JP7189155B2 - 癌関連障害の治療のためのキナゾリン－ピラゾール誘導体 - Google Patents
癌関連障害の治療のためのキナゾリン－ピラゾール誘導体 Download PDFInfo
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- JP7189155B2 JP7189155B2 JP2019563142A JP2019563142A JP7189155B2 JP 7189155 B2 JP7189155 B2 JP 7189155B2 JP 2019563142 A JP2019563142 A JP 2019563142A JP 2019563142 A JP2019563142 A JP 2019563142A JP 7189155 B2 JP7189155 B2 JP 7189155B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507540P | 2017-05-17 | 2017-05-17 | |
| US62/507,540 | 2017-05-17 | ||
| PCT/US2018/032868 WO2018213377A1 (en) | 2017-05-17 | 2018-05-16 | Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519664A JP2020519664A (ja) | 2020-07-02 |
| JP2020519664A5 JP2020519664A5 (enExample) | 2022-07-21 |
| JP7189155B2 true JP7189155B2 (ja) | 2022-12-13 |
Family
ID=64274816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563142A Active JP7189155B2 (ja) | 2017-05-17 | 2018-05-16 | 癌関連障害の治療のためのキナゾリン－ピラゾール誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11220492B2 (enExample) |
| EP (1) | EP3634417B1 (enExample) |
| JP (1) | JP7189155B2 (enExample) |
| CN (1) | CN110636846B (enExample) |
| ES (1) | ES2951809T3 (enExample) |
| PL (1) | PL3634417T3 (enExample) |
| WO (1) | WO2018213377A1 (enExample) |
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| AR117844A1 (es) * | 2019-01-22 | 2021-09-01 | Merck Patent Gmbh | Derivados de tiazolopiridina como antagonistas del receptor de adenosina |
| ES3070946T3 (en) | 2019-03-12 | 2026-06-18 | Arcus Biosciences Inc | Treatment of an oncogenene driven cancer having a kras or egfr mutation by decreasing adenosine production or antagonizing adenosine activation |
| CA3135487A1 (en) | 2019-03-29 | 2020-10-08 | Arcus Biosciences, Inc. | Treatment of cancer utilizing an identified adenosine fingerprint |
| CA3173831A1 (en) | 2020-03-19 | 2021-09-23 | Arcus Biosciences, Inc. | Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha |
| CA3179320A1 (en) | 2020-06-17 | 2021-12-23 | Arcus Biosciences, Inc. | Crystalline forms of a cd73 inhibitor and uses thereof |
| CN112326961B (zh) * | 2020-10-30 | 2021-08-06 | 福州迈新生物技术开发有限公司 | 一种非小细胞肺癌中pd-l1阳性肿瘤细胞比例的分析方法和存储设备 |
| CN112691107B (zh) * | 2021-02-03 | 2022-09-02 | 北京斯利安药业有限公司 | 一种药物组合物及其应用 |
| WO2022166796A1 (zh) * | 2021-02-05 | 2022-08-11 | 上海齐鲁制药研究中心有限公司 | 嘧啶或吡啶并杂环类腺苷受体抑制剂及其制备方法和用途 |
| CN113642386B (zh) * | 2021-07-02 | 2024-06-21 | 广州金域医学检验中心有限公司 | 基于深度学习评价鼻咽癌治疗效果的方法、装置、设备和介质 |
| TW202325279A (zh) | 2021-10-29 | 2023-07-01 | 美商阿克思生物科學有限公司 | HIF-2α抑制劑及其使用方法 |
| CN119156228A (zh) | 2022-05-02 | 2024-12-17 | 艾库斯生物科学有限公司 | 抗tigit抗体及其用途 |
| EP4554680A1 (en) | 2022-07-15 | 2025-05-21 | Arcus Biosciences, Inc. | Inhibitors of hpk1 and methods of use thereof |
| WO2024020034A1 (en) | 2022-07-20 | 2024-01-25 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| EP4602041A1 (en) | 2022-10-14 | 2025-08-20 | Arcus Biosciences, Inc. | Hpk1 inhibitors and methods of use thereof |
| CN120091809A (zh) | 2022-10-20 | 2025-06-03 | 艾库斯生物科学有限公司 | Cd73化合物的冻干制剂 |
| EP4705292A1 (en) | 2023-05-05 | 2026-03-11 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| WO2024243502A1 (en) | 2023-05-25 | 2024-11-28 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| CN119139469B (zh) * | 2023-06-16 | 2026-07-24 | 武汉大学 | 腺苷受体抑制剂在制备用于治疗高脂血症与心脑血管疾病的药物中的应用 |
| WO2025054339A1 (en) | 2023-09-08 | 2025-03-13 | Arcus Biosciences, Inc. | Triazolopyridine compounds as inhibitors of kit |
| WO2025072330A1 (en) | 2023-09-26 | 2025-04-03 | Arcus Biosciences, Inc. | Kit inhibitor compounds and methods of use thereof |
| EP4788432A1 (en) | 2023-10-06 | 2026-08-12 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| US12384773B2 (en) | 2023-11-02 | 2025-08-12 | Arcus Biosciences, Inc. | Thiazole compounds and methods of use thereof |
| WO2026006759A1 (en) | 2024-06-28 | 2026-01-02 | Arcus Biosciences, Inc. | Pharmaceutical compositions, dosage forms, and methods of making and using same |
| WO2026035034A1 (ko) * | 2024-08-06 | 2026-02-12 | 주식회사 대웅제약 | 신규한 퀴나졸린 유도체 및 이를 포함하는 약학 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009530413A (ja) | 2006-03-17 | 2009-08-27 | シーブイ・セラピューティクス・インコーポレイテッド | Ａ２ｂアデノシン受容体拮抗物質を用いる肝疾患の予防および処置の方法 |
| JP2019524638A (ja) | 2017-01-20 | 2019-09-05 | アーカス バイオサイエンシズ インコーポレイティド | 癌関連障害の治療のためのアゾロピリミジン |
| JP2020518627A (ja) | 2017-05-05 | 2020-06-25 | アーカス バイオサイエンシズ インコーポレイティド | 癌関連障害の治療のためのキナゾリン−ピリジン誘導体 |
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2018
- 2018-05-16 CN CN201880032987.1A patent/CN110636846B/zh active Active
- 2018-05-16 WO PCT/US2018/032868 patent/WO2018213377A1/en not_active Ceased
- 2018-05-16 JP JP2019563142A patent/JP7189155B2/ja active Active
- 2018-05-16 PL PL18803171.0T patent/PL3634417T3/pl unknown
- 2018-05-16 EP EP18803171.0A patent/EP3634417B1/en active Active
- 2018-05-16 ES ES18803171T patent/ES2951809T3/es active Active
- 2018-05-16 US US16/614,063 patent/US11220492B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009530413A (ja) | 2006-03-17 | 2009-08-27 | シーブイ・セラピューティクス・インコーポレイテッド | Ａ２ｂアデノシン受容体拮抗物質を用いる肝疾患の予防および処置の方法 |
| JP2019524638A (ja) | 2017-01-20 | 2019-09-05 | アーカス バイオサイエンシズ インコーポレイティド | 癌関連障害の治療のためのアゾロピリミジン |
| JP2020518627A (ja) | 2017-05-05 | 2020-06-25 | アーカス バイオサイエンシズ インコーポレイティド | 癌関連障害の治療のためのキナゾリン−ピリジン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020519664A (ja) | 2020-07-02 |
| EP3634417A1 (en) | 2020-04-15 |
| ES2951809T3 (es) | 2023-10-25 |
| CN110636846A (zh) | 2019-12-31 |
| CN110636846B (zh) | 2023-05-16 |
| US11220492B2 (en) | 2022-01-11 |
| US20210214346A1 (en) | 2021-07-15 |
| EP3634417C0 (en) | 2023-07-12 |
| PL3634417T3 (pl) | 2023-09-25 |
| WO2018213377A1 (en) | 2018-11-22 |
| EP3634417B1 (en) | 2023-07-12 |
| EP3634417A4 (en) | 2021-01-13 |
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