KR102946423B1 - 신규한 벤조다이아제핀 유도체 및 그 용도 - Google Patents

신규한 벤조다이아제핀 유도체 및 그 용도

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Publication number
KR102946423B1
KR102946423B1 KR1020207037031A KR20207037031A KR102946423B1 KR 102946423 B1 KR102946423 B1 KR 102946423B1 KR 1020207037031 A KR1020207037031 A KR 1020207037031A KR 20207037031 A KR20207037031 A KR 20207037031A KR 102946423 B1 KR102946423 B1 KR 102946423B1
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South Korea
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compound
alkyl
delete delete
mmol
preparation
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Korean (ko)
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KR20210003938A (ko
Inventor
박태교
우성호
김선영
박수호
조종운
정두환
서동훈
이재호
이상광
윤상현
이향숙
박옥구
서범석
김세나
설미나
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주식회사 인투셀
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020207037031A 2018-05-29 2019-05-29 신규한 벤조다이아제핀 유도체 및 그 용도 Active KR102946423B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862677498P 2018-05-29 2018-05-29
US62/677,498 2018-05-29
PCT/IB2019/000691 WO2019229536A2 (en) 2018-05-29 2019-05-29 Novel benzodiazepine derivatives and uses thereof

Publications (2)

Publication Number Publication Date
KR20210003938A KR20210003938A (ko) 2021-01-12
KR102946423B1 true KR102946423B1 (ko) 2026-04-01

Family

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KR1020207037031A Active KR102946423B1 (ko) 2018-05-29 2019-05-29 신규한 벤조다이아제핀 유도체 및 그 용도

Country Status (12)

Country Link
US (2) US11084801B2 (https=)
EP (1) EP3802546A4 (https=)
JP (1) JP7465819B2 (https=)
KR (1) KR102946423B1 (https=)
CN (2) CN113444111A (https=)
AU (2) AU2019276833A1 (https=)
BR (1) BR112020023623A2 (https=)
CA (1) CA3100141A1 (https=)
EA (1) EA202092909A1 (https=)
IL (1) IL278973B2 (https=)
MX (1) MX2020012718A (https=)
WO (1) WO2019229536A2 (https=)

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WO2019008441A1 (en) 2017-07-04 2019-01-10 Intocell, Inc. COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
KR20210068591A (ko) 2018-10-31 2021-06-09 주식회사 인투셀 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도
EP3906064A4 (en) * 2019-01-03 2023-03-08 Intocell, Inc. CLEAVABLE LINKER COMPOUNDS AND USES THEREOF
WO2020141460A2 (en) 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
KR20220108783A (ko) * 2019-12-02 2022-08-03 주식회사 인투셀 분자 접합과 관련된 조성물 및 방법
KR20230028793A (ko) * 2020-06-26 2023-03-02 주식회사 인투셀 항-b7-h3 항체를 포함하는 항체-약물 접합체
CN114805432A (zh) * 2022-03-03 2022-07-29 西北工业大学 新型可光催化剪切的羧酸保护基及其氨基酸衍生物的制备方法
CN119424671A (zh) 2023-08-01 2025-02-14 上海新理念生物医药科技有限公司 含糖基吡啶型连接子的抗体药物偶联物
WO2025262641A1 (en) * 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof

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WO2013055993A1 (en) * 2011-10-14 2013-04-18 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
HK1211208A1 (zh) 2012-08-22 2016-05-20 Immunogen, Inc. 細胞毒性苯並二氮呯衍生物
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RU2729194C2 (ru) * 2013-12-27 2020-08-05 Займворкс Инк. Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов
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JP6676058B2 (ja) * 2015-01-14 2020-04-08 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
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KR20230028793A (ko) 2020-06-26 2023-03-02 주식회사 인투셀 항-b7-h3 항체를 포함하는 항체-약물 접합체

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Also Published As

Publication number Publication date
IL278973B1 (en) 2025-03-01
AU2023203485B2 (en) 2024-09-19
BR112020023623A2 (pt) 2021-02-17
AU2023203485A1 (en) 2023-07-06
US11807628B2 (en) 2023-11-07
AU2019276833A1 (en) 2020-11-26
EP3802546A2 (en) 2021-04-14
JP2021525730A (ja) 2021-09-27
EA202092909A1 (ru) 2021-04-07
IL278973A (en) 2021-01-31
WO2019229536A3 (en) 2020-03-05
JP7465819B2 (ja) 2024-04-11
MX2020012718A (es) 2021-02-16
US20190367488A1 (en) 2019-12-05
CA3100141A1 (en) 2019-12-05
US20220162190A1 (en) 2022-05-26
IL278973B2 (en) 2025-07-01
KR20210003938A (ko) 2021-01-12
EP3802546A4 (en) 2021-12-29
CN113444111A (zh) 2021-09-28
US11084801B2 (en) 2021-08-10
CN112166115A (zh) 2021-01-01
WO2019229536A2 (en) 2019-12-05

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