IL262007B2 - Modified aminopurine compounds, their compositions and methods of treatment using them - Google Patents

Modified aminopurine compounds, their compositions and methods of treatment using them

Info

Publication number
IL262007B2
IL262007B2 IL262007A IL26200718A IL262007B2 IL 262007 B2 IL262007 B2 IL 262007B2 IL 262007 A IL262007 A IL 262007A IL 26200718 A IL26200718 A IL 26200718A IL 262007 B2 IL262007 B2 IL 262007B2
Authority
IL
Israel
Prior art keywords
purin
cyclohexanecarboxamide
ylamino
chloro
difluorophenylamino
Prior art date
Application number
IL262007A
Other languages
English (en)
Hebrew (he)
Other versions
IL262007B (en
IL262007A (en
Inventor
Ellen Filvaroff
John F Boylan
Gordon L Bray
Robert Hubbard
David Mikolon
Heather Raymon
Tao Shi
Tam M Tran
Toshiya Tsuji
Lilly L Wong
Suichan Xu
Dan Zhu
Original Assignee
Signal Pharm Llc
Ellen Filvaroff
John F Boylan
Gordon L Bray
Robert Hubbard
David Mikolon
Heather Raymon
Tao Shi
Tam M Tran
Toshiya Tsuji
Lilly L Wong
Suichan Xu
Dan Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc, Ellen Filvaroff, John F Boylan, Gordon L Bray, Robert Hubbard, David Mikolon, Heather Raymon, Tao Shi, Tam M Tran, Toshiya Tsuji, Lilly L Wong, Suichan Xu, Dan Zhu filed Critical Signal Pharm Llc
Publication of IL262007A publication Critical patent/IL262007A/en
Publication of IL262007B publication Critical patent/IL262007B/en
Publication of IL262007B2 publication Critical patent/IL262007B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL262007A 2016-04-01 2017-03-31 Modified aminopurine compounds, their compositions and methods of treatment using them IL262007B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317412P 2016-04-01 2016-04-01
PCT/US2017/025252 WO2017173206A1 (en) 2016-04-01 2017-03-31 Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith

Publications (3)

Publication Number Publication Date
IL262007A IL262007A (en) 2018-10-31
IL262007B IL262007B (en) 2022-12-01
IL262007B2 true IL262007B2 (en) 2023-04-01

Family

ID=59959573

Family Applications (1)

Application Number Title Priority Date Filing Date
IL262007A IL262007B2 (en) 2016-04-01 2017-03-31 Modified aminopurine compounds, their compositions and methods of treatment using them

Country Status (15)

Country Link
US (1) US10576085B2 (OSRAM)
EP (1) EP3436018A4 (OSRAM)
JP (1) JP7014731B2 (OSRAM)
KR (1) KR102356433B1 (OSRAM)
CN (1) CN109069512B (OSRAM)
AU (1) AU2017241837B2 (OSRAM)
BR (1) BR112018070163A2 (OSRAM)
CA (1) CA3018986A1 (OSRAM)
CL (1) CL2018002787A1 (OSRAM)
EA (1) EA039392B1 (OSRAM)
IL (1) IL262007B2 (OSRAM)
MX (1) MX379513B (OSRAM)
NZ (1) NZ746554A (OSRAM)
SG (2) SG11201808388QA (OSRAM)
WO (1) WO2017173206A1 (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
US10202365B2 (en) 2015-02-06 2019-02-12 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EP3371171B1 (en) 2015-11-02 2023-10-25 Blueprint Medicines Corporation Inhibitors of ret
KR102359735B1 (ko) 2016-03-31 2022-02-08 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체
AU2017242893A1 (en) 2016-03-31 2018-08-09 Janssen Pharmaceuticals, Inc. Substituted indole derivatives as dengue viral replication inhibitors
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
WO2017173218A1 (en) 2016-04-01 2017-10-05 Signal Pharmaceuticals, Llc Solid forms of (1s,4s)-4-(2-(((3s4r)-3-fluorotetrahydro-2h-pyran-4-yl) amino)-8-((2,4,6-trichlorophenyl) amino)-9h-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use
CN109069482B (zh) 2016-04-01 2022-04-05 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
WO2018215316A1 (en) 2017-05-22 2018-11-29 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
BR112019024195A2 (pt) 2017-05-22 2020-06-23 Janssen Pharmaceuticals, Inc. Composto e composição farmacêutica de derivados de indolina substituídos como inibidores da replicação viral da dengue
KR20200062270A (ko) 2017-10-04 2020-06-03 셀진 코포레이션 시스-4-[2-{[(3s,4r)-3-플루오로옥산-4-일]아미노}-8-(2,4,6-트리클로로아닐리노)-9h-퓨린-9-일]-1-메틸시클로헥산-1-카르복스아미드의 조성물 및 이용 방법
WO2019195471A1 (en) 2018-04-03 2019-10-10 Blueprint Medicines Corporation Ret inhibitor for use in treating cancer having a ret alteration
WO2020033838A2 (en) * 2018-08-10 2020-02-13 Blueprint Medicines Corporation Treatment of egfr-mutant cancer
TWI849107B (zh) * 2019-04-16 2024-07-21 美商維瓦斯治療公司 雙環化合物
US12122787B2 (en) 2019-09-20 2024-10-22 Shanghai Jemincare Pharmaceuticals Co., Ltd Fused pyridone compound, and preparation method therefor and use thereof
CN115279368B (zh) * 2019-11-20 2024-05-24 维瓦斯治疗公司 杂芳基化合物
CA3183728A1 (en) 2020-05-29 2021-12-02 Blueprint Medicines Corporation Solid forms of pralsetinib
TW202202498A (zh) * 2020-07-01 2022-01-16 大陸商四川海思科製藥有限公司 一種並環雜環衍生物及其在醫藥上的應用
KR102664454B1 (ko) * 2021-08-03 2024-05-09 한국생명공학연구원 젬시타빈에 대한 민감성 향상을 위한 신규 표적 및 이의 활용
CN114681456A (zh) * 2022-02-23 2022-07-01 中山大学附属第六医院 Plx3397在结直肠癌的治疗中的用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006076595A1 (en) * 2005-01-13 2006-07-20 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391485A (en) 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
JPS63500636A (ja) 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするdna
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
IL99699A (en) 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
FI109088B (fi) 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
ATE457313T1 (de) 2003-12-23 2010-02-15 Novartis Ag Bicyclische heterocyclische p-38-kinase- inhibitoren
US7759342B2 (en) 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
US7521446B2 (en) 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
WO2007030438A2 (en) * 2005-09-06 2007-03-15 Pharmacopeia, Inc. Aminopurine derivatives for treating neurodegenerative diseases
WO2007062338A2 (en) 2005-11-18 2007-05-31 Astrazeneca Ab Solid formulations
CA2652263A1 (en) 2006-05-12 2007-11-22 Myriad Genetics, Inc. Therapeutic compounds and their use in cancer
JO3235B1 (ar) 2006-05-26 2018-03-08 Astex Therapeutics Ltd مركبات بيررولوبيريميدين و استعمالاتها
RU2496780C2 (ru) 2006-10-27 2013-10-27 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Твердые формы
WO2009130342A1 (es) 2008-04-23 2009-10-29 Farmasierra Manufacturing, S.L. Formulación farmacéutica mejorada a base de ibuprofeno y codeína
WO2011071491A1 (en) 2009-12-09 2011-06-16 Signal Pharmaceuticals, Llc Isotopologues of 4-[9-(tetrahydro-furan-3-yl)-8-(2, 4, 6- trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol
US8680076B2 (en) 2010-10-25 2014-03-25 Signal Pharmaceuticals, Llc Methods of treatment, improvement and prevention using haloaryl substituted aminopurines
US8603527B2 (en) 2010-10-25 2013-12-10 Signal Pharmaceuticals, Llc Pharmaceutical formulations of a substituted diaminopurine
US9466042B2 (en) 2012-01-24 2016-10-11 International Business Machines Corporation Facilitating the design of information technology solutions
US20160082015A1 (en) 2013-04-18 2016-03-24 President And Fellows Of Harvard College Methods, compositions and kits for promoting motor neuron survival and treating and diagnosing neurodegenerative disorders
GB201321737D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
ES2980464T3 (es) * 2014-10-06 2024-10-01 Signal Pharm Llc Productos intermedios sintéticos útiles para preparar compuestos de aminopurina sustituidos
CN115131834A (zh) * 2015-08-13 2022-09-30 小米科技有限责任公司 移动设备及其屏幕模组、指纹采集方法、装置及电子设备
WO2017173218A1 (en) * 2016-04-01 2017-10-05 Signal Pharmaceuticals, Llc Solid forms of (1s,4s)-4-(2-(((3s4r)-3-fluorotetrahydro-2h-pyran-4-yl) amino)-8-((2,4,6-trichlorophenyl) amino)-9h-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006076595A1 (en) * 2005-01-13 2006-07-20 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

Also Published As

Publication number Publication date
MX2018011992A (es) 2019-01-24
AU2017241837A1 (en) 2018-10-25
EP3436018A1 (en) 2019-02-06
SG11201808388QA (en) 2018-10-30
MX379513B (es) 2025-03-11
BR112018070163A2 (pt) 2019-01-29
IL262007B (en) 2022-12-01
EA201892229A1 (ru) 2019-03-29
CL2018002787A1 (es) 2019-01-18
JP7014731B2 (ja) 2022-02-01
US10576085B2 (en) 2020-03-03
KR102356433B1 (ko) 2022-01-27
NZ746554A (en) 2023-03-31
US20170281633A1 (en) 2017-10-05
IL262007A (en) 2018-10-31
KR20180126497A (ko) 2018-11-27
EP3436018A4 (en) 2019-11-13
CN109069512B (zh) 2022-06-14
AU2017241837B2 (en) 2021-07-22
CA3018986A1 (en) 2017-10-05
SG10202009589UA (en) 2020-10-29
CN109069512A (zh) 2018-12-21
JP2019510066A (ja) 2019-04-11
WO2017173206A1 (en) 2017-10-05
EA039392B1 (ru) 2022-01-21

Similar Documents

Publication Publication Date Title
US10576085B2 (en) Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
TWI415610B (zh) 3-(4-胺基-1-酮基-1,3-二氫-異吲哚-2-基)-哌啶-2,6-二酮在治療特定白血病之用途
US10973822B2 (en) Combination therapy for treatment of hematological cancers and solid tumors
US10004735B2 (en) Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines
US9782427B2 (en) Methods for treating cancer using TOR kinase inhibitor combination therapy
CN108430473B (zh) 抗增殖化合物以及其药物组合物和用途
TW201242601A (en) Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione
US10513519B2 (en) Solid forms of (1S,4S)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use
CA2908954A1 (en) Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer
US7893045B2 (en) Methods for treating lymphomas in certain patient populations and screening patients for said therapy
HK40033324A (en) Isotopologues of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
HK1233943B (en) Methods for treating cancer using tor kinase inhibitor combination therapy
HK1233943A1 (en) Methods for treating cancer using tor kinase inhibitor combination therapy
NZ629860B (en) Methods for treating cancer using tor kinase inhibitor combination therapy