JP7227912B2 - キメラ抗原受容体の調節 - Google Patents
キメラ抗原受容体の調節 Download PDFInfo
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- JP7227912B2 JP7227912B2 JP2019542407A JP2019542407A JP7227912B2 JP 7227912 B2 JP7227912 B2 JP 7227912B2 JP 2019542407 A JP2019542407 A JP 2019542407A JP 2019542407 A JP2019542407 A JP 2019542407A JP 7227912 B2 JP7227912 B2 JP 7227912B2
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/52—Isomerases (5)
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C12Y—ENZYMES
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- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/622—Single chain antibody (scFv)
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
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- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
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- Molecular Biology (AREA)
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- Public Health (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
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- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762456649P | 2017-02-08 | 2017-02-08 | |
| US62/456,649 | 2017-02-08 | ||
| US201762457124P | 2017-02-09 | 2017-02-09 | |
| US62/457,124 | 2017-02-09 | ||
| PCT/US2018/017464 WO2018148440A1 (en) | 2017-02-08 | 2018-02-08 | Regulating chimeric antigen receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505932A JP2020505932A (ja) | 2020-02-27 |
| JP2020505932A5 JP2020505932A5 (enExample) | 2021-03-25 |
| JP7227912B2 true JP7227912B2 (ja) | 2023-02-24 |
Family
ID=63107041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019542407A Active JP7227912B2 (ja) | 2017-02-08 | 2018-02-08 | キメラ抗原受容体の調節 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11311609B2 (enExample) |
| EP (2) | EP4119552A1 (enExample) |
| JP (1) | JP7227912B2 (enExample) |
| CN (1) | CN111386263A (enExample) |
| AU (1) | AU2018219289A1 (enExample) |
| CA (1) | CA3053006C (enExample) |
| WO (1) | WO2018148440A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10039809B2 (en) | 2013-12-18 | 2018-08-07 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| CA2994969A1 (en) * | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| US10806737B2 (en) | 2016-12-23 | 2020-10-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| CN110753693A (zh) | 2016-12-23 | 2020-02-04 | 阿尔维纳斯运营股份有限公司 | Egfr蛋白水解靶向嵌合分子和相关使用方法 |
| IL325835A (en) | 2016-12-23 | 2026-03-01 | Univ Yale | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| IL300417A (en) | 2017-01-26 | 2023-04-01 | Arvinas Operations Inc | Bifunctional benzothiophene compounds, preparations containing them and their use in therapy |
| US12023385B2 (en) * | 2017-02-08 | 2024-07-02 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation with heterobifunctional compounds |
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| CN113307864A (zh) | 2015-06-12 | 2021-08-27 | 艾希奥美公司 | 用于产生嵌合多肽的方法和组合物 |
| WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| EP3319944A4 (en) | 2015-07-10 | 2019-04-24 | Arvinas, Inc. | MDM2-BASED MODULATORS OF PROTEOLYSIS AND RELATED USE METHODS |
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2018
- 2018-02-08 EP EP22182901.3A patent/EP4119552A1/en not_active Withdrawn
- 2018-02-08 EP EP18750939.3A patent/EP3580212A4/en not_active Withdrawn
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- 2018-02-08 JP JP2019542407A patent/JP7227912B2/ja active Active
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- 2018-02-08 US US16/483,204 patent/US11311609B2/en active Active
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| WO2016149254A1 (en) | 2015-03-17 | 2016-09-22 | Chimera Bioengineering, Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
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| AU2018219289A1 (en) | 2019-09-05 |
| EP3580212A4 (en) | 2021-03-17 |
| CN111386263A (zh) | 2020-07-07 |
| WO2018148440A1 (en) | 2018-08-16 |
| US11311609B2 (en) | 2022-04-26 |
| JP2020505932A (ja) | 2020-02-27 |
| EP3580212A1 (en) | 2019-12-18 |
| CA3053006A1 (en) | 2018-08-16 |
| CA3053006C (en) | 2023-09-05 |
| EP4119552A1 (en) | 2023-01-18 |
| US20190365875A1 (en) | 2019-12-05 |
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