JP7014731B2 - 置換アミノプリン化合物、その組成物、及びそれらを用いた治療方法 - Google Patents
置換アミノプリン化合物、その組成物、及びそれらを用いた治療方法 Download PDFInfo
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- JP7014731B2 JP7014731B2 JP2018551358A JP2018551358A JP7014731B2 JP 7014731 B2 JP7014731 B2 JP 7014731B2 JP 2018551358 A JP2018551358 A JP 2018551358A JP 2018551358 A JP2018551358 A JP 2018551358A JP 7014731 B2 JP7014731 B2 JP 7014731B2
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- Prior art keywords
- purine
- cyclohexanecarboxamide
- ylamino
- chloro
- difluorophenylamino
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
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| PCT/US2017/025252 WO2017173206A1 (en) | 2016-04-01 | 2017-03-31 | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
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| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| TWI757256B (zh) | 2015-11-02 | 2022-03-11 | 美商纜圖藥品公司 | 轉染過程重排之抑制劑 |
| KR102359735B1 (ko) | 2016-03-31 | 2022-02-08 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| KR102359743B1 (ko) | 2016-03-31 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PT3436019T (pt) | 2016-04-01 | 2021-11-04 | Signal Pharm Llc | (1s,4s)-4-(2-(((3s,4r)-3-fluorotetra-hidro-2h-piran-4- il)amino)-8-((2,4,6-triclorofenil)amino)-9h-purin-9-il)-1- metilciclo-hexano-1-carboxamida e métodos de utilização dos mesmos |
| SG11201808237UA (en) | 2016-04-01 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| BR112019024311A2 (pt) | 2017-05-22 | 2020-07-28 | Janssen Pharmaceuticals, Inc. | derivados de indolina substituídos como inibidores da replicação viral do dengue |
| CN111432841A (zh) | 2017-10-04 | 2020-07-17 | 细胞基因公司 | 顺式-4-[2-{[(3s,4r)-3-氟噁烷-4-基]氨基}-8-(2,4,6-三氯苯胺基)-9h-嘌呤-9-基]-1-甲基环己烷-1-甲酰胺的组合物和使用方法 |
| JP7422084B2 (ja) | 2018-04-03 | 2024-01-25 | ブループリント メディシンズ コーポレイション | Ｒｅｔ変化を有する癌の処置において使用するためのｒｅｔ阻害剤 |
| EP3833372A4 (en) * | 2018-08-10 | 2022-06-08 | Blueprint Medicines Corporation | TREATMENT OF EGFR MUTANT CANCER |
| AU2020257207A1 (en) * | 2019-04-16 | 2021-11-25 | Vivace Therapeutics, Inc. | Bicyclic compounds |
| US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| EP4061364A4 (en) * | 2019-11-20 | 2023-09-13 | Vivace Therapeutics, Inc. | HETEROARYL COMPOUNDS |
| CA3183728A1 (en) | 2020-05-29 | 2021-12-02 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| TW202202498A (zh) * | 2020-07-01 | 2022-01-16 | 大陸商四川海思科製藥有限公司 | 一種並環雜環衍生物及其在醫藥上的應用 |
| KR102664454B1 (ko) * | 2021-08-03 | 2024-05-09 | 한국생명공학연구원 | 젬시타빈에 대한 민감성 향상을 위한 신규 표적 및 이의 활용 |
| CN114681456A (zh) * | 2022-02-23 | 2022-07-01 | 中山大学附属第六医院 | Plx3397在结直肠癌的治疗中的用途 |
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| JP2008526989A (ja) | 2005-01-13 | 2008-07-24 | シグナル ファーマシューティカルズ，エルエルシー | ハロアリール置換アミノプリン、その組成物、およびそれによる治療の方法 |
| JP2009535346A (ja) | 2006-04-26 | 2009-10-01 | シグナル ファーマシューティカルズ，エルエルシー | ハロアリール置換アミノプリン、その組成物及びそれによる治療方法 |
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| Publication number | Publication date |
|---|---|
| BR112018070163A2 (pt) | 2019-01-29 |
| JP2019510066A (ja) | 2019-04-11 |
| IL262007A (en) | 2018-10-31 |
| KR20180126497A (ko) | 2018-11-27 |
| IL262007B2 (en) | 2023-04-01 |
| EA201892229A1 (ru) | 2019-03-29 |
| CN109069512B (zh) | 2022-06-14 |
| CN109069512A (zh) | 2018-12-21 |
| US10576085B2 (en) | 2020-03-03 |
| MX379513B (es) | 2025-03-11 |
| KR102356433B1 (ko) | 2022-01-27 |
| WO2017173206A1 (en) | 2017-10-05 |
| CL2018002787A1 (es) | 2019-01-18 |
| EP3436018A1 (en) | 2019-02-06 |
| NZ746554A (en) | 2023-03-31 |
| MX2018011992A (es) | 2019-01-24 |
| SG11201808388QA (en) | 2018-10-30 |
| EA039392B1 (ru) | 2022-01-21 |
| US20170281633A1 (en) | 2017-10-05 |
| AU2017241837A1 (en) | 2018-10-25 |
| EP3436018A4 (en) | 2019-11-13 |
| CA3018986A1 (en) | 2017-10-05 |
| IL262007B (en) | 2022-12-01 |
| AU2017241837B2 (en) | 2021-07-22 |
| SG10202009589UA (en) | 2020-10-29 |
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