CN112513285B - 用于肌酸酐/肌酸传感器的改进的校准精度方法 - Google Patents

用于肌酸酐/肌酸传感器的改进的校准精度方法 Download PDF

Info

Publication number
CN112513285B
CN112513285B CN201980045247.6A CN201980045247A CN112513285B CN 112513285 B CN112513285 B CN 112513285B CN 201980045247 A CN201980045247 A CN 201980045247A CN 112513285 B CN112513285 B CN 112513285B
Authority
CN
China
Prior art keywords
creatine
creatinine
concentration
sensor
crea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980045247.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN112513285A (zh
Inventor
徐晓贤
普拉萨德·帕米迪
大卫·雷蒙迪
米克洛斯·埃尔德希
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Werfen North America
Original Assignee
Instrumentation Laboratory Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instrumentation Laboratory Co filed Critical Instrumentation Laboratory Co
Publication of CN112513285A publication Critical patent/CN112513285A/zh
Application granted granted Critical
Publication of CN112513285B publication Critical patent/CN112513285B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D67/00Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002Organic membrane manufacture
    • B01D67/0009Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/00091Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching by evaporation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D67/00Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002Organic membrane manufacture
    • B01D67/0009Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0011Casting solutions therefor
    • B01D67/00111Polymer pretreatment in the casting solutions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D67/00Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002Organic membrane manufacture
    • B01D67/0009Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0013Casting processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D69/00Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10Supported membranes; Membrane supports
    • B01D69/107Organic support material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D69/00Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12Composite membranes; Ultra-thin membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D69/00Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12Composite membranes; Ultra-thin membranes
    • B01D69/1213Laminated layers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D69/00Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14Dynamic membranes
    • B01D69/141Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/142Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers"
    • B01D69/144Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers" containing embedded or bound biomolecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D71/00Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06Organic material
    • B01D71/54Polyureas; Polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/002Electrode membranes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/002Electrode membranes
    • C12Q1/003Functionalisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/005Enzyme electrodes involving specific analytes or enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/308Electrodes, e.g. test electrodes; Half-cells at least partially made of carbon
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333Ion-selective electrodes or membranes
    • G01N27/3335Ion-selective electrodes or membranes the membrane containing at least one organic component
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10Complex mathematical operations
    • G06F17/18Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/30Microarray design
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2323/00Details relating to membrane preparation
    • B01D2323/12Specific ratios of components used
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2325/00Details relating to properties of membranes
    • B01D2325/34Molecular weight or degree of polymerisation
    • B01D2325/341At least two polymers of same structure but different molecular weight
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/58Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333Ion-selective electrodes or membranes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00Computer-aided design [CAD]
    • G06F30/30Circuit design
    • G06F30/32Circuit design at the digital level
    • G06F30/33Design verification, e.g. functional simulation or model checking
    • G06F30/3308Design verification, e.g. functional simulation or model checking using simulation
    • G06F30/331Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Dispersion Chemistry (AREA)
  • Computational Mathematics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Mathematical Analysis (AREA)
CN201980045247.6A 2019-04-05 2019-06-03 用于肌酸酐/肌酸传感器的改进的校准精度方法 Active CN112513285B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962830191P 2019-04-05 2019-04-05
US62/830,191 2019-04-05
PCT/US2019/035152 WO2020204972A1 (en) 2019-04-05 2019-06-03 Improved calibration accuracy method for creatinine/creatine sensors

Publications (2)

Publication Number Publication Date
CN112513285A CN112513285A (zh) 2021-03-16
CN112513285B true CN112513285B (zh) 2024-06-25

Family

ID=67138031

Family Applications (6)

Application Number Title Priority Date Filing Date
CN201980045247.6A Active CN112513285B (zh) 2019-04-05 2019-06-03 用于肌酸酐/肌酸传感器的改进的校准精度方法
CN201980043651.XA Pending CN112638513A (zh) 2019-04-05 2019-06-03 用于肌酸酐/肌酸传感器的外部膜组合物
CN202411896882.4A Pending CN119776481A (zh) 2019-04-05 2019-06-03 用于改进的肌酸酐测量准确度的组合物和方法及其用途
CN201980043652.4A Active CN112534059B (zh) 2019-04-05 2019-06-03 用于改进的肌酸酐测量准确度的组合物和方法及其用途
CN201980043624.2A Active CN112534058B (zh) 2019-04-05 2019-06-03 脲生物传感器和脲生物传感器在室温下的稳定化
CN201980042702.7A Pending CN112424369A (zh) 2019-04-05 2019-06-03 多酶型生物传感器和多酶型生物传感器在室温下的稳定化

Family Applications After (5)

Application Number Title Priority Date Filing Date
CN201980043651.XA Pending CN112638513A (zh) 2019-04-05 2019-06-03 用于肌酸酐/肌酸传感器的外部膜组合物
CN202411896882.4A Pending CN119776481A (zh) 2019-04-05 2019-06-03 用于改进的肌酸酐测量准确度的组合物和方法及其用途
CN201980043652.4A Active CN112534059B (zh) 2019-04-05 2019-06-03 用于改进的肌酸酐测量准确度的组合物和方法及其用途
CN201980043624.2A Active CN112534058B (zh) 2019-04-05 2019-06-03 脲生物传感器和脲生物传感器在室温下的稳定化
CN201980042702.7A Pending CN112424369A (zh) 2019-04-05 2019-06-03 多酶型生物传感器和多酶型生物传感器在室温下的稳定化

Country Status (10)

Country Link
US (6) US11327042B2 (https=)
EP (5) EP3947710A1 (https=)
JP (6) JP7135121B2 (https=)
KR (5) KR102480669B1 (https=)
CN (6) CN112513285B (https=)
AU (3) AU2019440163B2 (https=)
CA (3) CA3105013C (https=)
DK (2) DK3947708T3 (https=)
ES (1) ES3038379T3 (https=)
WO (5) WO2020204975A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11327042B2 (en) 2019-04-05 2022-05-10 Instrumentation Laboratory Company Compositions and methods for improved creatinine measurement accuracy and uses thereof
US12139741B2 (en) 2019-10-25 2024-11-12 Instrumentation Laboratory Company Biocide compositions compatible with enzyme biosensors and methods of use thereof
US12298268B2 (en) * 2020-05-21 2025-05-13 Nova Biomedical Corporation Single-use disposable reference sensor
US20230041320A1 (en) * 2021-08-03 2023-02-09 Polymer Technology Systems, Inc. Systems and Methods for Quantifying The Specific Activity of Creatininase
ES3054584T3 (en) 2022-02-09 2026-02-04 Instr Laboratory Co Sensor for measuring ionized magnesium
CN114705674B (zh) * 2022-05-10 2025-07-22 光景生物科技(苏州)有限公司 一种全血中肌酸和肌酐的定量检测方法
WO2025029820A1 (en) * 2023-07-31 2025-02-06 Abbott Diabetes Care Inc. Background interference mitigation for high sensitivity creatinine sensing
KR102800865B1 (ko) 2024-07-31 2025-05-07 전남대학교 산학협력단 신규한 크레아티닌 정량 장치

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7815788B2 (en) * 2000-08-11 2010-10-19 Roche Diagnostics Operations, Inc. Creatinine sensor calibration
CN102608176A (zh) * 2005-05-17 2012-07-25 雷迪奥米特医学公司 用二价锰离子溶液稳定或再活化肌酸酐传感器的方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5861459A (ja) * 1981-10-07 1983-04-12 Hitachi Ltd クレアチンとクレアチニンの分析装置
JPS6475000A (en) * 1987-09-14 1989-03-20 Shimadzu Corp Method and equipment for analyzing creatinine
US5464747A (en) * 1993-10-29 1995-11-07 Boehringer Mannheim Corporation Oxidation-resistant muteins of β-galactosidase fragments
EP0944731B1 (en) * 1996-11-14 2006-01-18 Radiometer Medical ApS Enzyme sensor
DE69810194T2 (de) 1997-06-03 2003-11-20 Matsushita Electric Industrial Co. Ltd., Osaka Cholesterinsensor
JP3635263B2 (ja) 2000-03-01 2005-04-06 ラジオメーター・メディカル・アクティーゼルスカブ 固体状態参照系を持つ電極デバイス
AT408662B (de) * 2000-05-16 2002-02-25 Hoffmann La Roche Creatinin-sensor
US6872297B2 (en) 2001-05-31 2005-03-29 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6960466B2 (en) 2001-05-31 2005-11-01 Instrumentation Laboratory Company Composite membrane containing a cross-linked enzyme matrix for a biosensor
US6767441B1 (en) 2001-07-31 2004-07-27 Nova Biomedical Corporation Biosensor with peroxidase enzyme
ES2633729T3 (es) * 2001-08-22 2017-09-25 Instrumentation Laboratory Company Método para calibrar sensores electroquímicos
JP4567333B2 (ja) 2001-08-24 2010-10-20 センサーテック・リミテッド 高感度電位差測定センサを製造する方法
US7285198B2 (en) 2004-02-23 2007-10-23 Mysticmd, Inc. Strip electrode with conductive nano tube printing
GB0227424D0 (en) 2002-11-25 2002-12-31 Univ Warwick Coatings
US20040256227A1 (en) 2003-02-11 2004-12-23 Jungwon Shin Electrochemical urea sensors and methods of making the same
JP4088312B2 (ja) 2003-10-30 2008-05-21 アークレイ株式会社 バイオセンサおよびその製造方法
DK1692522T3 (da) 2003-11-28 2012-04-02 Radiometer Medical Aps Referencevæske
US7699964B2 (en) * 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US8989833B2 (en) * 2004-07-13 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US7959791B2 (en) 2005-05-17 2011-06-14 Radiometer Medical Aps Enzyme sensor with a cover membrane layer covered by a hydrophilic polymer
WO2006122553A1 (en) * 2005-05-17 2006-11-23 Radiometer Medical Aps Enzyme sensor including a water-containing spacer layer
WO2006122552A1 (en) * 2005-05-17 2006-11-23 Radiometer Medical Aps Method of stabilising or reactivating a creatinine sensor with a solution of a divalent manganese ion
KR100726963B1 (ko) * 2005-06-15 2007-06-14 김경훈 바이오센서용 우레아제 고정화막의 제조 방법
US7799195B2 (en) * 2005-09-02 2010-09-21 Vladislav Dolnik Neutral polysaccharide wall coating for electrophoretic separations in capillaries and microchannels
US8617366B2 (en) * 2005-12-12 2013-12-31 Nova Biomedical Corporation Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device
US9556471B2 (en) * 2006-08-09 2017-01-31 Flir Detection, Inc. Enzyme containing liquid and delivery system for detection of analytes on surfaces
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
IES20070774A2 (en) 2007-10-24 2008-12-24 Nat Univ Ireland Maynooth Monitoring target endogenous species in the brain
US8268604B2 (en) 2007-12-20 2012-09-18 Abbott Point Of Care Inc. Compositions for forming immobilized biological layers for sensing
US20120181189A1 (en) 2009-09-24 2012-07-19 Fresenius Medical Care Holdings, Inc. Amperometric Creatinine Biosensor With Immobilized Enzyme-Polymer Composition And Systems Using Same, And Methods
US9233788B2 (en) * 2010-01-22 2016-01-12 Bayer Healthcare Llc Biosensor desiccant system having enhanced measurement performance
JP2014153243A (ja) 2013-02-12 2014-08-25 Tanita Corp バイオセンサおよびこれを用いた測定方法
WO2014159193A1 (en) * 2013-03-14 2014-10-02 Instrumentation Laboratory Company Whole blood hemolysis sensor
WO2014150876A2 (en) 2013-03-15 2014-09-25 Abbott Point Of Care Inc Biosensor structures for improved point of care testing and methods of manufacture thereof
EP4530635A3 (en) 2014-12-18 2025-06-25 Radiometer Medical ApS Method for calibrating a device for measuring the concentration of creatinine
DK3234562T3 (da) 2014-12-18 2020-02-03 Radiometer Medical Aps Kalibreringskoncept til amperometrisk creatininsensor med korrigering for endogene modulatorer
DK3234563T3 (da) 2014-12-18 2025-02-10 Radiometer Medical Aps Fremgangsmåde til kalibrering af en indretning til måling af koncentrationen af kreatinin
EP3380833B1 (en) * 2015-11-27 2019-12-25 Radiometer Medical ApS An outer layer for enzyme sensors
JP7011906B2 (ja) * 2017-08-25 2022-01-27 国立大学法人 筑波大学 クレアチニンセンサ
KR102573459B1 (ko) * 2017-08-28 2023-09-04 디에스엠 아이피 어셋츠 비.브이. 폴리우레탄 블렌드를 포함하는 합성 멤브레인 조성물
US11327042B2 (en) 2019-04-05 2022-05-10 Instrumentation Laboratory Company Compositions and methods for improved creatinine measurement accuracy and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7815788B2 (en) * 2000-08-11 2010-10-19 Roche Diagnostics Operations, Inc. Creatinine sensor calibration
CN102608176A (zh) * 2005-05-17 2012-07-25 雷迪奥米特医学公司 用二价锰离子溶液稳定或再活化肌酸酐传感器的方法

Also Published As

Publication number Publication date
JP2022068299A (ja) 2022-05-09
EP3947709A1 (en) 2022-02-09
JP7127159B2 (ja) 2022-08-29
AU2019439465B2 (en) 2025-01-02
CN112534058A (zh) 2021-03-19
KR20210014666A (ko) 2021-02-09
JP7082691B2 (ja) 2022-06-08
US11293890B2 (en) 2022-04-05
CN112638513A (zh) 2021-04-09
DK3947711T3 (da) 2024-01-15
JP2021527194A (ja) 2021-10-11
CN112534059B (zh) 2025-01-07
ES3038379T3 (en) 2025-10-13
AU2019439424A1 (en) 2021-01-07
US12529673B2 (en) 2026-01-20
KR102519406B1 (ko) 2023-04-10
WO2020204976A1 (en) 2020-10-08
KR20210014667A (ko) 2021-02-09
WO2020204975A1 (en) 2020-10-08
US11327042B2 (en) 2022-05-10
KR20210013626A (ko) 2021-02-04
US20200318152A1 (en) 2020-10-08
KR102937635B1 (ko) 2026-03-12
EP3946697C0 (en) 2025-08-06
EP3946697B1 (en) 2025-08-06
EP3947711A1 (en) 2022-02-09
EP3947710A1 (en) 2022-02-09
US20220187234A1 (en) 2022-06-16
CN112513285A (zh) 2021-03-16
CA3101513A1 (en) 2020-10-08
CA3105013C (en) 2023-03-28
CN112534059A (zh) 2021-03-19
KR20210013625A (ko) 2021-02-04
EP3946697A1 (en) 2022-02-09
JP2021528640A (ja) 2021-10-21
CN112424369A (zh) 2021-02-26
KR102480669B1 (ko) 2022-12-26
AU2019440163A1 (en) 2021-01-07
CN112534058B (zh) 2024-12-27
JP7015401B2 (ja) 2022-02-02
US11460431B2 (en) 2022-10-04
KR20210149577A (ko) 2021-12-09
US20200319211A1 (en) 2020-10-08
JP7100162B2 (ja) 2022-07-12
EP3947711B1 (en) 2023-12-20
CA3105191A1 (en) 2020-10-08
WO2020204973A1 (en) 2020-10-08
JP7135121B2 (ja) 2022-09-12
US11761921B2 (en) 2023-09-19
CA3105011A1 (en) 2020-10-08
AU2019440163B2 (en) 2022-01-27
JP2021524587A (ja) 2021-09-13
KR102519408B1 (ko) 2023-04-10
JP2021527224A (ja) 2021-10-11
AU2019439424B2 (en) 2022-10-13
US20200319136A1 (en) 2020-10-08
EP3947708A1 (en) 2022-02-09
WO2020204972A1 (en) 2020-10-08
CA3104896A1 (en) 2020-10-08
AU2019439465A1 (en) 2021-05-20
EP3947708B1 (en) 2024-02-14
KR102574622B1 (ko) 2023-09-06
US20200319134A1 (en) 2020-10-08
US20200319210A1 (en) 2020-10-08
DK3947708T3 (da) 2024-03-11
CA3105013A1 (en) 2020-10-08
WO2020204974A1 (en) 2020-10-08
JP2021525888A (ja) 2021-09-27
CN119776481A (zh) 2025-04-08

Similar Documents

Publication Publication Date Title
CN112513285B (zh) 用于肌酸酐/肌酸传感器的改进的校准精度方法
AU2024205186A1 (en) Spatial separation of particules in a particle containing solution for biomedical sensing and detection
Johnson et al. Real-time quantitative PCR, pathogen detection and MIQE
Grgicak et al. Investigation of reproducibility and error associated with qPCR methods using Quantifiler® Duo DNA quantification kit
US10978173B2 (en) Method for reducing noise level of data set for a target analyte
Jing et al. Reference materials for molecular diagnostics: Current achievements and future strategies
US6601006B2 (en) Methods for the calibration of analyte assays
CA3101513C (en) Improved calibration accuracy method for creatinine/creatine sensors
CA3105011C (en) Compositions and methods for improved creatinine measurement accuracy and uses thereof
US20060199221A1 (en) Correction for temperature dependence assays
Jimenez Valencia et al. Rapid quantification of plasma creatinine using a novel kinetic enzymatic assay
US20140356977A1 (en) Method and Apparatus for Performing Automated Affinity Based Assays
WO2025128481A1 (en) Correcting calibration data used by diagnostic analyzers based on reagent storage conditions
JPS6073465A (ja) 自動分析装置

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant