JP2018537091A - 中鎖トリグリセリド組成物 - Google Patents
中鎖トリグリセリド組成物 Download PDFInfo
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- JP2018537091A JP2018537091A JP2018525699A JP2018525699A JP2018537091A JP 2018537091 A JP2018537091 A JP 2018537091A JP 2018525699 A JP2018525699 A JP 2018525699A JP 2018525699 A JP2018525699 A JP 2018525699A JP 2018537091 A JP2018537091 A JP 2018537091A
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Abstract
Description
一実施形態において、MCT−C8とMCT−C10の比は、58:42〜62:38(mol/mol)である。
別の実施形態において、MCT−C8とMCT−C10の比は、約60:40(mol/mol)である。
一実施形態において、MCT−C8とMCT−C10の比は、87:13〜83:17(mol/mol)である。
別の実施形態において、MCT−C8とMCT−C10の比は、約85:15(mol/mol)である。
一実施形態において、MCT−C8とMCT−C10の比は、18:82〜22:78(mol/mol)である。
別の実施形態において、MCT−C8とMCT−C10の比は、約20:80(mol/mol)である。
ある実施形態において、組成物は、医療用食品、経管栄養物、栄養補助食品又は栄養組成物の形態であり得る。
別の実施形態において、組成物は、完全栄養製品の形態であり得る。別の実施形態において、組成物は、栄養の一部を提供し得る。
別の実施形態において、組成物は、粉末、好ましくは、噴霧乾燥粉末の形態である。
一実施形態において、組成物は、油中水型エマルジョンの形態である。
トリグリセリド(トリアシルグリセロール又はトリアシルグリセリドとしても知られる)は、グリセロールと3つの脂肪酸から誘導されるエステルである。
オクタン酸(カプリル酸としても知られる)は、式CH3(CH2)6COOHの飽和脂肪酸である。
デカン酸(カプリン酸としても知られる)は、式CH3(CH2)8COOHの飽和脂肪酸である。
中鎖トリグリセリド(MCT)を含む組成物が本明細書で提供され、この組成物は、(i)8個の炭素原子をそれぞれ有する3つの脂肪酸部分を含むホモトリグリセリドMCT(MCT−C8)と、(ii)10個の炭素原子をそれぞれ有する3つの脂肪酸部分を含むホモトリグリセリドMCT(MCT−C10)とを含む。
本明細書に記載される組成物は、経腸的又は非経口的に投与され得る。
本明細書における治療への言及は全て治癒的、緩和的及び予防的治療を含むことを理解されたい。治療にはまた、疾患の重症度が進行するのを抑止することも含まれ得る。
MCTは、経口吸収後、遊離脂肪酸に代謝され更にケトンに代謝される。遊離脂肪酸は、最初にβ−ヒドロキシ酪酸(BHB)に代謝され、次いでアセト酢酸(AcA)に代謝される。
本発明者は、C8/C10比が同じである、MCT−C8とMCT−C10のブレンド(PLUS)が、哺乳動物に投与したとき、より多くの血漿C10遊離脂肪酸を提供する上で、MCT(mixC8/10)よりも優れることを見出した。同時に、ケトン濃度が8%増加する。
Claims (15)
- 中鎖トリグリセリド(MCT)を含む組成物であって、(i)8個の炭素原子をそれぞれ有する3つの脂肪酸部分を含むMCT(MCT−C8)と、(ii)10個の炭素原子をそれぞれ有する3つの脂肪酸部分を含むMCT(MCT−C10)とを含み、MCT−C8とMCT−C10の比は、10:90〜90:10(mol/mol)であり、MCT−C8とMCT−C10の合計量は、前記組成物中の前記MCTの少なくとも50モル%を占める、組成物。
- MCT−C8とMCT−C10の比が、20:80〜85:15、20:80〜80:20、30:70〜85:15、40:60〜75:25、50:50〜70:30、50:50〜67:33、55:45〜65:35又は58:42〜62:38(mol/mol)である、請求項1に記載の組成物。
- MCT−C8とMCT−C10の合計量が、前記組成物中の前記MCTの少なくとも90、95、98又は99モル%を占める、請求項1又は2に記載の組成物。
- 中鎖トリグリセリド(MCT)を含む組成物であって、(i)8個の炭素原子をそれぞれ有する3つの脂肪酸部分を含むMCT(MCT−C8)と、(ii)10個の炭素原子をそれぞれ有する3つの脂肪酸部分を含むMCT(MCT−C10)とを含み、MCT−C8とMCT−C10の比は、50:50〜67:33(mol/mol)である、組成物。
- 前記8個の炭素原子をそれぞれ有する3つの脂肪酸部分がオクタン酸部分であり、かつ/又は前記10個の炭素原子をそれぞれ有する3つの脂肪酸部分がデカン酸部分である、請求項1〜4のいずれか一項に記載の組成物。
- 神経の健康状態を促進若しくは維持し、又は認知機能を向上させる、1つ以上の作用物質を更に含み、前記作用物質は、ビタミン、コリン、ホスファチジルセリン、α−リポ酸、CoQ10、アセチル−L−カルニチン、ハーブ抽出物(イチョウ、オトメアゼナ、シャンカプシュピ及びスノーフレークなど)、オメガ−3又はオメガ−6多価不飽和脂肪酸(遊離脂肪酸としてのエイコサペンタエン酸、ドコサペンタエン酸又はドコサヘキサエン酸など)、脂肪族エステル(エチルエステル、トリグリセリド又はモノグリセリド形態など)及び魚油抽出物からなる群から選択される、請求項1〜5のいずれか一項に記載の組成物。
- 対象にケトン及び/又はC10脂肪酸をもたらすことにおける使用のための請求項1〜6のいずれか一項に記載の組成物。
- 前記ケトンがβ−ヒドロキシ酪酸及びアセト酢酸から選択される、請求項7に記載の使用のための組成物。
- 対象における脳エネルギーの欠乏状態、神経学的状態、片頭痛、記憶障害、加齢による記憶障害、脳損傷、脳卒中、アミロイド側索硬化症、多発性硬化症、認知障害、集中治療後認知障害、加齢による認知障害、アルツハイマー病、パーキンソン病、ハンチントン病、先天性代謝異常症(グルコーストランスポーター1欠損症症候群及びピルビン酸脱水素酵素複合体欠損症など)、双極性障害、統合失調症及び/又はてんかんの治療又は予防における使用のための請求項1〜9のいずれか一項に記載の組成物。
- 経腸的に投与される、請求項7〜10のいずれか一項に記載の使用のための組成物。
- 食料品又は食物の形態である、請求項7〜11のいずれか一項に記載の使用のための組成物。
- 医療用食品、経管栄養物、栄養組成物又は栄養補助食品の形態である、請求項7〜12のいずれか一項に記載の使用のための組成物。
- 飲料、マヨネーズ、サラダドレッシング、マーガリン、低脂肪スプレッド、乳製品、チーズスプレッド、プロセスチーズ、乳製品デザート、フレーバーミルク、クリーム、発酵乳製品、チーズ、バター、コンデンスミルク製品、アイスクリームミックス、大豆製品、低温殺菌液状卵、ベーカリー製品、菓子製品、菓子バー、チョコレートバー、高脂肪バー、液状エマルジョン、噴霧乾燥粉末、凍結乾燥粉末、UHTプリン、低温殺菌プリン、ゲル、ゼリー、ヨーグルト、又は脂肪ベースのフィリング若しくは含水フィリングを有する食品の形態である、請求項7〜13のいずれか一項に記載の使用のための組成物。
- 対象にケトン及び/又はC10脂肪酸をもたらすための、請求項1〜6のいずれか一項に記載の組成物の使用。
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