CA3039425A1 - Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol formulation - Google Patents

Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol formulation Download PDF

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Publication number
CA3039425A1
CA3039425A1 CA3039425A CA3039425A CA3039425A1 CA 3039425 A1 CA3039425 A1 CA 3039425A1 CA 3039425 A CA3039425 A CA 3039425A CA 3039425 A CA3039425 A CA 3039425A CA 3039425 A1 CA3039425 A1 CA 3039425A1
Authority
CA
Canada
Prior art keywords
amifostine
gel
solution
aminothiol
freeze
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3039425A
Other languages
English (en)
French (fr)
Inventor
Xiuping WANG-ZHANG
Perrine PIVETTE
Karine GONZALEZ
Eric Deutsch
Celine Clemenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CLEVEXEL PHARMA
Institut Gustave Roussy (IGR)
Universite Paris Saclay
Original Assignee
CLEVEXEL PHARMA
Institut Gustave Roussy (IGR)
Universite Paris Saclay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CLEVEXEL PHARMA, Institut Gustave Roussy (IGR), Universite Paris Saclay filed Critical CLEVEXEL PHARMA
Publication of CA3039425A1 publication Critical patent/CA3039425A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA3039425A 2016-11-30 2017-11-29 Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol formulation Pending CA3039425A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16306582.4 2016-11-30
EP16306582.4A EP3330251A1 (en) 2016-11-30 2016-11-30 Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol
PCT/EP2017/080881 WO2018100008A1 (en) 2016-11-30 2017-11-29 Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol formulation

Publications (1)

Publication Number Publication Date
CA3039425A1 true CA3039425A1 (en) 2018-06-07

Family

ID=57542923

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3039425A Pending CA3039425A1 (en) 2016-11-30 2017-11-29 Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol formulation

Country Status (11)

Country Link
US (1) US11021442B2 (https=)
EP (2) EP3330251A1 (https=)
JP (1) JP7138104B2 (https=)
KR (1) KR102596798B1 (https=)
CN (1) CN110300742B (https=)
AU (1) AU2017369603B2 (https=)
CA (1) CA3039425A1 (https=)
IL (1) IL266811B (https=)
MX (1) MX386559B (https=)
WO (1) WO2018100008A1 (https=)
ZA (1) ZA201902119B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4303224A4 (en) * 2021-03-03 2025-02-19 Tohoku University PROTEIN FOLDING AGENTS

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3824880A1 (en) * 2019-11-25 2021-05-26 Clevexel Pharma Freeze-dried powder containing 2-[(3-aminopropyl)amino]ethanethiol and its use for preparing a thermogel
CN116283682B (zh) * 2023-02-21 2024-08-02 梯尔希（南京）药物研发有限公司 一种同位素标记的氨磷汀代谢物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU670567A1 (ru) * 1978-02-06 1979-06-30 Предприятие П/Я В-2343 Способ получени дихлоргидрата бета-меркаптоэтил-1,3-пропилендиамина
US6239119B1 (en) 1998-04-27 2001-05-29 Medimmune Oncology, Inc. Topical administration of amifostine and related compounds
US6407278B2 (en) * 1998-11-16 2002-06-18 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and methods for the preparation and use of the same
MXPA03004546A (es) * 2000-11-22 2003-09-10 Rxkinetix Inc Tratamiento de mucositis.
WO2013163423A1 (en) * 2012-04-25 2013-10-31 Musc Foundation For Research Development Compositions and methods for wound healing and tissue repair
FR2994844B1 (fr) * 2012-08-31 2015-01-02 Assist Publ Hopitaux De Paris Formulation gelifiante a base de ketamine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4303224A4 (en) * 2021-03-03 2025-02-19 Tohoku University PROTEIN FOLDING AGENTS

Also Published As

Publication number Publication date
IL266811A (en) 2019-07-31
AU2017369603B2 (en) 2021-04-29
MX386559B (es) 2025-03-19
JP7138104B2 (ja) 2022-09-15
US20200239414A1 (en) 2020-07-30
EP3330251A1 (en) 2018-06-06
KR20190085526A (ko) 2019-07-18
BR112019011006A2 (pt) 2019-10-08
KR102596798B1 (ko) 2023-10-31
BR112019011006A8 (pt) 2023-04-11
IL266811B (en) 2021-10-31
EP3548464A1 (en) 2019-10-09
CN110300742A (zh) 2019-10-01
WO2018100008A1 (en) 2018-06-07
CN110300742B (zh) 2022-02-18
JP2019535801A (ja) 2019-12-12
AU2017369603A1 (en) 2019-05-02
ZA201902119B (en) 2023-01-25
MX2019006310A (es) 2019-08-12
US11021442B2 (en) 2021-06-01

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