CN110300742B - 制备冻干2-[(3-氨基丙基)氨基]乙硫醇制剂的方法 - Google Patents

制备冻干2-[(3-氨基丙基)氨基]乙硫醇制剂的方法 Download PDF

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Publication number
CN110300742B
CN110300742B CN201780074153.2A CN201780074153A CN110300742B CN 110300742 B CN110300742 B CN 110300742B CN 201780074153 A CN201780074153 A CN 201780074153A CN 110300742 B CN110300742 B CN 110300742B
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amifostine
gel
poloxamer
amino
ethanethiol
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CN201780074153.2A
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English (en)
Chinese (zh)
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CN110300742A (zh
Inventor
王张秀平
珀赖因·皮弗蒂
卡琳·冈萨雷斯
埃里克·多伊奇
赛琳·克莱芒松
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Thackeray Paris, University of
Institut Gustave Roussy (IGR)
Dynamix Pharmaceuticals Ltd
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Institut Gustave Roussy (IGR)
Dynamix Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201780074153.2A 2016-11-30 2017-11-29 制备冻干2-[(3-氨基丙基)氨基]乙硫醇制剂的方法 Active CN110300742B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16306582.4 2016-11-30
EP16306582.4A EP3330251A1 (en) 2016-11-30 2016-11-30 Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol
PCT/EP2017/080881 WO2018100008A1 (en) 2016-11-30 2017-11-29 Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol formulation

Publications (2)

Publication Number Publication Date
CN110300742A CN110300742A (zh) 2019-10-01
CN110300742B true CN110300742B (zh) 2022-02-18

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CN201780074153.2A Active CN110300742B (zh) 2016-11-30 2017-11-29 制备冻干2-[(3-氨基丙基)氨基]乙硫醇制剂的方法

Country Status (11)

Country Link
US (1) US11021442B2 (https=)
EP (2) EP3330251A1 (https=)
JP (1) JP7138104B2 (https=)
KR (1) KR102596798B1 (https=)
CN (1) CN110300742B (https=)
AU (1) AU2017369603B2 (https=)
CA (1) CA3039425A1 (https=)
IL (1) IL266811B (https=)
MX (1) MX386559B (https=)
WO (1) WO2018100008A1 (https=)
ZA (1) ZA201902119B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3824880A1 (en) * 2019-11-25 2021-05-26 Clevexel Pharma Freeze-dried powder containing 2-[(3-aminopropyl)amino]ethanethiol and its use for preparing a thermogel
EP4303224A4 (en) * 2021-03-03 2025-02-19 Tohoku University PROTEIN FOLDING AGENTS
CN116283682B (zh) * 2023-02-21 2024-08-02 梯尔希（南京）药物研发有限公司 一种同位素标记的氨磷汀代谢物的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU670567A1 (ru) * 1978-02-06 1979-06-30 Предприятие П/Я В-2343 Способ получени дихлоргидрата бета-меркаптоэтил-1,3-пропилендиамина
CN1333694A (zh) * 1998-11-16 2002-01-30 美国生物科学有限公司 稳定的无定形氨磷汀组合物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239119B1 (en) 1998-04-27 2001-05-29 Medimmune Oncology, Inc. Topical administration of amifostine and related compounds
MXPA03004546A (es) * 2000-11-22 2003-09-10 Rxkinetix Inc Tratamiento de mucositis.
WO2013163423A1 (en) * 2012-04-25 2013-10-31 Musc Foundation For Research Development Compositions and methods for wound healing and tissue repair
FR2994844B1 (fr) * 2012-08-31 2015-01-02 Assist Publ Hopitaux De Paris Formulation gelifiante a base de ketamine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU670567A1 (ru) * 1978-02-06 1979-06-30 Предприятие П/Я В-2343 Способ получени дихлоргидрата бета-меркаптоэтил-1,3-пропилендиамина
CN1333694A (zh) * 1998-11-16 2002-01-30 美国生物科学有限公司 稳定的无定形氨磷汀组合物及其制备方法和用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Immobilization of Aminothiols on Poly(oxyethyleneH-phosphonate)s and Poly(oxyethylene phosphate)s—An Approach to Polymeric Protective Agentsfor Radiotherapy of Cancer;KOLIO TROEV等;《Journal of polymer science part A :polymer chemistry》;20070131;第45卷(第7期);13-16 *
lyophilization of pharmaceticals I:effect of certain physiacl-chemical properties;Patrick Deluca等;《journal of pharmaceutical science》;19650401;P617-624 *
WR1065 Mitigates AZT-ddI-Induced Mutagenesis and Inhibits Viral Replication;Dale M. Walker等;《Environmental and Molecular mutagenesis》;20090731;第50卷(第6期);第462页左栏第二段 *
WR1065 Mitigates AZT-ddI-Induced Mutagenesis and Inhibits;Dale M. Walker等;《Environmental and Molecular mutagenesis》;20090731;第50卷(第6期);第462页左栏第二段 *

Also Published As

Publication number Publication date
IL266811A (en) 2019-07-31
AU2017369603B2 (en) 2021-04-29
MX386559B (es) 2025-03-19
JP7138104B2 (ja) 2022-09-15
US20200239414A1 (en) 2020-07-30
EP3330251A1 (en) 2018-06-06
KR20190085526A (ko) 2019-07-18
BR112019011006A2 (pt) 2019-10-08
KR102596798B1 (ko) 2023-10-31
BR112019011006A8 (pt) 2023-04-11
IL266811B (en) 2021-10-31
EP3548464A1 (en) 2019-10-09
CN110300742A (zh) 2019-10-01
WO2018100008A1 (en) 2018-06-07
CA3039425A1 (en) 2018-06-07
JP2019535801A (ja) 2019-12-12
AU2017369603A1 (en) 2019-05-02
ZA201902119B (en) 2023-01-25
MX2019006310A (es) 2019-08-12
US11021442B2 (en) 2021-06-01

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Address after: Paris France

Patentee after: DYNAMIX PHARMACEUTICALS Ltd.

Patentee after: INSTITUT GUSTAVE ROUSSY

Patentee after: University of Thackeray, Paris

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Patentee before: DYNAMIX PHARMACEUTICALS Ltd.

Patentee before: Gustavroussi Institute

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