dimensional region of a sample
EP3798711A1 (en) * 2019-09-27 2021-03-31 Leica Microsystems CMS GmbH Imaging device and method for imaging an object using a microscope
WO2021146619A1 (en) * 2020-01-16 2021-07-22 The Johns Hopkins University Snapshot hyperspectral imager for emission and reactions (shear)
GB2600996A (en) * 2020-11-17 2022-05-18 Ffei Ltd Image scanning apparatus and method

Family Cites Families (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3555280A (en) * 1966-04-19 1971-01-12 Hycon Mfg Co Automatic focus sensor and control
US3497690A (en) * 1967-09-21 1970-02-24 Bausch & Lomb Method and apparatus for classifying biological cells by measuring the size and fluorescent response thereof
DE1597211B1 (en) * 1967-09-26 1970-06-11 Fernseh Gmbh Color television camera
JPS49133042A (en) 1973-04-09 1974-12-20
NL7807532A (en) 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
US4414575A (en) * 1980-11-21 1983-11-08 Hitachi Denshi Kabushiki Kaisha Autofocus system
US4677680A (en) 1982-08-31 1987-06-30 Dai Nippon Insatsu Kabushiki Kaisha Method and device for inspecting image
US4703017C1 (en) 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
JP2531605B2 (en) 1984-02-24 1996-09-04 株式会社東芝 Image registration device
US5122453A (en) 1984-03-28 1992-06-16 Technicon Instruments Corporation Method for discriminating surface stained lymphocytes
JPS60258671A (en) 1984-06-05 1985-12-20 Nec Corp Processor
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US4662742A (en) 1985-05-10 1987-05-05 Becton, Dickinson And Company Scatter/fluorescene beam splitter in a flow cytometry apparatus
US4845197A (en) 1985-09-09 1989-07-04 Agri-Diagnostics Associates Monoclonal antibodies and methods for fungal pathogen detection
US5985549A (en) 1985-10-22 1999-11-16 University Of Massachusetts Non-isotopic in-situ hybridization method for detection of nucleic acids
US4770992A (en) 1985-11-27 1988-09-13 Den Engh Gerrit J Van Detection of specific DNA sequences by flow cytometry
US4777525A (en) 1985-12-23 1988-10-11 Preston Jr Kendall Apparatus and method for a multi-resolution electro-optical imaging, display and storage/retrieval system
CA1338860C (en) 1987-04-13 1997-01-21 Peter Parker Radiolabelling of proteins
US4786165A (en) 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
EP0280559B1 (en) 1987-02-27 1993-10-20 EASTMAN KODAK COMPANY (a New Jersey corporation) Agglutination immunoassay and kit for determination of a multivalent immune species using a buffered salt wash solution
EP0281327B1 (en) 1987-02-27 1993-06-30 EASTMAN KODAK COMPANY (a New Jersey corporation) Immunoreactive reagent, method of preparation and its use to determine an immunoreactive species
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
IL92124A (en) 1988-10-28 1996-10-31 Sidney Pestka Recombinant proteins modified to contain non-naturally occurring phosphorylation sites
US6150503A (en) 1988-10-28 2000-11-21 Pestka Biomedical Laboratories, Inc. Phosphorylated fusion proteins
US5266486A (en) 1989-05-12 1993-11-30 Nvl Photronics Corporation Method and apparatus for detecting biological activities in a specimen
DE3919222A1 (en) * 1989-06-13 1990-12-20 B & G Foerdertechnik Gmbh WIRING MACHINE
US5107522A (en) 1990-02-05 1992-04-21 Sharp Kabushiki Kaisha Automatic frequency control circuit
JP3181050B2 (en) 1990-04-20 2001-07-03 株式会社日立製作所 Projection exposure method and apparatus
US5159642A (en) 1990-07-13 1992-10-27 Toa Medical Electronics Co., Ltd. Particle image analyzing apparatus
US5141609A (en) 1990-11-16 1992-08-25 The Trustees Of The Leland Stanford Junior University Method and device employing time-delayed integration for detecting sample components after separation
US5257182B1 (en) 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method
US5784162A (en) 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US5817462A (en) 1995-02-21 1998-10-06 Applied Spectral Imaging Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding
JP3084295B2 (en) 1991-02-27 2000-09-04 シスメックス株式会社 Flow image cytometer
JP3084296B2 (en) 1991-02-27 2000-09-04 シスメックス株式会社 Flow image cytometer
JP3121849B2 (en) 1991-02-27 2001-01-09 シスメックス株式会社 Flow image cytometer
JPH0734012B2 (en) 1991-02-27 1995-04-12 東亜医用電子株式会社 Flow image cytometer
US5436144A (en) 1991-04-08 1995-07-25 Health Research, Inc. Process for performing PCR in mammalian cells
US5657164A (en) 1991-05-28 1997-08-12 Discovision Associates Optical beamsplitter
US5548395A (en) 1991-09-20 1996-08-20 Toa Medical Electronics Co., Ltd. Particle analyzer
JP3212647B2 (en) 1991-10-24 2001-09-25 シスメックス株式会社 Imaging flow cytometer
JP3102935B2 (en) 1991-11-20 2000-10-23 シスメックス株式会社 Imaging flow cytometer
US5686960A (en) * 1992-01-14 1997-11-11 Michael Sussman Image input device having optical deflection elements for capturing multiple sub-images
US5422712A (en) 1992-04-01 1995-06-06 Toa Medical Electronics Co., Ltd. Apparatus for measuring fluorescent spectra of particles in a flow
JP3145486B2 (en) * 1992-06-12 2001-03-12 シスメックス株式会社 Imaging flow cytometer
US5351311A (en) 1992-07-28 1994-09-27 The United States Of America As Represented By The Secretary Of The Navy Neural network for detection and correction of local boundary misalignments between images
US6159686A (en) 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US5733721A (en) 1992-11-20 1998-03-31 The Board Of Regents Of The University Of Oklahoma Cell analysis method using quantitative fluorescence image analysis
EP0682671A4 (en) * 1993-02-01 1998-01-14 Seq Ltd Methods and apparatus for dna sequencing.
US5547849A (en) 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
EP0649014B1 (en) 1993-09-16 2005-11-23 Sysmex Corporation Particle analyzing apparatus
JP3290786B2 (en) 1993-11-26 2002-06-10 シスメックス株式会社 Particle analyzer
JP3344635B2 (en) 1993-12-27 2002-11-11 シャープ株式会社 Color liquid crystal display
JPH07286953A (en) * 1994-04-19 1995-10-31 Toa Medical Electronics Co Ltd Imaging flow sight meter
JP3156503B2 (en) 1994-05-27 2001-04-16 松下電器産業株式会社 Driving method of solid-state imaging device and signal processing circuit of solid-state imaging device
AU3544995A (en) * 1994-09-20 1996-04-09 Neopath, Inc. Apparatus for identification and integration of multiple cell patterns
US5621460A (en) 1994-10-11 1997-04-15 Lockheed Martin Corporation Optical differentiation between plants and background utilizing a single CCD camera
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5556790A (en) 1994-12-05 1996-09-17 Pettit; John W. Method for Automated DNA sequencing
WO1996041304A1 (en) * 1995-06-07 1996-12-19 The Trustees Of Columbia University In The City Of New York Apparatus and methods for determining the three-dimensional shape of an object using active illumination and relative blurring in two images due to defocus
US5844670A (en) * 1995-07-28 1998-12-01 Ricoh Co., Ltd. Method of and systems for measuring eccentricity of an aspherical lens surface
FI97665C (en) 1995-11-21 1997-01-27 Planmed Oy Procedures and apparatus for photographing an object
US6007994A (en) 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
US5764792A (en) 1996-01-19 1998-06-09 Oncor, Inc. Method and apparatus for processing images
JP3640461B2 (en) 1996-04-03 2005-04-20 シスメックス株式会社 Particle analyzer
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US5959953A (en) 1996-07-03 1999-09-28 Zen Research Nv Methods and apparatus for performing cross-talk correction in a multi-track optical disk reader based on magnification error
US5929986A (en) 1996-08-26 1999-07-27 Kaiser Optical Systems, Inc. Synchronous spectral line imaging methods and apparatus
US5760899A (en) 1996-09-04 1998-06-02 Erim International, Inc. High-sensitivity multispectral sensor
US5754291A (en) 1996-09-19 1998-05-19 Molecular Dynamics, Inc. Micro-imaging system
US5855753A (en) 1996-11-26 1999-01-05 The Trustees Of Princeton University Method for electrohydrodynamically assembling patterned colloidal structures
CA2282658C (en) * 1997-02-27 2003-02-25 Cellomics, Inc. A system for cell-based screening
US6259807B1 (en) 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US20040241759A1 (en) 1997-06-16 2004-12-02 Eileen Tozer High throughput screening of libraries
JP2001525534A (en) 1997-07-12 2001-12-11 オプティカル インサイツ，リミティド ライアビリティー カンパニー Multispectral two-dimensional image spectrometer
WO1999006941A2 (en) 1997-07-31 1999-02-11 University Of California, Berkeley Apparatus and methods for image and signal processing
US5900942A (en) 1997-09-26 1999-05-04 The United States Of America As Represented By Administrator Of National Aeronautics And Space Administration Multi spectral imaging system
US6007775A (en) 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
US6115119A (en) 1997-10-21 2000-09-05 Bigelow Laboratory For Ocean Science Device and method for studying particles in a fluid
US6051835A (en) 1998-01-07 2000-04-18 Bio-Rad Laboratories, Inc. Spectral imaging apparatus and methodology
US6510319B2 (en) 1998-02-05 2003-01-21 Lucent Technologies Inc. Method for optimizing forward link power levels during soft handoffs in a wireless telecommunications network
JP3747621B2 (en) 1998-03-26 2006-02-22 コニカミノルタオプト株式会社 Color projection display device
JPH11295208A (en) 1998-04-13 1999-10-29 Sysmex Corp Particle image pickup apparatus
CA2331897C (en) 1998-05-14 2008-11-18 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
US20010012620A1 (en) 1998-06-03 2001-08-09 Rich Ivan N. Method of reducing cell proliferation by inducing apoptosis in differentially selected cell subpopulations
FR2784189B3 (en) 1998-10-05 2000-11-03 Commissariat Energie Atomique BIOCHIP AND DEVICE FOR READING A BIOCHIP COMPRISING A PLURALITY OF MOLECULAR RECOGNITION AREAS
US6330081B1 (en) 1998-11-20 2001-12-11 Agfa Corporation Crosstalk cancellation in a multi-color CCD signal processor
JP3871456B2 (en) 1998-12-10 2007-01-24 シスメックス株式会社 Particle image analyzer
US6549664B1 (en) 1998-12-31 2003-04-15 Siros Technologies, Inc. Sparse modulation codes for holographic data storage
US6256096B1 (en) 1999-01-11 2001-07-03 Softray Flow cytometry apparatus and method
US20010006416A1 (en) 1999-01-11 2001-07-05 Johnson Paul E. Ribbon flow cytometry apparatus and methods
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US7057732B2 (en) 1999-01-25 2006-06-06 Amnis Corporation Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
US6975400B2 (en) 1999-01-25 2005-12-13 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6473176B2 (en) 1999-01-25 2002-10-29 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6707551B2 (en) 2000-01-24 2004-03-16 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
US6671044B2 (en) 1999-01-25 2003-12-30 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells in broad flat flow
US20060257884A1 (en) 2004-05-20 2006-11-16 Amnis Corporation Methods for preparing and analyzing cells having chromosomal abnormalities
US6580504B1 (en) 1999-01-25 2003-06-17 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
US6249341B1 (en) * 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6608682B2 (en) * 1999-01-25 2003-08-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
CA2372447A1 (en) 1999-02-19 2000-08-24 Fox Chase Cancer Center Methods of decomposing complex data
US6381363B1 (en) 1999-03-15 2002-04-30 Grass Valley (U.S.), Inc. Histogram-based segmentation of images and video via color moments
US6330361B1 (en) 1999-03-16 2001-12-11 Litton Systems, Inc. Adaptively aligned optical correlator and method
US6156465A (en) 1999-04-12 2000-12-05 Cymbolic Sciences Inc. Crosstalk correction
US6716588B2 (en) 1999-12-09 2004-04-06 Cellomics, Inc. System for cell-based screening
US6727066B2 (en) 2000-07-28 2004-04-27 Incyte Corporation Genes expressed in treated human C3A liver cell cultures
US6608680B2 (en) 2000-08-25 2003-08-19 Amnis Corporation TDI imaging system for kinetic studies
AU2001290568A1 (en) 2000-08-25 2002-03-04 Amnis Corporation Measuring the velocity of small moving objects such as cells
US6583865B2 (en) * 2000-08-25 2003-06-24 Amnis Corporation Alternative detector configuration and mode of operation of a time delay integration particle analyzer
US6934408B2 (en) 2000-08-25 2005-08-23 Amnis Corporation Method and apparatus for reading reporter labeled beads
US6875973B2 (en) 2000-08-25 2005-04-05 Amnis Corporation Auto focus for a flow imaging system
US6778263B2 (en) 2000-08-25 2004-08-17 Amnis Corporation Methods of calibrating an imaging system using calibration beads
AU2002211835A1 (en) 2000-09-29 2002-04-08 Clinomics Laboratories, Inc. Oncology tissue microarrays
AU2002211913A1 (en) 2000-10-12 2002-04-22 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
US7009651B2 (en) 2000-10-12 2006-03-07 Amnis Corporation System and method for high numeric aperture imaging systems
US7033819B2 (en) 2000-11-08 2006-04-25 Surface Logix, Inc. System for monitoring cell motility in real-time
US6873733B2 (en) 2001-01-19 2005-03-29 The Regents Of The University Of Colorado Combined wavefront coding and amplitude contrast imaging systems
AU2002324422A1 (en) 2001-02-21 2002-12-23 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
US20020126275A1 (en) 2001-03-12 2002-09-12 Johnson Paul E. LED illuminated particle detection apparatus and methods
US20030048931A1 (en) 2001-03-23 2003-03-13 Peter Johnson Quantification and differentiation of tissue based upon quantitative image analysis
WO2002077903A2 (en) 2001-03-26 2002-10-03 Cellomics, Inc. Methods for determining the organization of a cellular component of interest
US6519355B2 (en) * 2001-03-28 2003-02-11 Alan C. Nelson Optical projection imaging system and method for automatically detecting cells having nuclear and cytoplasmic densitometric features associated with disease
US7050620B2 (en) 2001-03-30 2006-05-23 Heckman Carol A Method of assaying shape and structural features in cells
WO2002086416A2 (en) 2001-04-25 2002-10-31 Amnis Corporation Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
WO2002103335A1 (en) 2001-06-18 2002-12-27 Amnis Corporation Spectral deconvolution of fluorescent markers
AU2002319621A1 (en) 2001-07-17 2003-03-03 Amnis Corporation Computational methods for the segmentation of images of objects from background in a flow imaging instrument
US7435578B2 (en) 2001-08-06 2008-10-14 Vanderbilt University Device and methods for monitoring the status of at least one cell
US20030104439A1 (en) 2001-11-30 2003-06-05 Finch Rosalynde J. Methods of identifying cellular target molecules
EP1316793A1 (en) 2001-12-03 2003-06-04 Christian Leist Process and apparatus for characterization of a collection of cells
CA2468861C (en) 2001-12-05 2012-06-12 The Regents Of The University Of California Robotic microscopy systems
US6927922B2 (en) 2001-12-18 2005-08-09 The University Of Rochester Imaging using a multifocal aspheric lens to obtain extended depth of field
US6658143B2 (en) 2002-04-29 2003-12-02 Amersham Biosciences Corp. Ray-based image analysis for biological specimens
CA2500805A1 (en) * 2002-09-13 2004-03-25 Arcturus Bioscience, Inc. Interactive and automated tissue image analysis
EP1625226A4 (en) * 2003-03-27 2007-01-10 Bartron Medical Imaging Llc System and method for rapidly identifying pathogens, bacteria and abnormal cells
US7180673B2 (en) 2003-03-28 2007-02-20 Cdm Optics, Inc. Mechanically-adjustable optical phase filters for modifying depth of field, aberration-tolerance, anti-aliasing in optical systems
US7106502B1 (en) * 2003-08-21 2006-09-12 The United States Of America As Represented By The Administrator Of National Aeronautics And Space Administration Operation of a Cartesian robotic system in a compact microscope imaging system with intelligent controls
AU2004273992B2 (en) 2003-09-19 2010-01-21 The General Hospital Corporation Fluorescence polarization imaging devices and methods
US8103080B2 (en) 2004-03-16 2012-01-24 Amnis Corporation Method for imaging and differential analysis of cells
CA2598602A1 (en) 2004-03-16 2005-10-20 Amnis Corporation Image based quantitation of molecular translocation
GB2416043B (en) * 2004-07-06 2008-02-06 Cairn Res Ltd Optical imaging device

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