JP7240335B2 - 抗bcma重鎖のみ抗体 - Google Patents

抗bcma重鎖のみ抗体 Download PDF

Info

Publication number
JP7240335B2
JP7240335B2 JP2019571347A JP2019571347A JP7240335B2 JP 7240335 B2 JP7240335 B2 JP 7240335B2 JP 2019571347 A JP2019571347 A JP 2019571347A JP 2019571347 A JP2019571347 A JP 2019571347A JP 7240335 B2 JP7240335 B2 JP 7240335B2
Authority
JP
Japan
Prior art keywords
antibody
heavy chain
bcma
seq
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019571347A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020524000A5 (enExample
JP2020524000A (ja
Inventor
ネイサン トリンクライン,
シェリー フォース オルドレッド,
スターリン クラーク,
ショーテン, ウィム ヴァン
Original Assignee
テネオワン, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テネオワン, インコーポレイテッド filed Critical テネオワン, インコーポレイテッド
Publication of JP2020524000A publication Critical patent/JP2020524000A/ja
Publication of JP2020524000A5 publication Critical patent/JP2020524000A5/ja
Priority to JP2023032495A priority Critical patent/JP7465382B2/ja
Application granted granted Critical
Publication of JP7240335B2 publication Critical patent/JP7240335B2/ja
Priority to JP2024058155A priority patent/JP2024084776A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/522CH1 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2019571347A 2017-06-20 2018-06-20 抗bcma重鎖のみ抗体 Active JP7240335B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023032495A JP7465382B2 (ja) 2017-06-20 2023-03-03 抗bcma重鎖のみ抗体
JP2024058155A JP2024084776A (ja) 2017-06-20 2024-03-29 抗bcma重鎖のみ抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762522295P 2017-06-20 2017-06-20
US62/522,295 2017-06-20
PCT/US2018/038506 WO2018237006A1 (en) 2017-06-20 2018-06-20 Anti-bcma heavy chain-only antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023032495A Division JP7465382B2 (ja) 2017-06-20 2023-03-03 抗bcma重鎖のみ抗体

Publications (3)

Publication Number Publication Date
JP2020524000A JP2020524000A (ja) 2020-08-13
JP2020524000A5 JP2020524000A5 (enExample) 2021-08-19
JP7240335B2 true JP7240335B2 (ja) 2023-03-15

Family

ID=62875335

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019571347A Active JP7240335B2 (ja) 2017-06-20 2018-06-20 抗bcma重鎖のみ抗体
JP2023032495A Active JP7465382B2 (ja) 2017-06-20 2023-03-03 抗bcma重鎖のみ抗体
JP2024058155A Pending JP2024084776A (ja) 2017-06-20 2024-03-29 抗bcma重鎖のみ抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023032495A Active JP7465382B2 (ja) 2017-06-20 2023-03-03 抗bcma重鎖のみ抗体
JP2024058155A Pending JP2024084776A (ja) 2017-06-20 2024-03-29 抗bcma重鎖のみ抗体

Country Status (9)

Country Link
US (2) US11427642B2 (enExample)
EP (1) EP3642236A1 (enExample)
JP (3) JP7240335B2 (enExample)
CN (3) CN118146370A (enExample)
AU (2) AU2018288803B2 (enExample)
BR (1) BR112019026803A2 (enExample)
CA (1) CA3065951A1 (enExample)
MX (2) MX2019015563A (enExample)
WO (1) WO2018237006A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017223111A1 (en) 2016-06-21 2017-12-28 Teneobio, Inc. Cd3 binding antibodies
US12495776B2 (en) 2016-08-24 2025-12-16 Teneobio, Inc. Transgenic non-human animals producing modified heavy chain-only antibodies
MY200988A (en) 2016-09-14 2024-01-27 Teneobio Inc CD3 Binding Antibodies
EP3559035A1 (en) 2016-12-21 2019-10-30 TeneoBio, Inc. Anti-bcma heavy chain-only antibodies
CN118146370A (zh) 2017-06-20 2024-06-07 特纳奥尼股份有限公司 仅有重链的抗bcma抗体
CA3067584A1 (en) 2017-06-20 2018-12-27 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
CN111094345B (zh) * 2017-06-30 2023-10-27 美国卫生和人力服务部 具有人结构域的抗b细胞成熟抗原嵌合抗原受体
WO2019126756A1 (en) 2017-12-22 2019-06-27 Teneobio, Inc. Heavy chain antibodies binding to cd22
EP3802611A2 (en) 2018-06-01 2021-04-14 Novartis AG Binding molecules against bcma and uses thereof
CN116769032A (zh) 2018-07-20 2023-09-19 坦尼奥第二公司 与cd19结合的重链抗体
EA202192736A1 (ru) 2019-04-05 2022-01-27 Тенеобио, Инк. Антитела, содержащие только тяжелые цепи, которые связываются с псма
CU20210096A7 (es) 2019-05-21 2022-06-06 Novartis Ag Moléculas de unión a cd19
PH12021553145A1 (en) 2019-06-14 2022-07-25 Teneobio Inc Multispecific heavy chain antibodies binding to cd22 and cd3
CN112574308A (zh) * 2019-09-30 2021-03-30 和铂医药(苏州)有限公司 靶向bcma的抗体、双特异性抗体及其用途
MX2022007222A (es) * 2019-12-16 2022-09-21 Nanjing Legend Biotech Co Ltd Anticuerpos de dominio único y receptores quiméricos para antígenos dirigidos a bcma y métodos de uso de estos.
CA3214992A1 (en) 2020-04-29 2021-11-04 Teneobio, Inc. Multispecific heavy chain antibodies with modified heavy chain constant regions
KR20250007022A (ko) 2020-04-29 2025-01-13 테네오원, 인코포레이티드 변형된 중쇄 불변 영역을 갖는 다중특이적 중쇄 항체
PE20230464A1 (es) * 2020-06-30 2023-03-14 Teneobio Inc Union de anticuerpos multiespecificos a bcma
AR127408A1 (es) * 2021-10-20 2024-01-17 Takeda Pharmaceuticals Co Composiciones dirigidas a bcma y métodos de uso de las mismas

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110129458A1 (en) 2007-09-07 2011-06-02 Ablynx N.V. Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
JP2012521211A (ja) 2009-03-24 2012-09-13 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム 結合分子
JP2014500879A (ja) 2010-11-16 2014-01-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Bcma発現に相関性を有する疾患を治療する因子及び方法
JP2014520088A (ja) 2011-05-27 2014-08-21 グラクソ グループ リミテッド Bcma(cd269/tnfrsf17)結合タンパク質
JP2015535002A (ja) 2012-11-01 2015-12-07 マックス−デルブルック−セントラム フアー モレキュラーレ メデジン Cd269(bcma)に対する抗体
JP2016500256A (ja) 2012-12-07 2016-01-12 アムジエン・インコーポレーテツド Bcma抗原結合タンパク質
WO2017025038A1 (en) 2015-08-11 2017-02-16 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors based on single-domain antibodies and methods of use thereof
US20170051068A1 (en) 2015-08-17 2017-02-23 Janssen Pharmaceutica Nv Anti-BCMA Antibodies, Bispecific Antigen Binding Molecules that Bind BCMA and CD3, and Uses Thereof

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA1288073C (en) 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US6750325B1 (en) 1989-12-21 2004-06-15 Celltech R&D Limited CD3 specific recombinant antibody
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5968509A (en) 1990-10-05 1999-10-19 Btp International Limited Antibodies with binding affinity for the CD3 antigen
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
GB9206422D0 (en) 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
US7381803B1 (en) 1992-03-27 2008-06-03 Pdl Biopharma, Inc. Humanized antibodies against CD3
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
AU728657B2 (en) 1996-03-18 2001-01-18 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
AU751659B2 (en) 1997-05-02 2002-08-22 Genentech Inc. A method for making multispecific antibodies having heteromultimeric and common components
JP4253826B2 (ja) 1999-09-07 2009-04-15 カシオ計算機株式会社 画像読取装置
WO2001024812A1 (en) 1999-10-06 2001-04-12 N.V. Nutricia USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA
UA74798C2 (uk) 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
AU2002238052A1 (en) 2001-02-20 2002-09-04 Zymogenetics, Inc. Antibodies that bind both bcma and taci
CN1195779C (zh) 2001-05-24 2005-04-06 中国科学院遗传与发育生物学研究所 抗人卵巢癌抗人cd3双特异性抗体
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
US7608429B2 (en) 2002-10-31 2009-10-27 Genentech, Inc. Methods and compositions for increasing antibody production
US7575893B2 (en) 2003-01-23 2009-08-18 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
WO2004106381A1 (en) 2003-05-31 2004-12-09 Micromet Ag Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
EP1753783B1 (en) 2004-06-03 2014-08-06 Novimmune SA Anti-cd3 antibodies and methods of use thereof
EP4353819A3 (en) 2004-07-22 2024-07-17 Erasmus University Medical Center Rotterdam Binding molecules
ES2498794T3 (es) 2005-02-18 2014-09-25 Medarex, L.L.C. Anticuerpos monoclonales contra CD30 que carecen de restos fucosilo
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
BRPI0615745A2 (pt) 2005-09-12 2011-05-24 Novimmune Sa formulação de anticorpo anti-cd3
WO2007042261A2 (en) 2005-10-11 2007-04-19 Micromet Ag Compositions comprising cross-species-specific antibodies and uses thereof
JP2009518025A (ja) 2005-12-06 2009-05-07 ドマンティス リミテッド 細胞表面標的に対して結合特異性を有する二重特異性リガンドおよびその使用方法
WO2007117600A2 (en) 2006-04-07 2007-10-18 Macrogenics, Inc. Combination therapy for treating autoimmune diseases
WO2008016431A2 (en) 2006-07-29 2008-02-07 Robert Lamar Bjork Bi-specific monoclonal antibody (specific for both cd3 and cd11b) therapeutic drug
CN103694350B (zh) 2007-04-03 2018-04-24 安进研发(慕尼黑)股份有限公司 跨物种特异性CD3-ε结合结构域
PT2336329E (pt) 2007-06-01 2012-12-24 Omt Inc Composições e métodos para inibição de genes de imunoglobulina endógena e produção de anticorpos transgénicos humanos idiotípicos
CA2720682A1 (en) 2008-04-25 2009-10-29 Zymogenetics, Inc. Levels of bcma protein expression on b cells and use in diagnostic methods
US20100122358A1 (en) 2008-06-06 2010-05-13 Crescendo Biologics Limited H-Chain-only antibodies
EP4180458A1 (en) 2008-10-01 2023-05-17 Amgen Research (Munich) GmbH Cross-species-specific psma x cd3 bispecific single chain antibody
NZ594985A (en) 2009-03-10 2013-07-26 Biogen Idec Inc Anti-bcma (b-cell maturation antigen, cd269, tnfrsf17) antibodies
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
DK2505654T4 (da) 2010-02-08 2020-07-27 Regeneron Pharma Mus med fælles letkæde
TWI653333B (zh) 2010-04-01 2019-03-11 安進研究(慕尼黑)有限責任公司 跨物種專一性之PSMAxCD3雙專一性單鏈抗體
WO2012122512A1 (en) 2011-03-10 2012-09-13 Hco Antibody, Inc. Recombinant production of mixtures of single chain antibodies
US20130101599A1 (en) 2011-04-21 2013-04-25 Boehringer Ingelheim International Gmbh Bcma-based stratification and therapy for multiple myeloma patients
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對bcma之e3以及cd3的結合分子
RU2673153C2 (ru) 2012-04-20 2018-11-22 АПТЕВО РИСЁРЧ ЭНД ДИВЕЛОПМЕНТ ЭлЭлСи Полипептиды, связывающиеся с cd3
US20150203591A1 (en) 2012-08-02 2015-07-23 Regeneron Pharmaceuticals, Inc. Mutivalent antigen-binding proteins
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
KR20220041953A (ko) 2012-12-14 2022-04-01 오픈 모노클로날 테크놀로지, 인코포레이티드 인간 이디오타입을 갖는 설치류 항체를 인코딩하는 폴리뉴클레오티드 및 이를 포함하는 동물
EP2953974B1 (en) 2013-02-05 2017-12-20 EngMab Sàrl Bispecific antibodies against cd3epsilon and bcma
TW201522378A (zh) 2013-10-31 2015-06-16 Sanofi Sa 用於治療人類癌症的特異性抗cd38抗體
AP2016009222A0 (en) 2013-11-04 2016-05-31 Glenmark Pharmaceuticals Sa Production of t cell retargeting hetero-dimeric immunoglobulins
WO2015095412A1 (en) 2013-12-19 2015-06-25 Zhong Wang Bispecific antibody with two single-domain antigen-binding fragments
WO2015121383A1 (en) 2014-02-12 2015-08-20 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
BR112016022385A2 (pt) 2014-03-28 2018-06-19 Xencor, Inc anticorpos específicos que se ligam a cd38 e cd3
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗bcmaキメラ抗原受容体を使用した癌の処置
BR112017001579A2 (pt) 2014-07-25 2017-11-21 Cytomx Therapeutics Inc anticorpos anti-cd3, anticorpos anti-cd3 ativáveis, anticorpos anti-cd3 multiespecíficos, anticorpos anti-cd3 ativáveis multiespecíficos e métodos de uso dos mesmos
SG11201702502XA (en) 2014-10-22 2017-05-30 Crescendo Biolog Ltd Transgenic mice
EP3023437A1 (en) 2014-11-20 2016-05-25 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
PL3221357T3 (pl) 2014-11-20 2020-11-02 F. Hoffmann-La Roche Ag Wspólne łańcuchy lekkie i sposoby zastosowania
LT3230321T (lt) 2014-12-12 2019-12-10 Bluebird Bio Inc Bcma chimeriniai antigeno receptoriai
GB201500461D0 (en) 2015-01-12 2015-02-25 Cresendo Biolog Ltd Therapeutic molecules
CN108136218B (zh) 2015-05-20 2022-12-13 詹森生物科技公司 用于治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体
WO2017081211A2 (en) 2015-11-10 2017-05-18 University Medical Center Hamburg - Eppendorf Antigen-binding polypeptides directed against cd38
WO2017223111A1 (en) 2016-06-21 2017-12-28 Teneobio, Inc. Cd3 binding antibodies
US12495776B2 (en) 2016-08-24 2025-12-16 Teneobio, Inc. Transgenic non-human animals producing modified heavy chain-only antibodies
MY200988A (en) * 2016-09-14 2024-01-27 Teneobio Inc CD3 Binding Antibodies
IL266424B2 (en) 2016-11-02 2023-09-01 Engmab Sarl A bispecific antibody against bcma and cd3 and an immunological drug for combined treatment in multiple myeloma
EP3559035A1 (en) 2016-12-21 2019-10-30 TeneoBio, Inc. Anti-bcma heavy chain-only antibodies
CA3067584A1 (en) 2017-06-20 2018-12-27 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
CN118146370A (zh) 2017-06-20 2024-06-07 特纳奥尼股份有限公司 仅有重链的抗bcma抗体
WO2019000223A1 (en) 2017-06-27 2019-01-03 Nanjing Legend Biotech Co., Ltd. ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF
CN111094345B (zh) 2017-06-30 2023-10-27 美国卫生和人力服务部 具有人结构域的抗b细胞成熟抗原嵌合抗原受体
WO2019126756A1 (en) 2017-12-22 2019-06-27 Teneobio, Inc. Heavy chain antibodies binding to cd22
US20200339685A1 (en) 2017-12-27 2020-10-29 Teneobio, Inc. Cd3-delta/epsilon heterodimer specific antibodies
KR20210013184A (ko) 2018-05-24 2021-02-03 아얄라 파마큐티컬즈 아이엔씨. 비스플루오로알킬-1,4-벤조디아제피논 화합물과 면역요법제를 포함하는 조성물 및 이의 사용 방법
CN116769032A (zh) 2018-07-20 2023-09-19 坦尼奥第二公司 与cd19结合的重链抗体
KR20210063354A (ko) 2018-09-21 2021-06-01 테네오바이오, 인코포레이티드 이종이량체 다중특이적 항체의 정제 방법
EP3870611A1 (en) 2018-10-26 2021-09-01 TeneoBio, Inc. Heavy chain antibodies binding to cd38
EA202192736A1 (ru) 2019-04-05 2022-01-27 Тенеобио, Инк. Антитела, содержащие только тяжелые цепи, которые связываются с псма
PH12021553145A1 (en) 2019-06-14 2022-07-25 Teneobio Inc Multispecific heavy chain antibodies binding to cd22 and cd3
MX2022007613A (es) 2019-12-18 2022-07-19 Teneofour Inc Union de anticuerpos de cadena pesada a cd38.
US20210403587A1 (en) 2020-04-29 2021-12-30 Teneobio, Inc. Methods of treating multiple myeloma
CA3214992A1 (en) 2020-04-29 2021-11-04 Teneobio, Inc. Multispecific heavy chain antibodies with modified heavy chain constant regions
KR20250007022A (ko) 2020-04-29 2025-01-13 테네오원, 인코포레이티드 변형된 중쇄 불변 영역을 갖는 다중특이적 중쇄 항체
PE20230464A1 (es) 2020-06-30 2023-03-14 Teneobio Inc Union de anticuerpos multiespecificos a bcma

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110129458A1 (en) 2007-09-07 2011-06-02 Ablynx N.V. Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
JP2012521211A (ja) 2009-03-24 2012-09-13 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム 結合分子
JP2014500879A (ja) 2010-11-16 2014-01-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Bcma発現に相関性を有する疾患を治療する因子及び方法
JP2014520088A (ja) 2011-05-27 2014-08-21 グラクソ グループ リミテッド Bcma(cd269/tnfrsf17)結合タンパク質
JP2015535002A (ja) 2012-11-01 2015-12-07 マックス−デルブルック−セントラム フアー モレキュラーレ メデジン Cd269(bcma)に対する抗体
JP2016500256A (ja) 2012-12-07 2016-01-12 アムジエン・インコーポレーテツド Bcma抗原結合タンパク質
WO2017025038A1 (en) 2015-08-11 2017-02-16 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors based on single-domain antibodies and methods of use thereof
US20170051068A1 (en) 2015-08-17 2017-02-23 Janssen Pharmaceutica Nv Anti-BCMA Antibodies, Bispecific Antigen Binding Molecules that Bind BCMA and CD3, and Uses Thereof

Also Published As

Publication number Publication date
US20200157232A1 (en) 2020-05-21
CN118146370A (zh) 2024-06-07
JP2024084776A (ja) 2024-06-25
AU2018288803B2 (en) 2025-02-27
CA3065951A1 (en) 2018-12-27
US20230060847A1 (en) 2023-03-02
US11427642B2 (en) 2022-08-30
CN117567624A (zh) 2024-02-20
EP3642236A1 (en) 2020-04-29
JP2023071876A (ja) 2023-05-23
AU2018288803A1 (en) 2020-02-06
CN110945026A (zh) 2020-03-31
AU2025203751A1 (en) 2025-06-19
MX2019015563A (es) 2020-07-28
JP7465382B2 (ja) 2024-04-10
JP2020524000A (ja) 2020-08-13
WO2018237006A1 (en) 2018-12-27
CN110945026B (zh) 2024-03-19
MX2024014319A (es) 2024-12-06
BR112019026803A2 (pt) 2020-06-30

Similar Documents

Publication Publication Date Title
JP7589269B2 (ja) 抗bcma重鎖のみ抗体
JP7465382B2 (ja) 抗bcma重鎖のみ抗体
US20240124599A1 (en) Anti-bcma heavy chain-only antibodies
HK40022776A (en) Anti-bcma heavy chain-only antibodies
HK40022776B (zh) 仅有重链的抗bcma抗体

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191223

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210618

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210618

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20211207

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20211209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20211207

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220422

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220510

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220804

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221107

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230207

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230303

R150 Certificate of patent or registration of utility model

Ref document number: 7240335

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D02