JP7278961B2 - Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 - Google Patents

Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 Download PDF

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JP7278961B2
JP7278961B2 JP2019553220A JP2019553220A JP7278961B2 JP 7278961 B2 JP7278961 B2 JP 7278961B2 JP 2019553220 A JP2019553220 A JP 2019553220A JP 2019553220 A JP2019553220 A JP 2019553220A JP 7278961 B2 JP7278961 B2 JP 7278961B2
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cells
car
dasatinib
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ponatinib
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JP2020515581A (ja
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リン，レイチェル
マッコール，クリスタル
ウェバー，エヴァン
マロ―トラー，サンジェイ
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Leland Stanford Junior University
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JP2019553220A 2017-03-31 2018-03-30 Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法 Active JP7278961B2 (ja)

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JP2023011257A JP2023055805A (ja) 2017-03-31 2023-01-27 Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法
JP2024123405A JP2024153812A (ja) 2017-03-31 2024-07-30 Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法

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US201762479930P 2017-03-31 2017-03-31
US62/479,930 2017-03-31
PCT/US2018/025394 WO2018183842A1 (en) 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling

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JP2019553214A Active JP7249287B2 (ja) 2017-03-31 2018-03-30 Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法
JP2022193805A Active JP7674328B2 (ja) 2017-03-31 2022-12-02 Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法
JP2023011257A Pending JP2023055805A (ja) 2017-03-31 2023-01-27 Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法
JP2024123405A Pending JP2024153812A (ja) 2017-03-31 2024-07-30 Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法
JP2024200383A Pending JP2025026930A (ja) 2017-03-31 2024-11-18 Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法

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JP2022193805A Active JP7674328B2 (ja) 2017-03-31 2022-12-02 Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法
JP2023011257A Pending JP2023055805A (ja) 2017-03-31 2023-01-27 Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法
JP2024123405A Pending JP2024153812A (ja) 2017-03-31 2024-07-30 Ｔ細胞受容体のシグナル伝達を阻害するまたは調節することによってｔ細胞の疲弊を治療する方法
JP2024200383A Pending JP2025026930A (ja) 2017-03-31 2024-11-18 Ｔ細胞受容体シグナル伝達を阻害または調節することによって、ｔ細胞枯渇を処置する方法

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CN (3) CN110603044B (enExample)
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WO2019110815A1 (en) * 2017-12-07 2019-06-13 Julius-Maximilians-Universität Würzburg Control and modulation of the function of gene-modified chimeric antigen receptor t cells with dasatinib and other tyrosine kinase inhibitors
US20210393628A1 (en) * 2018-10-30 2021-12-23 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for modulating t cell exhaustion
CN113573719A (zh) * 2018-11-08 2021-10-29 朱诺治疗学股份有限公司 治疗和t细胞调节的方法和组合
US12600971B2 (en) 2019-02-13 2026-04-14 Beam Therapeutics Inc. Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
AU2020231810B2 (en) * 2019-03-01 2025-12-18 National University Of Singapore Engineered immune cells
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