DK3947711T3 - Urinstofbiosensorer, der er stabiliseret ved rumtemperatur - Google Patents

Urinstofbiosensorer, der er stabiliseret ved rumtemperatur Download PDF

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Publication number
DK3947711T3
DK3947711T3 DK19739734.2T DK19739734T DK3947711T3 DK 3947711 T3 DK3947711 T3 DK 3947711T3 DK 19739734 T DK19739734 T DK 19739734T DK 3947711 T3 DK3947711 T3 DK 3947711T3
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Prior art keywords
stabilized
room temperature
biosensors
urea
urea biosensors
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DK19739734.2T
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English (en)
Inventor
Xiaoxian Xu
Prasad Pamidi
Hyoungsik Yim
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Instr Laboratory Co
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Publication of DK3947711T3 publication Critical patent/DK3947711T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/00091—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching by evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0011—Casting solutions therefor
    • B01D67/00111—Polymer pretreatment in the casting solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0013—Casting processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/107—Organic support material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/1213—Laminated layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/142—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers"
    • B01D69/144—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers" containing embedded or bound biomolecules
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    • B01D71/06—Organic material
    • B01D71/54—Polyureas; Polyurethanes
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
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    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
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    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • G—PHYSICS
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
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  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Electrochemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Dispersion Chemistry (AREA)
  • Evolutionary Biology (AREA)
  • Pure & Applied Mathematics (AREA)
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  • Medical Informatics (AREA)
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  • Mathematical Optimization (AREA)
DK19739734.2T 2019-04-05 2019-06-03 Urinstofbiosensorer, der er stabiliseret ved rumtemperatur DK3947711T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962830191P 2019-04-05 2019-04-05
PCT/US2019/035153 WO2020204973A1 (en) 2019-04-05 2019-06-03 Urea biosensors and stabilization of urea biosensors at room temperature

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Publication Number Publication Date
DK3947711T3 true DK3947711T3 (da) 2024-01-15

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Application Number Title Priority Date Filing Date
DK19734962.4T DK3947708T3 (da) 2019-04-05 2019-06-03 Fremgangsmåde og system til forbedret kalibrering af kreatinin/kreatin-sensorer
DK19739734.2T DK3947711T3 (da) 2019-04-05 2019-06-03 Urinstofbiosensorer, der er stabiliseret ved rumtemperatur

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DK19734962.4T DK3947708T3 (da) 2019-04-05 2019-06-03 Fremgangsmåde og system til forbedret kalibrering af kreatinin/kreatin-sensorer

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US (6) US11327042B2 (da)
EP (5) EP3947710A1 (da)
JP (6) JP7082691B2 (da)
KR (5) KR102519406B1 (da)
CN (5) CN112638513A (da)
AU (3) AU2019439424B2 (da)
CA (5) CA3105013C (da)
DK (2) DK3947708T3 (da)
WO (5) WO2020204975A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3947710A1 (en) 2019-04-05 2022-02-09 Instrumentation Laboratory Company Multi-enzymatic biosensors and stabilization of multi-enzymatic biosensors at room temperature
US20230041320A1 (en) * 2021-08-03 2023-02-09 Polymer Technology Systems, Inc. Systems and Methods for Quantifying The Specific Activity of Creatininase

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5861459A (ja) * 1981-10-07 1983-04-12 Hitachi Ltd クレアチンとクレアチニンの分析装置
JPS6475000A (en) * 1987-09-14 1989-03-20 Shimadzu Corp Method and equipment for analyzing creatinine
US5464747A (en) * 1993-10-29 1995-11-07 Boehringer Mannheim Corporation Oxidation-resistant muteins of β-galactosidase fragments
DE69735127T2 (de) 1996-11-14 2006-08-31 Radiometer Medical Aps Enzymsensor
EP0884392B1 (en) * 1997-06-03 2002-12-18 Matsushita Electric Industrial Co., Ltd. Cholesterol sensor
DE60138694D1 (de) * 2000-03-01 2009-06-25 Radiometer Medical Aps Elektrodeneinrichtung mit festkörper-bezugssystem
AT408662B (de) * 2000-05-16 2002-02-25 Hoffmann La Roche Creatinin-sensor
AT409040B (de) 2000-08-11 2002-05-27 Roche Diagnostics Gmbh Creatininsensor-kalibration
US6872297B2 (en) 2001-05-31 2005-03-29 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6960466B2 (en) 2001-05-31 2005-11-01 Instrumentation Laboratory Company Composite membrane containing a cross-linked enzyme matrix for a biosensor
US6767441B1 (en) 2001-07-31 2004-07-27 Nova Biomedical Corporation Biosensor with peroxidase enzyme
ATE487130T1 (de) * 2001-08-22 2010-11-15 Instrumentation Lab Co Verfahren und vorrichtung zur kalibrierung von sensoren
US8404096B2 (en) 2001-08-24 2013-03-26 Sensortec Limited Methods for producing highly sensitive potentiometric sensors
GB0227424D0 (en) * 2002-11-25 2002-12-31 Univ Warwick Coatings
US20040256227A1 (en) 2003-02-11 2004-12-23 Jungwon Shin Electrochemical urea sensors and methods of making the same
KR100814193B1 (ko) 2003-10-30 2008-03-17 아크레이 가부시키가이샤 바이오 센서 및 그 제조 방법
WO2005052596A1 (en) * 2003-11-28 2005-06-09 Radiometer Medical Aps A reference solution
GB2426826B (en) * 2004-02-23 2008-06-25 Joel S Douglas Strip electrode with conductive nano tube printing
US7959791B2 (en) 2005-05-17 2011-06-14 Radiometer Medical Aps Enzyme sensor with a cover membrane layer covered by a hydrophilic polymer
WO2006122552A1 (en) * 2005-05-17 2006-11-23 Radiometer Medical Aps Method of stabilising or reactivating a creatinine sensor with a solution of a divalent manganese ion
CN102608176B (zh) * 2005-05-17 2016-08-10 雷迪奥米特医学公司 用二价锰离子溶液稳定或再活化肌酸酐传感器的方法
WO2006122553A1 (en) * 2005-05-17 2006-11-23 Radiometer Medical Aps Enzyme sensor including a water-containing spacer layer
KR100726963B1 (ko) * 2005-06-15 2007-06-14 김경훈 바이오센서용 우레아제 고정화막의 제조 방법
US8617366B2 (en) * 2005-12-12 2013-12-31 Nova Biomedical Corporation Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device
US9556471B2 (en) * 2006-08-09 2017-01-31 Flir Detection, Inc. Enzyme containing liquid and delivery system for detection of analytes on surfaces
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
IES20070774A2 (en) 2007-10-24 2008-12-24 Nat Univ Ireland Maynooth Monitoring target endogenous species in the brain
US8268604B2 (en) 2007-12-20 2012-09-18 Abbott Point Of Care Inc. Compositions for forming immobilized biological layers for sensing
US20120181189A1 (en) * 2009-09-24 2012-07-19 Fresenius Medical Care Holdings, Inc. Amperometric Creatinine Biosensor With Immobilized Enzyme-Polymer Composition And Systems Using Same, And Methods
US9233788B2 (en) * 2010-01-22 2016-01-12 Bayer Healthcare Llc Biosensor desiccant system having enhanced measurement performance
JP2014153243A (ja) 2013-02-12 2014-08-25 Tanita Corp バイオセンサおよびこれを用いた測定方法
JP6181280B2 (ja) * 2013-03-14 2017-08-16 インストゥルメンテーション ラボラトリー カンパニー 全血溶血センサ
US9487811B2 (en) 2013-03-15 2016-11-08 Abbott Point Of Care Inc. Biosensor structures for improved point of care testing and methods of manufacture thereof
EP3234563A1 (en) * 2014-12-18 2017-10-25 Radiometer Medical ApS Method for calibrating a device for measuring the concentration of creatinine
US20170363567A1 (en) * 2014-12-18 2017-12-21 Radiometer Medical Aps Method for calibrating a device for measuring the concentration of creatinine
CN107110813B (zh) * 2014-12-18 2020-04-17 雷迪奥米特医学公司 对内源性调节剂进行校正的安培型肌酸酐传感器的校准概念
JP6826117B2 (ja) * 2015-11-27 2021-02-03 ラジオメーター・メディカル・アー・ペー・エス 酵素センサ用の外層
JP7011906B2 (ja) * 2017-08-25 2022-01-27 国立大学法人 筑波大学 クレアチニンセンサ
CN111148776B (zh) * 2017-08-28 2022-06-03 帝斯曼知识产权资产管理有限公司 包含聚氨酯共混物的合成膜组合物
EP3947710A1 (en) 2019-04-05 2022-02-09 Instrumentation Laboratory Company Multi-enzymatic biosensors and stabilization of multi-enzymatic biosensors at room temperature

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