JP7472122B2 - コルチコステロイドを投与する方法 - Google Patents
コルチコステロイドを投与する方法 Download PDFInfo
- Publication number
- JP7472122B2 JP7472122B2 JP2021525303A JP2021525303A JP7472122B2 JP 7472122 B2 JP7472122 B2 JP 7472122B2 JP 2021525303 A JP2021525303 A JP 2021525303A JP 2021525303 A JP2021525303 A JP 2021525303A JP 7472122 B2 JP7472122 B2 JP 7472122B2
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- JP
- Japan
- Prior art keywords
- dose
- corticosteroid
- urinary
- patient
- hsd1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024063590A JP2024098991A (ja) | 2018-11-20 | 2024-04-10 | コルチコステロイドを投与する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862769932P | 2018-11-20 | 2018-11-20 | |
| US62/769,932 | 2018-11-20 | ||
| PCT/US2019/046449 WO2020106337A1 (en) | 2018-11-20 | 2019-08-14 | Methods for administering corticosteroids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024063590A Division JP2024098991A (ja) | 2018-11-20 | 2024-04-10 | コルチコステロイドを投与する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022507103A JP2022507103A (ja) | 2022-01-18 |
| JPWO2020106337A5 JPWO2020106337A5 (enExample) | 2022-08-23 |
| JP7472122B2 true JP7472122B2 (ja) | 2024-04-22 |
Family
ID=70774135
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021525303A Active JP7472122B2 (ja) | 2018-11-20 | 2019-08-14 | コルチコステロイドを投与する方法 |
| JP2024063590A Pending JP2024098991A (ja) | 2018-11-20 | 2024-04-10 | コルチコステロイドを投与する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024063590A Pending JP2024098991A (ja) | 2018-11-20 | 2024-04-10 | コルチコステロイドを投与する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12220412B2 (enExample) |
| EP (1) | EP3883578A4 (enExample) |
| JP (2) | JP7472122B2 (enExample) |
| CN (1) | CN113329754A (enExample) |
| AU (2) | AU2019384074B2 (enExample) |
| BR (1) | BR112021009653A2 (enExample) |
| CA (1) | CA3120339A1 (enExample) |
| IL (2) | IL283069B2 (enExample) |
| MX (2) | MX2021005801A (enExample) |
| WO (1) | WO2020106337A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022076398A1 (en) * | 2020-10-07 | 2022-04-14 | Surface Ophthalmics, Inc. | Pharmaceutical kits and their use for treating dry eye disease |
| AU2019384074B2 (en) | 2018-11-20 | 2025-04-10 | Sparrow Pharmaceuticals, Inc. | Methods for administering corticosteroids |
| JP2022516099A (ja) | 2018-12-27 | 2022-02-24 | サーフィス オフサルミクス,インコーポレイテッド | 眼科用医薬組成物及び癌表面疾患の処置方法 |
| CA3128954A1 (en) * | 2019-02-08 | 2020-08-13 | Sanofi | Biotechnological optimization of microorganisms for the 1,2-dehydrogenation of steroids |
| US12310981B2 (en) | 2021-05-10 | 2025-05-27 | Surface Ophthalmics, Inc. | Use of chondroitin sulfate for relieving ocular pain |
| US12440510B2 (en) | 2021-05-10 | 2025-10-14 | Surface Ophthalmics, Inc. | Use of chondroitin sulfate for relieving ocular pain |
| WO2023225507A1 (en) * | 2022-05-16 | 2023-11-23 | Sparrow Pharmaceuticals, Inc. | Methods and compositions for treating glucocorticoid excess |
| CA3250533A1 (en) | 2022-05-16 | 2023-11-23 | Sparrow Pharmaceuticals, Inc. | METHODS AND COMPOSITIONS FOR TREATING EXCESS GLUCOCORTICOIDS |
| WO2025072521A1 (en) * | 2023-09-27 | 2025-04-03 | Sparrow Pharmaceuticals, Inc. | Methods and compositions for treating glucocorticoid-mediated diseases |
| GB202408335D0 (en) | 2024-06-11 | 2024-07-24 | Astrazeneca Ab | Therapies for wound treatment |
Citations (6)
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| JP2004528308A (ja) | 2001-03-23 | 2004-09-16 | ザ ユニバーシティ オブ エディンバラ | 脂質プロフィールのモジュレーション |
| US20050277647A1 (en) | 2004-04-29 | 2005-12-15 | Link James T | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US20060094699A1 (en) | 2003-04-11 | 2006-05-04 | Kampen Gita Camilla T | Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy |
| WO2010121814A1 (en) | 2009-04-22 | 2010-10-28 | Ontochem Gmbh | Pharmaceutical composition, comprising a steroid-dehydrogenase-reductase inhibitor, and a mineralocorticoid receptor antagonist |
| WO2012033070A1 (ja) | 2010-09-07 | 2012-03-15 | アステラス製薬株式会社 | 疼痛治療剤 |
| US20130338169A1 (en) | 2004-04-29 | 2013-12-19 | Abbvie Inc. | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
Family Cites Families (46)
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| US3907821A (en) | 1974-11-20 | 1975-09-23 | Upjohn Co | 2-{8 3-{8 1-(DIMETHYLAMINO)CYCLOPROPYL{8 -4H-1,2,4-triazol-4-yl{8 {0 benzophenone |
| US4577020A (en) | 1983-01-25 | 1986-03-18 | The Upjohn Company | Aminoalkyl and aminoalkenyl triazoles as anti-psychotic agents |
| IL84093A (en) | 1986-10-09 | 1992-09-06 | Ciba Geigy Ag | Aralkyl-4h-1,2,4-triazole derivatives,their preparation and pharmaceutical compositions containing them |
| GB0101447D0 (en) | 2001-01-19 | 2001-03-07 | Univ Edinburgh | Regulation of glucocorticoid concentration |
| AUPR878201A0 (en) | 2001-11-09 | 2001-12-06 | Fujisawa Pharmaceutical Co., Ltd. | New compounds |
| US20030148987A1 (en) | 2001-12-21 | 2003-08-07 | Morris David J. | Selective 11beta-HSD inhibitors and methods of use thereof |
| JP4368683B2 (ja) | 2002-02-01 | 2009-11-18 | メルク エンド カムパニー インコーポレーテッド | 糖尿病、肥満症および脂質代謝異常の治療に有用な11−ベータ−ヒドロキシステロイドデヒドロゲナーゼ1阻害剤 |
| AR040241A1 (es) | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
| PL375256A1 (en) | 2002-08-09 | 2005-11-28 | Astra Zeneca Ab | 1,2,4-oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| JP2006522747A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 縮合1,2,4−トリアゾールの薬学的使用 |
| DE602004027171D1 (de) | 2003-04-11 | 2010-06-24 | High Point Pharmaceuticals Llc | Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase |
| WO2004089367A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Pharmaceutical use of substituted 1,2,4-triazoles |
| US8026264B2 (en) | 2003-05-29 | 2011-09-27 | Merck Sharp And Dohme Corp. | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 |
| JP2007509959A (ja) | 2003-10-28 | 2007-04-19 | アムゲン インコーポレイティッド | トリアゾール化合物およびそれに関連する使用法 |
| JP2005170939A (ja) | 2003-11-20 | 2005-06-30 | Takeda Chem Ind Ltd | 糖尿病の予防・治療剤 |
| EA200600990A1 (ru) | 2003-12-19 | 2006-10-27 | Пфайзер Инк. | Производные бензосульфониламинопиридин-2-ила и родственные соединения в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы 1 типа (11-бета-hsd-1) для лечения диабета и ожирения |
| US7507832B2 (en) | 2003-12-22 | 2009-03-24 | Eli Lilly And Company | Triazole PPAR modulators |
| EP1732904B1 (en) | 2004-03-29 | 2014-03-19 | Merck Sharp & Dohme Corp. | Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 |
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| CA2866220A1 (en) * | 2012-03-13 | 2013-09-19 | Abbvie Inc. | Method for selecting or identifying a subject for v1b antagonist therapy |
| CN113018300B (zh) * | 2014-07-09 | 2025-11-25 | 爱普制药有限责任公司 | 用于治疗神经病症的方法 |
| EA036757B1 (ru) | 2015-04-07 | 2020-12-17 | Интерсепт Фармасьютикалз, Инк. | Фармацевтические композиции для комбинированной терапии |
| US10648506B2 (en) | 2016-07-07 | 2020-05-12 | Raul Mendoza | Walking rig creeper interface |
| WO2018117063A1 (ja) | 2016-12-20 | 2018-06-28 | アステラス製薬株式会社 | 焦燥性興奮治療剤 |
| AU2019384074B2 (en) | 2018-11-20 | 2025-04-10 | Sparrow Pharmaceuticals, Inc. | Methods for administering corticosteroids |
| EP3821892A1 (en) | 2019-11-12 | 2021-05-19 | University of Leeds | (s)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl) acetic acid for use in treating wounds |
| EP3878446A1 (en) | 2020-03-09 | 2021-09-15 | Universite De Geneve | Hsd11b1 inhibitors for use in immunotherapy and uses thereof |
| WO2023225507A1 (en) | 2022-05-16 | 2023-11-23 | Sparrow Pharmaceuticals, Inc. | Methods and compositions for treating glucocorticoid excess |
| CA3250533A1 (en) | 2022-05-16 | 2023-11-23 | Sparrow Pharmaceuticals, Inc. | METHODS AND COMPOSITIONS FOR TREATING EXCESS GLUCOCORTICOIDS |
-
2019
- 2019-08-14 AU AU2019384074A patent/AU2019384074B2/en active Active
- 2019-08-14 CN CN201980076112.6A patent/CN113329754A/zh active Pending
- 2019-08-14 CA CA3120339A patent/CA3120339A1/en active Pending
- 2019-08-14 JP JP2021525303A patent/JP7472122B2/ja active Active
- 2019-08-14 EP EP19886299.7A patent/EP3883578A4/en active Pending
- 2019-08-14 MX MX2021005801A patent/MX2021005801A/es unknown
- 2019-08-14 BR BR112021009653-1A patent/BR112021009653A2/pt unknown
- 2019-08-14 IL IL283069A patent/IL283069B2/en unknown
- 2019-08-14 IL IL319327A patent/IL319327A/en unknown
- 2019-08-14 WO PCT/US2019/046449 patent/WO2020106337A1/en not_active Ceased
- 2019-08-14 US US17/289,516 patent/US12220412B2/en active Active
-
2021
- 2021-05-17 MX MX2025002836A patent/MX2025002836A/es unknown
-
2024
- 2024-04-10 JP JP2024063590A patent/JP2024098991A/ja active Pending
- 2024-12-13 US US18/980,242 patent/US20250205227A1/en active Pending
-
2025
- 2025-04-30 AU AU2025203033A patent/AU2025203033A1/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004528308A (ja) | 2001-03-23 | 2004-09-16 | ザ ユニバーシティ オブ エディンバラ | 脂質プロフィールのモジュレーション |
| US20060094699A1 (en) | 2003-04-11 | 2006-05-04 | Kampen Gita Camilla T | Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy |
| US20050277647A1 (en) | 2004-04-29 | 2005-12-15 | Link James T | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US20130338169A1 (en) | 2004-04-29 | 2013-12-19 | Abbvie Inc. | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| WO2010121814A1 (en) | 2009-04-22 | 2010-10-28 | Ontochem Gmbh | Pharmaceutical composition, comprising a steroid-dehydrogenase-reductase inhibitor, and a mineralocorticoid receptor antagonist |
| WO2012033070A1 (ja) | 2010-09-07 | 2012-03-15 | アステラス製薬株式会社 | 疼痛治療剤 |
Non-Patent Citations (1)
| Title |
|---|
| British Journal of Pharmacology,2018年,175,pp.3784-3796 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL283069B1 (en) | 2025-05-01 |
| AU2025203033A1 (en) | 2025-05-22 |
| CN113329754A (zh) | 2021-08-31 |
| US20210393622A1 (en) | 2021-12-23 |
| CA3120339A1 (en) | 2020-05-28 |
| BR112021009653A2 (pt) | 2021-08-17 |
| WO2020106337A1 (en) | 2020-05-28 |
| US20250205227A1 (en) | 2025-06-26 |
| JP2022507103A (ja) | 2022-01-18 |
| MX2021005801A (es) | 2021-08-05 |
| EP3883578A1 (en) | 2021-09-29 |
| AU2019384074B2 (en) | 2025-04-10 |
| US12220412B2 (en) | 2025-02-11 |
| MX2025002836A (es) | 2025-04-02 |
| IL283069B2 (en) | 2025-09-01 |
| IL319327A (en) | 2025-05-01 |
| JP2024098991A (ja) | 2024-07-24 |
| AU2019384074A1 (en) | 2021-06-03 |
| EP3883578A4 (en) | 2022-07-27 |
| IL283069A (en) | 2021-06-30 |
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