JP2019535801A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019535801A5 JP2019535801A5 JP2019529868A JP2019529868A JP2019535801A5 JP 2019535801 A5 JP2019535801 A5 JP 2019535801A5 JP 2019529868 A JP2019529868 A JP 2019529868A JP 2019529868 A JP2019529868 A JP 2019529868A JP 2019535801 A5 JP2019535801 A5 JP 2019535801A5
- Authority
- JP
- Japan
- Prior art keywords
- ethanethiol
- aminopropyl
- amino
- process according
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- YHPLKWQJMAYFCN-UHFFFAOYSA-N WR-1065 Chemical compound NCCCNCCS YHPLKWQJMAYFCN-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- JKOQGQFVAUAYPM-UHFFFAOYSA-N amifostine Chemical compound NCCCNCCSP(O)(O)=O JKOQGQFVAUAYPM-UHFFFAOYSA-N 0.000 claims 3
- 229960001097 amifostine Drugs 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 206010015150 Erythema Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 208000003265 stomatitis Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306582.4 | 2016-11-30 | ||
| EP16306582.4A EP3330251A1 (en) | 2016-11-30 | 2016-11-30 | Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol |
| PCT/EP2017/080881 WO2018100008A1 (en) | 2016-11-30 | 2017-11-29 | Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol formulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535801A JP2019535801A (ja) | 2019-12-12 |
| JP2019535801A5 true JP2019535801A5 (https=) | 2020-12-10 |
| JP7138104B2 JP7138104B2 (ja) | 2022-09-15 |
Family
ID=57542923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529868A Active JP7138104B2 (ja) | 2016-11-30 | 2017-11-29 | ２－［（３－アミノプロピル）アミノ］エタンチオールの感熱性ゲル組成物およびその調製プロセス |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11021442B2 (https=) |
| EP (2) | EP3330251A1 (https=) |
| JP (1) | JP7138104B2 (https=) |
| KR (1) | KR102596798B1 (https=) |
| CN (1) | CN110300742B (https=) |
| AU (1) | AU2017369603B2 (https=) |
| CA (1) | CA3039425A1 (https=) |
| IL (1) | IL266811B (https=) |
| MX (1) | MX386559B (https=) |
| WO (1) | WO2018100008A1 (https=) |
| ZA (1) | ZA201902119B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3824880A1 (en) * | 2019-11-25 | 2021-05-26 | Clevexel Pharma | Freeze-dried powder containing 2-[(3-aminopropyl)amino]ethanethiol and its use for preparing a thermogel |
| EP4303224A4 (en) * | 2021-03-03 | 2025-02-19 | Tohoku University | PROTEIN FOLDING AGENTS |
| CN116283682B (zh) * | 2023-02-21 | 2024-08-02 | 梯尔希（南京）药物研发有限公司 | 一种同位素标记的氨磷汀代谢物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU670567A1 (ru) * | 1978-02-06 | 1979-06-30 | Предприятие П/Я В-2343 | Способ получени дихлоргидрата бета-меркаптоэтил-1,3-пропилендиамина |
| US6239119B1 (en) | 1998-04-27 | 2001-05-29 | Medimmune Oncology, Inc. | Topical administration of amifostine and related compounds |
| US6407278B2 (en) * | 1998-11-16 | 2002-06-18 | Medimmune Oncology, Inc. | Stable amorphous amifostine compositions and methods for the preparation and use of the same |
| MXPA03004546A (es) * | 2000-11-22 | 2003-09-10 | Rxkinetix Inc | Tratamiento de mucositis. |
| WO2013163423A1 (en) * | 2012-04-25 | 2013-10-31 | Musc Foundation For Research Development | Compositions and methods for wound healing and tissue repair |
| FR2994844B1 (fr) * | 2012-08-31 | 2015-01-02 | Assist Publ Hopitaux De Paris | Formulation gelifiante a base de ketamine |
-
2016
- 2016-11-30 EP EP16306582.4A patent/EP3330251A1/en not_active Withdrawn
-
2017
- 2017-11-29 EP EP17825118.7A patent/EP3548464A1/en active Pending
- 2017-11-29 CN CN201780074153.2A patent/CN110300742B/zh active Active
- 2017-11-29 US US16/465,505 patent/US11021442B2/en active Active
- 2017-11-29 JP JP2019529868A patent/JP7138104B2/ja active Active
- 2017-11-29 KR KR1020197016544A patent/KR102596798B1/ko active Active
- 2017-11-29 AU AU2017369603A patent/AU2017369603B2/en active Active
- 2017-11-29 MX MX2019006310A patent/MX386559B/es unknown
- 2017-11-29 WO PCT/EP2017/080881 patent/WO2018100008A1/en not_active Ceased
- 2017-11-29 CA CA3039425A patent/CA3039425A1/en active Pending
-
2019
- 2019-04-04 ZA ZA2019/02119A patent/ZA201902119B/en unknown
- 2019-05-22 IL IL266811A patent/IL266811B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102395712B1 (ko) | 백신 조성물 | |
| FI3258919T4 (fi) | Nasaalinen jauheformulaatio hypoglykemian hoitoon | |
| JP2019535801A5 (https=) | ||
| JP2020530007A5 (https=) | ||
| JP2014512402A5 (https=) | ||
| JP2017512189A5 (https=) | ||
| JP2011088927A5 (https=) | ||
| JP2015535243A5 (https=) | ||
| JP2020521797A5 (https=) | ||
| JP2014525449A5 (https=) | ||
| JPWO2019156137A5 (https=) | ||
| MX2021015447A (es) | Métodos de tratamiento del cáncer dirigidos a tumores fríos. | |
| JP6235614B2 (ja) | 注射用ｈｐｐｈ凍結乾燥粉末注射剤およびその製造方法 | |
| CN110300742B (zh) | 制备冻干2-[(3-氨基丙基)氨基]乙硫醇制剂的方法 | |
| WO2017171653A1 (en) | A composition comprising pic for treatment of cancer | |
| JP2019503994A5 (https=) | ||
| JP2026505092A5 (https=) | ||
| JP2019505571A5 (https=) | ||
| AU2020393375B2 (en) | Freeze-dried powder containing 2-[(3-aminopropyl)amino]ethanethiol and its use for preparing a thermogel | |
| CN103923208B (zh) | 一种重组人角质细胞生长因子-2突变体的活性稳定剂 | |
| SU66123A1 (ru) | Способ получени нейтрального флавакридина (смеси сол нокислого 3,6-диаминоакридина и хлорметилата 3,6-диаминоакредина) | |
| CN108289840A (zh) | 用于静脉内注射Danirixin的制剂 | |
| BR112019011006B1 (pt) | Composição de termogel, processo para a preparação de uma composição de termogel e usos da composição de termogel | |
| SU87235A1 (ru) | Способ получени сухого протравител дл сем н хлопчатника | |
| JP2022510947A5 (https=) |