MA42612A - Composés hétérocycliques fumagillol, et procédés correspondants de fabrication et d'utilisation - Google Patents
Composés hétérocycliques fumagillol, et procédés correspondants de fabrication et d'utilisationInfo
- Publication number
- MA42612A MA42612A MA042612A MA42612A MA42612A MA 42612 A MA42612 A MA 42612A MA 042612 A MA042612 A MA 042612A MA 42612 A MA42612 A MA 42612A MA 42612 A MA42612 A MA 42612A
- Authority
- MA
- Morocco
- Prior art keywords
- fumagillol
- manufacturing
- heterocyclic compounds
- corresponding processes
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562203742P | 2015-08-11 | 2015-08-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA42612A true MA42612A (fr) | 2018-06-20 |
Family
ID=56799580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA042612A MA42612A (fr) | 2015-08-11 | 2016-08-11 | Composés hétérocycliques fumagillol, et procédés correspondants de fabrication et d'utilisation |
Country Status (15)
Country | Link |
---|---|
US (5) | US20180230137A1 (fr) |
EP (1) | EP3334728A1 (fr) |
JP (1) | JP2018522929A (fr) |
KR (1) | KR20180035907A (fr) |
CN (1) | CN108026085A (fr) |
AR (1) | AR105671A1 (fr) |
AU (1) | AU2016306558A1 (fr) |
CA (1) | CA2995366A1 (fr) |
EA (1) | EA201890449A1 (fr) |
IL (1) | IL257443A (fr) |
MA (1) | MA42612A (fr) |
MX (1) | MX2018001733A (fr) |
PH (1) | PH12018500315A1 (fr) |
TW (1) | TW201718550A (fr) |
WO (1) | WO2017027684A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2850079B1 (fr) | 2012-05-09 | 2018-05-02 | Zafgen, Inc. | Dérivés de fumigillol, procédés pour leurs préparation et leurs utilisation |
AR105671A1 (es) * | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
WO2018148638A1 (fr) * | 2017-02-10 | 2018-08-16 | Zafgen, Inc. | Compositions pharmaceutiques d'inhibiteurs de metap-2 |
WO2019118612A1 (fr) * | 2017-12-12 | 2019-06-20 | Zafgen, Inc. | Composés de ciblage |
WO2019173505A1 (fr) * | 2018-03-06 | 2019-09-12 | Zafgen, Inc. | Méthodes de traitement de troubles liés à la régulation glycémique |
CN109180551A (zh) * | 2018-07-17 | 2019-01-11 | 宜春学院 | 一种四元氮杂环中间体的制备方法 |
CN113453721A (zh) | 2018-10-26 | 2021-09-28 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
CN111606836B (zh) * | 2020-06-12 | 2021-01-15 | 上海馨远医药科技有限公司 | 一种R-N-Boc-3-吡咯烷乙酸的制备方法 |
GB202011996D0 (en) | 2020-07-31 | 2020-09-16 | Adorx Therapeutics Ltd | Antagonist compounds |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5164410A (en) | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
PH26256A (en) * | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
US5180738A (en) | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
US5166172A (en) | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
EP0359036B1 (fr) | 1988-09-01 | 1997-03-26 | Takeda Chemical Industries, Ltd. | Dérivés de fumagillol |
US5288722A (en) | 1989-03-06 | 1994-02-22 | Takeda Chemical Industries, Ltd. | 6-amino-6-desoxyfumagillols, production and use thereof |
DE69001187T2 (de) | 1989-03-06 | 1993-07-08 | Takeda Chemical Industries Ltd | 6-epifumagillole, ihre herstellung und ihre verwendung. |
US6017954A (en) | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
US5290807A (en) | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
EP0415294A3 (en) | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
TW282399B (fr) | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
DE69330690T2 (de) | 1992-01-30 | 2002-06-20 | Takeda Chemical Industries Ltd | Verfahren zur Herstellung hoch-wasserlöslicher Zyklodextrinkomplexe |
ATE153854T1 (de) | 1992-12-16 | 1997-06-15 | Takeda Chemical Industries Ltd | Stabile pharmazeutische zubereitung mit fumagillolderivaten |
NZ304906A (en) | 1995-03-27 | 1999-06-29 | Sanofi Sa | Use of fumagillol or a fumagillol ester and an optionally saturated alkylcarboxylic or alkyldicarboxylic acid to fight intestinal infections |
US6180626B1 (en) | 1995-10-11 | 2001-01-30 | Fujisawa Pharmaceutical Co., Ltd. | Vascular-permeability suppressants |
EP0799616A1 (fr) | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Composition orale contenant un dérivé de fumagillol |
WO1998005293A2 (fr) | 1996-08-02 | 1998-02-12 | The Children's Medical Center Corporation | Procede de regulation du systeme reproductif femelle au moyen d'inhibiteurs de l'angiogenese |
US6281245B1 (en) | 1996-10-28 | 2001-08-28 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof |
WO1998056372A1 (fr) | 1997-06-09 | 1998-12-17 | Massachusetts Institute Of Technology | Inhibiteurs de la methionine aminopeptidase de type 2 et leurs utilisations |
DE69824750T2 (de) | 1997-10-31 | 2005-07-07 | Children's Medical Center Corp., Boston | Methoden zur regulierung der grösse und des wachstums von durchblutetem normalem gewebe |
US6242494B1 (en) | 1998-05-01 | 2001-06-05 | Abbott Laboratories | Substituted β-amino acid inhibitors of methionine aminopeptidase-2 |
KR100357542B1 (ko) | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 푸마질롤 유도체 및 그 제조방법 |
KR100357541B1 (ko) | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
KR100293504B1 (ko) | 1998-06-05 | 2001-07-12 | 김윤 | 서방형전립선염치료제조성물 |
JP2000116337A (ja) | 1998-10-09 | 2000-04-25 | Nippon Shokuhin Kako Co Ltd | ペットフード |
US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
CZ20013834A3 (cs) | 1999-04-28 | 2002-04-17 | Aventis Pharma Deutschland Gmbh | Deriváty kyselin se třemi arylovými zbytky jako ligandy receptorů PPAR a farmaceutické prostředky, které je obsahují |
AU7989400A (en) | 1999-10-01 | 2001-05-10 | Smithkline Beecham Corporation | Compounds and methods |
US20030220371A1 (en) | 2000-04-12 | 2003-11-27 | Kallander Lara S. | Compounds and methods |
US6323228B1 (en) | 2000-09-15 | 2001-11-27 | Abbott Laboratories | 3-substituted indole angiogenesis inhibitors |
PE20020376A1 (es) | 2000-09-29 | 2002-05-13 | Abbott Lab | Polipeptidos antiangiogenicos y metodos para inhibir la angiogenesis |
PL366216A1 (en) | 2000-11-01 | 2005-01-24 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
US6548477B1 (en) | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
WO2002078699A1 (fr) | 2001-03-29 | 2002-10-10 | Smithkline Beecham Corporation | Composes et procedes |
US20020183242A1 (en) | 2001-04-11 | 2002-12-05 | Jack Henkin | Peptide antiangiogenic drugs |
US7087768B2 (en) | 2001-09-27 | 2006-08-08 | Equispharm Co., Ltd. | Fumagillol derivatives and preparing method thereof |
US6803382B2 (en) | 2001-11-09 | 2004-10-12 | Galderma Research & Development, S.N.C. | Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof |
KR100451485B1 (ko) | 2002-03-28 | 2004-10-06 | 주식회사종근당 | 푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물 |
US6877863B2 (en) | 2002-06-12 | 2005-04-12 | Silicon Optix Inc. | Automatic keystone correction system and method |
US6989392B2 (en) | 2002-06-18 | 2006-01-24 | Abbott Laboratories | 2-Aminoquinolines as melanin concentrating hormone receptor antagonists |
US7030262B2 (en) | 2002-08-06 | 2006-04-18 | Abbott Laboratories | 3-Amino-2-hydroxyalkanoic acids and their prodrugs |
US20040067266A1 (en) | 2002-10-07 | 2004-04-08 | Toppo Frank R. | Weight loss compound |
US7491718B2 (en) | 2002-10-08 | 2009-02-17 | Abbott Laboratories | Sulfonamides having antiangiogenic and anticancer activity |
US20040157836A1 (en) | 2002-10-08 | 2004-08-12 | Comess Kenneth M. | Sulfonamides having antiangiogenic and anticancer activity |
WO2004078113A2 (fr) | 2003-03-04 | 2004-09-16 | Pharmacia Corporation | Traitement et prevention de l'obesite au moyen d'inhibiteurs de cox-2 seul ou en combinaison avec des agents d'amaigrissement |
CA2550873A1 (fr) | 2003-12-29 | 2005-07-21 | Praecis Pharmaceuticals, Inc. | Inhibiteurs de methionine aminopeptidase-2 et leur utilisation |
KR100552043B1 (ko) | 2004-02-28 | 2006-02-20 | 주식회사종근당 | 푸마질롤 유도체를 포함하는 비만치료용 조성물 |
RU2007103178A (ru) | 2004-06-30 | 2008-08-10 | Комбинаторкс, Инкорпорейтед (Us) | Способы и реагенты для лечения метаболических нарушений |
WO2006010498A2 (fr) | 2004-07-28 | 2006-02-02 | Bayer Healthcare Ag | Diagnostics et therapeutiques pour des maladies associees a methionine aminopeptidase 2 (metap2) |
US20060045865A1 (en) | 2004-08-27 | 2006-03-02 | Spherics, Inc. | Controlled regional oral delivery |
JP2008528574A (ja) | 2005-01-26 | 2008-07-31 | チョン クン ダン ファーマシューティカル コープ. | フマギロール誘導体またはフマギロール誘導体の製造方法およびこれを含む医薬用組成物 |
FR2886855B1 (fr) | 2005-06-08 | 2009-07-17 | Agronomique Inst Nat Rech | Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques |
WO2006138475A2 (fr) | 2005-06-16 | 2006-12-28 | Jenrin Discovery | Inhibiteurs de mao-b utilises pour le traitement de l'obesite |
WO2009003110A2 (fr) | 2007-06-26 | 2008-12-31 | Children's Medical Center Corporation | Polymersomes inhibiteurs de metap-2 destinés à l'administration thérapeutique |
MX2010005857A (es) | 2007-11-28 | 2010-11-22 | Mersana Therapeutics Inc | Conjugados de analogos de fumagillina biodegradables biocompatibles. |
US8299067B2 (en) * | 2008-03-27 | 2012-10-30 | Versitech Limited | 5-demethoxyfumagillol and derivatives thereof |
AU2009270799B2 (en) | 2008-07-18 | 2016-05-19 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
US8729097B2 (en) | 2008-10-06 | 2014-05-20 | The Johns Hopkins University | Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and SIRT1, and methods of treating disorders |
EP2358203A4 (fr) | 2008-10-24 | 2012-06-06 | Univ Wake Forest | Composés anticancéreux à base de platine et d'acridine et procédés pour les utiliser |
US20120010259A1 (en) | 2008-12-04 | 2012-01-12 | Vath James E | Methods of Treating an Overweight or Obese Subject |
US8642650B2 (en) | 2008-12-04 | 2014-02-04 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
WO2010065879A2 (fr) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Procédés de traitement d'un sujet en surpoids ou obèse |
US20120004162A1 (en) | 2008-12-04 | 2012-01-05 | Vath James E | Methods of Treating an Overweight or Obese Subject |
AU2010303270A1 (en) | 2009-10-09 | 2012-05-03 | Zafgen Corporation | Sulphone compounds for use in the treatment of obesity |
AU2011204267B2 (en) | 2010-01-08 | 2015-12-03 | Zafgen Corporation | Fumagillol type compounds and methods of making and using same |
US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
US20130023513A1 (en) | 2010-01-12 | 2013-01-24 | Hughes Thomas E | Methods and Compositions for Treating Cardiovascular Disorders |
US20130266578A1 (en) | 2010-04-07 | 2013-10-10 | Thomas E. Hughes | Methods of treating an overweight subject |
US20130210821A1 (en) | 2010-05-27 | 2013-08-15 | James E. Vath | Methods for Treating Obesity |
KR20130043207A (ko) | 2010-07-22 | 2013-04-29 | 자프겐 인크. | 트리시클릭 화합물 및 이의 제조 및 사용 방법 |
CN103370307B (zh) | 2010-10-12 | 2016-05-25 | 扎夫根股份有限公司 | 磺酰胺化合物及其制备方法和使用方法 |
NZ610569A (en) | 2010-11-09 | 2015-06-26 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
US20140073691A1 (en) | 2010-11-10 | 2014-03-13 | Zafgen, Inc. | Methods and composition for Treating Thyroid Hormone Related Disorders |
BR112013013411A2 (pt) | 2010-11-29 | 2016-09-13 | Zafgen Inc | tratamento de obesidade usando administração não diária de 6-0-(4-dimetilaminoetxi) cinamoil fumagilol |
US20130316994A1 (en) | 2010-11-29 | 2013-11-28 | Zafgen, Inc. | Methods of Reducing Risk of Hepatobiliary Dysfunction During Rapid Weight Loss with METAP-2 Inhibitors |
US20140011870A1 (en) | 2010-11-29 | 2014-01-09 | Zafgen, Inc. | Methods of Treating Obesity Using an Effective Dose of a METAP-2 Inhibitor |
JP6058557B2 (ja) | 2011-01-26 | 2017-01-11 | ザフゲン,インコーポレイテッド | テトラゾール化合物ならびにその作製方法および使用方法 |
WO2012122264A1 (fr) | 2011-03-08 | 2012-09-13 | Zafgen Corporation | Dérivés d'oxaspiro[2.5]octane et analogues |
BR112013028534A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos |
BR112013028666A2 (pt) | 2011-05-06 | 2017-08-08 | Zafgen Inc | compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo |
BR112013028665A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
WO2013033430A1 (fr) | 2011-09-02 | 2013-03-07 | Wake Forest School Of Medicine | Administration ciblée et conceptions de promédicaments pour composés anticancéreux à base de platine et d'acridine et méthodes associées |
EP2763671A2 (fr) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Méthodes de traitement de troubles liés à l âge |
JP6035347B2 (ja) | 2012-01-18 | 2016-11-30 | ザフゲン,インコーポレイテッド | 三環式スルホンアミド化合物ならびにその作製および使用方法 |
EP2804856B1 (fr) | 2012-01-18 | 2017-03-15 | Zafgen, Inc. | Composés sulfones tricycliques et leurs procédés de fabrication et d'utilisation |
KR20150016303A (ko) | 2012-05-07 | 2015-02-11 | 자프겐 인크. | 6-o-(4-디메틸아미노에톡시) 신나모일 푸마지롤의 옥살레이트 염의 다형체 염 및 이의 제조 및 사용 방법 |
CA2872876A1 (fr) | 2012-05-08 | 2013-11-14 | Zafgen, Inc. | Traitement de l'obesite hypothalamique au moyen d'inhibiteurs de metap2 |
EP2850079B1 (fr) * | 2012-05-09 | 2018-05-02 | Zafgen, Inc. | Dérivés de fumigillol, procédés pour leurs préparation et leurs utilisation |
EP2968250B1 (fr) | 2013-03-14 | 2019-06-19 | Zafgen, Inc. | Méthodes de traitement de maladie rénale et d'autres troubles |
AR105671A1 (es) * | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
-
2016
- 2016-08-10 AR ARP160102461A patent/AR105671A1/es unknown
- 2016-08-11 EA EA201890449A patent/EA201890449A1/ru unknown
- 2016-08-11 MX MX2018001733A patent/MX2018001733A/es unknown
- 2016-08-11 MA MA042612A patent/MA42612A/fr unknown
- 2016-08-11 EP EP16756874.0A patent/EP3334728A1/fr not_active Withdrawn
- 2016-08-11 CN CN201680054518.0A patent/CN108026085A/zh active Pending
- 2016-08-11 WO PCT/US2016/046511 patent/WO2017027684A1/fr active Application Filing
- 2016-08-11 JP JP2018507023A patent/JP2018522929A/ja not_active Withdrawn
- 2016-08-11 KR KR1020187006637A patent/KR20180035907A/ko unknown
- 2016-08-11 CA CA2995366A patent/CA2995366A1/fr not_active Abandoned
- 2016-08-11 US US15/752,000 patent/US20180230137A1/en not_active Abandoned
- 2016-08-11 TW TW105125677A patent/TW201718550A/zh unknown
- 2016-08-11 AU AU2016306558A patent/AU2016306558A1/en not_active Abandoned
- 2016-11-17 US US15/354,834 patent/US9682965B2/en not_active Expired - Fee Related
-
2017
- 2017-05-16 US US15/596,512 patent/US10023561B2/en not_active Expired - Fee Related
-
2018
- 2018-02-08 IL IL257443A patent/IL257443A/en unknown
- 2018-02-12 PH PH12018500315A patent/PH12018500315A1/en unknown
- 2018-11-20 US US16/196,458 patent/US20190084969A1/en not_active Abandoned
- 2018-11-20 US US16/196,448 patent/US20190084968A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20190084969A1 (en) | 2019-03-21 |
JP2018522929A (ja) | 2018-08-16 |
PH12018500315A1 (en) | 2018-08-13 |
KR20180035907A (ko) | 2018-04-06 |
MX2018001733A (es) | 2018-09-06 |
US20170066749A1 (en) | 2017-03-09 |
IL257443A (en) | 2018-04-30 |
AU2016306558A1 (en) | 2018-03-01 |
AR105671A1 (es) | 2017-10-25 |
CA2995366A1 (fr) | 2017-02-16 |
TW201718550A (zh) | 2017-06-01 |
EA201890449A1 (ru) | 2018-10-31 |
US20190084968A1 (en) | 2019-03-21 |
US9682965B2 (en) | 2017-06-20 |
WO2017027684A1 (fr) | 2017-02-16 |
US10023561B2 (en) | 2018-07-17 |
US20170342058A1 (en) | 2017-11-30 |
US20180230137A1 (en) | 2018-08-16 |
CN108026085A (zh) | 2018-05-11 |
EP3334728A1 (fr) | 2018-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA42612A (fr) | Composés hétérocycliques fumagillol, et procédés correspondants de fabrication et d'utilisation | |
MA49858A (fr) | Composés, compositions et procédés | |
MA43827A (fr) | Composés di-nucléotides cycliques et leurs procédés d'utilisation | |
MA50063A (fr) | Composés, compositions et procédés | |
DK3692040T3 (da) | Kemiske forbindelser | |
MA42055A (fr) | Composés antimicrobiens et procédés de fabrication et d'utilisation de ceux-ci | |
MA47131A (fr) | Composés benzyl-amide phosphodiamide antiviraux | |
DK3532607T3 (da) | Restimulation af kryokonserverede, tumorinfiltrerende lymfocytter | |
MA49861A (fr) | Composés de benzoxazépine oxazolidinone et leurs procédés d'utilisation | |
MA47440A (fr) | Sulfonylurées, composés apparentés, et leur utilisation | |
DK3436444T3 (da) | Heterocyklisk forbindelse | |
MA45940A (fr) | Composé hétérocyclique | |
MA51669A (fr) | Composés | |
CL2020000951A1 (es) | Célula. | |
MA39915A (fr) | Composés de pladiénolide pyridine et leurs procédés d'utilisation | |
MA49560A (fr) | Composés cétoniques bicycliques et leurs procédés d'utilisation | |
DK3568403T3 (da) | Kemiske forbindelser til belægning af nanostrukturer | |
DK3612519T3 (da) | Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl forbindelser | |
MA48475A (fr) | Procédés de fabrication de niraparib | |
DK3390407T3 (da) | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser | |
BR112017023150A2 (pt) | compostos herbicidas. | |
MA49623A (fr) | Composés chimiques | |
DK3368519T3 (da) | Hidtil ukendte, heterocykliske antiøstrogener | |
DK3571394T3 (da) | Inertireaktion for netstabilitet | |
DK3458467T3 (da) | Fremgangsmåde til 6,7-alfa-epoxidering af steroid-4,6-diener |