JP7064072B2 - 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 - Google Patents

嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 Download PDF

Info

Publication number
JP7064072B2
JP7064072B2 JP2020537292A JP2020537292A JP7064072B2 JP 7064072 B2 JP7064072 B2 JP 7064072B2 JP 2020537292 A JP2020537292 A JP 2020537292A JP 2020537292 A JP2020537292 A JP 2020537292A JP 7064072 B2 JP7064072 B2 JP 7064072B2
Authority
JP
Japan
Prior art keywords
carboxamide
sulfonyl
cyclopropane
quinoline
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2020537292A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020534360A5 (enExample
JP2020534360A (ja
Inventor
アルテンバック，ロバート・ジェイ
ボグダン，アンドリュー
クティ，シルバン
デロワ，ニコラ
グフェッサー，グレゴリー・エイ
オスマン，クリストファー・ガエタン
キム，フィリップ・アール
リウ，ボー
マイ，ティ・トゥ・チャン
マラグ，カリネ・ファビエンヌ
メラヨ・メラヨ，ヌリア
ピコレ，オリビエ・ローラン
ピッツォネロ，マチュー・ラファエル
サール，ジーニア・ビー
ファン・デル・プラス，スティーブン・エミエル
ワン，シュエチン
イエン，ミン・シー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galapagos NV
Original Assignee
Galapagos NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos NV filed Critical Galapagos NV
Publication of JP2020534360A publication Critical patent/JP2020534360A/ja
Priority to JP2021156375A priority Critical patent/JP7064073B2/ja
Priority to JP2021156376A priority patent/JP7064074B2/ja
Publication of JP2020534360A5 publication Critical patent/JP2020534360A5/ja
Priority to JP2022007648A priority patent/JP2022062093A/ja
Application granted granted Critical
Publication of JP7064072B2 publication Critical patent/JP7064072B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Sanitary Thin Papers (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
JP2020537292A 2017-09-14 2018-09-13 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 Expired - Fee Related JP7064072B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021156375A JP7064073B2 (ja) 2017-09-14 2021-09-27 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2021156376A JP7064074B2 (ja) 2017-09-14 2021-09-27 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2022007648A JP2022062093A (ja) 2017-09-14 2022-01-21 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762558430P 2017-09-14 2017-09-14
US62/558,430 2017-09-14
US201762608846P 2017-12-21 2017-12-21
US62/608,846 2017-12-21
PCT/IB2018/057020 WO2019053634A1 (en) 2017-09-14 2018-09-13 MODULATORS OF THE TRANSMEMBRANE CONDUCTANCE REGULATORY PROTEIN OF CYSTIC FIBROSIS AND METHODS OF USE

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP2021156376A Division JP7064074B2 (ja) 2017-09-14 2021-09-27 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2021156375A Division JP7064073B2 (ja) 2017-09-14 2021-09-27 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2022007648A Division JP2022062093A (ja) 2017-09-14 2022-01-21 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法

Publications (3)

Publication Number Publication Date
JP2020534360A JP2020534360A (ja) 2020-11-26
JP2020534360A5 JP2020534360A5 (enExample) 2021-10-21
JP7064072B2 true JP7064072B2 (ja) 2022-05-10

Family

ID=63713961

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2020537292A Expired - Fee Related JP7064072B2 (ja) 2017-09-14 2018-09-13 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2021156375A Expired - Fee Related JP7064073B2 (ja) 2017-09-14 2021-09-27 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2021156376A Expired - Fee Related JP7064074B2 (ja) 2017-09-14 2021-09-27 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2022007648A Pending JP2022062093A (ja) 2017-09-14 2022-01-21 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021156375A Expired - Fee Related JP7064073B2 (ja) 2017-09-14 2021-09-27 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2021156376A Expired - Fee Related JP7064074B2 (ja) 2017-09-14 2021-09-27 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
JP2022007648A Pending JP2022062093A (ja) 2017-09-14 2022-01-21 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法

Country Status (34)

Country Link
US (6) US10988454B2 (enExample)
EP (4) EP3681864B1 (enExample)
JP (4) JP7064072B2 (enExample)
KR (1) KR20200086661A (enExample)
CN (1) CN111954664A (enExample)
AU (1) AU2018332512A1 (enExample)
BR (1) BR112020005102A2 (enExample)
CA (1) CA3074945A1 (enExample)
CL (1) CL2020000664A1 (enExample)
CO (1) CO2020004249A2 (enExample)
CR (1) CR20200157A (enExample)
CY (3) CY1123761T1 (enExample)
DK (3) DK3736270T3 (enExample)
EC (1) ECSP20021913A (enExample)
ES (3) ES2887449T3 (enExample)
HR (3) HRP20210099T1 (enExample)
HU (3) HUE055050T2 (enExample)
IL (1) IL273163A (enExample)
LT (3) LT3736267T (enExample)
MA (1) MA50240B1 (enExample)
MD (3) MD3736267T2 (enExample)
MX (1) MX2020002806A (enExample)
PE (1) PE20210140A1 (enExample)
PH (1) PH12020500509A1 (enExample)
PL (3) PL3681864T3 (enExample)
PT (3) PT3736267T (enExample)
RS (3) RS62190B1 (enExample)
RU (1) RU2020113350A (enExample)
SG (1) SG11202002101RA (enExample)
SI (3) SI3681864T1 (enExample)
SM (3) SMT202100140T1 (enExample)
UA (1) UA125541C2 (enExample)
WO (1) WO2019053634A1 (enExample)
ZA (1) ZA202002363B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202140422A (zh) 2014-10-06 2021-11-01 美商維泰克斯製藥公司 囊腫纖維化症跨膜傳導調節蛋白之調節劑
GEP20217329B (en) 2016-09-30 2021-12-10 Vertex Pharma Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
EA202192783A1 (ru) 2016-12-09 2022-02-24 Вертекс Фармасьютикалз Инкорпорейтед Модулятор регулятора трансмембранной проводимости при муковисцидозе, фармацевтические композиции, способы лечения и способ получения указанного модулятора
MA54105A (fr) 2017-06-08 2021-09-15 Vertex Pharma Méthodes de traitement de la fibrose kystique
IL272032B2 (en) 2017-07-17 2026-04-01 Vertex Pharma Combination therapy for the treatment of cystic fibrosis including N-(1,3-DIMETHYLPYRAZOL-4-YL)SULFONYL-6-[3-(3,3,3-TRIFLUORO-2,2- DIMETHYL-PROPOXY)PYRAZOL-1-YL]-2-[(4S)-2,2,4- TRIMETHYLPYRROLIDIN-1-YL]PYRIDINE-3-CARBOXAMIDE and
MA49752A (fr) 2017-08-02 2021-04-21 Vertex Pharma Procédés de préparation de composés de pyrrolidine
US10988454B2 (en) * 2017-09-14 2021-04-27 Abbvie Overseas S.À.R.L. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
KR102717072B1 (ko) 2017-10-18 2024-10-15 인사이트 코포레이션 Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체
CA3078893A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of cftr modulators
KR102716244B1 (ko) 2017-12-08 2024-10-14 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
RS64018B1 (sr) 2018-02-15 2023-03-31 Vertex Pharma Makrocikli kao modulatori transmembranskog regulatora provodnosti cistične fibroze, njihove farmaceutske kompozicije, njihova upotreba u lečenju cistične fibroze i proces njihove izrade
WO2019200246A1 (en) 2018-04-13 2019-10-17 Alexander Russell Abela Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
CN113226464A (zh) * 2018-12-18 2021-08-06 诺华股份有限公司 N-(吡啶-2-基磺酰基)环丙烷甲酰胺衍生物及其在治疗cftr介导的疾病中的用途
TWI848092B (zh) 2019-04-03 2024-07-11 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白調節劑
US11873300B2 (en) 2019-08-14 2024-01-16 Vertex Pharmaceuticals Incorporated Crystalline forms of CFTR modulators
TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
TWI899097B (zh) 2019-08-14 2025-10-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
WO2022036060A1 (en) 2020-08-13 2022-02-17 Vertex Pharmaceuticals Incorporated Crystalline forms of cftr modulators
US12612416B2 (en) 2020-10-07 2026-04-28 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
MX2023006770A (es) 2020-12-10 2023-08-14 Vertex Pharma Metodos de tratamiento para fibrosis quistica.
EP4274828A1 (en) * 2021-01-06 2023-11-15 AbbVie Global Enterprises Ltd. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
WO2022150173A1 (en) * 2021-01-06 2022-07-14 AbbVie Global Enterprises Ltd. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
CN116217392A (zh) * 2023-02-21 2023-06-06 厦门医学院 一种洛索洛芬钠关键中间体2-(4-卤甲基苯基)丙酸酯的合成方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008127399A2 (en) 2006-11-03 2008-10-23 Vertex Pharmaceuticals Incorporated Azaindole derivatives as cftr modulators
WO2009120803A2 (en) 2008-03-25 2009-10-01 The Regents Of The University Of California Water soluble small molecule inhibitors of the cystic fibrosis transmembrane conductance regulator
WO2010053471A1 (en) 2008-11-06 2010-05-14 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
WO2011113894A1 (en) 2010-03-19 2011-09-22 Novartis Ag Pyridine and pyrazine derivative for the treatment of cf
WO2016057572A1 (en) 2014-10-06 2016-04-14 Mark Thomas Miller Modulators of cystic fibrosis transmembrane conductance regulator
WO2016069757A1 (en) 2014-10-31 2016-05-06 Abbvie Inc. Substituted chromanes and method of use
WO2017060874A1 (en) 2015-10-09 2017-04-13 Abbvie S.Á.R.L N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB602426A (en) * 1945-10-24 1948-05-26 Geigy Ag J R Manufacture of aromatic acyl-sulphonamides
IL154981A0 (en) * 2000-10-10 2003-10-31 Smithkline Beecham Corp Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents
WO2005120497A2 (en) 2004-06-04 2005-12-22 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-cftr and uses thereof
CA2881078C (en) 2004-06-24 2018-10-02 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN101687883B (zh) 2007-05-25 2012-05-23 沃泰克斯药物股份有限公司 囊性纤维化跨膜传导调节因子的调节剂
RU2010111550A (ru) * 2007-08-29 2011-10-10 Шеринг Корпорейшн (US) 2,3-замещенные индольные производные для лечения вирусных инфекций
US8765757B2 (en) * 2007-11-16 2014-07-01 Merck Sharp & Dohme Corp. 3-heterocyclic substituted indole derivatives and methods of use thereof
BRPI0820669A2 (pt) 2007-12-10 2020-08-04 Novartis Ag compostos orgânicos
ES2422741T3 (es) 2007-12-13 2013-09-13 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
NZ592504A (en) 2008-10-23 2013-04-26 Vertex Pharma Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
EP2382197B1 (en) 2008-12-30 2016-10-05 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CN102458122A (zh) * 2009-04-20 2012-05-16 人类健康研究所 含有哒嗪磺胺衍生物的化合物、组合物和方法
ES2553771T3 (es) 2010-10-08 2015-12-11 Nivalis Therapeutics, Inc. Nuevos compuestos de quinolina sustituidos como inhibidores de la S-nitrosoglutatión reductasa
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
CN103946221B (zh) 2011-09-16 2016-08-03 诺华股份有限公司 用于治疗囊性纤维化的杂环化合物
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
JP6165733B2 (ja) 2011-09-16 2017-07-19 ノバルティス アーゲー Ｎ−置換ヘテロシクリルカルボキサミド類
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
BR112014006535A2 (pt) 2011-09-20 2017-03-28 Univ North Carolina Chapel Hill regulação dos canais de sódio através das proteínas plunc
CA3122383A1 (en) 2013-05-07 2014-11-13 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis.
AU2014304562B8 (en) 2013-08-08 2018-07-05 Galapagos Nv Thieno[2,3-c]pyrans as CFTR modulators
CN103484818A (zh) 2013-09-25 2014-01-01 京东方科技集团股份有限公司 蒸镀方法、蒸镀装置和发光器件
CA2942386A1 (en) 2014-03-13 2015-09-17 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
AU2015229117A1 (en) 2014-03-13 2016-09-29 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing CFTR activity
KR102132215B1 (ko) 2014-04-03 2020-07-09 삼성전자주식회사 자기 터널 접합 구조물 형성 방법 및 이를 이용한 자기 메모리 소자의 제조 방법
CA2966023A1 (en) 2014-10-31 2016-05-06 Abbvie S.A.R.L. Substituted tetrahydropyrans and method of use
US10047051B2 (en) 2015-06-02 2018-08-14 Abbvie S.Á.R.L. Substituted pyridines and method of use
US9840513B2 (en) 2015-07-16 2017-12-12 Abbvie S.Á.R.L. Substituted tricyclics and method of use
AU2017256172A1 (en) 2016-04-26 2018-09-06 AbbVie S.à.r.l. Modulators of cystic fibrosis transmembrane conductance regulator protein
US10138227B2 (en) 2016-06-03 2018-11-27 Abbvie S.Á.R.L. Heteroaryl substituted pyridines and methods of use
US9981910B2 (en) 2016-10-07 2018-05-29 Abbvie S.Á.R.L. Substituted pyrrolidines and methods of use
US10399940B2 (en) 2016-10-07 2019-09-03 Abbvie S.Á.R.L. Substituted pyrrolidines and methods of use
US10988454B2 (en) * 2017-09-14 2021-04-27 Abbvie Overseas S.À.R.L. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008127399A2 (en) 2006-11-03 2008-10-23 Vertex Pharmaceuticals Incorporated Azaindole derivatives as cftr modulators
WO2009120803A2 (en) 2008-03-25 2009-10-01 The Regents Of The University Of California Water soluble small molecule inhibitors of the cystic fibrosis transmembrane conductance regulator
WO2010053471A1 (en) 2008-11-06 2010-05-14 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
WO2011113894A1 (en) 2010-03-19 2011-09-22 Novartis Ag Pyridine and pyrazine derivative for the treatment of cf
WO2016057572A1 (en) 2014-10-06 2016-04-14 Mark Thomas Miller Modulators of cystic fibrosis transmembrane conductance regulator
WO2016069757A1 (en) 2014-10-31 2016-05-06 Abbvie Inc. Substituted chromanes and method of use
WO2017060874A1 (en) 2015-10-09 2017-04-13 Abbvie S.Á.R.L N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use

Also Published As

Publication number Publication date
CA3074945A1 (en) 2019-03-21
US10988454B2 (en) 2021-04-27
DK3736270T3 (da) 2021-08-09
US20200277274A1 (en) 2020-09-03
RU2020113350A (ru) 2021-10-15
MD3681864T2 (ro) 2021-05-31
MA50240B1 (fr) 2021-03-31
US20200277275A1 (en) 2020-09-03
JP2022000461A (ja) 2022-01-04
ES2881881T3 (es) 2021-11-30
US20200277276A1 (en) 2020-09-03
JP7064074B2 (ja) 2022-05-10
PH12020500509A1 (en) 2021-05-31
PT3736270T (pt) 2021-08-10
SG11202002101RA (en) 2020-04-29
ECSP20021913A (es) 2020-05-29
SI3736270T1 (sl) 2021-09-30
US10844041B2 (en) 2020-11-24
US20200277273A1 (en) 2020-09-03
BR112020005102A2 (pt) 2020-09-24
PL3681864T4 (pl) 2021-05-17
CY1124401T1 (el) 2022-07-22
CR20200157A (es) 2021-02-16
HUE052873T2 (hu) 2021-05-28
RU2020113350A3 (enExample) 2022-04-14
SI3736267T1 (sl) 2021-09-30
SI3681864T1 (sl) 2021-08-31
UA125541C2 (uk) 2022-04-13
JP2020534360A (ja) 2020-11-26
WO2019053634A1 (en) 2019-03-21
HRP20211198T1 (hr) 2021-10-29
JP7064073B2 (ja) 2022-05-10
US10981890B2 (en) 2021-04-20
DK3681864T3 (da) 2021-01-25
EP3681864B1 (en) 2020-10-28
JP2022062093A (ja) 2022-04-19
PL3736270T3 (pl) 2021-11-15
PL3681864T3 (pl) 2021-05-17
US20190077784A1 (en) 2019-03-14
MX2020002806A (es) 2020-10-12
HUE055050T2 (hu) 2021-10-28
HRP20211200T1 (hr) 2021-10-29
RS62185B1 (sr) 2021-08-31
PL3736267T3 (pl) 2021-11-15
MD3736267T2 (ro) 2021-11-30
LT3736270T (lt) 2021-08-25
CN111954664A (zh) 2020-11-17
IL273163A (en) 2020-04-30
EP3865474A1 (en) 2021-08-18
KR20200086661A (ko) 2020-07-17
RS61899B1 (sr) 2021-06-30
CL2020000664A1 (es) 2020-11-06
CY1124615T1 (el) 2022-07-22
CO2020004249A2 (es) 2020-08-31
SMT202100140T1 (it) 2021-05-07
MA50240A (fr) 2020-07-22
PT3736267T (pt) 2021-08-10
LT3681864T (lt) 2021-02-25
JP2022000460A (ja) 2022-01-04
SMT202100556T1 (it) 2022-01-10
EP3736267B1 (en) 2021-05-05
EP3736270B1 (en) 2021-05-05
US10844042B2 (en) 2020-11-24
HRP20210099T1 (hr) 2021-03-05
ZA202002363B (en) 2021-06-30
CY1123761T1 (el) 2022-05-27
SMT202100493T1 (it) 2021-09-14
AU2018332512A1 (en) 2020-04-23
US10829473B2 (en) 2020-11-10
US20210238159A1 (en) 2021-08-05
LT3736267T (lt) 2021-08-25
ES2887449T3 (es) 2021-12-22
EP3736270A1 (en) 2020-11-11
EP3681864A1 (en) 2020-07-22
PE20210140A1 (es) 2021-01-21
MD3736270T2 (ro) 2021-11-30
RS62190B1 (sr) 2021-08-31
PT3681864T (pt) 2021-02-25
EP3736267A1 (en) 2020-11-11
DK3736267T3 (da) 2021-08-09
HUE055241T2 (hu) 2021-11-29
ES2856751T3 (es) 2021-09-28

Similar Documents

Publication Publication Date Title
JP7064073B2 (ja) 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法
ES3018793T3 (en) Bcl-2 inhibitors
TWI618700B (zh) 化合物及其作為β－位置ＡＰＰ裂解酶（ＢＡＣＥ）抑制劑之用途
JP2019529519A (ja) 置換されたピロリジン類及び使用方法
CA2991273A1 (en) Substituted tricyclics and method of use
BR112016008133B1 (pt) amino-heteroaril benzamidas como inibidores de quinase, seus usos, e composição farmacêutica
BR112015027055B1 (pt) Bi-heteroarilas, usos das mesmas, e composição farmacêutica
BR112021005870B1 (pt) Inibidores de pde4 contendo boro
CN112209925A (zh) Ret选择性抑制剂及其制备方法和用途
HK40059779A (en) Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
HK40033129B (en) Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
HK40033129A (en) Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
HK40029716B (en) Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
HK40029716A (en) Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
BR122024017489A2 (pt) Compostos inibidores do receptor de activina tipo quinase, composição farmacêutica compreendendo os referidos compostos, uso e método para sintetizar os mesmos
BR112018071184B1 (pt) Compostos inibidores do receptor de activina tipo quinase, composição farmacêutica compreendendo os referidos compostos, uso e método para sintetizar os mesmos
BR112018000649B1 (pt) Compostos tricíclicos substituídos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos no tratamento de fibrose cística

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210913

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210913

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20210913

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20211124

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20211224

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20220121

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220121

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220208

R150 Certificate of patent or registration of utility model

Ref document number: 7064072

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees