JP7270546B2 - 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル - Google Patents

個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル Download PDF

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JP7270546B2
JP7270546B2 JP2019550821A JP2019550821A JP7270546B2 JP 7270546 B2 JP7270546 B2 JP 7270546B2 JP 2019550821 A JP2019550821 A JP 2019550821A JP 2019550821 A JP2019550821 A JP 2019550821A JP 7270546 B2 JP7270546 B2 JP 7270546B2
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vitamin
omega
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levels
homocysteine
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JP2020516862A (ja
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ジーン ボウマン，
ジュリー， ロール ハドリー－ラベ，
イェルン， アントニウス， ヨハンネス シュミット，
コリーナ ボシャット，
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ソシエテ・デ・プロデュイ・ネスレ・エス・アー
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2019550821A 2017-04-11 2017-12-11 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル Active JP7270546B2 (ja)

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JP2022129344A JP7434458B2 (ja) 2017-04-11 2022-08-15 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル

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US201762484119P 2017-04-11 2017-04-11
US201762484156P 2017-04-11 2017-04-11
US62/484,156 2017-04-11
US62/484,119 2017-04-11
EP17193916.8 2017-09-29
EP17193916.8A EP3388061A1 (en) 2017-04-11 2017-09-29 Omega 3 fatty acids, no releasing compound, vitamin b12 and choline as neuroprotectant in patients with no dementia
US201762580574P 2017-11-02 2017-11-02
US62/580,574 2017-11-02
PCT/EP2017/082148 WO2018188771A1 (en) 2017-04-11 2017-12-11 Omega-3 fatty acid and vitamin d levels to identify and attenuate cognitive aging in individuals

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JP2019550821A Active JP7270546B2 (ja) 2017-04-11 2017-12-11 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル
JP2019550713A Pending JP2020516586A (ja) 2017-04-11 2018-04-05 認知症ではない個体において、認知的加齢を軽減する組成物及び方法
JP2019551444A Active JP7270547B2 (ja) 2017-04-11 2018-04-05 個体における認知的加齢を特定及び軽減するためのオメガ－３脂肪酸、ホモシステイン及びビタミンｄのレベル。
JP2022129344A Active JP7434458B2 (ja) 2017-04-11 2022-08-15 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル
JP2022129345A Active JP7434459B2 (ja) 2017-04-11 2022-08-15 個体における認知的加齢を特定及び軽減するためのオメガ－３脂肪酸、ホモシステイン及びビタミンｄのレベル
JP2022206897A Active JP7524294B2 (ja) 2017-04-11 2022-12-23 認知症ではない個体において認知的加齢を軽減する組成物の製造方法

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JP2019551444A Active JP7270547B2 (ja) 2017-04-11 2018-04-05 個体における認知的加齢を特定及び軽減するためのオメガ－３脂肪酸、ホモシステイン及びビタミンｄのレベル。
JP2022129344A Active JP7434458B2 (ja) 2017-04-11 2022-08-15 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル
JP2022129345A Active JP7434459B2 (ja) 2017-04-11 2022-08-15 個体における認知的加齢を特定及び軽減するためのオメガ－３脂肪酸、ホモシステイン及びビタミンｄのレベル
JP2022206897A Active JP7524294B2 (ja) 2017-04-11 2022-12-23 認知症ではない個体において認知的加齢を軽減する組成物の製造方法

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JP7270546B2 (ja) * 2017-04-11 2023-05-10 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル
CN113252806B (zh) * 2021-03-25 2023-08-29 嘉兴学院 S-腺苷同型半胱氨酸在制备用于诊断或治疗川崎病的产品中的用途

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JP2020516864A (ja) 2017-04-11 2020-06-11 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 個体における認知的加齢を特定及び軽減するためのオメガ−３脂肪酸、ホモシステイン及びビタミンｄのレベル。

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