JP7138104B2 - ２－［（３－アミノプロピル）アミノ］エタンチオールの感熱性ゲル組成物およびその調製プロセス - Google Patents

２－［（３－アミノプロピル）アミノ］エタンチオールの感熱性ゲル組成物およびその調製プロセス Download PDF

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JP7138104B2
JP7138104B2 JP2019529868A JP2019529868A JP7138104B2 JP 7138104 B2 JP7138104 B2 JP 7138104B2 JP 2019529868 A JP2019529868 A JP 2019529868A JP 2019529868 A JP2019529868 A JP 2019529868A JP 7138104 B2 JP7138104 B2 JP 7138104B2
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amifostine
gel
solution
ethanethiol
aminopropyl
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Japanese (ja)
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JP2019535801A5 (https=
JP2019535801A (ja
Inventor
ワン－ジャン，シューピン
ピヴェッテ，ペリーヌ
ゴンザレス，キャリーヌ
ドイチュ，エリック
クレメンソン，セリーヌ
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CLEVEXEL PHARMA
Institut Gustave Roussy (IGR)
Universite Paris Saclay
Original Assignee
CLEVEXEL PHARMA
Institut Gustave Roussy (IGR)
Universite Paris Saclay
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2019529868A 2016-11-30 2017-11-29 ２－［（３－アミノプロピル）アミノ］エタンチオールの感熱性ゲル組成物およびその調製プロセス Active JP7138104B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16306582.4 2016-11-30
EP16306582.4A EP3330251A1 (en) 2016-11-30 2016-11-30 Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol
PCT/EP2017/080881 WO2018100008A1 (en) 2016-11-30 2017-11-29 Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol formulation

Publications (3)

Publication Number Publication Date
JP2019535801A JP2019535801A (ja) 2019-12-12
JP2019535801A5 JP2019535801A5 (https=) 2020-12-10
JP7138104B2 true JP7138104B2 (ja) 2022-09-15

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JP2019529868A Active JP7138104B2 (ja) 2016-11-30 2017-11-29 ２－［（３－アミノプロピル）アミノ］エタンチオールの感熱性ゲル組成物およびその調製プロセス

Country Status (11)

Country Link
US (1) US11021442B2 (https=)
EP (2) EP3330251A1 (https=)
JP (1) JP7138104B2 (https=)
KR (1) KR102596798B1 (https=)
CN (1) CN110300742B (https=)
AU (1) AU2017369603B2 (https=)
CA (1) CA3039425A1 (https=)
IL (1) IL266811B (https=)
MX (1) MX386559B (https=)
WO (1) WO2018100008A1 (https=)
ZA (1) ZA201902119B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3824880A1 (en) * 2019-11-25 2021-05-26 Clevexel Pharma Freeze-dried powder containing 2-[(3-aminopropyl)amino]ethanethiol and its use for preparing a thermogel
EP4303224A4 (en) * 2021-03-03 2025-02-19 Tohoku University PROTEIN FOLDING AGENTS
CN116283682B (zh) * 2023-02-21 2024-08-02 梯尔希（南京）药物研发有限公司 一种同位素标记的氨磷汀代谢物的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004513957A (ja) 2000-11-22 2004-05-13 アールエックスキネティックス，インコーポレイテッド 粘膜炎の治療
JP2015515282A (ja) 2012-04-25 2015-05-28 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント 創傷治癒および組織修復のための組成物および方法
JP2015526505A (ja) 2012-08-31 2015-09-10 アシスタンス プブリク−オピトウ ドゥ パリ ケタミンを含有するゲル化製剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU670567A1 (ru) * 1978-02-06 1979-06-30 Предприятие П/Я В-2343 Способ получени дихлоргидрата бета-меркаптоэтил-1,3-пропилендиамина
US6239119B1 (en) 1998-04-27 2001-05-29 Medimmune Oncology, Inc. Topical administration of amifostine and related compounds
US6407278B2 (en) * 1998-11-16 2002-06-18 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and methods for the preparation and use of the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004513957A (ja) 2000-11-22 2004-05-13 アールエックスキネティックス，インコーポレイテッド 粘膜炎の治療
JP2015515282A (ja) 2012-04-25 2015-05-28 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント 創傷治癒および組織修復のための組成物および方法
JP2015526505A (ja) 2012-08-31 2015-09-10 アシスタンス プブリク−オピトウ ドゥ パリ ケタミンを含有するゲル化製剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Environ. Mol. Mutagen.，2009年，Vol.50，No.6，p.460-472

Also Published As

Publication number Publication date
IL266811A (en) 2019-07-31
AU2017369603B2 (en) 2021-04-29
MX386559B (es) 2025-03-19
US20200239414A1 (en) 2020-07-30
EP3330251A1 (en) 2018-06-06
KR20190085526A (ko) 2019-07-18
BR112019011006A2 (pt) 2019-10-08
KR102596798B1 (ko) 2023-10-31
BR112019011006A8 (pt) 2023-04-11
IL266811B (en) 2021-10-31
EP3548464A1 (en) 2019-10-09
CN110300742A (zh) 2019-10-01
WO2018100008A1 (en) 2018-06-07
CN110300742B (zh) 2022-02-18
CA3039425A1 (en) 2018-06-07
JP2019535801A (ja) 2019-12-12
AU2017369603A1 (en) 2019-05-02
ZA201902119B (en) 2023-01-25
MX2019006310A (es) 2019-08-12
US11021442B2 (en) 2021-06-01

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