JP7135121B2 - 尿素バイオセンサ及び室温における尿素バイオセンサの安定化 - Google Patents

尿素バイオセンサ及び室温における尿素バイオセンサの安定化 Download PDF

Info

Publication number
JP7135121B2
JP7135121B2 JP2020570928A JP2020570928A JP7135121B2 JP 7135121 B2 JP7135121 B2 JP 7135121B2 JP 2020570928 A JP2020570928 A JP 2020570928A JP 2020570928 A JP2020570928 A JP 2020570928A JP 7135121 B2 JP7135121 B2 JP 7135121B2
Authority
JP
Japan
Prior art keywords
urea
membrane
urease
ammonium
polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020570928A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021527224A (ja
JP2021527224A5 (https=
Inventor
シュウ，シャオシャン
パミディ，プラサード
イム，ヒョンシク
Original Assignee
インストゥルメンテーション ラボラトリー カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by インストゥルメンテーション ラボラトリー カンパニー filed Critical インストゥルメンテーション ラボラトリー カンパニー
Publication of JP2021527224A publication Critical patent/JP2021527224A/ja
Publication of JP2021527224A5 publication Critical patent/JP2021527224A5/ja
Application granted granted Critical
Publication of JP7135121B2 publication Critical patent/JP7135121B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/00091—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching by evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0011—Casting solutions therefor
    • B01D67/00111—Polymer pretreatment in the casting solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0013—Casting processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/107—Organic support material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/1213—Laminated layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/142—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers"
    • B01D69/144—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers" containing embedded or bound biomolecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/54—Polyureas; Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/308—Electrodes, e.g. test electrodes; Half-cells at least partially made of carbon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/30—Microarray design
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/12—Specific ratios of components used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/34—Molecular weight or degree of polymerisation
    • B01D2325/341—At least two polymers of same structure but different molecular weight
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/30—Circuit design
    • G06F30/32—Circuit design at the digital level
    • G06F30/33—Design verification, e.g. functional simulation or model checking
    • G06F30/3308—Design verification, e.g. functional simulation or model checking using simulation
    • G06F30/331—Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Dispersion Chemistry (AREA)
  • Computational Mathematics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Mathematical Analysis (AREA)
JP2020570928A 2019-04-05 2019-06-03 尿素バイオセンサ及び室温における尿素バイオセンサの安定化 Active JP7135121B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962830191P 2019-04-05 2019-04-05
US62/830,191 2019-04-05
PCT/US2019/035153 WO2020204973A1 (en) 2019-04-05 2019-06-03 Urea biosensors and stabilization of urea biosensors at room temperature

Publications (3)

Publication Number Publication Date
JP2021527224A JP2021527224A (ja) 2021-10-11
JP2021527224A5 JP2021527224A5 (https=) 2021-12-23
JP7135121B2 true JP7135121B2 (ja) 2022-09-12

Family

ID=67138031

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2020570928A Active JP7135121B2 (ja) 2019-04-05 2019-06-03 尿素バイオセンサ及び室温における尿素バイオセンサの安定化
JP2020570972A Active JP7015401B2 (ja) 2019-04-05 2019-06-03 クレアチニン／クレアチンセンサのための外膜組成物
JP2020567148A Active JP7082691B2 (ja) 2019-04-05 2019-06-03 クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法
JP2020570732A Active JP7100162B2 (ja) 2019-04-05 2019-06-03 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用
JP2020571701A Active JP7127159B2 (ja) 2019-04-05 2019-06-03 マルチ酵素バイオセンサ及び室温におけるマルチ酵素バイオセンサの安定化
JP2022024293A Pending JP2022068299A (ja) 2019-04-05 2022-02-18 クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2020570972A Active JP7015401B2 (ja) 2019-04-05 2019-06-03 クレアチニン／クレアチンセンサのための外膜組成物
JP2020567148A Active JP7082691B2 (ja) 2019-04-05 2019-06-03 クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法
JP2020570732A Active JP7100162B2 (ja) 2019-04-05 2019-06-03 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用
JP2020571701A Active JP7127159B2 (ja) 2019-04-05 2019-06-03 マルチ酵素バイオセンサ及び室温におけるマルチ酵素バイオセンサの安定化
JP2022024293A Pending JP2022068299A (ja) 2019-04-05 2022-02-18 クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法

Country Status (10)

Country Link
US (6) US11327042B2 (https=)
EP (5) EP3947710A1 (https=)
JP (6) JP7135121B2 (https=)
KR (5) KR102480669B1 (https=)
CN (6) CN112513285B (https=)
AU (3) AU2019440163B2 (https=)
CA (3) CA3105013C (https=)
DK (2) DK3947708T3 (https=)
ES (1) ES3038379T3 (https=)
WO (5) WO2020204975A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11327042B2 (en) 2019-04-05 2022-05-10 Instrumentation Laboratory Company Compositions and methods for improved creatinine measurement accuracy and uses thereof
US12139741B2 (en) 2019-10-25 2024-11-12 Instrumentation Laboratory Company Biocide compositions compatible with enzyme biosensors and methods of use thereof
US12298268B2 (en) * 2020-05-21 2025-05-13 Nova Biomedical Corporation Single-use disposable reference sensor
US20230041320A1 (en) * 2021-08-03 2023-02-09 Polymer Technology Systems, Inc. Systems and Methods for Quantifying The Specific Activity of Creatininase
ES3054584T3 (en) 2022-02-09 2026-02-04 Instr Laboratory Co Sensor for measuring ionized magnesium
CN114705674B (zh) * 2022-05-10 2025-07-22 光景生物科技(苏州)有限公司 一种全血中肌酸和肌酐的定量检测方法
WO2025029820A1 (en) * 2023-07-31 2025-02-06 Abbott Diabetes Care Inc. Background interference mitigation for high sensitivity creatinine sensing
KR102800865B1 (ko) 2024-07-31 2025-05-07 전남대학교 산학협력단 신규한 크레아티닌 정량 장치

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005501254A (ja) 2001-08-24 2005-01-13 センサー−テック・リミテッド 高感度電位差測定センサを製造する方法
JP2008502921A (ja) 2004-06-09 2008-01-31 インストゥルメンテーション ラボラトリー カンパニー 電気化学尿素センサおよびその製造方法
WO2008028011A2 (en) 2006-08-31 2008-03-06 Nanogen Inc. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
JP2011508221A (ja) 2007-12-20 2011-03-10 アボット ポイント オブ ケア インコーポレイテッド 感知のための固定化生物層を形成するための組成物

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5861459A (ja) * 1981-10-07 1983-04-12 Hitachi Ltd クレアチンとクレアチニンの分析装置
JPS6475000A (en) * 1987-09-14 1989-03-20 Shimadzu Corp Method and equipment for analyzing creatinine
US5464747A (en) * 1993-10-29 1995-11-07 Boehringer Mannheim Corporation Oxidation-resistant muteins of β-galactosidase fragments
EP0944731B1 (en) * 1996-11-14 2006-01-18 Radiometer Medical ApS Enzyme sensor
DE69810194T2 (de) 1997-06-03 2003-11-20 Matsushita Electric Industrial Co. Ltd., Osaka Cholesterinsensor
JP3635263B2 (ja) 2000-03-01 2005-04-06 ラジオメーター・メディカル・アクティーゼルスカブ 固体状態参照系を持つ電極デバイス
AT408662B (de) * 2000-05-16 2002-02-25 Hoffmann La Roche Creatinin-sensor
AT409040B (de) 2000-08-11 2002-05-27 Roche Diagnostics Gmbh Creatininsensor-kalibration
US6872297B2 (en) 2001-05-31 2005-03-29 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6960466B2 (en) 2001-05-31 2005-11-01 Instrumentation Laboratory Company Composite membrane containing a cross-linked enzyme matrix for a biosensor
US6767441B1 (en) 2001-07-31 2004-07-27 Nova Biomedical Corporation Biosensor with peroxidase enzyme
ES2633729T3 (es) * 2001-08-22 2017-09-25 Instrumentation Laboratory Company Método para calibrar sensores electroquímicos
US7285198B2 (en) 2004-02-23 2007-10-23 Mysticmd, Inc. Strip electrode with conductive nano tube printing
GB0227424D0 (en) 2002-11-25 2002-12-31 Univ Warwick Coatings
JP4088312B2 (ja) 2003-10-30 2008-05-21 アークレイ株式会社 バイオセンサおよびその製造方法
DK1692522T3 (da) 2003-11-28 2012-04-02 Radiometer Medical Aps Referencevæske
US7699964B2 (en) * 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US8989833B2 (en) * 2004-07-13 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US7959791B2 (en) 2005-05-17 2011-06-14 Radiometer Medical Aps Enzyme sensor with a cover membrane layer covered by a hydrophilic polymer
WO2006122553A1 (en) * 2005-05-17 2006-11-23 Radiometer Medical Aps Enzyme sensor including a water-containing spacer layer
WO2006122552A1 (en) * 2005-05-17 2006-11-23 Radiometer Medical Aps Method of stabilising or reactivating a creatinine sensor with a solution of a divalent manganese ion
DK1889075T3 (da) 2005-05-17 2013-09-02 Radiometer Medical Aps Fremgangsmåde til stabilisering eller reaktivering af en kreatininsensor med en opløsning af en divalent manganion
KR100726963B1 (ko) * 2005-06-15 2007-06-14 김경훈 바이오센서용 우레아제 고정화막의 제조 방법
US7799195B2 (en) * 2005-09-02 2010-09-21 Vladislav Dolnik Neutral polysaccharide wall coating for electrophoretic separations in capillaries and microchannels
US8617366B2 (en) * 2005-12-12 2013-12-31 Nova Biomedical Corporation Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device
US9556471B2 (en) * 2006-08-09 2017-01-31 Flir Detection, Inc. Enzyme containing liquid and delivery system for detection of analytes on surfaces
IES20070774A2 (en) 2007-10-24 2008-12-24 Nat Univ Ireland Maynooth Monitoring target endogenous species in the brain
US20120181189A1 (en) 2009-09-24 2012-07-19 Fresenius Medical Care Holdings, Inc. Amperometric Creatinine Biosensor With Immobilized Enzyme-Polymer Composition And Systems Using Same, And Methods
US9233788B2 (en) * 2010-01-22 2016-01-12 Bayer Healthcare Llc Biosensor desiccant system having enhanced measurement performance
JP2014153243A (ja) 2013-02-12 2014-08-25 Tanita Corp バイオセンサおよびこれを用いた測定方法
WO2014159193A1 (en) * 2013-03-14 2014-10-02 Instrumentation Laboratory Company Whole blood hemolysis sensor
WO2014150876A2 (en) 2013-03-15 2014-09-25 Abbott Point Of Care Inc Biosensor structures for improved point of care testing and methods of manufacture thereof
EP4530635A3 (en) 2014-12-18 2025-06-25 Radiometer Medical ApS Method for calibrating a device for measuring the concentration of creatinine
DK3234562T3 (da) 2014-12-18 2020-02-03 Radiometer Medical Aps Kalibreringskoncept til amperometrisk creatininsensor med korrigering for endogene modulatorer
DK3234563T3 (da) 2014-12-18 2025-02-10 Radiometer Medical Aps Fremgangsmåde til kalibrering af en indretning til måling af koncentrationen af kreatinin
EP3380833B1 (en) * 2015-11-27 2019-12-25 Radiometer Medical ApS An outer layer for enzyme sensors
JP7011906B2 (ja) * 2017-08-25 2022-01-27 国立大学法人 筑波大学 クレアチニンセンサ
KR102573459B1 (ko) * 2017-08-28 2023-09-04 디에스엠 아이피 어셋츠 비.브이. 폴리우레탄 블렌드를 포함하는 합성 멤브레인 조성물
US11327042B2 (en) 2019-04-05 2022-05-10 Instrumentation Laboratory Company Compositions and methods for improved creatinine measurement accuracy and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005501254A (ja) 2001-08-24 2005-01-13 センサー−テック・リミテッド 高感度電位差測定センサを製造する方法
JP2008502921A (ja) 2004-06-09 2008-01-31 インストゥルメンテーション ラボラトリー カンパニー 電気化学尿素センサおよびその製造方法
WO2008028011A2 (en) 2006-08-31 2008-03-06 Nanogen Inc. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
JP2011508221A (ja) 2007-12-20 2011-03-10 アボット ポイント オブ ケア インコーポレイテッド 感知のための固定化生物層を形成するための組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Julia M.C.S. Magalhaes ほか１名，Urea potentiometric biosensor based on urease immobilized on chitosan membranes，Talanta，1998年，47，pp.183-191

Also Published As

Publication number Publication date
JP2022068299A (ja) 2022-05-09
EP3947709A1 (en) 2022-02-09
JP7127159B2 (ja) 2022-08-29
AU2019439465B2 (en) 2025-01-02
CN112534058A (zh) 2021-03-19
KR20210014666A (ko) 2021-02-09
JP7082691B2 (ja) 2022-06-08
US11293890B2 (en) 2022-04-05
CN112638513A (zh) 2021-04-09
DK3947711T3 (da) 2024-01-15
JP2021527194A (ja) 2021-10-11
CN112534059B (zh) 2025-01-07
ES3038379T3 (en) 2025-10-13
AU2019439424A1 (en) 2021-01-07
US12529673B2 (en) 2026-01-20
KR102519406B1 (ko) 2023-04-10
CN112513285B (zh) 2024-06-25
WO2020204976A1 (en) 2020-10-08
KR20210014667A (ko) 2021-02-09
WO2020204975A1 (en) 2020-10-08
US11327042B2 (en) 2022-05-10
KR20210013626A (ko) 2021-02-04
US20200318152A1 (en) 2020-10-08
KR102937635B1 (ko) 2026-03-12
EP3946697C0 (en) 2025-08-06
EP3946697B1 (en) 2025-08-06
EP3947711A1 (en) 2022-02-09
EP3947710A1 (en) 2022-02-09
US20220187234A1 (en) 2022-06-16
CN112513285A (zh) 2021-03-16
CA3101513A1 (en) 2020-10-08
CA3105013C (en) 2023-03-28
CN112534059A (zh) 2021-03-19
KR20210013625A (ko) 2021-02-04
EP3946697A1 (en) 2022-02-09
JP2021528640A (ja) 2021-10-21
CN112424369A (zh) 2021-02-26
KR102480669B1 (ko) 2022-12-26
AU2019440163A1 (en) 2021-01-07
CN112534058B (zh) 2024-12-27
JP7015401B2 (ja) 2022-02-02
US11460431B2 (en) 2022-10-04
KR20210149577A (ko) 2021-12-09
US20200319211A1 (en) 2020-10-08
JP7100162B2 (ja) 2022-07-12
EP3947711B1 (en) 2023-12-20
CA3105191A1 (en) 2020-10-08
WO2020204973A1 (en) 2020-10-08
US11761921B2 (en) 2023-09-19
CA3105011A1 (en) 2020-10-08
AU2019440163B2 (en) 2022-01-27
JP2021524587A (ja) 2021-09-13
KR102519408B1 (ko) 2023-04-10
JP2021527224A (ja) 2021-10-11
AU2019439424B2 (en) 2022-10-13
US20200319136A1 (en) 2020-10-08
EP3947708A1 (en) 2022-02-09
WO2020204972A1 (en) 2020-10-08
CA3104896A1 (en) 2020-10-08
AU2019439465A1 (en) 2021-05-20
EP3947708B1 (en) 2024-02-14
KR102574622B1 (ko) 2023-09-06
US20200319134A1 (en) 2020-10-08
US20200319210A1 (en) 2020-10-08
DK3947708T3 (da) 2024-03-11
CA3105013A1 (en) 2020-10-08
WO2020204974A1 (en) 2020-10-08
JP2021525888A (ja) 2021-09-27
CN119776481A (zh) 2025-04-08

Similar Documents

Publication Publication Date Title
JP7135121B2 (ja) 尿素バイオセンサ及び室温における尿素バイオセンサの安定化
EP1456635B1 (en) Analytical instruments, biosensors and methods
AU2005254966B2 (en) Electrochemical urea sensors and methods of making the same
JPH0679003B2 (ja) 酵素／電極式中センサー
JP2021527224A5 (https=)
JP2021524587A5 (https=)
Vaddiraju et al. Enhanced glucose sensor linearity using poly (vinyl alcohol) hydrogels
Rhemrev-Boom et al. On-line continuous monitoring of glucose or lactate by ultraslow microdialysis combined with a flow-through nanoliter biosensor based on poly (m-phenylenediamine) ultra-thin polymer membrane as enzyme electrode
JP4627912B2 (ja) バイオセンサ
Yin et al. Enzyme immobilization on nitrocellulose film for pH-EGFET type biosensors
Böhm et al. A flow-through amperometric sensor based on dialysis tubing and free enzyme reactors
Chen et al. Biocompatible needle‐type glucose sensor with potential for use in vivo
Demirkiran et al. Immobilization of glucose oxidase in silica sol-gel film for application to biosensor and amperometric determination of glucose
Chen et al. Multifunctional biocompatible membrane and its application to fabricate a miniaturized glucose sensor with potential for use in vivo
RU2580288C2 (ru) Способ изготовления микробиосенсора для определения глюкозы или лактата
JP2006053115A (ja) 過酸化水素およびオキシダーゼ基質計測用電極
Aziz Quantitative Analysis Of Performance Of A Hydrogen Peroxide–Based Glucose Biosensor
Yang et al. Using MPTMS as permselective membranes of biosensors
CS241022B2 (cs) Molekulárně selektivní senzor a způsob jeho výroby

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210224

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20210224

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210812

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210813

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20211112

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220202

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220601

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20220601

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220609

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20220628

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20220629

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220812

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220831

R150 Certificate of patent or registration of utility model

Ref document number: 7135121

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250