JP7146750B2 - 非常に強力な糖質コルチコイドの構造およびデザインのための機構 - Google Patents

非常に強力な糖質コルチコイドの構造およびデザインのための機構 Download PDF

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JP7146750B2
JP7146750B2 JP2019520039A JP2019520039A JP7146750B2 JP 7146750 B2 JP7146750 B2 JP 7146750B2 JP 2019520039 A JP2019520039 A JP 2019520039A JP 2019520039 A JP2019520039 A JP 2019520039A JP 7146750 B2 JP7146750 B2 JP 7146750B2
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JP2019532071A (ja
JP2019532071A5 (enExample
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フアチアン エリック シュー，
ユアンゼン ヘ，
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ヴァン アンデル リサーチ インスティテュート
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019520039A 2016-10-14 2017-10-13 非常に強力な糖質コルチコイドの構造およびデザインのための機構 Active JP7146750B2 (ja)

Priority Applications (1)

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JP2022113322A JP2022132464A (ja) 2016-10-14 2022-07-14 非常に強力な糖質コルチコイドの構造およびデザインのための機構

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US201662408314P 2016-10-14 2016-10-14
US62/408,314 2016-10-14
PCT/US2017/056447 WO2018071736A1 (en) 2016-10-14 2017-10-13 Structures and mechanism for the design of highly potent glucocorticoids

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JP2022113322A Division JP2022132464A (ja) 2016-10-14 2022-07-14 非常に強力な糖質コルチコイドの構造およびデザインのための機構

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JP2019532071A JP2019532071A (ja) 2019-11-07
JP2019532071A5 JP2019532071A5 (enExample) 2020-11-12
JP7146750B2 true JP7146750B2 (ja) 2022-10-04

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JP2019520039A Active JP7146750B2 (ja) 2016-10-14 2017-10-13 非常に強力な糖質コルチコイドの構造およびデザインのための機構
JP2022113322A Withdrawn JP2022132464A (ja) 2016-10-14 2022-07-14 非常に強力な糖質コルチコイドの構造およびデザインのための機構

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US (1) US10954265B2 (enExample)
EP (1) EP3525870B1 (enExample)
JP (2) JP7146750B2 (enExample)
KR (1) KR102497070B1 (enExample)
CN (1) CN110382033B (enExample)
ES (1) ES2945983T3 (enExample)
MA (1) MA46539A (enExample)
PH (1) PH12019500801A1 (enExample)
RU (1) RU2019111101A (enExample)
SG (1) SG11201903209TA (enExample)
WO (1) WO2018071736A1 (enExample)
ZA (1) ZA201902595B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024396409A1 (en) * 2023-12-08 2026-07-09 Zhejiang Palo Alto Pharmaceuticals, Inc. High-efficacy glucocorticoid polymorph, preparation method therefor, and use thereof
WO2025157225A1 (zh) * 2024-01-24 2025-07-31 浙江柏拉阿图医药科技有限公司 一种高效力糖皮质激素化合物及其制备和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100256105A1 (en) 2009-04-03 2010-10-07 Astrazeneca R&D Novel compounds
JP2010540612A (ja) 2007-10-04 2010-12-24 アストラゼネカ・アクチエボラーグ グルココルチコイド活性を有するステロイド［３，２−ｃ］ピラゾール化合物
JP2016531852A (ja) 2013-09-25 2016-10-13 ヴァン アンデル リサーチ インスティテュート 非常に強力なグルココルチコイド

Family Cites Families (15)

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DK66202C (da) 1945-03-03 1948-01-12 Danske Securitas As Kodekontakt til elektriske Alarmanlæg.
DK71662C (da) 1946-09-05 1950-11-06 Ingenioer Frank Broadbent Tørrecentrifuge.
US4049813A (en) 1976-07-15 1977-09-20 Sandoz, Inc. Substituted isoxazolo pyridinones
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
WO2002102807A1 (en) 2001-06-14 2002-12-27 Banyu Pharmaceutical Co., Ltd. Novel isoxazolopyridone derivatives and use thereof
GB0119911D0 (en) 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
KR20060118536A (ko) * 2003-11-13 2006-11-23 콤비네이토릭스, 인코포레이티드 면역염증성 질환의 치료 방법 및 시약
KR20080039442A (ko) * 2005-09-02 2008-05-07 니콕스 에스. 에이. 스테로이드 니트록시 유도체들
CN1813768A (zh) * 2005-11-18 2006-08-09 成都力思特制药股份有限公司 治疗呼吸系统疾病的药用组合物及其在制药中的应用
US20110160167A1 (en) * 2007-12-20 2011-06-30 Astrazeneca Ab Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists
US8173670B2 (en) 2009-01-13 2012-05-08 Van Andel Research Institute Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
TW201111392A (en) * 2009-06-16 2011-04-01 Schering Corp Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
TWI695831B (zh) * 2014-09-13 2020-06-11 香港商南北兄弟藥業投資有限公司 Ｃｒｔｈ２拮抗劑化合物及其用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540612A (ja) 2007-10-04 2010-12-24 アストラゼネカ・アクチエボラーグ グルココルチコイド活性を有するステロイド［３，２−ｃ］ピラゾール化合物
US20100256105A1 (en) 2009-04-03 2010-10-07 Astrazeneca R&D Novel compounds
JP2016531852A (ja) 2013-09-25 2016-10-13 ヴァン アンデル リサーチ インスティテュート 非常に強力なグルココルチコイド

Also Published As

Publication number Publication date
KR20190068577A (ko) 2019-06-18
WO2018071736A9 (en) 2019-05-23
CN110382033B (zh) 2022-04-15
RU2019111101A (ru) 2020-11-16
ES2945983T3 (es) 2023-07-11
JP2022132464A (ja) 2022-09-08
EP3525870A4 (en) 2020-04-29
CN110382033A (zh) 2019-10-25
US20190263853A1 (en) 2019-08-29
JP2019532071A (ja) 2019-11-07
US10954265B2 (en) 2021-03-23
EP3525870B1 (en) 2023-05-10
WO2018071736A1 (en) 2018-04-19
KR102497070B1 (ko) 2023-02-06
SG11201903209TA (en) 2019-05-30
EP3525870A1 (en) 2019-08-21
ZA201902595B (en) 2021-04-28
RU2019111101A3 (enExample) 2020-11-27
PH12019500801A1 (en) 2019-11-11
MA46539A (fr) 2019-08-21

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