AU2018243571B2 - Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling - Google Patents

Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling Download PDF

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AU2018243571B2
AU2018243571B2 AU2018243571A AU2018243571A AU2018243571B2 AU 2018243571 B2 AU2018243571 B2 AU 2018243571B2 AU 2018243571 A AU2018243571 A AU 2018243571A AU 2018243571 A AU2018243571 A AU 2018243571A AU 2018243571 B2 AU2018243571 B2 AU 2018243571B2
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cells
cell
genetically engineered
dasatinib
car
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AU2018243571A1 (en
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Rachel LYNN
Crystal Mackall
Sanjay Malhotra
Evan WEBER
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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AU2018243571A 2017-03-31 2018-03-30 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling Active AU2018243571B2 (en)

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AU2024203919A AU2024203919A1 (en) 2017-03-31 2024-06-07 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling

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US201762479930P 2017-03-31 2017-03-31
US62/479,930 2017-03-31
PCT/US2018/025394 WO2018183842A1 (en) 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling

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AU2024203919A Pending AU2024203919A1 (en) 2017-03-31 2024-06-07 Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling

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US (3) US11938153B2 (enExample)
EP (2) EP3600357A4 (enExample)
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