JP2021524587A5 - - Google Patents
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- JP2021524587A5 JP2021524587A5 JP2020571701A JP2020571701A JP2021524587A5 JP 2021524587 A5 JP2021524587 A5 JP 2021524587A5 JP 2020571701 A JP2020571701 A JP 2020571701A JP 2020571701 A JP2020571701 A JP 2020571701A JP 2021524587 A5 JP2021524587 A5 JP 2021524587A5
- Authority
- JP
- Japan
- Prior art keywords
- enzymes
- electrode
- polysaccharide
- biosensor
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000790 Enzymes Proteins 0.000 claims 27
- 102000004190 Enzymes Human genes 0.000 claims 27
- 150000004676 glycans Chemical class 0.000 claims 19
- 229920001282 polysaccharide Polymers 0.000 claims 19
- 239000005017 polysaccharide Substances 0.000 claims 19
- 230000004888 barrier function Effects 0.000 claims 10
- 238000009792 diffusion process Methods 0.000 claims 10
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 229920000831 ionic polymer Polymers 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 6
- 108010077078 Creatinase Proteins 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- 229940109239 creatinine Drugs 0.000 claims 4
- 229920000554 ionomer Polymers 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- LFKLPJRVSHJZPL-UHFFFAOYSA-N 1,2:7,8-diepoxyoctane Chemical compound C1OC1CCCCC1CO1 LFKLPJRVSHJZPL-UHFFFAOYSA-N 0.000 claims 3
- CFHWRTNORXTUDE-UHFFFAOYSA-N 2-[6-(oxiran-2-yl)hexyl]oxirane Chemical compound C1OC1CCCCCCC1CO1 CFHWRTNORXTUDE-UHFFFAOYSA-N 0.000 claims 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims 3
- 229920002873 Polyethylenimine Polymers 0.000 claims 3
- 108010039918 Polylysine Proteins 0.000 claims 3
- 102000007327 Protamines Human genes 0.000 claims 3
- 108010007568 Protamines Proteins 0.000 claims 3
- 229960003624 creatine Drugs 0.000 claims 3
- 239000006046 creatine Substances 0.000 claims 3
- 229920002006 poly(N-vinylimidazole) polymer Polymers 0.000 claims 3
- 229920000083 poly(allylamine) Polymers 0.000 claims 3
- 229920000333 poly(propyleneimine) Polymers 0.000 claims 3
- 229920000656 polylysine Polymers 0.000 claims 3
- 229920002635 polyurethane Polymers 0.000 claims 3
- 239000004814 polyurethane Substances 0.000 claims 3
- 229920002717 polyvinylpyridine Polymers 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 229940048914 protamine Drugs 0.000 claims 3
- OVBFMUAFNIIQAL-UHFFFAOYSA-N 1,4-diisocyanatobutane Chemical compound O=C=NCCCCN=C=O OVBFMUAFNIIQAL-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229920000557 Nafion® Polymers 0.000 claims 2
- 108010060059 Sarcosine Oxidase Proteins 0.000 claims 2
- 102000008118 Sarcosine oxidase Human genes 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 238000005266 casting Methods 0.000 claims 2
- 229920002301 cellulose acetate Polymers 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- UQSQSQZYBQSBJZ-UHFFFAOYSA-N fluorosulfonic acid Chemical compound OS(F)(=O)=O UQSQSQZYBQSBJZ-UHFFFAOYSA-N 0.000 claims 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 2
- 229910052737 gold Inorganic materials 0.000 claims 2
- 239000010931 gold Substances 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- -1 poly (tetrafluoroethylene) Polymers 0.000 claims 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 2
- 239000004800 polyvinyl chloride Substances 0.000 claims 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims 2
- 238000003860 storage Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 1
- 239000000956 alloy Substances 0.000 claims 1
- 229910045601 alloy Inorganic materials 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 239000002041 carbon nanotube Substances 0.000 claims 1
- 229910021393 carbon nanotube Inorganic materials 0.000 claims 1
- 239000003575 carbonaceous material Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000007772 electrode material Substances 0.000 claims 1
- 229910002804 graphite Inorganic materials 0.000 claims 1
- 239000010439 graphite Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 1
- 239000000832 lactitol Substances 0.000 claims 1
- 229960003451 lactitol Drugs 0.000 claims 1
- 235000010448 lactitol Nutrition 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962830191P | 2019-04-05 | 2019-04-05 | |
| US62/830,191 | 2019-04-05 | ||
| PCT/US2019/035156 WO2020204975A1 (en) | 2019-04-05 | 2019-06-03 | Multi-enzymatic biosensors and stabilization of multi-enzymatic biosensors at room temperature |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021524587A JP2021524587A (ja) | 2021-09-13 |
| JP2021524587A5 true JP2021524587A5 (https=) | 2021-10-21 |
| JP7127159B2 JP7127159B2 (ja) | 2022-08-29 |
Family
ID=67138031
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570928A Active JP7135121B2 (ja) | 2019-04-05 | 2019-06-03 | 尿素バイオセンサ及び室温における尿素バイオセンサの安定化 |
| JP2020570972A Active JP7015401B2 (ja) | 2019-04-05 | 2019-06-03 | クレアチニン／クレアチンセンサのための外膜組成物 |
| JP2020567148A Active JP7082691B2 (ja) | 2019-04-05 | 2019-06-03 | クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法 |
| JP2020570732A Active JP7100162B2 (ja) | 2019-04-05 | 2019-06-03 | 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用 |
| JP2020571701A Active JP7127159B2 (ja) | 2019-04-05 | 2019-06-03 | マルチ酵素バイオセンサ及び室温におけるマルチ酵素バイオセンサの安定化 |
| JP2022024293A Pending JP2022068299A (ja) | 2019-04-05 | 2022-02-18 | クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570928A Active JP7135121B2 (ja) | 2019-04-05 | 2019-06-03 | 尿素バイオセンサ及び室温における尿素バイオセンサの安定化 |
| JP2020570972A Active JP7015401B2 (ja) | 2019-04-05 | 2019-06-03 | クレアチニン／クレアチンセンサのための外膜組成物 |
| JP2020567148A Active JP7082691B2 (ja) | 2019-04-05 | 2019-06-03 | クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法 |
| JP2020570732A Active JP7100162B2 (ja) | 2019-04-05 | 2019-06-03 | 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022024293A Pending JP2022068299A (ja) | 2019-04-05 | 2022-02-18 | クレアチニン／クレアチンセンサーのキャリブレーション精度を改善する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US11327042B2 (https=) |
| EP (5) | EP3947710A1 (https=) |
| JP (6) | JP7135121B2 (https=) |
| KR (5) | KR102480669B1 (https=) |
| CN (6) | CN112513285B (https=) |
| AU (3) | AU2019440163B2 (https=) |
| CA (3) | CA3105013C (https=) |
| DK (2) | DK3947708T3 (https=) |
| ES (1) | ES3038379T3 (https=) |
| WO (5) | WO2020204975A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11327042B2 (en) | 2019-04-05 | 2022-05-10 | Instrumentation Laboratory Company | Compositions and methods for improved creatinine measurement accuracy and uses thereof |
| US12139741B2 (en) | 2019-10-25 | 2024-11-12 | Instrumentation Laboratory Company | Biocide compositions compatible with enzyme biosensors and methods of use thereof |
| US12298268B2 (en) * | 2020-05-21 | 2025-05-13 | Nova Biomedical Corporation | Single-use disposable reference sensor |
| US20230041320A1 (en) * | 2021-08-03 | 2023-02-09 | Polymer Technology Systems, Inc. | Systems and Methods for Quantifying The Specific Activity of Creatininase |
| ES3054584T3 (en) | 2022-02-09 | 2026-02-04 | Instr Laboratory Co | Sensor for measuring ionized magnesium |
| CN114705674B (zh) * | 2022-05-10 | 2025-07-22 | 光景生物科技(苏州)有限公司 | 一种全血中肌酸和肌酐的定量检测方法 |
| WO2025029820A1 (en) * | 2023-07-31 | 2025-02-06 | Abbott Diabetes Care Inc. | Background interference mitigation for high sensitivity creatinine sensing |
| KR102800865B1 (ko) | 2024-07-31 | 2025-05-07 | 전남대학교 산학협력단 | 신규한 크레아티닌 정량 장치 |
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| JPS5861459A (ja) * | 1981-10-07 | 1983-04-12 | Hitachi Ltd | クレアチンとクレアチニンの分析装置 |
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| AT408662B (de) * | 2000-05-16 | 2002-02-25 | Hoffmann La Roche | Creatinin-sensor |
| AT409040B (de) | 2000-08-11 | 2002-05-27 | Roche Diagnostics Gmbh | Creatininsensor-kalibration |
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| DK1692522T3 (da) | 2003-11-28 | 2012-04-02 | Radiometer Medical Aps | Referencevæske |
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| KR100726963B1 (ko) * | 2005-06-15 | 2007-06-14 | 김경훈 | 바이오센서용 우레아제 고정화막의 제조 방법 |
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| US20120181189A1 (en) | 2009-09-24 | 2012-07-19 | Fresenius Medical Care Holdings, Inc. | Amperometric Creatinine Biosensor With Immobilized Enzyme-Polymer Composition And Systems Using Same, And Methods |
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| EP4530635A3 (en) | 2014-12-18 | 2025-06-25 | Radiometer Medical ApS | Method for calibrating a device for measuring the concentration of creatinine |
| DK3234562T3 (da) | 2014-12-18 | 2020-02-03 | Radiometer Medical Aps | Kalibreringskoncept til amperometrisk creatininsensor med korrigering for endogene modulatorer |
| DK3234563T3 (da) | 2014-12-18 | 2025-02-10 | Radiometer Medical Aps | Fremgangsmåde til kalibrering af en indretning til måling af koncentrationen af kreatinin |
| EP3380833B1 (en) * | 2015-11-27 | 2019-12-25 | Radiometer Medical ApS | An outer layer for enzyme sensors |
| JP7011906B2 (ja) * | 2017-08-25 | 2022-01-27 | 国立大学法人 筑波大学 | クレアチニンセンサ |
| KR102573459B1 (ko) * | 2017-08-28 | 2023-09-04 | 디에스엠 아이피 어셋츠 비.브이. | 폴리우레탄 블렌드를 포함하는 합성 멤브레인 조성물 |
| US11327042B2 (en) | 2019-04-05 | 2022-05-10 | Instrumentation Laboratory Company | Compositions and methods for improved creatinine measurement accuracy and uses thereof |
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2019
- 2019-06-03 US US16/429,993 patent/US11327042B2/en active Active
- 2019-06-03 KR KR1020207037321A patent/KR102480669B1/ko active Active
- 2019-06-03 CN CN201980045247.6A patent/CN112513285B/zh active Active
- 2019-06-03 CN CN201980043651.XA patent/CN112638513A/zh active Pending
- 2019-06-03 US US16/430,028 patent/US11460431B2/en active Active
- 2019-06-03 EP EP19734964.0A patent/EP3947710A1/en active Pending
- 2019-06-03 EP EP19734962.4A patent/EP3947708B1/en active Active
- 2019-06-03 US US16/429,922 patent/US11293890B2/en active Active
- 2019-06-03 JP JP2020570928A patent/JP7135121B2/ja active Active
- 2019-06-03 CA CA3105013A patent/CA3105013C/en active Active
- 2019-06-03 KR KR1020207037324A patent/KR102574622B1/ko active Active
- 2019-06-03 CN CN202411896882.4A patent/CN119776481A/zh active Pending
- 2019-06-03 AU AU2019440163A patent/AU2019440163B2/en active Active
- 2019-06-03 JP JP2020570972A patent/JP7015401B2/ja active Active
- 2019-06-03 CN CN201980043652.4A patent/CN112534059B/zh active Active
- 2019-06-03 EP EP19734963.2A patent/EP3947709A1/en active Pending
- 2019-06-03 WO PCT/US2019/035156 patent/WO2020204975A1/en not_active Ceased
- 2019-06-03 EP EP19739734.2A patent/EP3947711B1/en active Active
- 2019-06-03 US US16/430,057 patent/US11761921B2/en active Active
- 2019-06-03 CA CA3105191A patent/CA3105191A1/en active Pending
- 2019-06-03 CN CN201980043624.2A patent/CN112534058B/zh active Active
- 2019-06-03 WO PCT/US2019/035152 patent/WO2020204972A1/en not_active Ceased
- 2019-06-03 CA CA3104896A patent/CA3104896A1/en active Pending
- 2019-06-03 KR KR1020207037741A patent/KR102937635B1/ko active Active
- 2019-06-03 EP EP19740656.4A patent/EP3946697B1/en active Active
- 2019-06-03 WO PCT/US2019/035153 patent/WO2020204973A1/en not_active Ceased
- 2019-06-03 CN CN201980042702.7A patent/CN112424369A/zh active Pending
- 2019-06-03 KR KR1020207037318A patent/KR102519406B1/ko active Active
- 2019-06-03 JP JP2020567148A patent/JP7082691B2/ja active Active
- 2019-06-03 KR KR1020207037316A patent/KR102519408B1/ko active Active
- 2019-06-03 US US16/429,886 patent/US12529673B2/en active Active
- 2019-06-03 WO PCT/US2019/035157 patent/WO2020204976A1/en not_active Ceased
- 2019-06-03 WO PCT/US2019/035155 patent/WO2020204974A1/en not_active Ceased
- 2019-06-03 AU AU2019439424A patent/AU2019439424B2/en active Active
- 2019-06-03 DK DK19734962.4T patent/DK3947708T3/da active
- 2019-06-03 AU AU2019439465A patent/AU2019439465B2/en active Active
- 2019-06-03 JP JP2020570732A patent/JP7100162B2/ja active Active
- 2019-06-03 JP JP2020571701A patent/JP7127159B2/ja active Active
- 2019-06-03 ES ES19740656T patent/ES3038379T3/es active Active
- 2019-06-03 DK DK19739734.2T patent/DK3947711T3/da active
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2022
- 2022-02-18 JP JP2022024293A patent/JP2022068299A/ja active Pending
- 2022-02-25 US US17/680,487 patent/US20220187234A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
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