CN110636846B - 用于治疗癌症相关疾病的喹唑啉吡唑衍生物 - Google Patents
用于治疗癌症相关疾病的喹唑啉吡唑衍生物 Download PDFInfo
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- CN110636846B CN110636846B CN201880032987.1A CN201880032987A CN110636846B CN 110636846 B CN110636846 B CN 110636846B CN 201880032987 A CN201880032987 A CN 201880032987A CN 110636846 B CN110636846 B CN 110636846B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507540P | 2017-05-17 | 2017-05-17 | |
| US62/507,540 | 2017-05-17 | ||
| PCT/US2018/032868 WO2018213377A1 (en) | 2017-05-17 | 2018-05-16 | Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110636846A CN110636846A (zh) | 2019-12-31 |
| CN110636846B true CN110636846B (zh) | 2023-05-16 |
Family
ID=64274816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880032987.1A Active CN110636846B (zh) | 2017-05-17 | 2018-05-16 | 用于治疗癌症相关疾病的喹唑啉吡唑衍生物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11220492B2 (enExample) |
| EP (1) | EP3634417B1 (enExample) |
| JP (1) | JP7189155B2 (enExample) |
| CN (1) | CN110636846B (enExample) |
| ES (1) | ES2951809T3 (enExample) |
| PL (1) | PL3634417T3 (enExample) |
| WO (1) | WO2018213377A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR117844A1 (es) * | 2019-01-22 | 2021-09-01 | Merck Patent Gmbh | Derivados de tiazolopiridina como antagonistas del receptor de adenosina |
| CA3133078A1 (en) | 2019-03-12 | 2020-09-17 | Arcus Biosciences, Inc. | Treatment of oncogene-driven cancers |
| CN113874397A (zh) | 2019-03-29 | 2021-12-31 | 艾库斯生物科学有限公司 | 利用鉴定的腺苷指纹治疗癌症 |
| EP4121409A1 (en) | 2020-03-19 | 2023-01-25 | Arcus Biosciences, Inc. | Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha |
| WO2021257643A1 (en) | 2020-06-17 | 2021-12-23 | Arcus Biosciences, Inc. | Crystalline forms of a cd73 inhibitor and uses thereof |
| CN112326961B (zh) * | 2020-10-30 | 2021-08-06 | 福州迈新生物技术开发有限公司 | 一种非小细胞肺癌中pd-l1阳性肿瘤细胞比例的分析方法和存储设备 |
| CN112691107B (zh) * | 2021-02-03 | 2022-09-02 | 北京斯利安药业有限公司 | 一种药物组合物及其应用 |
| TW202245774A (zh) * | 2021-02-05 | 2022-12-01 | 大陸商上海齊魯製藥研究中心有限公司 | 嘧啶或吡啶並雜環類腺苷受體抑制劑及其製備方法和用途 |
| CN113642386B (zh) * | 2021-07-02 | 2024-06-21 | 广州金域医学检验中心有限公司 | 基于深度学习评价鼻咽癌治疗效果的方法、装置、设备和介质 |
| CA3236553A1 (en) | 2021-10-29 | 2023-05-04 | Joel Worley BEATTY | Inhibitors of hif-2alpha and methods of use thereof |
| CA3256561A1 (en) | 2022-05-02 | 2023-11-09 | Arcus Biosciences, Inc. | Anti-tigit antibodies and their uses |
| WO2024015251A1 (en) | 2022-07-15 | 2024-01-18 | Arcus Biosciences, Inc. | Inhibitors of hpk1 and methods of use thereof |
| WO2024020034A1 (en) | 2022-07-20 | 2024-01-25 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| EP4602041A1 (en) | 2022-10-14 | 2025-08-20 | Arcus Biosciences, Inc. | Hpk1 inhibitors and methods of use thereof |
| TW202428286A (zh) | 2022-10-20 | 2024-07-16 | 美商阿克思生物科學有限公司 | Ｃｄ７３化合物之凍乾配方 |
| WO2024233360A1 (en) | 2023-05-05 | 2024-11-14 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| WO2024243502A1 (en) | 2023-05-25 | 2024-11-28 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| CN119139469A (zh) * | 2023-06-16 | 2024-12-17 | 武汉大学 | 腺苷受体抑制剂在制备用于治疗高脂血症与心脑血管疾病的药物中的应用 |
| WO2025054339A1 (en) | 2023-09-08 | 2025-03-13 | Arcus Biosciences, Inc. | Triazolopyridine compounds as inhibitors of kit |
| WO2025072330A1 (en) | 2023-09-26 | 2025-04-03 | Arcus Biosciences, Inc. | Kit inhibitor compounds and methods of use thereof |
| WO2025076299A1 (en) | 2023-10-06 | 2025-04-10 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| US12384773B2 (en) | 2023-11-02 | 2025-08-12 | Arcus Biosciences, Inc. | Thiazole compounds and methods of use thereof |
Citations (6)
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| WO2005095350A1 (en) * | 2004-03-23 | 2005-10-13 | Amgen Inc. | Pyrazole compounds and uses related thereto |
| WO2006091898A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Pyrazolyl substituted xanthines |
| WO2011050284A1 (en) * | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Pyrazolylpyridine antiviral agents |
| WO2013130811A1 (en) * | 2012-02-29 | 2013-09-06 | Chemocentryx, Inc. | Pyrazol-1-yl benzene sulfonamides as ccr9 antagonists |
| US8748435B2 (en) * | 2011-04-01 | 2014-06-10 | Novartis Ag | Pyrazolo pyrimidine derivatives |
| US8937078B2 (en) * | 2009-02-10 | 2015-01-20 | Janssen Pharmaceutica Nv | Quinazolinones as prolyl hydroxylase inhibitors |
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| DE69330713T2 (de) | 1992-03-13 | 2002-07-04 | Merck Sharp & Dohme Ltd., Hoddesdon | Imidazol-, triazol- und tetrazolderivate |
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| US5952294A (en) | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
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| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
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| PE20091953A1 (es) | 2008-05-08 | 2010-01-09 | Du Pont | Azoles sustituidos como fungicidas |
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| HRP20170908T1 (hr) | 2008-12-09 | 2017-09-22 | F. Hoffmann - La Roche Ag | Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice |
| WO2010108187A2 (en) | 2009-03-20 | 2010-09-23 | Brandeis University | Compounds and methods for treating mammalian gastrointestinal microbial infections |
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-
2018
- 2018-05-16 ES ES18803171T patent/ES2951809T3/es active Active
- 2018-05-16 EP EP18803171.0A patent/EP3634417B1/en active Active
- 2018-05-16 JP JP2019563142A patent/JP7189155B2/ja active Active
- 2018-05-16 PL PL18803171.0T patent/PL3634417T3/pl unknown
- 2018-05-16 WO PCT/US2018/032868 patent/WO2018213377A1/en not_active Ceased
- 2018-05-16 CN CN201880032987.1A patent/CN110636846B/zh active Active
- 2018-05-16 US US16/614,063 patent/US11220492B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005095350A1 (en) * | 2004-03-23 | 2005-10-13 | Amgen Inc. | Pyrazole compounds and uses related thereto |
| WO2006091898A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Pyrazolyl substituted xanthines |
| US8937078B2 (en) * | 2009-02-10 | 2015-01-20 | Janssen Pharmaceutica Nv | Quinazolinones as prolyl hydroxylase inhibitors |
| WO2011050284A1 (en) * | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Pyrazolylpyridine antiviral agents |
| US8748435B2 (en) * | 2011-04-01 | 2014-06-10 | Novartis Ag | Pyrazolo pyrimidine derivatives |
| WO2013130811A1 (en) * | 2012-02-29 | 2013-09-06 | Chemocentryx, Inc. | Pyrazol-1-yl benzene sulfonamides as ccr9 antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| US11220492B2 (en) | 2022-01-11 |
| EP3634417A4 (en) | 2021-01-13 |
| EP3634417C0 (en) | 2023-07-12 |
| ES2951809T3 (es) | 2023-10-25 |
| US20210214346A1 (en) | 2021-07-15 |
| JP2020519664A (ja) | 2020-07-02 |
| CN110636846A (zh) | 2019-12-31 |
| JP7189155B2 (ja) | 2022-12-13 |
| EP3634417B1 (en) | 2023-07-12 |
| PL3634417T3 (pl) | 2023-09-25 |
| WO2018213377A1 (en) | 2018-11-22 |
| EP3634417A1 (en) | 2020-04-15 |
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