JP7465819B2 - 新規ベンゾジアゼピン誘導体及びそれらの使用 - Google Patents

新規ベンゾジアゼピン誘導体及びそれらの使用 Download PDF

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JP7465819B2
JP7465819B2 JP2020566662A JP2020566662A JP7465819B2 JP 7465819 B2 JP7465819 B2 JP 7465819B2 JP 2020566662 A JP2020566662 A JP 2020566662A JP 2020566662 A JP2020566662 A JP 2020566662A JP 7465819 B2 JP7465819 B2 JP 7465819B2
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alkyl
mmol
integer
aryl
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JP2021525730A (ja
JP2021525730A5 (https=
JPWO2019229536A5 (https=
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パーク，デギョ
ウ，スン，ホ
キム，スンヨン
パーク，スホ
チョ，ジョンウン
ジュン，トゥファン
ソ，ドンフン
リ，ジェホ
リ，サングァン
ユン，サンヒョン
リ，ヒャン，ソク
パーク，オック
ソ，ボムソク
キム，セナ
ソル，ミナ
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イントゥーセル，インコーポレーティッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020566662A 2018-05-29 2019-05-29 新規ベンゾジアゼピン誘導体及びそれらの使用 Active JP7465819B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862677498P 2018-05-29 2018-05-29
US62/677,498 2018-05-29
PCT/IB2019/000691 WO2019229536A2 (en) 2018-05-29 2019-05-29 Novel benzodiazepine derivatives and uses thereof

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JP2021525730A JP2021525730A (ja) 2021-09-27
JP2021525730A5 JP2021525730A5 (https=) 2022-06-07
JPWO2019229536A5 JPWO2019229536A5 (https=) 2022-06-07
JP7465819B2 true JP7465819B2 (ja) 2024-04-11

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US (2) US11084801B2 (https=)
EP (1) EP3802546A4 (https=)
JP (1) JP7465819B2 (https=)
KR (1) KR102946423B1 (https=)
CN (2) CN113444111A (https=)
AU (2) AU2019276833A1 (https=)
BR (1) BR112020023623A2 (https=)
CA (1) CA3100141A1 (https=)
EA (1) EA202092909A1 (https=)
IL (1) IL278973B2 (https=)
MX (1) MX2020012718A (https=)
WO (1) WO2019229536A2 (https=)

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WO2019008441A1 (en) 2017-07-04 2019-01-10 Intocell, Inc. COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
KR20210068591A (ko) 2018-10-31 2021-06-09 주식회사 인투셀 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도
EP3906064A4 (en) * 2019-01-03 2023-03-08 Intocell, Inc. CLEAVABLE LINKER COMPOUNDS AND USES THEREOF
WO2020141460A2 (en) 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
KR20220108783A (ko) * 2019-12-02 2022-08-03 주식회사 인투셀 분자 접합과 관련된 조성물 및 방법
KR20230028793A (ko) * 2020-06-26 2023-03-02 주식회사 인투셀 항-b7-h3 항체를 포함하는 항체-약물 접합체
CN114805432A (zh) * 2022-03-03 2022-07-29 西北工业大学 新型可光催化剪切的羧酸保护基及其氨基酸衍生物的制备方法
CN119424671A (zh) 2023-08-01 2025-02-14 上海新理念生物医药科技有限公司 含糖基吡啶型连接子的抗体药物偶联物
WO2025262641A1 (en) * 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof

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JP2014534200A (ja) 2011-10-14 2014-12-18 シアトル ジェネティクス，インコーポレーテッド ピロロベンゾジアゼピンおよび標的コンジュゲート
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JP2018503639A (ja) 2015-01-14 2018-02-08 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
JP2018510163A (ja) 2015-03-19 2018-04-12 セレラント セラピューティクス インコーポレイテッド イソキノリジノベンゾジアゼピン
JP7174757B2 (ja) 2017-07-04 2022-11-17 イントゥーセル，インコーポレーティッド 切断可能なリンカーを含む化合物及びその使用

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KR20210068591A (ko) 2018-10-31 2021-06-09 주식회사 인투셀 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도
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KR20230028793A (ko) 2020-06-26 2023-03-02 주식회사 인투셀 항-b7-h3 항체를 포함하는 항체-약물 접합체

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JP2012516896A (ja) 2009-02-05 2012-07-26 イミュノジェン・インコーポレーテッド 新規ベンゾジアゼピン誘導体
JP2014534200A (ja) 2011-10-14 2014-12-18 シアトル ジェネティクス，インコーポレーテッド ピロロベンゾジアゼピンおよび標的コンジュゲート
JP2018502131A (ja) 2015-01-14 2018-01-25 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
JP2018503639A (ja) 2015-01-14 2018-02-08 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
JP2018510163A (ja) 2015-03-19 2018-04-12 セレラント セラピューティクス インコーポレイテッド イソキノリジノベンゾジアゼピン
WO2017201442A1 (en) 2016-05-20 2017-11-23 Abbvie Stemcentrx Llc Anti-dll3 drug conjugates for treating tumors at risk of neuroendocrine transition
JP7174757B2 (ja) 2017-07-04 2022-11-17 イントゥーセル，インコーポレーティッド 切断可能なリンカーを含む化合物及びその使用

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Publication number Publication date
IL278973B1 (en) 2025-03-01
AU2023203485B2 (en) 2024-09-19
BR112020023623A2 (pt) 2021-02-17
KR102946423B1 (ko) 2026-04-01
AU2023203485A1 (en) 2023-07-06
US11807628B2 (en) 2023-11-07
AU2019276833A1 (en) 2020-11-26
EP3802546A2 (en) 2021-04-14
JP2021525730A (ja) 2021-09-27
EA202092909A1 (ru) 2021-04-07
IL278973A (en) 2021-01-31
WO2019229536A3 (en) 2020-03-05
MX2020012718A (es) 2021-02-16
US20190367488A1 (en) 2019-12-05
CA3100141A1 (en) 2019-12-05
US20220162190A1 (en) 2022-05-26
IL278973B2 (en) 2025-07-01
KR20210003938A (ko) 2021-01-12
EP3802546A4 (en) 2021-12-29
CN113444111A (zh) 2021-09-28
US11084801B2 (en) 2021-08-10
CN112166115A (zh) 2021-01-01
WO2019229536A2 (en) 2019-12-05

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