JP2020534360A5 - - Google Patents
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- JP2020534360A5 JP2020534360A5 JP2020537292A JP2020537292A JP2020534360A5 JP 2020534360 A5 JP2020534360 A5 JP 2020534360A5 JP 2020537292 A JP2020537292 A JP 2020537292A JP 2020537292 A JP2020537292 A JP 2020537292A JP 2020534360 A5 JP2020534360 A5 JP 2020534360A5
- Authority
- JP
- Japan
- Prior art keywords
- methylquinoline
- cyclopropane
- carboxamide
- sulfonyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021156375A JP7064073B2 (ja) | 2017-09-14 | 2021-09-27 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2021156376A JP7064074B2 (ja) | 2017-09-14 | 2021-09-27 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2022007648A JP2022062093A (ja) | 2017-09-14 | 2022-01-21 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762558430P | 2017-09-14 | 2017-09-14 | |
| US62/558,430 | 2017-09-14 | ||
| US201762608846P | 2017-12-21 | 2017-12-21 | |
| US62/608,846 | 2017-12-21 | ||
| PCT/IB2018/057020 WO2019053634A1 (en) | 2017-09-14 | 2018-09-13 | MODULATORS OF THE TRANSMEMBRANE CONDUCTANCE REGULATORY PROTEIN OF CYSTIC FIBROSIS AND METHODS OF USE |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021156376A Division JP7064074B2 (ja) | 2017-09-14 | 2021-09-27 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2021156375A Division JP7064073B2 (ja) | 2017-09-14 | 2021-09-27 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2022007648A Division JP2022062093A (ja) | 2017-09-14 | 2022-01-21 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534360A JP2020534360A (ja) | 2020-11-26 |
| JP2020534360A5 true JP2020534360A5 (enExample) | 2021-10-21 |
| JP7064072B2 JP7064072B2 (ja) | 2022-05-10 |
Family
ID=63713961
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020537292A Expired - Fee Related JP7064072B2 (ja) | 2017-09-14 | 2018-09-13 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2021156375A Expired - Fee Related JP7064073B2 (ja) | 2017-09-14 | 2021-09-27 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2021156376A Expired - Fee Related JP7064074B2 (ja) | 2017-09-14 | 2021-09-27 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2022007648A Pending JP2022062093A (ja) | 2017-09-14 | 2022-01-21 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021156375A Expired - Fee Related JP7064073B2 (ja) | 2017-09-14 | 2021-09-27 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2021156376A Expired - Fee Related JP7064074B2 (ja) | 2017-09-14 | 2021-09-27 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
| JP2022007648A Pending JP2022062093A (ja) | 2017-09-14 | 2022-01-21 | 嚢胞性線維症膜貫通コンダクタンス調節因子タンパク質のモジュレーター及び使用の方法 |
Country Status (34)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202140422A (zh) | 2014-10-06 | 2021-11-01 | 美商維泰克斯製藥公司 | 囊腫纖維化症跨膜傳導調節蛋白之調節劑 |
| GEP20217329B (en) | 2016-09-30 | 2021-12-10 | Vertex Pharma | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| EA202192783A1 (ru) | 2016-12-09 | 2022-02-24 | Вертекс Фармасьютикалз Инкорпорейтед | Модулятор регулятора трансмембранной проводимости при муковисцидозе, фармацевтические композиции, способы лечения и способ получения указанного модулятора |
| MA54105A (fr) | 2017-06-08 | 2021-09-15 | Vertex Pharma | Méthodes de traitement de la fibrose kystique |
| IL272032B2 (en) | 2017-07-17 | 2026-04-01 | Vertex Pharma | Combination therapy for the treatment of cystic fibrosis including N-(1,3-DIMETHYLPYRAZOL-4-YL)SULFONYL-6-[3-(3,3,3-TRIFLUORO-2,2- DIMETHYL-PROPOXY)PYRAZOL-1-YL]-2-[(4S)-2,2,4- TRIMETHYLPYRROLIDIN-1-YL]PYRIDINE-3-CARBOXAMIDE and |
| MA49752A (fr) | 2017-08-02 | 2021-04-21 | Vertex Pharma | Procédés de préparation de composés de pyrrolidine |
| US10988454B2 (en) * | 2017-09-14 | 2021-04-27 | Abbvie Overseas S.À.R.L. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| KR102717072B1 (ko) | 2017-10-18 | 2024-10-15 | 인사이트 코포레이션 | Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체 |
| CA3078893A1 (en) | 2017-10-19 | 2019-04-25 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of cftr modulators |
| KR102716244B1 (ko) | 2017-12-08 | 2024-10-14 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법 |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| RS64018B1 (sr) | 2018-02-15 | 2023-03-31 | Vertex Pharma | Makrocikli kao modulatori transmembranskog regulatora provodnosti cistične fibroze, njihove farmaceutske kompozicije, njihova upotreba u lečenju cistične fibroze i proces njihove izrade |
| WO2019200246A1 (en) | 2018-04-13 | 2019-10-17 | Alexander Russell Abela | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165) |
| CN113226464A (zh) * | 2018-12-18 | 2021-08-06 | 诺华股份有限公司 | N-(吡啶-2-基磺酰基)环丙烷甲酰胺衍生物及其在治疗cftr介导的疾病中的用途 |
| TWI848092B (zh) | 2019-04-03 | 2024-07-11 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白調節劑 |
| US11873300B2 (en) | 2019-08-14 | 2024-01-16 | Vertex Pharmaceuticals Incorporated | Crystalline forms of CFTR modulators |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| TWI899097B (zh) | 2019-08-14 | 2025-10-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| WO2022036060A1 (en) | 2020-08-13 | 2022-02-17 | Vertex Pharmaceuticals Incorporated | Crystalline forms of cftr modulators |
| US12612416B2 (en) | 2020-10-07 | 2026-04-28 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| MX2023006770A (es) | 2020-12-10 | 2023-08-14 | Vertex Pharma | Metodos de tratamiento para fibrosis quistica. |
| EP4274828A1 (en) * | 2021-01-06 | 2023-11-15 | AbbVie Global Enterprises Ltd. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| WO2022150173A1 (en) * | 2021-01-06 | 2022-07-14 | AbbVie Global Enterprises Ltd. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| CN116217392A (zh) * | 2023-02-21 | 2023-06-06 | 厦门医学院 | 一种洛索洛芬钠关键中间体2-(4-卤甲基苯基)丙酸酯的合成方法 |
Family Cites Families (41)
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| GB602426A (en) * | 1945-10-24 | 1948-05-26 | Geigy Ag J R | Manufacture of aromatic acyl-sulphonamides |
| IL154981A0 (en) * | 2000-10-10 | 2003-10-31 | Smithkline Beecham Corp | Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents |
| WO2005120497A2 (en) | 2004-06-04 | 2005-12-22 | The Regents Of The University Of California | Compounds having activity in increasing ion transport by mutant-cftr and uses thereof |
| CA2881078C (en) | 2004-06-24 | 2018-10-02 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| MX2009004702A (es) | 2006-11-03 | 2009-06-19 | Vertex Pharma | Derivados de azaindol como moduladores del regulador de conductancia de transmembrana de fibrosis quistica. |
| CN101687883B (zh) | 2007-05-25 | 2012-05-23 | 沃泰克斯药物股份有限公司 | 囊性纤维化跨膜传导调节因子的调节剂 |
| RU2010111550A (ru) * | 2007-08-29 | 2011-10-10 | Шеринг Корпорейшн (US) | 2,3-замещенные индольные производные для лечения вирусных инфекций |
| US8765757B2 (en) * | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| BRPI0820669A2 (pt) | 2007-12-10 | 2020-08-04 | Novartis Ag | compostos orgânicos |
| ES2422741T3 (es) | 2007-12-13 | 2013-09-13 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| JP2011517674A (ja) | 2008-03-25 | 2011-06-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 嚢胞性線維症膜コンダクタンス制御因子の水溶性小分子阻害剤 |
| NZ592504A (en) | 2008-10-23 | 2013-04-26 | Vertex Pharma | Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide |
| KR20160013251A (ko) | 2008-11-06 | 2016-02-03 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｐ-결합 카세트 수송자의 조절자 |
| EP2382197B1 (en) | 2008-12-30 | 2016-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| CN102458122A (zh) * | 2009-04-20 | 2012-05-16 | 人类健康研究所 | 含有哒嗪磺胺衍生物的化合物、组合物和方法 |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| ES2553771T3 (es) | 2010-10-08 | 2015-12-11 | Nivalis Therapeutics, Inc. | Nuevos compuestos de quinolina sustituidos como inhibidores de la S-nitrosoglutatión reductasa |
| WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
| CN103946221B (zh) | 2011-09-16 | 2016-08-03 | 诺华股份有限公司 | 用于治疗囊性纤维化的杂环化合物 |
| WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| JP6165733B2 (ja) | 2011-09-16 | 2017-07-19 | ノバルティス アーゲー | Ｎ−置換ヘテロシクリルカルボキサミド類 |
| WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| BR112014006535A2 (pt) | 2011-09-20 | 2017-03-28 | Univ North Carolina Chapel Hill | regulação dos canais de sódio através das proteínas plunc |
| CA3122383A1 (en) | 2013-05-07 | 2014-11-13 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis. |
| AU2014304562B8 (en) | 2013-08-08 | 2018-07-05 | Galapagos Nv | Thieno[2,3-c]pyrans as CFTR modulators |
| CN103484818A (zh) | 2013-09-25 | 2014-01-01 | 京东方科技集团股份有限公司 | 蒸镀方法、蒸镀装置和发光器件 |
| CA2942386A1 (en) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| AU2015229117A1 (en) | 2014-03-13 | 2016-09-29 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
| KR102132215B1 (ko) | 2014-04-03 | 2020-07-09 | 삼성전자주식회사 | 자기 터널 접합 구조물 형성 방법 및 이를 이용한 자기 메모리 소자의 제조 방법 |
| TW202140422A (zh) | 2014-10-06 | 2021-11-01 | 美商維泰克斯製藥公司 | 囊腫纖維化症跨膜傳導調節蛋白之調節劑 |
| US9642831B2 (en) | 2014-10-31 | 2017-05-09 | Abbvie S.Á.R.L. | Substituted chromanes and method of use |
| CA2966023A1 (en) | 2014-10-31 | 2016-05-06 | Abbvie S.A.R.L. | Substituted tetrahydropyrans and method of use |
| US10047051B2 (en) | 2015-06-02 | 2018-08-14 | Abbvie S.Á.R.L. | Substituted pyridines and method of use |
| US9840513B2 (en) | 2015-07-16 | 2017-12-12 | Abbvie S.Á.R.L. | Substituted tricyclics and method of use |
| PL3359541T3 (pl) | 2015-10-09 | 2021-01-11 | AbbVie Overseas S.à r.l. | N-SULFONYLOWANE PIRAZOLO[3,4-b]PIRYDYNO-6-KARBOKSAMIDY I SPOSÓB ZASTOSOWANIA |
| AU2017256172A1 (en) | 2016-04-26 | 2018-09-06 | AbbVie S.à.r.l. | Modulators of cystic fibrosis transmembrane conductance regulator protein |
| US10138227B2 (en) | 2016-06-03 | 2018-11-27 | Abbvie S.Á.R.L. | Heteroaryl substituted pyridines and methods of use |
| US9981910B2 (en) | 2016-10-07 | 2018-05-29 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| US10399940B2 (en) | 2016-10-07 | 2019-09-03 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| US10988454B2 (en) * | 2017-09-14 | 2021-04-27 | Abbvie Overseas S.À.R.L. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
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2018
- 2018-09-12 US US16/129,458 patent/US10988454B2/en active Active
- 2018-09-13 EP EP18779798.0A patent/EP3681864B1/en active Active
- 2018-09-13 WO PCT/IB2018/057020 patent/WO2019053634A1/en not_active Ceased
- 2018-09-13 PL PL18779798T patent/PL3681864T3/pl unknown
- 2018-09-13 HU HUE20183405A patent/HUE055050T2/hu unknown
- 2018-09-13 CR CR20200157A patent/CR20200157A/es unknown
- 2018-09-13 RS RS20210975A patent/RS62190B1/sr unknown
- 2018-09-13 SM SM20210140T patent/SMT202100140T1/it unknown
- 2018-09-13 SI SI201830193T patent/SI3681864T1/sl unknown
- 2018-09-13 LT LTEP20183405.8T patent/LT3736267T/lt unknown
- 2018-09-13 CA CA3074945A patent/CA3074945A1/en not_active Abandoned
- 2018-09-13 PE PE2020000670A patent/PE20210140A1/es unknown
- 2018-09-13 PT PT201834058T patent/PT3736267T/pt unknown
- 2018-09-13 SI SI201830344T patent/SI3736267T1/sl unknown
- 2018-09-13 LT LTEP20183402.5T patent/LT3736270T/lt unknown
- 2018-09-13 MD MDE20201160T patent/MD3736267T2/ro not_active IP Right Cessation
- 2018-09-13 KR KR1020207010867A patent/KR20200086661A/ko not_active Abandoned
- 2018-09-13 PL PL20183405T patent/PL3736267T3/pl unknown
- 2018-09-13 UA UAA202002356A patent/UA125541C2/uk unknown
- 2018-09-13 ES ES20183405T patent/ES2887449T3/es active Active
- 2018-09-13 HU HUE20183402A patent/HUE055241T2/hu unknown
- 2018-09-13 PL PL20183402T patent/PL3736270T3/pl unknown
- 2018-09-13 ES ES20183402T patent/ES2881881T3/es active Active
- 2018-09-13 JP JP2020537292A patent/JP7064072B2/ja not_active Expired - Fee Related
- 2018-09-13 RU RU2020113350A patent/RU2020113350A/ru unknown
- 2018-09-13 PT PT201834025T patent/PT3736270T/pt unknown
- 2018-09-13 ES ES18779798T patent/ES2856751T3/es active Active
- 2018-09-13 EP EP21164249.1A patent/EP3865474A1/en not_active Withdrawn
- 2018-09-13 MD MDE20201159T patent/MD3736270T2/ro not_active IP Right Cessation
- 2018-09-13 LT LTEP18779798.0T patent/LT3681864T/lt unknown
- 2018-09-13 SM SM20210556T patent/SMT202100556T1/it unknown
- 2018-09-13 SG SG11202002101RA patent/SG11202002101RA/en unknown
- 2018-09-13 EP EP20183402.5A patent/EP3736270B1/en active Active
- 2018-09-13 MD MDE20200741T patent/MD3681864T2/ro not_active IP Right Cessation
- 2018-09-13 AU AU2018332512A patent/AU2018332512A1/en not_active Abandoned
- 2018-09-13 BR BR112020005102-0A patent/BR112020005102A2/pt not_active Application Discontinuation
- 2018-09-13 EP EP20183405.8A patent/EP3736267B1/en active Active
- 2018-09-13 HR HRP20210099TT patent/HRP20210099T1/hr unknown
- 2018-09-13 HU HUE18779798A patent/HUE052873T2/hu unknown
- 2018-09-13 SM SM20210493T patent/SMT202100493T1/it unknown
- 2018-09-13 DK DK20183402.5T patent/DK3736270T3/da active
- 2018-09-13 MA MA50240A patent/MA50240B1/fr unknown
- 2018-09-13 DK DK18779798.0T patent/DK3681864T3/da active
- 2018-09-13 CN CN201880073855.3A patent/CN111954664A/zh active Pending
- 2018-09-13 RS RS20210082A patent/RS61899B1/sr unknown
- 2018-09-13 MX MX2020002806A patent/MX2020002806A/es unknown
- 2018-09-13 RS RS20210973A patent/RS62185B1/sr unknown
- 2018-09-13 SI SI201830345T patent/SI3736270T1/sl unknown
- 2018-09-13 DK DK20183405.8T patent/DK3736267T3/da active
- 2018-09-13 PT PT187797980T patent/PT3681864T/pt unknown
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2020
- 2020-03-09 IL IL273163A patent/IL273163A/en unknown
- 2020-03-12 PH PH12020500509A patent/PH12020500509A1/en unknown
- 2020-03-13 CL CL2020000664A patent/CL2020000664A1/es unknown
- 2020-04-07 CO CONC2020/0004249A patent/CO2020004249A2/es unknown
- 2020-04-14 EC ECSENADI202021913A patent/ECSP20021913A/es unknown
- 2020-05-04 ZA ZA2020/02363A patent/ZA202002363B/en unknown
- 2020-05-19 US US16/878,421 patent/US10844042B2/en active Active
- 2020-05-19 US US16/878,430 patent/US10829473B2/en active Active
- 2020-05-19 US US16/878,416 patent/US10844041B2/en active Active
- 2020-05-19 US US16/878,468 patent/US10981890B2/en active Active
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2021
- 2021-01-28 CY CY20211100074T patent/CY1123761T1/el unknown
- 2021-04-15 US US17/231,482 patent/US20210238159A1/en not_active Abandoned
- 2021-07-26 HR HRP20211198TT patent/HRP20211198T1/hr unknown
- 2021-07-26 HR HRP20211200TT patent/HRP20211200T1/hr unknown
- 2021-08-03 CY CY20211100695T patent/CY1124615T1/el unknown
- 2021-08-04 CY CY20211100697T patent/CY1124401T1/el unknown
- 2021-09-27 JP JP2021156375A patent/JP7064073B2/ja not_active Expired - Fee Related
- 2021-09-27 JP JP2021156376A patent/JP7064074B2/ja not_active Expired - Fee Related
-
2022
- 2022-01-21 JP JP2022007648A patent/JP2022062093A/ja active Pending
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