JP6997627B2 - Ｃｄｋ９阻害剤としての多環式アミド誘導体 - Google Patents

Ｃｄｋ９阻害剤としての多環式アミド誘導体 Download PDF

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Publication number
JP6997627B2
JP6997627B2 JP2017567737A JP2017567737A JP6997627B2 JP 6997627 B2 JP6997627 B2 JP 6997627B2 JP 2017567737 A JP2017567737 A JP 2017567737A JP 2017567737 A JP2017567737 A JP 2017567737A JP 6997627 B2 JP6997627 B2 JP 6997627B2
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pyridine
chloro
cyclohexanecarboxamide
dihydro
acetamide
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Japanese (ja)
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JP2018522869A5 (https=
JP2018522869A (ja
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カート・ゴードン・パイク
ベルナール・クリストフ・バルラーム
ジャネット・ホーキンス
クリストファー・デ・サビ
メリッサ・メアリー・バズビンダー
アレクサンダー・ハード
ミッシェル・ラム
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
JP2017567737A 2015-06-29 2016-06-27 Ｃｄｋ９阻害剤としての多環式アミド誘導体 Active JP6997627B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562185852P 2015-06-29 2015-06-29
US62/185,852 2015-06-29
PCT/EP2016/064899 WO2017001354A1 (en) 2015-06-29 2016-06-27 Polycyclic amide derivatives as cdk9 inhibitors

Publications (3)

Publication Number Publication Date
JP2018522869A JP2018522869A (ja) 2018-08-16
JP2018522869A5 JP2018522869A5 (https=) 2019-07-18
JP6997627B2 true JP6997627B2 (ja) 2022-01-17

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US (4) US9845331B2 (https=)
EP (2) EP3539961B1 (https=)
JP (1) JP6997627B2 (https=)
KR (1) KR102663113B1 (https=)
CN (1) CN107873028B (https=)
AR (1) AR105179A1 (https=)
AU (1) AU2016286200B2 (https=)
BR (1) BR122019013677B1 (https=)
CA (1) CA2989499C (https=)
CL (1) CL2017003306A1 (https=)
CO (1) CO2017013713A2 (https=)
CR (2) CR20170596A (https=)
CY (2) CY1122111T1 (https=)
DK (2) DK3313838T3 (https=)
DO (2) DOP2017000295A (https=)
EA (1) EA035383B1 (https=)
ES (2) ES2728356T3 (https=)
HR (2) HRP20211970T1 (https=)
HU (2) HUE057343T2 (https=)
IL (1) IL256393B (https=)
LT (2) LT3313838T (https=)
ME (1) ME03404B (https=)
MX (1) MX371034B (https=)
MY (1) MY201673A (https=)
NI (1) NI201700174A (https=)
PE (1) PE20180530A1 (https=)
PH (1) PH12017502334B1 (https=)
PL (2) PL3313838T3 (https=)
PT (2) PT3539961T (https=)
RS (2) RS58712B1 (https=)
SI (2) SI3313838T1 (https=)
SM (2) SMT201900298T1 (https=)
SV (1) SV2017005598A (https=)
TN (1) TN2017000486A1 (https=)
TR (1) TR201909286T4 (https=)
TW (1) TWI723028B (https=)
WO (1) WO2017001354A1 (https=)
ZA (1) ZA201800563B (https=)

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WO2019058348A1 (en) 2017-09-25 2019-03-28 Astrazeneca Ab COMBINATION OF A BTK INHIBITOR AND A CDK9 INHIBITOR TO TREAT CANCER
WO2019074748A1 (en) * 2017-10-09 2019-04-18 Merck Sharp & Dohme Corp. NOVEL SUBSTITUTED PHENYL-OXETANE AND PHENYLTETRAHYDROFURAN COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO)
CN108129288B (zh) * 2017-12-27 2021-01-22 上海毕得医药科技股份有限公司 一种反式-3-羟基环丁基甲酸的合成方法
TW202344250A (zh) 2018-11-14 2023-11-16 瑞典商阿斯特捷利康公司 治療癌症之方法
US20220267321A1 (en) * 2019-06-27 2022-08-25 Medshine Discovery Inc. Azaindole pyrazole compounds as cdk9 inhibitors
KR20220079851A (ko) * 2019-09-11 2022-06-14 프렐루드 테라퓨틱스, 인코포레이티드 Cdk 억제제 및 약제로서의 이의 용도
US12570607B2 (en) 2019-12-09 2026-03-10 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Compound as cyclin-dependent kinase 9 inhibitor and use thereof
EP4140997A4 (en) * 2020-05-12 2023-09-06 Suzhou Alphama Biotechnology Co., Ltd. PYRIDINE ACETAMIDE DERIVATIVE AS CDK INHIBITOR, PREPARATION METHOD AND USE THEREOF
EP4141004A4 (en) * 2020-05-12 2023-08-23 Suzhou Alphama Biotechnology Co., Ltd. POLYCYCLIC AMIDE DERIVATIVE SERVING AS A CDK9 INHIBITOR, METHOD FOR PREPARING IT AND ITS USE
EP4171654A1 (en) 2020-06-24 2023-05-03 AstraZeneca UK Limited Combination of antibody-drug conjugate and cdk9 inhibitor
US20230271942A1 (en) 2020-08-07 2023-08-31 Pharmablock Sciences (Nanjing), Inc. Cdk9 inhibitor and use thereof
TWI809330B (zh) * 2020-11-20 2023-07-21 大陸商勁方醫藥科技(上海)有限公司 Cdk9抑制劑的多晶型物及其製法和用途
WO2022247785A1 (zh) * 2021-05-24 2022-12-01 石药集团中奇制药技术（石家庄）有限公司 一种周期蛋白依赖性激酶9抑制剂的用途
WO2022247796A1 (zh) * 2021-05-24 2022-12-01 石药集团中奇制药技术（石家庄）有限公司 周期蛋白依赖性激酶9抑制剂的用途
WO2023284775A1 (zh) * 2021-07-14 2023-01-19 上海海雁医药科技有限公司 吡唑衍生物及其中间体和制备方法
CN115703738B (zh) * 2021-08-16 2024-06-21 中国科学院上海药物研究所 含2-芳杂环取代的脲类化合物、其制备方法和用途
KR20240137563A (ko) * 2021-12-23 2024-09-20 카톨리에케 유니버시테이트 루벤 Yap/taz-tead 억제를 위한 테트라히드로피라졸로피리미딘 및 관련 유사체
EP4574823A1 (en) 2022-08-17 2025-06-25 Korea Research Institute of Chemical Technology Compounds for inhibiting or decomposing cdk2 and/or cdk9, and medicinal uses thereof
CN117659022A (zh) * 2022-09-06 2024-03-08 苏州阿尔脉生物科技有限公司 脲基取代吡啶类化合物、包含其的药物组合物及其医药用途
US20240360075A1 (en) * 2023-04-19 2024-10-31 Alcon Inc. N-substituted c6 cyclyl carboxamide compounds and uses thereof
WO2025076115A1 (en) * 2023-10-02 2025-04-10 Prelude Therapeutics Incorporated Cdk inhibitors and their use as pharmaceuticals
WO2026024933A1 (en) * 2024-07-24 2026-01-29 Prelude Therapeutics Incorporated Cdk inhibitors and their use as pharmaceuticals

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WO2011101640A1 (en) 2010-02-19 2011-08-25 Medical Research Council Technology Fused heterocyclic compounds for use in the treatment of malaria
WO2011124539A1 (de) 2010-04-07 2011-10-13 Bayer Cropscience Ag Bicyclische pyridinylpyrazole
WO2012101063A1 (en) 2011-01-28 2012-08-02 Novartis Ag N-acyl pyridine biaryl compounds and their uses
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WO2011101640A1 (en) 2010-02-19 2011-08-25 Medical Research Council Technology Fused heterocyclic compounds for use in the treatment of malaria
WO2011124539A1 (de) 2010-04-07 2011-10-13 Bayer Cropscience Ag Bicyclische pyridinylpyrazole
WO2012101063A1 (en) 2011-01-28 2012-08-02 Novartis Ag N-acyl pyridine biaryl compounds and their uses
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MX2017016244A (es) 2018-04-20
US20210171541A1 (en) 2021-06-10
CY1125066T1 (el) 2023-03-24
NI201700174A (es) 2018-10-19
CR20170596A (es) 2018-07-04
EP3539961B1 (en) 2021-10-06
EA201890094A1 (ru) 2018-07-31
RS62781B1 (sr) 2022-01-31
SI3539961T1 (sl) 2022-02-28
CA2989499C (en) 2023-10-31
TN2017000486A1 (en) 2019-04-12
ME03404B (me) 2020-01-20
RS58712B1 (sr) 2019-06-28
AU2016286200B2 (en) 2018-10-04
US11352369B2 (en) 2022-06-07
DOP2017000295A (es) 2017-12-31
WO2017001354A1 (en) 2017-01-05
BR122019013677B1 (pt) 2024-01-02
HUE057343T2 (hu) 2022-05-28
CL2017003306A1 (es) 2018-06-29
CR20210297A (es) 2021-09-29
TW201718573A (zh) 2017-06-01
PT3313838T (pt) 2019-06-24
SMT201900298T1 (it) 2019-07-11
DOP2018000207A (es) 2018-10-15
CN107873028B (zh) 2021-02-02
ES2902148T3 (es) 2022-03-25
HRP20211970T1 (hr) 2022-03-18
HUE043440T2 (hu) 2019-08-28
MX371034B (es) 2020-01-13
TR201909286T4 (tr) 2019-07-22
MY201673A (en) 2024-03-12
DK3539961T3 (da) 2022-01-03
US20160376287A1 (en) 2016-12-29
JP2018522869A (ja) 2018-08-16
US20220340592A1 (en) 2022-10-27
PL3313838T3 (pl) 2019-08-30
US9845331B2 (en) 2017-12-19
PH12017502334A1 (en) 2018-06-25
ZA201800563B (en) 2022-08-31
EA035383B1 (ru) 2020-06-04
EP3313838A1 (en) 2018-05-02
IL256393B (en) 2021-12-01
TWI723028B (zh) 2021-04-01
LT3539961T (lt) 2021-12-27
EP3539961A1 (en) 2019-09-18
US20180093998A1 (en) 2018-04-05
AR105179A1 (es) 2017-09-13
EP3313838B1 (en) 2019-04-03
DK3313838T3 (da) 2019-06-11
PE20180530A1 (es) 2018-03-19
PT3539961T (pt) 2021-12-20
BR112017027394A2 (pt) 2018-11-06
CY1122111T1 (el) 2020-11-25
SMT202200005T1 (it) 2022-03-21
KR102663113B1 (ko) 2024-05-02
US10717746B2 (en) 2020-07-21
CA2989499A1 (en) 2017-01-05
SI3313838T1 (sl) 2019-06-28
AU2016286200A1 (en) 2018-02-08
CO2017013713A2 (es) 2018-03-28
PL3539961T3 (pl) 2022-02-14
ES2728356T3 (es) 2019-10-23
HRP20190748T1 (hr) 2019-06-14
IL256393A (en) 2018-02-28
LT3313838T (lt) 2019-06-10
PH12017502334B1 (en) 2023-05-26
CN107873028A (zh) 2018-04-03
SV2017005598A (es) 2018-02-23
KR20180021830A (ko) 2018-03-05

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