JP7118957B2 - オキシステロールおよびその使用方法 - Google Patents

オキシステロールおよびその使用方法 Download PDF

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Publication number
JP7118957B2
JP7118957B2 JP2019520736A JP2019520736A JP7118957B2 JP 7118957 B2 JP7118957 B2 JP 7118957B2 JP 2019520736 A JP2019520736 A JP 2019520736A JP 2019520736 A JP2019520736 A JP 2019520736A JP 7118957 B2 JP7118957 B2 JP 7118957B2
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Prior art keywords
compound
substituted
unsubstituted
pharmaceutically acceptable
acceptable salt
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JP2019520736A
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Japanese (ja)
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JP2019532078A (ja
JP2019532078A5 (cg-RX-API-DMAC7.html
Inventor
フランセスコ ジー． サリトゥロ，
アルバート ジェイ． ロビチャウド，
ボテーラ， ガブリエル マルティネス
ボイド エル． ハリソン，
アンドリュー グリフィン，
ダニエル ラ，
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Sage Therapeutics, LLC
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Sage Therapeutics, LLC
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Publication of JP2019532078A publication Critical patent/JP2019532078A/ja
Publication of JP2019532078A5 publication Critical patent/JP2019532078A5/ja
Priority to JP2022039315A priority Critical patent/JP2022069555A/ja
Application granted granted Critical
Publication of JP7118957B2 publication Critical patent/JP7118957B2/ja
Priority to JP2024009591A priority patent/JP2024028631A/ja
Priority to JP2025097029A priority patent/JP2025123284A/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2019520736A 2016-10-18 2017-10-18 オキシステロールおよびその使用方法 Active JP7118957B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022039315A JP2022069555A (ja) 2016-10-18 2022-03-14 オキシステロールおよびその使用方法
JP2024009591A JP2024028631A (ja) 2016-10-18 2024-01-25 オキシステロールおよびその使用方法
JP2025097029A JP2025123284A (ja) 2016-10-18 2025-06-10 オキシステロールおよびその使用方法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201662409767P 2016-10-18 2016-10-18
US201662409772P 2016-10-18 2016-10-18
US201662409764P 2016-10-18 2016-10-18
US201662409761P 2016-10-18 2016-10-18
US201662409774P 2016-10-18 2016-10-18
US62/409,761 2016-10-18
US62/409,774 2016-10-18
US62/409,767 2016-10-18
US62/409,764 2016-10-18
US62/409,772 2016-10-18
PCT/US2017/057277 WO2018075699A1 (en) 2016-10-18 2017-10-18 Oxysterols and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022039315A Division JP2022069555A (ja) 2016-10-18 2022-03-14 オキシステロールおよびその使用方法

Publications (3)

Publication Number Publication Date
JP2019532078A JP2019532078A (ja) 2019-11-07
JP2019532078A5 JP2019532078A5 (cg-RX-API-DMAC7.html) 2020-11-26
JP7118957B2 true JP7118957B2 (ja) 2022-08-16

Family

ID=60263023

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019520736A Active JP7118957B2 (ja) 2016-10-18 2017-10-18 オキシステロールおよびその使用方法
JP2022039315A Withdrawn JP2022069555A (ja) 2016-10-18 2022-03-14 オキシステロールおよびその使用方法
JP2024009591A Pending JP2024028631A (ja) 2016-10-18 2024-01-25 オキシステロールおよびその使用方法
JP2025097029A Pending JP2025123284A (ja) 2016-10-18 2025-06-10 オキシステロールおよびその使用方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2022039315A Withdrawn JP2022069555A (ja) 2016-10-18 2022-03-14 オキシステロールおよびその使用方法
JP2024009591A Pending JP2024028631A (ja) 2016-10-18 2024-01-25 オキシステロールおよびその使用方法
JP2025097029A Pending JP2025123284A (ja) 2016-10-18 2025-06-10 オキシステロールおよびその使用方法

Country Status (16)

Country Link
US (3) US11149054B2 (cg-RX-API-DMAC7.html)
EP (2) EP4252848A3 (cg-RX-API-DMAC7.html)
JP (4) JP7118957B2 (cg-RX-API-DMAC7.html)
KR (2) KR20230142639A (cg-RX-API-DMAC7.html)
CN (4) CN110267966B (cg-RX-API-DMAC7.html)
AU (3) AU2017345400B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019008032A2 (cg-RX-API-DMAC7.html)
CA (2) CA3041088C (cg-RX-API-DMAC7.html)
DK (1) DK3529257T3 (cg-RX-API-DMAC7.html)
ES (1) ES2952106T3 (cg-RX-API-DMAC7.html)
IL (2) IL297804A (cg-RX-API-DMAC7.html)
MA (1) MA46566A (cg-RX-API-DMAC7.html)
MX (4) MX2019004578A (cg-RX-API-DMAC7.html)
RU (1) RU2019115113A (cg-RX-API-DMAC7.html)
TW (3) TWI892042B (cg-RX-API-DMAC7.html)
WO (1) WO2018075699A1 (cg-RX-API-DMAC7.html)

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SMT202300232T1 (it) 2011-09-08 2023-09-06 Sage Therapeutics Inc Steroidi neuroattivi, composizioni e relativi usi
AU2014243773B2 (en) 2013-03-13 2018-12-13 Sage Therapeutics, Inc. Neuroactive steroids and methods of use thereof
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
AU2016289971C1 (en) 2015-07-06 2022-12-08 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
BR122021005552B1 (pt) 2015-07-06 2024-01-02 Sage Therapeutics, Inc Compostos oxiesteróis, seus usos e composição farmacêutica
EP3436022B1 (en) 2016-04-01 2022-03-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PT3481846T (pt) 2016-07-07 2021-08-13 Sage Therapeutics Inc 24-hidroxiesteroides 11-substituídos para utilização no tratamento de afeções relacionadas com nmda
WO2018064649A1 (en) 2016-09-30 2018-04-05 Sage Therapeutics, Inc. C7 substituted oxysterols and methods as nmda modulators
RU2019115112A (ru) 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
RU2019115113A (ru) 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
WO2020260558A1 (en) 2019-06-27 2020-12-30 Phenex Pharmaceuticals Ag 3-modified iso-/isoallo-lithocholic acid derivatives or their homo-analogs for preventing and treating clostridioides difficile-associated diseases
GB201913752D0 (en) 2019-09-24 2019-11-06 Syngenta Crop Protection Ag Herbicidal compounds
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
GB201914277D0 (en) 2019-10-03 2019-11-20 Syngenta Crop Protection Ag Herbicidal compounds
GB201917898D0 (en) 2019-12-06 2020-01-22 Syngenta Crop Protection Ag Herbicidal compounds
JP2023531735A (ja) * 2020-06-26 2023-07-25 デュレクト コーポレーション インスリン抵抗性、糖尿病、及び前糖尿病の少なくとも１つを処置するための酸素化コレステロールスルフェート類の使用
MX2023014719A (es) 2021-06-11 2024-02-15 Sage Therapeutics Inc Esteroide neuroactivo para el tratamiento de la enfermedad de alzheimer.
EP4405370A1 (en) 2021-09-22 2024-07-31 Sage Therapeutics, Inc. Deuterated positive nmda-modulating compounds and methods of use thereof
EP4430056A1 (en) * 2021-11-10 2024-09-18 Umecrine AB 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators
CN116143859A (zh) * 2022-12-09 2023-05-23 江苏佳尔科药业集团股份有限公司 5α-孕甾-3,20-二酮的制备方法
WO2025221731A1 (en) * 2024-04-15 2025-10-23 Sage Therapeutics, Inc. Nmda receptor-modulating compounds and methods of use thereof

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JP2014526469A (ja) 2011-09-08 2014-10-06 セージ セラピューティクス， インコーポレイテッド 神経刺激性のステロイド、組成物、およびそれらの使用
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WO2016057713A1 (en) 2014-10-07 2016-04-14 Sage Therapeutics, Inc. Neuroactive compounds and methods of use thereof
JP2016513663A (ja) 2013-03-13 2016-05-16 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイドおよびその使用方法
JP2016514967A (ja) 2013-03-13 2016-05-26 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド、組成物およびそれらの使用

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