BR112020023623A2 - derivados de benzodiazepina e seus usos - Google Patents

derivados de benzodiazepina e seus usos Download PDF

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Publication number
BR112020023623A2
BR112020023623A2 BR112020023623-3A BR112020023623A BR112020023623A2 BR 112020023623 A2 BR112020023623 A2 BR 112020023623A2 BR 112020023623 A BR112020023623 A BR 112020023623A BR 112020023623 A2 BR112020023623 A2 BR 112020023623A2
Authority
BR
Brazil
Prior art keywords
alkyl
compound
mmol
fact
independently
Prior art date
Application number
BR112020023623-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Taekyo Park
Sanghyeon Yun
Hyang Sook Lee
Okku Park
Beomseok Seo
Sena Kim
Minah Seol
Sung Ho Woo
Sunyoung Kim
Suho Park
Jongun Cho
Doohwan Jung
Donghoon Seo
Jaeho Lee
Sangkwang Lee
Original Assignee
Intocell, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intocell, Inc. filed Critical Intocell, Inc.
Publication of BR112020023623A2 publication Critical patent/BR112020023623A2/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112020023623-3A 2018-05-29 2019-05-29 derivados de benzodiazepina e seus usos BR112020023623A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862677498P 2018-05-29 2018-05-29
US62/677,498 2018-05-29
PCT/IB2019/000691 WO2019229536A2 (en) 2018-05-29 2019-05-29 Novel benzodiazepine derivatives and uses thereof

Publications (1)

Publication Number Publication Date
BR112020023623A2 true BR112020023623A2 (pt) 2021-02-17

Family

ID=68692822

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020023623-3A BR112020023623A2 (pt) 2018-05-29 2019-05-29 derivados de benzodiazepina e seus usos

Country Status (12)

Country Link
US (2) US11084801B2 (https=)
EP (1) EP3802546A4 (https=)
JP (1) JP7465819B2 (https=)
KR (1) KR102946423B1 (https=)
CN (2) CN113444111A (https=)
AU (2) AU2019276833A1 (https=)
BR (1) BR112020023623A2 (https=)
CA (1) CA3100141A1 (https=)
EA (1) EA202092909A1 (https=)
IL (1) IL278973B2 (https=)
MX (1) MX2020012718A (https=)
WO (1) WO2019229536A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120682290A (zh) 2017-07-04 2025-09-23 尹图赛利有限公司 包含可裂解接头的化合物及其用途
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
CN112930350A (zh) 2018-10-31 2021-06-08 尹图赛利有限公司 稠合杂环苯并二氮杂䓬衍生物及其用途
WO2020141459A1 (en) * 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
KR20210099658A (ko) 2019-01-03 2021-08-12 주식회사 인투셀 절단가능 링커를 포함하는 화합물 및 이의 용도
KR20220108783A (ko) * 2019-12-02 2022-08-03 주식회사 인투셀 분자 접합과 관련된 조성물 및 방법
BR112022026401A2 (pt) * 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3
CN114805432A (zh) * 2022-03-03 2022-07-29 西北工业大学 新型可光催化剪切的羧酸保护基及其氨基酸衍生物的制备方法
CN119424671A (zh) 2023-08-01 2025-02-14 上海新理念生物医药科技有限公司 含糖基吡啶型连接子的抗体药物偶联物
WO2025262641A1 (en) * 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof

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US5843937A (en) 1996-05-23 1998-12-01 Panorama Research, Inc. DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
GB0819095D0 (en) * 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
RU2683325C2 (ru) 2009-02-05 2019-03-28 Иммьюноджен, Инк. Новые производные бензодиазепина
CN103997893B (zh) 2011-10-14 2019-04-12 西雅图基因公司 吡咯并苯并二氮杂卓和靶向结合物
EP2751111B1 (en) * 2011-10-14 2017-04-26 MedImmune Limited Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
HK1211208A1 (zh) 2012-08-22 2016-05-20 Immunogen, Inc. 細胞毒性苯並二氮呯衍生物
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
WO2015095953A1 (en) * 2013-12-27 2015-07-02 The Centre For Drug Research And Development Sulfonamide-containing linkage systems for drug conjugates
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
MX2017009145A (es) * 2015-01-14 2017-11-22 Bristol Myers Squibb Co Dimeros de benzodiazepina, conjugados de estos, y sus metodos de preparacion y uso.
BR112017014937A2 (pt) 2015-01-14 2018-03-13 Bristol-Myers Squibb Company dímeros de benzodiazepina ligados em ponte a heteroarileno, conjugados dos mesmos, e métodos de preparação e uso
DK3270965T3 (da) 2015-03-18 2020-06-08 Seattle Genetics Inc Cd48-antistoffer og konjugater deraf
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
MA45054A (fr) 2016-05-20 2019-03-27 Abbvie Stemcentrx Llc Conjugués médicament-anticorps dll3 pour le traitement de tumeurs à risque de transition neuroendocrinienne
WO2018053552A2 (en) * 2016-09-19 2018-03-22 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
KR102648564B1 (ko) * 2017-03-24 2024-03-19 씨젠 인크. 글루쿠로니드 약물-링커의 제조 공정 및 그 중간물
WO2018195243A1 (en) 2017-04-20 2018-10-25 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
CN120682290A (zh) 2017-07-04 2025-09-23 尹图赛利有限公司 包含可裂解接头的化合物及其用途
GB201714115D0 (en) * 2017-09-04 2017-10-18 Femtogenix Ltd Cytotoxic agents
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
CN112930350A (zh) 2018-10-31 2021-06-08 尹图赛利有限公司 稠合杂环苯并二氮杂䓬衍生物及其用途
KR102503143B1 (ko) 2019-03-06 2023-02-24 주식회사 레고켐 바이오사이언스 인간 dlk1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
BR112022026401A2 (pt) 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3

Also Published As

Publication number Publication date
US20220162190A1 (en) 2022-05-26
IL278973B2 (en) 2025-07-01
US20190367488A1 (en) 2019-12-05
IL278973B1 (en) 2025-03-01
KR20210003938A (ko) 2021-01-12
WO2019229536A3 (en) 2020-03-05
CN112166115A (zh) 2021-01-01
JP7465819B2 (ja) 2024-04-11
KR102946423B1 (ko) 2026-04-01
US11807628B2 (en) 2023-11-07
US11084801B2 (en) 2021-08-10
IL278973A (en) 2021-01-31
AU2023203485A1 (en) 2023-07-06
JP2021525730A (ja) 2021-09-27
EP3802546A4 (en) 2021-12-29
MX2020012718A (es) 2021-02-16
AU2023203485B2 (en) 2024-09-19
EA202092909A1 (ru) 2021-04-07
CN113444111A (zh) 2021-09-28
CA3100141A1 (en) 2019-12-05
EP3802546A2 (en) 2021-04-14
WO2019229536A2 (en) 2019-12-05
AU2019276833A1 (en) 2020-11-26

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B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]