JP7195283B2 - T細胞前リンパ球性白血病の処置への使用のためのチノスタムスチン - Google Patents
T細胞前リンパ球性白血病の処置への使用のためのチノスタムスチン Download PDFInfo
- Publication number
- JP7195283B2 JP7195283B2 JP2019568675A JP2019568675A JP7195283B2 JP 7195283 B2 JP7195283 B2 JP 7195283B2 JP 2019568675 A JP2019568675 A JP 2019568675A JP 2019568675 A JP2019568675 A JP 2019568675A JP 7195283 B2 JP7195283 B2 JP 7195283B2
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- JP
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- Prior art keywords
- cells
- pll
- edo
- tinostamstine
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1709402.0 | 2017-06-13 | ||
| GBGB1709402.0A GB201709402D0 (en) | 2017-06-13 | 2017-06-13 | Compounds for treating t-pll |
| PCT/EP2018/065664 WO2018229132A1 (en) | 2017-06-13 | 2018-06-13 | Tinostamustine for use in the treatment of t-cell prolymphocytic leukaemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020523359A JP2020523359A (ja) | 2020-08-06 |
| JP2020523359A5 JP2020523359A5 (enExample) | 2021-07-26 |
| JP7195283B2 true JP7195283B2 (ja) | 2022-12-23 |
Family
ID=59358363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019568675A Active JP7195283B2 (ja) | 2017-06-13 | 2018-06-13 | T細胞前リンパ球性白血病の処置への使用のためのチノスタムスチン |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11318117B2 (enExample) |
| EP (1) | EP3638231B1 (enExample) |
| JP (1) | JP7195283B2 (enExample) |
| KR (1) | KR102655833B1 (enExample) |
| AR (1) | AR112101A1 (enExample) |
| AU (1) | AU2018285821B2 (enExample) |
| BR (1) | BR112019026484A2 (enExample) |
| CA (1) | CA3067276A1 (enExample) |
| ES (1) | ES2966954T3 (enExample) |
| GB (1) | GB201709402D0 (enExample) |
| IL (1) | IL271017A (enExample) |
| MX (1) | MX392103B (enExample) |
| TW (1) | TW201919616A (enExample) |
| WO (1) | WO2018229132A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US11266631B2 (en) | 2016-10-11 | 2022-03-08 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| WO2020128912A1 (en) * | 2018-12-18 | 2020-06-25 | Mundipharma International Corporation Limited | Compounds for treating lymphoma or a t-cell malignant disease |
| EP4007585A4 (en) * | 2019-08-02 | 2023-11-08 | OneHealthCompany, Inc. | TREATMENT OF CANINE CANCERS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015181154A1 (en) | 2014-05-28 | 2015-12-03 | Euro-Celtique S.A | Pharmaceutical combination comprising a class iii receptor tyrosine kinase inhibitor and the alkylating histone-deacetylase inhibitor fusion molecule edo-s101 together with its use in the treatment of cancer |
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| DE34727C (de) | Ch. H. TH. HAVEMANN in Paris, 16 rue Bleue | Verfahren zur direkten Gewinnung metallischen Bleis | ||
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| US6407079B1 (en) | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| GB9126209D0 (en) | 1991-12-10 | 1992-02-12 | Orion Yhtymae Oy | Drug formulations for parenteral use |
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| US5882941A (en) | 1994-05-04 | 1999-03-16 | Massachusette Institute Of Technology | Programmable genotoxic agents and uses therefor |
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| DE69819721T2 (de) | 1997-06-13 | 2004-09-23 | Cydex Inc., Overland Park | Zusammensetzung mit erhöhter lagerstabilität enthaltend cyclodextrin und wirkstoffe oder wirkstoff-vorstufen, die in wasserunlösliche komponenten zersetzt werden |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
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| US6392053B2 (en) | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
| US20020076409A1 (en) | 2000-07-12 | 2002-06-20 | March Carl J. | Method for treating cancer |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| EP2083005A1 (en) | 2000-09-29 | 2009-07-29 | TopoTarget UK Limited | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors |
| AU2002243231A1 (en) | 2000-11-21 | 2002-07-24 | Wake Forest University | Method of treating autoimmune diseases |
| CN1764648A (zh) | 2003-01-13 | 2006-04-26 | 安斯泰来制药有限公司 | 作为组蛋白脱乙酰酶(hdac)抑制剂的异羟肟酸衍生物 |
| AU2004215624B2 (en) | 2003-02-25 | 2011-06-02 | Topotarget Uk Limited | Hydroxamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors |
| JP2007501775A (ja) | 2003-08-07 | 2007-02-01 | ノバルティス アクチエンゲゼルシャフト | 免疫抑制剤としてのヒストンデアセチラーゼ阻害剤 |
| US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US8227636B2 (en) | 2004-04-05 | 2012-07-24 | Merck Hdac Research, Llc | Histone deacetylase inhibitor prodrugs |
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| TW200922564A (en) | 2007-09-10 | 2009-06-01 | Curis Inc | CDK inhibitors containing a zinc binding moiety |
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| JP5670335B2 (ja) | 2008-09-25 | 2015-02-18 | セファロン、インク. | ベンダムスチン液体製剤 |
| JP5773874B2 (ja) | 2008-10-08 | 2015-09-02 | セファロン、インク. | ベンダムスチンの調製方法 |
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| JO3659B1 (ar) | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| US8748470B2 (en) | 2011-03-17 | 2014-06-10 | The University Of Chicago | Methods for treating ovarian cancer by inhibiting fatty acid binding proteins |
| EP2755648B1 (en) | 2011-09-13 | 2017-03-08 | Pharmacyclics LLC | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
| CN102993102B (zh) | 2011-09-16 | 2016-08-24 | 杭州民生药业有限公司 | [1-甲基-2-(7’-庚异羟肟酸基)-5-n,n-二(2’-氯乙基)]-1h-苯并咪唑的合成方法 |
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| TWI573792B (zh) | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
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| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| AU2015356779A1 (en) | 2014-12-05 | 2017-07-13 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine for use in the treatment of lymphoma |
| CN106580971B (zh) | 2015-10-20 | 2019-11-12 | 杭州梯诺医药科技有限公司 | 一种药物组合物及其制备方法 |
| US11266631B2 (en) | 2016-10-11 | 2022-03-08 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
| US20180098969A1 (en) | 2016-10-11 | 2018-04-12 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
| GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| WO2020128912A1 (en) | 2018-12-18 | 2020-06-25 | Mundipharma International Corporation Limited | Compounds for treating lymphoma or a t-cell malignant disease |
-
2017
- 2017-06-13 GB GBGB1709402.0A patent/GB201709402D0/en not_active Ceased
-
2018
- 2018-06-13 ES ES18733527T patent/ES2966954T3/es active Active
- 2018-06-13 WO PCT/EP2018/065664 patent/WO2018229132A1/en not_active Ceased
- 2018-06-13 KR KR1020197037098A patent/KR102655833B1/ko active Active
- 2018-06-13 AR ARP180101622A patent/AR112101A1/es unknown
- 2018-06-13 CA CA3067276A patent/CA3067276A1/en active Pending
- 2018-06-13 JP JP2019568675A patent/JP7195283B2/ja active Active
- 2018-06-13 TW TW107120389A patent/TW201919616A/zh unknown
- 2018-06-13 US US16/621,898 patent/US11318117B2/en active Active
- 2018-06-13 AU AU2018285821A patent/AU2018285821B2/en active Active
- 2018-06-13 BR BR112019026484-1A patent/BR112019026484A2/pt not_active Application Discontinuation
- 2018-06-13 MX MX2019015208A patent/MX392103B/es unknown
- 2018-06-13 EP EP18733527.8A patent/EP3638231B1/en active Active
-
2019
- 2019-11-28 IL IL271017A patent/IL271017A/en unknown
-
2022
- 2022-04-27 US US17/730,276 patent/US11918558B2/en active Active
-
2024
- 2024-01-25 US US18/422,118 patent/US12370178B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015181154A1 (en) | 2014-05-28 | 2015-12-03 | Euro-Celtique S.A | Pharmaceutical combination comprising a class iii receptor tyrosine kinase inhibitor and the alkylating histone-deacetylase inhibitor fusion molecule edo-s101 together with its use in the treatment of cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102655833B1 (ko) | 2024-04-08 |
| TW201919616A (zh) | 2019-06-01 |
| AU2018285821A1 (en) | 2019-12-19 |
| WO2018229132A1 (en) | 2018-12-20 |
| KR20200015563A (ko) | 2020-02-12 |
| US12370178B2 (en) | 2025-07-29 |
| US20220401417A1 (en) | 2022-12-22 |
| JP2020523359A (ja) | 2020-08-06 |
| EP3638231B1 (en) | 2023-12-20 |
| MX2019015208A (es) | 2022-05-03 |
| BR112019026484A2 (pt) | 2020-07-14 |
| ES2966954T3 (es) | 2024-04-25 |
| MX392103B (es) | 2025-03-21 |
| IL271017A (en) | 2020-01-30 |
| AR112101A1 (es) | 2019-09-18 |
| US20240316009A1 (en) | 2024-09-26 |
| GB201709402D0 (en) | 2017-07-26 |
| EP3638231A1 (en) | 2020-04-22 |
| AU2018285821B2 (en) | 2024-07-04 |
| US11318117B2 (en) | 2022-05-03 |
| US11918558B2 (en) | 2024-03-05 |
| US20200113871A1 (en) | 2020-04-16 |
| EP3638231C0 (en) | 2023-12-20 |
| CA3067276A1 (en) | 2018-12-20 |
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