EA202092909A1 - Новый бензодиазепин, его производные и применение - Google Patents
Новый бензодиазепин, его производные и применениеInfo
- Publication number
- EA202092909A1 EA202092909A1 EA202092909A EA202092909A EA202092909A1 EA 202092909 A1 EA202092909 A1 EA 202092909A1 EA 202092909 A EA202092909 A EA 202092909A EA 202092909 A EA202092909 A EA 202092909A EA 202092909 A1 EA202092909 A1 EA 202092909A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- applications
- new benzodiazepine
- benzodiazepine
- new
- Prior art date
Links
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 title 1
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862677498P | 2018-05-29 | 2018-05-29 | |
| PCT/IB2019/000691 WO2019229536A2 (en) | 2018-05-29 | 2019-05-29 | Novel benzodiazepine derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202092909A1 true EA202092909A1 (ru) | 2021-04-07 |
Family
ID=68692822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202092909A EA202092909A1 (ru) | 2018-05-29 | 2019-05-29 | Новый бензодиазепин, его производные и применение |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11084801B2 (https=) |
| EP (1) | EP3802546A4 (https=) |
| JP (1) | JP7465819B2 (https=) |
| KR (1) | KR102946423B1 (https=) |
| CN (2) | CN113444111A (https=) |
| AU (2) | AU2019276833A1 (https=) |
| BR (1) | BR112020023623A2 (https=) |
| CA (1) | CA3100141A1 (https=) |
| EA (1) | EA202092909A1 (https=) |
| IL (1) | IL278973B2 (https=) |
| MX (1) | MX2020012718A (https=) |
| WO (1) | WO2019229536A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019008441A1 (en) | 2017-07-04 | 2019-01-10 | Intocell, Inc. | COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF |
| MX2020012718A (es) | 2018-05-29 | 2021-02-16 | Intocell Inc | Derivados de benzodiazepinas novedosos y usos de los mismos. |
| KR20210068591A (ko) | 2018-10-31 | 2021-06-09 | 주식회사 인투셀 | 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도 |
| EP3906064A4 (en) * | 2019-01-03 | 2023-03-08 | Intocell, Inc. | CLEAVABLE LINKER COMPOUNDS AND USES THEREOF |
| WO2020141460A2 (en) | 2019-01-03 | 2020-07-09 | Intocell, Inc. | Compounds comprising cleavable linker and uses thereof |
| KR20220108783A (ko) * | 2019-12-02 | 2022-08-03 | 주식회사 인투셀 | 분자 접합과 관련된 조성물 및 방법 |
| KR20230028793A (ko) * | 2020-06-26 | 2023-03-02 | 주식회사 인투셀 | 항-b7-h3 항체를 포함하는 항체-약물 접합체 |
| CN114805432A (zh) * | 2022-03-03 | 2022-07-29 | 西北工业大学 | 新型可光催化剪切的羧酸保护基及其氨基酸衍生物的制备方法 |
| CN119424671A (zh) | 2023-08-01 | 2025-02-14 | 上海新理念生物医药科技有限公司 | 含糖基吡啶型连接子的抗体药物偶联物 |
| WO2025262641A1 (en) * | 2024-06-19 | 2025-12-26 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843937A (en) | 1996-05-23 | 1998-12-01 | Panorama Research, Inc. | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
| GB0819095D0 (en) * | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| CN102365021B (zh) | 2009-02-05 | 2015-07-15 | 伊缪诺金公司 | 新型苯并二氮杂*衍生物 |
| CA2850103C (en) * | 2011-10-14 | 2019-09-10 | Spirogen Sarl | Pyrrolobenzodiazepines |
| WO2013055993A1 (en) * | 2011-10-14 | 2013-04-18 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| HK1211208A1 (zh) | 2012-08-22 | 2016-05-20 | Immunogen, Inc. | 細胞毒性苯並二氮呯衍生物 |
| US10131682B2 (en) | 2012-11-24 | 2018-11-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules |
| RU2729194C2 (ru) * | 2013-12-27 | 2020-08-05 | Займворкс Инк. | Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| TW201632531A (zh) * | 2015-01-14 | 2016-09-16 | 必治妥美雅史谷比公司 | 苯二氮呯二聚物，其結合物及製造與使用方法 |
| JP6676058B2 (ja) * | 2015-01-14 | 2020-04-08 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法 |
| MX382582B (es) | 2015-03-18 | 2025-03-13 | Seagen Inc | Anticuerpos contra cúmulo de diferenciación 48 (cd48) y sus conjugados. |
| US9504694B2 (en) * | 2015-03-19 | 2016-11-29 | Cellerant Therapeutics, Inc. | Isoquinolidinobenzodiazepines |
| JP2019516705A (ja) * | 2016-05-20 | 2019-06-20 | アッヴィ・ステムセントルクス・エル・エル・シー | 神経内分泌移行のリスクのある腫瘍を治療するための抗ｄｌｌ３薬物コンジュゲート |
| WO2018053552A2 (en) * | 2016-09-19 | 2018-03-22 | Cellerant Therapeutics, Inc. | Isoquinolidinobenzodiazepines |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| AU2018237683A1 (en) * | 2017-03-24 | 2019-10-31 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| WO2018195243A1 (en) | 2017-04-20 | 2018-10-25 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives and conjugates thereof |
| WO2019008441A1 (en) * | 2017-07-04 | 2019-01-10 | Intocell, Inc. | COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF |
| GB201714115D0 (en) * | 2017-09-04 | 2017-10-18 | Femtogenix Ltd | Cytotoxic agents |
| MX2020012718A (es) | 2018-05-29 | 2021-02-16 | Intocell Inc | Derivados de benzodiazepinas novedosos y usos de los mismos. |
| KR20210068591A (ko) | 2018-10-31 | 2021-06-09 | 주식회사 인투셀 | 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도 |
| KR102503143B1 (ko) | 2019-03-06 | 2023-02-24 | 주식회사 레고켐 바이오사이언스 | 인간 dlk1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
| KR20230028793A (ko) | 2020-06-26 | 2023-03-02 | 주식회사 인투셀 | 항-b7-h3 항체를 포함하는 항체-약물 접합체 |
-
2019
- 2019-05-29 MX MX2020012718A patent/MX2020012718A/es unknown
- 2019-05-29 IL IL278973A patent/IL278973B2/en unknown
- 2019-05-29 EA EA202092909A patent/EA202092909A1/ru unknown
- 2019-05-29 AU AU2019276833A patent/AU2019276833A1/en not_active Abandoned
- 2019-05-29 WO PCT/IB2019/000691 patent/WO2019229536A2/en not_active Ceased
- 2019-05-29 CA CA3100141A patent/CA3100141A1/en active Pending
- 2019-05-29 CN CN202110592302.2A patent/CN113444111A/zh active Pending
- 2019-05-29 JP JP2020566662A patent/JP7465819B2/ja active Active
- 2019-05-29 BR BR112020023623-3A patent/BR112020023623A2/pt unknown
- 2019-05-29 EP EP19811692.3A patent/EP3802546A4/en active Pending
- 2019-05-29 KR KR1020207037031A patent/KR102946423B1/ko active Active
- 2019-05-29 US US16/425,237 patent/US11084801B2/en active Active
- 2019-05-29 CN CN201980035084.3A patent/CN112166115A/zh active Pending
-
2021
- 2021-06-30 US US17/363,814 patent/US11807628B2/en active Active
-
2023
- 2023-06-05 AU AU2023203485A patent/AU2023203485B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL278973B1 (en) | 2025-03-01 |
| AU2023203485B2 (en) | 2024-09-19 |
| BR112020023623A2 (pt) | 2021-02-17 |
| KR102946423B1 (ko) | 2026-04-01 |
| AU2023203485A1 (en) | 2023-07-06 |
| US11807628B2 (en) | 2023-11-07 |
| AU2019276833A1 (en) | 2020-11-26 |
| EP3802546A2 (en) | 2021-04-14 |
| JP2021525730A (ja) | 2021-09-27 |
| IL278973A (en) | 2021-01-31 |
| WO2019229536A3 (en) | 2020-03-05 |
| JP7465819B2 (ja) | 2024-04-11 |
| MX2020012718A (es) | 2021-02-16 |
| US20190367488A1 (en) | 2019-12-05 |
| CA3100141A1 (en) | 2019-12-05 |
| US20220162190A1 (en) | 2022-05-26 |
| IL278973B2 (en) | 2025-07-01 |
| KR20210003938A (ko) | 2021-01-12 |
| EP3802546A4 (en) | 2021-12-29 |
| CN113444111A (zh) | 2021-09-28 |
| US11084801B2 (en) | 2021-08-10 |
| CN112166115A (zh) | 2021-01-01 |
| WO2019229536A2 (en) | 2019-12-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA202092909A1 (ru) | Новый бензодиазепин, его производные и применение | |
| MX2021006154A (es) | Degradadores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos. | |
| MX2022007576A (es) | Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. | |
| EA202191180A1 (ru) | Производные конденсированного гетероциклического бензодиазепина и их применение | |
| MX2021014441A (es) | Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos. | |
| MX2021014443A (es) | Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos. | |
| MX2020006812A (es) | Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. | |
| MX2022007841A (es) | Degradadores del regulador dependiente de actina asociado a la matriz relacionado con el complejo switch/sacarosa no fermentable de la subfamilia a de la cromatina (smarca)y usos de los mismos. | |
| EA201990615A1 (ru) | Пирролобензодиазепиновые конъюгаты | |
| EA201891024A1 (ru) | Соединения-ингибиторы tank-связывающей киназы | |
| EA201890749A1 (ru) | ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) И ИХ ПРИМЕНЕНИЕ | |
| EA202092692A1 (ru) | Аналоги рапамицина и их применения | |
| EA201891202A1 (ru) | Композиции, содержащие бактериальные штаммы | |
| MX2018016038A (es) | Compuestos y metodos para modular la funcion del acido ribonucleico (arn). | |
| EA201890050A1 (ru) | Композиции, содержащие бактериальные штаммы | |
| EA201890049A1 (ru) | Композиции, содержащие бактериальные штаммы | |
| CY1124338T1 (el) | Αναστολεις 3-φωσφογλυκερικης αφυδρογονασης και χρησεις αυτων | |
| PH12019501872A1 (en) | Anti-tryptase antibodies, compositions thereof, and uses thereof | |
| EA202091337A1 (ru) | Ингибиторы гистонацетилтрансфераз семейства myst | |
| EA201891586A1 (ru) | Антипролиферативные соединения и их фармацевтические композиции и применения | |
| EA202192101A1 (ru) | Соединения и их применение | |
| EA201792262A1 (ru) | Пироглутамат вортиоксетина | |
| EA201992302A1 (ru) | Соединения, используемые в качестве ингибиторов alcat1 | |
| EA201990064A1 (ru) | Противомалярийные композиции и варианты их применения | |
| EA202090971A1 (ru) | Способы применения и композиции, содержащие дулаглутид |