JP2021527224A5 - - Google Patents
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- JP2021527224A5 JP2021527224A5 JP2020570928A JP2020570928A JP2021527224A5 JP 2021527224 A5 JP2021527224 A5 JP 2021527224A5 JP 2020570928 A JP2020570928 A JP 2020570928A JP 2020570928 A JP2020570928 A JP 2020570928A JP 2021527224 A5 JP2021527224 A5 JP 2021527224A5
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- urease
- polymer
- urea
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 31
- 239000004202 carbamide Substances 0.000 claims description 31
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 21
- 108090000790 Enzymes Proteins 0.000 claims description 19
- 102000004190 Enzymes Human genes 0.000 claims description 19
- 238000009792 diffusion process Methods 0.000 claims description 19
- 239000012528 membrane Substances 0.000 claims description 19
- 229920005597 polymer membrane Polymers 0.000 claims description 16
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 239000002131 composite material Substances 0.000 claims description 5
- 108010046334 Urease Proteins 0.000 claims 21
- 229920000642 polymer Polymers 0.000 claims 20
- 150000004676 glycans Chemical class 0.000 claims 19
- 229920001282 polysaccharide Polymers 0.000 claims 19
- 239000005017 polysaccharide Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 15
- 239000000243 solution Substances 0.000 claims 14
- 239000004800 polyvinyl chloride Substances 0.000 claims 9
- 229920000554 ionomer Polymers 0.000 claims 8
- 229920002635 polyurethane Polymers 0.000 claims 8
- 239000004814 polyurethane Substances 0.000 claims 8
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 7
- RMIXHJPMNBXMBU-UHFFFAOYSA-N Nonactin Natural products CC1C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC2CCC1O2 RMIXHJPMNBXMBU-UHFFFAOYSA-N 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229920000915 polyvinyl chloride Polymers 0.000 claims 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 229920000557 Nafion® Polymers 0.000 claims 4
- 229920001756 Polyvinyl chloride acetate Polymers 0.000 claims 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 4
- 229920002301 cellulose acetate Polymers 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims 4
- 229910052709 silver Inorganic materials 0.000 claims 4
- 239000004332 silver Substances 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- RMIXHJPMNBXMBU-QIIXEHPYSA-N Nonactin Chemical group C[C@H]([C@H]1CC[C@H](O1)C[C@@H](OC(=O)[C@@H](C)[C@@H]1CC[C@@H](O1)C[C@@H](C)OC(=O)[C@H](C)[C@H]1CC[C@H](O1)C[C@H](C)OC(=O)[C@H]1C)C)C(=O)O[C@H](C)C[C@H]2CC[C@@H]1O2 RMIXHJPMNBXMBU-QIIXEHPYSA-N 0.000 claims 3
- 230000004888 barrier function Effects 0.000 claims 3
- 238000005266 casting Methods 0.000 claims 3
- -1 cyclotritetracontane Chemical compound 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000002555 ionophore Substances 0.000 claims 3
- 230000000236 ionophoric effect Effects 0.000 claims 3
- 229920002379 silicone rubber Polymers 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- LFKLPJRVSHJZPL-UHFFFAOYSA-N 1,2:7,8-diepoxyoctane Chemical compound C1OC1CCCCC1CO1 LFKLPJRVSHJZPL-UHFFFAOYSA-N 0.000 claims 2
- CFHWRTNORXTUDE-UHFFFAOYSA-N 2-[6-(oxiran-2-yl)hexyl]oxirane Chemical compound C1OC1CCCCCCC1CO1 CFHWRTNORXTUDE-UHFFFAOYSA-N 0.000 claims 2
- 108010002156 Depsipeptides Proteins 0.000 claims 2
- CTZNINKRTKCWGU-UHFFFAOYSA-N Dinactin Natural products CC1C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(C)CC2CCC1O2 CTZNINKRTKCWGU-UHFFFAOYSA-N 0.000 claims 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims 2
- YPUPRVWRYDPGCW-UHFFFAOYSA-N Monactin Natural products CC1C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(C)CC2CCC1O2 YPUPRVWRYDPGCW-UHFFFAOYSA-N 0.000 claims 2
- VHKXXVVRRDYCIK-CWCPJSEDSA-N Narasin Chemical compound C[C@H]1C[C@H](C)[C@H]([C@@H](CC)C(O)=O)O[C@H]1[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(C=C[C@@H](O)[C@@]3(O[C@@](C)(CC3)[C@@H]3O[C@@H](C)[C@@](O)(CC)CC3)O2)O1 VHKXXVVRRDYCIK-CWCPJSEDSA-N 0.000 claims 2
- VHKXXVVRRDYCIK-UHFFFAOYSA-N Narasin Natural products CC1CC(C)C(C(CC)C(O)=O)OC1C(C)C(O)C(C)C(=O)C(CC)C1C(C)CC(C)C2(C=CC(O)C3(OC(C)(CC3)C3OC(C)C(O)(CC)CC3)O2)O1 VHKXXVVRRDYCIK-UHFFFAOYSA-N 0.000 claims 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 2
- 229910021607 Silver chloride Inorganic materials 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- ZBDGIMZKOJALMU-MVWQHRGOSA-N dinactin Chemical compound C[C@@H]([C@@H]1CC[C@@H](O1)C[C@@H](OC(=O)[C@@H](C)[C@H]1CC[C@H](O1)C[C@@H](C)OC(=O)[C@@H](C)[C@@H]1CC[C@@H](O1)C[C@H](CC)OC(=O)[C@H]1C)CC)C(=O)O[C@H](C)C[C@@H]2CC[C@H]1O2 ZBDGIMZKOJALMU-MVWQHRGOSA-N 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 239000008151 electrolyte solution Substances 0.000 claims 2
- UQSQSQZYBQSBJZ-UHFFFAOYSA-N fluorosulfonic acid Chemical compound OS(F)(=O)=O UQSQSQZYBQSBJZ-UHFFFAOYSA-N 0.000 claims 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 2
- 229910052737 gold Inorganic materials 0.000 claims 2
- 239000010931 gold Substances 0.000 claims 2
- 239000000832 lactitol Substances 0.000 claims 2
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 2
- 229960003451 lactitol Drugs 0.000 claims 2
- 235000010448 lactitol Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- YPUPRVWRYDPGCW-GGOMOPATSA-N monactin Chemical compound C[C@H]([C@H]1CC[C@H](O1)C[C@@H](OC(=O)[C@@H](C)[C@@H]1CC[C@@H](O1)C[C@@H](C)OC(=O)[C@H](C)[C@H]1CC[C@H](O1)C[C@H](C)OC(=O)[C@H]1C)CC)C(=O)O[C@H](C)C[C@H]2CC[C@@H]1O2 YPUPRVWRYDPGCW-GGOMOPATSA-N 0.000 claims 2
- 229960001851 narasin Drugs 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 2
- 239000004945 silicone rubber Substances 0.000 claims 2
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims 2
- 238000003860 storage Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- NKNPHSJWQZXWIX-DCVDGXQQSA-N Tetranactin Chemical compound C[C@H]([C@H]1CC[C@H](O1)C[C@@H](OC(=O)[C@@H](C)[C@@H]1CC[C@@H](O1)C[C@@H](CC)OC(=O)[C@H](C)[C@H]1CC[C@H](O1)C[C@H](CC)OC(=O)[C@H]1C)CC)C(=O)O[C@H](CC)C[C@H]2CC[C@@H]1O2 NKNPHSJWQZXWIX-DCVDGXQQSA-N 0.000 claims 1
- NKNPHSJWQZXWIX-UHFFFAOYSA-N Tetranactin Natural products CC1C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(CC)CC2CCC1O2 NKNPHSJWQZXWIX-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- XUCNUKMRBVNAPB-UHFFFAOYSA-N fluoroethene Chemical group FC=C XUCNUKMRBVNAPB-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229920006254 polymer film Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000005060 rubber Substances 0.000 claims 1
- DFQMKYUSAALDDY-MQEBUAKTSA-N trinactin Chemical compound C[C@@H]([C@@H]1CC[C@@H](O1)C[C@H](OC(=O)[C@H](C)[C@H]1CC[C@H](O1)C[C@H](CC)OC(=O)[C@@H](C)[C@@H]1CC[C@@H](O1)C[C@@H](CC)OC(=O)[C@@H]1C)CC)C(=O)O[C@@H](C)C[C@@H]2CC[C@H]1O2 DFQMKYUSAALDDY-MQEBUAKTSA-N 0.000 claims 1
- DFQMKYUSAALDDY-UHFFFAOYSA-N trinactin Natural products CC1C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(CC)CC(O2)CCC2C(C)C(=O)OC(C)CC2CCC1O2 DFQMKYUSAALDDY-UHFFFAOYSA-N 0.000 claims 1
- 239000000538 analytical sample Substances 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962830191P | 2019-04-05 | 2019-04-05 | |
| US62/830,191 | 2019-04-05 | ||
| PCT/US2019/035153 WO2020204973A1 (en) | 2019-04-05 | 2019-06-03 | Urea biosensors and stabilization of urea biosensors at room temperature |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021527224A JP2021527224A (ja) | 2021-10-11 |
| JP2021527224A5 true JP2021527224A5 (https=) | 2021-12-23 |
| JP7135121B2 JP7135121B2 (ja) | 2022-09-12 |
Family
ID=67138031
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570928A Active JP7135121B2 (ja) | 2019-04-05 | 2019-06-03 | 尿素バイオセンサ及び室温における尿素バイオセンサの安定化 |
| JP2020570972A Active JP7015401B2 (ja) | 2019-04-05 | 2019-06-03 | クレアチニン／クレアチンセンサのための外膜組成物 |
| JP2020567148A Active JP7082691B2 (ja) | 2019-04-05 | 2019-06-03 | クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法 |
| JP2020570732A Active JP7100162B2 (ja) | 2019-04-05 | 2019-06-03 | 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用 |
| JP2020571701A Active JP7127159B2 (ja) | 2019-04-05 | 2019-06-03 | マルチ酵素バイオセンサ及び室温におけるマルチ酵素バイオセンサの安定化 |
| JP2022024293A Pending JP2022068299A (ja) | 2019-04-05 | 2022-02-18 | クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570972A Active JP7015401B2 (ja) | 2019-04-05 | 2019-06-03 | クレアチニン／クレアチンセンサのための外膜組成物 |
| JP2020567148A Active JP7082691B2 (ja) | 2019-04-05 | 2019-06-03 | クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法 |
| JP2020570732A Active JP7100162B2 (ja) | 2019-04-05 | 2019-06-03 | 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用 |
| JP2020571701A Active JP7127159B2 (ja) | 2019-04-05 | 2019-06-03 | マルチ酵素バイオセンサ及び室温におけるマルチ酵素バイオセンサの安定化 |
| JP2022024293A Pending JP2022068299A (ja) | 2019-04-05 | 2022-02-18 | クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US11327042B2 (https=) |
| EP (5) | EP3947710A1 (https=) |
| JP (6) | JP7135121B2 (https=) |
| KR (5) | KR102480669B1 (https=) |
| CN (6) | CN112513285B (https=) |
| AU (3) | AU2019440163B2 (https=) |
| CA (3) | CA3105013C (https=) |
| DK (2) | DK3947708T3 (https=) |
| ES (1) | ES3038379T3 (https=) |
| WO (5) | WO2020204975A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11327042B2 (en) | 2019-04-05 | 2022-05-10 | Instrumentation Laboratory Company | Compositions and methods for improved creatinine measurement accuracy and uses thereof |
| US12139741B2 (en) | 2019-10-25 | 2024-11-12 | Instrumentation Laboratory Company | Biocide compositions compatible with enzyme biosensors and methods of use thereof |
| US12298268B2 (en) * | 2020-05-21 | 2025-05-13 | Nova Biomedical Corporation | Single-use disposable reference sensor |
| US20230041320A1 (en) * | 2021-08-03 | 2023-02-09 | Polymer Technology Systems, Inc. | Systems and Methods for Quantifying The Specific Activity of Creatininase |
| ES3054584T3 (en) | 2022-02-09 | 2026-02-04 | Instr Laboratory Co | Sensor for measuring ionized magnesium |
| CN114705674B (zh) * | 2022-05-10 | 2025-07-22 | 光景生物科技(苏州)有限公司 | 一种全血中肌酸和肌酐的定量检测方法 |
| WO2025029820A1 (en) * | 2023-07-31 | 2025-02-06 | Abbott Diabetes Care Inc. | Background interference mitigation for high sensitivity creatinine sensing |
| KR102800865B1 (ko) | 2024-07-31 | 2025-05-07 | 전남대학교 산학협력단 | 신규한 크레아티닌 정량 장치 |
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