JP6997095B2 - 抗菌性化合物およびその使用 - Google Patents
抗菌性化合物およびその使用 Download PDFInfo
- Publication number
- JP6997095B2 JP6997095B2 JP2018546705A JP2018546705A JP6997095B2 JP 6997095 B2 JP6997095 B2 JP 6997095B2 JP 2018546705 A JP2018546705 A JP 2018546705A JP 2018546705 A JP2018546705 A JP 2018546705A JP 6997095 B2 JP6997095 B2 JP 6997095B2
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- dimethylamino
- methoxyquinoline
- bromo
- etoac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 COc(c(*)cc1c2)nc1ccc2Br Chemical compound COc(c(*)cc1c2)nc1ccc2Br 0.000 description 13
- UUZNNLAGACPGPQ-UHFFFAOYSA-N BrCc1c2OCCOc2ccc1 Chemical compound BrCc1c2OCCOc2ccc1 UUZNNLAGACPGPQ-UHFFFAOYSA-N 0.000 description 1
- YBARVXOICUUPIZ-UHFFFAOYSA-N CC(C)Oc(cc1CO)cnc1OC Chemical compound CC(C)Oc(cc1CO)cnc1OC YBARVXOICUUPIZ-UHFFFAOYSA-N 0.000 description 1
- KUDOTPINGRXDIQ-UHFFFAOYSA-N CC(C)Oc(cn1)cc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c2cc3cc(C#N)ccc3nc2OC)c1OC Chemical compound CC(C)Oc(cn1)cc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c2cc3cc(C#N)ccc3nc2OC)c1OC KUDOTPINGRXDIQ-UHFFFAOYSA-N 0.000 description 1
- GJSXJVVQQIFYMK-UHFFFAOYSA-N CC(C)[Si+](C(C)C)(C(C)C)Oc(c(OC)n1)cc(C=O)c1OC Chemical compound CC(C)[Si+](C(C)C)(C(C)C)Oc(c(OC)n1)cc(C=O)c1OC GJSXJVVQQIFYMK-UHFFFAOYSA-N 0.000 description 1
- QEKMLNXJBHKILA-UHFFFAOYSA-N CC(Cc1c2)(C(c3ccc(C)[s]3)O)C(OC)=Nc1ccc2Br Chemical compound CC(Cc1c2)(C(c3ccc(C)[s]3)O)C(OC)=Nc1ccc2Br QEKMLNXJBHKILA-UHFFFAOYSA-N 0.000 description 1
- JYBKIRQDEMJQOB-UHFFFAOYSA-N CC(c1c2[o]ccc2ccc1)=O Chemical compound CC(c1c2[o]ccc2ccc1)=O JYBKIRQDEMJQOB-UHFFFAOYSA-N 0.000 description 1
- VOVFRKRSDJDTPW-UHFFFAOYSA-N CCN(CC)c1ccc(C(C(CCN(C)C)(c2cc(OCC)nc(OCC)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)cn1 Chemical compound CCN(CC)c1ccc(C(C(CCN(C)C)(c2cc(OCC)nc(OCC)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)cn1 VOVFRKRSDJDTPW-UHFFFAOYSA-N 0.000 description 1
- AVWCXYQYVWPERI-UHFFFAOYSA-N CCN(CC)c1ncc(Cc2cc(cc(cc3)Br)c3nc2OC)cc1 Chemical compound CCN(CC)c1ncc(Cc2cc(cc(cc3)Br)c3nc2OC)cc1 AVWCXYQYVWPERI-UHFFFAOYSA-N 0.000 description 1
- SLNYGILVYLFNAF-UHFFFAOYSA-N CCOCOc(c(OC)n1)c(C=O)cc1OC Chemical compound CCOCOc(c(OC)n1)c(C=O)cc1OC SLNYGILVYLFNAF-UHFFFAOYSA-N 0.000 description 1
- WSVCJSPBEYKRPS-UHFFFAOYSA-N CCOCOc(c(OC)n1)ccc1OC Chemical compound CCOCOc(c(OC)n1)ccc1OC WSVCJSPBEYKRPS-UHFFFAOYSA-N 0.000 description 1
- GRKDLFVZKSGRFH-UHFFFAOYSA-N CCOc1cc(C(CCN(C)C)(C(c(cccc2OC)c2OC)c(cc(cc(cc2)Br)c2n2)c2OC)O)cc([O](C)CC)n1 Chemical compound CCOc1cc(C(CCN(C)C)(C(c(cccc2OC)c2OC)c(cc(cc(cc2)Br)c2n2)c2OC)O)cc([O](C)CC)n1 GRKDLFVZKSGRFH-UHFFFAOYSA-N 0.000 description 1
- CGCWULXCSIHDPY-UHFFFAOYSA-N CCOc1cc(C(CCN(C)C)=O)cc(OC)n1 Chemical compound CCOc1cc(C(CCN(C)C)=O)cc(OC)n1 CGCWULXCSIHDPY-UHFFFAOYSA-N 0.000 description 1
- PBDMLTFIPMQJDZ-UHFFFAOYSA-N CCOc1cc(C(CCN(C)C)=O)cc(OCC)n1 Chemical compound CCOc1cc(C(CCN(C)C)=O)cc(OCC)n1 PBDMLTFIPMQJDZ-UHFFFAOYSA-N 0.000 description 1
- QXDSPRQZLQJYGF-UHFFFAOYSA-N CCOc1cc(CBr)cc(OCC)n1 Chemical compound CCOc1cc(CBr)cc(OCC)n1 QXDSPRQZLQJYGF-UHFFFAOYSA-N 0.000 description 1
- FKDFYLOGSRSXDF-UHFFFAOYSA-O CCOc1cc(CBr)cc([OH2+])n1 Chemical compound CCOc1cc(CBr)cc([OH2+])n1 FKDFYLOGSRSXDF-UHFFFAOYSA-O 0.000 description 1
- FLLVJNVPFCSGDA-UHFFFAOYSA-N CCOc1cc(Cc2cc3cc(Br)ccc3nc2OC)cc(OCC)n1 Chemical compound CCOc1cc(Cc2cc3cc(Br)ccc3nc2OC)cc(OCC)n1 FLLVJNVPFCSGDA-UHFFFAOYSA-N 0.000 description 1
- JZQVZKDVVKWXGA-UHFFFAOYSA-N CCOc1nc(N(C)C)cc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c2cc(cc(cc3)C#N)c3nc2OC)c1 Chemical compound CCOc1nc(N(C)C)cc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c2cc(cc(cc3)C#N)c3nc2OC)c1 JZQVZKDVVKWXGA-UHFFFAOYSA-N 0.000 description 1
- PDCJFJABVXOBGH-UHFFFAOYSA-N CCOc1nc(OC(C)C)cc(C(CCN(C)[O](C)c2cc3cc(OC)n2)(C3c(cc(cc(cc2)Br)c2n2)c2OC)O)c1 Chemical compound CCOc1nc(OC(C)C)cc(C(CCN(C)[O](C)c2cc3cc(OC)n2)(C3c(cc(cc(cc2)Br)c2n2)c2OC)O)c1 PDCJFJABVXOBGH-UHFFFAOYSA-N 0.000 description 1
- CLVXIJHAJFAIAX-UHFFFAOYSA-N CCOc1nc(OC)cc(C(CCN(C)C)(C(c(ccnc2OC)c2OC)c(cc(cc(cc2)Br)c2n2)c2OC)O)c1 Chemical compound CCOc1nc(OC)cc(C(CCN(C)C)(C(c(ccnc2OC)c2OC)c(cc(cc(cc2)Br)c2n2)c2OC)O)c1 CLVXIJHAJFAIAX-UHFFFAOYSA-N 0.000 description 1
- DKLFKLMGQGYGBE-UHFFFAOYSA-N CCOc1nc(OC)cc(CBr)c1 Chemical compound CCOc1nc(OC)cc(CBr)c1 DKLFKLMGQGYGBE-UHFFFAOYSA-N 0.000 description 1
- BHWOBXCTHWJLTA-UHFFFAOYSA-N CCOc1nc(OC)cc(Cc(cc(cc(cc2)Br)c2n2)c2OC)c1 Chemical compound CCOc1nc(OC)cc(Cc(cc(cc(cc2)Br)c2n2)c2OC)c1 BHWOBXCTHWJLTA-UHFFFAOYSA-N 0.000 description 1
- XQPKVFYSVDNOKG-UHFFFAOYSA-O CCOc1nc([OH2+])cc(CO)c1 Chemical compound CCOc1nc([OH2+])cc(CO)c1 XQPKVFYSVDNOKG-UHFFFAOYSA-O 0.000 description 1
- XBZAYCPUGGMPLZ-UHFFFAOYSA-N CCSc1cc(C(N(C)OC)=O)cc(SCC)n1 Chemical compound CCSc1cc(C(N(C)OC)=O)cc(SCC)n1 XBZAYCPUGGMPLZ-UHFFFAOYSA-N 0.000 description 1
- LCHJJKRBBVKSEQ-UHFFFAOYSA-N CCSc1cc(C(O)=O)cc(SCC)n1 Chemical compound CCSc1cc(C(O)=O)cc(SCC)n1 LCHJJKRBBVKSEQ-UHFFFAOYSA-N 0.000 description 1
- VRDUTNGRWWPFRY-UHFFFAOYSA-N CCSc1cc(C(OC)=O)cc(N(C)C)n1 Chemical compound CCSc1cc(C(OC)=O)cc(N(C)C)n1 VRDUTNGRWWPFRY-UHFFFAOYSA-N 0.000 description 1
- ROEIEGUZGHJAOQ-UHFFFAOYSA-N CCSc1cc(CO)cc(N(C)C)n1 Chemical compound CCSc1cc(CO)cc(N(C)C)n1 ROEIEGUZGHJAOQ-UHFFFAOYSA-N 0.000 description 1
- MJSNHGRZXJGYJH-UHFFFAOYSA-N CCSc1cc(Cc(cc(cc(cc2)Br)c2n2)c2OC)cc(N(C)C)n1 Chemical compound CCSc1cc(Cc(cc(cc(cc2)Br)c2n2)c2OC)cc(N(C)C)n1 MJSNHGRZXJGYJH-UHFFFAOYSA-N 0.000 description 1
- DNPPLGHFXZNEQO-UHFFFAOYSA-N CN(C(c(cc(nc1OC)OC)c1OC)=O)OC Chemical compound CN(C(c(cc(nc1OC)OC)c1OC)=O)OC DNPPLGHFXZNEQO-UHFFFAOYSA-N 0.000 description 1
- LYKMXQJDBATYAF-UHFFFAOYSA-N CN(C(c(cc1)cnc1F)=O)OC Chemical compound CN(C(c(cc1)cnc1F)=O)OC LYKMXQJDBATYAF-UHFFFAOYSA-N 0.000 description 1
- SKSWHZGKTFRAEV-UHFFFAOYSA-N CN(C(c1c(CCC2)c2ccc1)=O)OC Chemical compound CN(C(c1c(CCC2)c2ccc1)=O)OC SKSWHZGKTFRAEV-UHFFFAOYSA-N 0.000 description 1
- LJENFWQECQEFCQ-UHFFFAOYSA-N CN(C(c1cc(OC)nc([PoH])c1)=O)OC Chemical compound CN(C(c1cc(OC)nc([PoH])c1)=O)OC LJENFWQECQEFCQ-UHFFFAOYSA-N 0.000 description 1
- UXTXQWKLDHHNFT-UHFFFAOYSA-N CN(C(c1cc(SC)nc(SC)c1)=O)OC Chemical compound CN(C(c1cc(SC)nc(SC)c1)=O)OC UXTXQWKLDHHNFT-UHFFFAOYSA-N 0.000 description 1
- HHDDKDPLFXIPBX-UHFFFAOYSA-N CN(C)CCC(C(c(cc(nc1OC)OC)c1OC)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O Chemical compound CN(C)CCC(C(c(cc(nc1OC)OC)c1OC)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O HHDDKDPLFXIPBX-UHFFFAOYSA-N 0.000 description 1
- WPESJVVJFUKWOM-UHFFFAOYSA-N CN(C)CCC(C(c(cc1OC)cnc1OC)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cccc(F)c1)O Chemical compound CN(C)CCC(C(c(cc1OC)cnc1OC)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cccc(F)c1)O WPESJVVJFUKWOM-UHFFFAOYSA-N 0.000 description 1
- PEJQWNBUKMHGGO-UHFFFAOYSA-N CN(C)CCC(C(c(ccnc1OC)c1F)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O Chemical compound CN(C)CCC(C(c(ccnc1OC)c1F)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O PEJQWNBUKMHGGO-UHFFFAOYSA-N 0.000 description 1
- USNCVNSQTQHAQU-UHFFFAOYSA-N CN(C)CCC(C(c(ccnc1OC)c1OC)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC2CCC2)nc(OC)c1)O Chemical compound CN(C)CCC(C(c(ccnc1OC)c1OC)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC2CCC2)nc(OC)c1)O USNCVNSQTQHAQU-UHFFFAOYSA-N 0.000 description 1
- FMFPRJPIQQQMRD-UHFFFAOYSA-N CN(C)CCC(C(c(ccnc1OC)c1OC)c1cc(cc(cc2)Br)c2nc1OC)(c1cc(C=CCC2)c2[o]1)O Chemical compound CN(C)CCC(C(c(ccnc1OC)c1OC)c1cc(cc(cc2)Br)c2nc1OC)(c1cc(C=CCC2)c2[o]1)O FMFPRJPIQQQMRD-UHFFFAOYSA-N 0.000 description 1
- DCPOTLPMRKZSLN-UHFFFAOYSA-N CN(C)CCC(C(c(ccnc1OC)c1OC)c1cc(cc(cc2)Br)c2nc1OC)(c1cc(N(C)C)nc(OC)c1)O Chemical compound CN(C)CCC(C(c(ccnc1OC)c1OC)c1cc(cc(cc2)Br)c2nc1OC)(c1cc(N(C)C)nc(OC)c1)O DCPOTLPMRKZSLN-UHFFFAOYSA-N 0.000 description 1
- PKNPBWZCQZNHOR-UHFFFAOYSA-N CN(C)CCC(C(c1cc(F)ccc1)c(cc(cc(cc1)C#N)c1n1)c1OC)(c1cccc2c1[o]cc2)O Chemical compound CN(C)CCC(C(c1cc(F)ccc1)c(cc(cc(cc1)C#N)c1n1)c1OC)(c1cccc2c1[o]cc2)O PKNPBWZCQZNHOR-UHFFFAOYSA-N 0.000 description 1
- MTTBYSKKRFRWGK-UHFFFAOYSA-N CN(C)CCC(C(c1cc(F)ccc1)c1cc2cc(Br)ccc2nc1OC)(c1cccc2c1[o]cc2)O Chemical compound CN(C)CCC(C(c1cc(F)ccc1)c1cc2cc(Br)ccc2nc1OC)(c1cccc2c1[o]cc2)O MTTBYSKKRFRWGK-UHFFFAOYSA-N 0.000 description 1
- GAWQVQBUGWQKLT-UHFFFAOYSA-N CN(C)CCC(C(c1cc(F)ccc1)c1cc2cc(C#N)ccc2nc1OC)(c1cc(cccc2)c2[o]1)O Chemical compound CN(C)CCC(C(c1cc(F)ccc1)c1cc2cc(C#N)ccc2nc1OC)(c1cc(cccc2)c2[o]1)O GAWQVQBUGWQKLT-UHFFFAOYSA-N 0.000 description 1
- OYDTTXUPMJGJQF-UHFFFAOYSA-N CN(C)CCC(C(c1cc(SC)nc(SC)c1)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O Chemical compound CN(C)CCC(C(c1cc(SC)nc(SC)c1)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O OYDTTXUPMJGJQF-UHFFFAOYSA-N 0.000 description 1
- JWUWQXHZWRUUJY-UHFFFAOYSA-N CN(C)CCC(C(c1cccc(F)c1)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O Chemical compound CN(C)CCC(C(c1cccc(F)c1)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O JWUWQXHZWRUUJY-UHFFFAOYSA-N 0.000 description 1
- VHSYJCCMBKWHLS-UHFFFAOYSA-N CN(C)CCC(C(c1cccc2c1CCC2)c1cc2cc(Br)ccc2nc1OC)(c1cc(OC)nc(OC)c1)O Chemical compound CN(C)CCC(C(c1cccc2c1CCC2)c1cc2cc(Br)ccc2nc1OC)(c1cc(OC)nc(OC)c1)O VHSYJCCMBKWHLS-UHFFFAOYSA-N 0.000 description 1
- SIMUFWJFAOUTGX-UHFFFAOYSA-N CN(C)CCC(C(c1ccccc1)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cccc2c1[o]cc2)O Chemical compound CN(C)CCC(C(c1ccccc1)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cccc2c1[o]cc2)O SIMUFWJFAOUTGX-UHFFFAOYSA-N 0.000 description 1
- KEAJHYWOWIQGHC-UHFFFAOYSA-N CN(C)CCC(C(c1ccnc(OC)c1OC)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC(F)F)c1)O Chemical compound CN(C)CCC(C(c1ccnc(OC)c1OC)c(cc(cc(cc1)Br)c1n1)c1OC)(c1cc(OC)nc(OC(F)F)c1)O KEAJHYWOWIQGHC-UHFFFAOYSA-N 0.000 description 1
- FWJRLORSMAIQJP-UHFFFAOYSA-N CN(C)CCC(c1cc(OC)nc(N(C)C)c1)=O Chemical compound CN(C)CCC(c1cc(OC)nc(N(C)C)c1)=O FWJRLORSMAIQJP-UHFFFAOYSA-N 0.000 description 1
- NRMPBFXRCREGOX-UHFFFAOYSA-N CN(C)CCC(c1cc(OC)nc(OC(F)F)c1)=O Chemical compound CN(C)CCC(c1cc(OC)nc(OC(F)F)c1)=O NRMPBFXRCREGOX-UHFFFAOYSA-N 0.000 description 1
- ZVSBRYDLABOZNT-UHFFFAOYSA-N CN(C)CCC(c1cc(OC)nc(OC2CCC2)c1)=O Chemical compound CN(C)CCC(c1cc(OC)nc(OC2CCC2)c1)=O ZVSBRYDLABOZNT-UHFFFAOYSA-N 0.000 description 1
- MPQBIRXWTJCLQL-UHFFFAOYSA-N CN(C)CCC(c1ccc2[o]ccc2c1)=O Chemical compound CN(C)CCC(c1ccc2[o]ccc2c1)=O MPQBIRXWTJCLQL-UHFFFAOYSA-N 0.000 description 1
- SRWYIFOWJPYJRF-UHFFFAOYSA-N CN(CCC(C(c1ccccc1)c(cc(cc(cc1)Br)c1n1)c1OC)(c1ccc2)O)c3cc1c2[o]3 Chemical compound CN(CCC(C(c1ccccc1)c(cc(cc(cc1)Br)c1n1)c1OC)(c1ccc2)O)c3cc1c2[o]3 SRWYIFOWJPYJRF-UHFFFAOYSA-N 0.000 description 1
- PXHXRBDNBNBGCZ-UHFFFAOYSA-N CN(CCC(c1cc(OC)nc(OC)c1)=O)Cc(ccc(OC)c1)c1OC Chemical compound CN(CCC(c1cc(OC)nc(OC)c1)=O)Cc(ccc(OC)c1)c1OC PXHXRBDNBNBGCZ-UHFFFAOYSA-N 0.000 description 1
- GROMGTLJTBVEKE-UHFFFAOYSA-N CNC(C1)C1c1ccc(C(OC)=O)c2c1[o]cc2 Chemical compound CNC(C1)C1c1ccc(C(OC)=O)c2c1[o]cc2 GROMGTLJTBVEKE-UHFFFAOYSA-N 0.000 description 1
- JHGXRBVWKRCVQH-UHFFFAOYSA-N CNCCC(C(c1cc(F)ccc1)c(cc(cc(cc1)[Br]=C)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O Chemical compound CNCCC(C(c1cc(F)ccc1)c(cc(cc(cc1)[Br]=C)c1n1)c1OC)(c1cc(OC)nc(OC)c1)O JHGXRBVWKRCVQH-UHFFFAOYSA-N 0.000 description 1
- RGFLVZYIBZFECP-UHFFFAOYSA-N COC(c1cc(OC)nc(OC(F)F)c1)=O Chemical compound COC(c1cc(OC)nc(OC(F)F)c1)=O RGFLVZYIBZFECP-UHFFFAOYSA-N 0.000 description 1
- FTPCVGOKWCGORL-UHFFFAOYSA-N COc(c(C=O)c1)nc(cc2)c1cc2Br Chemical compound COc(c(C=O)c1)nc(cc2)c1cc2Br FTPCVGOKWCGORL-UHFFFAOYSA-N 0.000 description 1
- YHMKQTJNQKEXIF-UHFFFAOYSA-N COc(c(Cc1c2[o]ccc2ccc1)cc1c2)nc1ccc2Br Chemical compound COc(c(Cc1c2[o]ccc2ccc1)cc1c2)nc1ccc2Br YHMKQTJNQKEXIF-UHFFFAOYSA-N 0.000 description 1
- SCJGVHIKRXCYHA-UHFFFAOYSA-N COc(c(Cc1cccc2c1CCCC2)cc1c2)nc1ccc2Br Chemical compound COc(c(Cc1cccc2c1CCCC2)cc1c2)nc1ccc2Br SCJGVHIKRXCYHA-UHFFFAOYSA-N 0.000 description 1
- GBZSNIICNLCJNF-UHFFFAOYSA-N COc(c(Cc1cccc2c1OCCO2)cc1c2)nc1ccc2Br Chemical compound COc(c(Cc1cccc2c1OCCO2)cc1c2)nc1ccc2Br GBZSNIICNLCJNF-UHFFFAOYSA-N 0.000 description 1
- RYPWBUNUTMJPHA-UHFFFAOYSA-N COc(cc1C=O)cnc1OC Chemical compound COc(cc1C=O)cnc1OC RYPWBUNUTMJPHA-UHFFFAOYSA-N 0.000 description 1
- HHWYYUUOGAUCKX-UHFFFAOYSA-N COc(ccc(CO)c1)c1F Chemical compound COc(ccc(CO)c1)c1F HHWYYUUOGAUCKX-UHFFFAOYSA-N 0.000 description 1
- JDMYHYMASPKSTB-UHFFFAOYSA-N COc(cccc1Cc2cc3cc(Br)ccc3nc2OC)c1OC Chemical compound COc(cccc1Cc2cc3cc(Br)ccc3nc2OC)c1OC JDMYHYMASPKSTB-UHFFFAOYSA-N 0.000 description 1
- GTISBCOECGJIDJ-UHFFFAOYSA-N COc(nc1OC)c(C=O)cc1O Chemical compound COc(nc1OC)c(C=O)cc1O GTISBCOECGJIDJ-UHFFFAOYSA-N 0.000 description 1
- LAYHLBIUZFTQRQ-UHFFFAOYSA-N COc(nc1OC)cc(CO)c1OC Chemical compound COc(nc1OC)cc(CO)c1OC LAYHLBIUZFTQRQ-UHFFFAOYSA-N 0.000 description 1
- PAFWZDDYLDEHJJ-UHFFFAOYSA-N COc(nc1OC)cc(Cc2cc3cc(Br)ccc3nc2OC)c1OC Chemical compound COc(nc1OC)cc(Cc2cc3cc(Br)ccc3nc2OC)c1OC PAFWZDDYLDEHJJ-UHFFFAOYSA-N 0.000 description 1
- OLKFDVOVESUMOR-UHFFFAOYSA-N COc1c(Cc([s]c(Cl)n2)c2Cl)cc(cc(cc2)Br)c2n1 Chemical compound COc1c(Cc([s]c(Cl)n2)c2Cl)cc(cc(cc2)Br)c2n1 OLKFDVOVESUMOR-UHFFFAOYSA-N 0.000 description 1
- IWXQHXRFAKXYAG-UHFFFAOYSA-N COc1c(Cc2cc3cc(Br)ccc3nc2OC)cccn1 Chemical compound COc1c(Cc2cc3cc(Br)ccc3nc2OC)cccn1 IWXQHXRFAKXYAG-UHFFFAOYSA-N 0.000 description 1
- OASAVBWVXOHHHC-UHFFFAOYSA-N COc1c(Cc2cccc(F)c2)cc(cc(cc2)Br)c2n1 Chemical compound COc1c(Cc2cccc(F)c2)cc(cc(cc2)Br)c2n1 OASAVBWVXOHHHC-UHFFFAOYSA-N 0.000 description 1
- YPAGNMISIIXEDQ-UHFFFAOYSA-N COc1cc(CBr)cnc1OC Chemical compound COc1cc(CBr)cnc1OC YPAGNMISIIXEDQ-UHFFFAOYSA-N 0.000 description 1
- BPYZYXZVKKIVAH-UHFFFAOYSA-N COc1cc(Cc(cc(cc(cc2)Br)c2n2)c2OC)cnc1OC Chemical compound COc1cc(Cc(cc(cc(cc2)Br)c2n2)c2OC)cnc1OC BPYZYXZVKKIVAH-UHFFFAOYSA-N 0.000 description 1
- KLWYYWVSFYRPLM-UHFFFAOYSA-N COc1ccc(CBr)cc1F Chemical compound COc1ccc(CBr)cc1F KLWYYWVSFYRPLM-UHFFFAOYSA-N 0.000 description 1
- MPWMWLDCFRTXNT-UHFFFAOYSA-N COc1nc(SC)cc(C(O)=O)c1 Chemical compound COc1nc(SC)cc(C(O)=O)c1 MPWMWLDCFRTXNT-UHFFFAOYSA-N 0.000 description 1
- SHSAVLQUXWXULM-UHFFFAOYSA-N COc1nc([PoH])cc(CO)c1 Chemical compound COc1nc([PoH])cc(CO)c1 SHSAVLQUXWXULM-UHFFFAOYSA-N 0.000 description 1
- WNVYXUBBVAZPCZ-UHFFFAOYSA-N CSc1cc(CO)cc(SC)n1 Chemical compound CSc1cc(CO)cc(SC)n1 WNVYXUBBVAZPCZ-UHFFFAOYSA-N 0.000 description 1
- RTGSKFCWCBDDQJ-UHFFFAOYSA-N Cc(ccc1n2)cc1cc(Cc(cccc1OC)c1F)c2OC Chemical compound Cc(ccc1n2)cc1cc(Cc(cccc1OC)c1F)c2OC RTGSKFCWCBDDQJ-UHFFFAOYSA-N 0.000 description 1
- POPGCNPYQNLCJV-UHFFFAOYSA-N Cc(cccc1C(C(CCN(C)C)(c2cc(OC)nc(OC(F)F)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)c1F Chemical compound Cc(cccc1C(C(CCN(C)C)(c2cc(OC)nc(OC(F)F)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)c1F POPGCNPYQNLCJV-UHFFFAOYSA-N 0.000 description 1
- FROBLYAPPGEAGY-UHFFFAOYSA-N Cc(cccc1C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)c1F Chemical compound Cc(cccc1C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)c1F FROBLYAPPGEAGY-UHFFFAOYSA-N 0.000 description 1
- WBEFLULHCBLLMW-UHFFFAOYSA-N Cc(cccc1C(C(CCN(C)C)(c2cc(SC)nc(SC)c2)O)c2cc3cc(C#N)ccc3nc2OC)c1F Chemical compound Cc(cccc1C(C(CCN(C)C)(c2cc(SC)nc(SC)c2)O)c2cc3cc(C#N)ccc3nc2OC)c1F WBEFLULHCBLLMW-UHFFFAOYSA-N 0.000 description 1
- RMJPFZPVFDLLRH-UHFFFAOYSA-N Cc1cc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)c(C)[s]1 Chemical compound Cc1cc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)c(C)[s]1 RMJPFZPVFDLLRH-UHFFFAOYSA-N 0.000 description 1
- HEJXQMJYSQFQOX-UHFFFAOYSA-N Cc1cc(C(CCN(C)C)(C(c(cccc2OC)c2OC)c2cc3cc(Br)ccc3nc2OC)O)cc(C)n1 Chemical compound Cc1cc(C(CCN(C)C)(C(c(cccc2OC)c2OC)c2cc3cc(Br)ccc3nc2OC)O)cc(C)n1 HEJXQMJYSQFQOX-UHFFFAOYSA-N 0.000 description 1
- DRPZOVDIBWJTRV-UHFFFAOYSA-N Cc1cc(C(c2cc(cc(cc3)Br)c3nc2OC)O)c(C)[s]1 Chemical compound Cc1cc(C(c2cc(cc(cc3)Br)c3nc2OC)O)c(C)[s]1 DRPZOVDIBWJTRV-UHFFFAOYSA-N 0.000 description 1
- WVIQPBIZBQRJAD-UHFFFAOYSA-N Cc1cc(C=O)c(C)[s]1 Chemical compound Cc1cc(C=O)c(C)[s]1 WVIQPBIZBQRJAD-UHFFFAOYSA-N 0.000 description 1
- PJSFBUYXIXJCIC-UHFFFAOYSA-N Cc1ccc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)[s]1 Chemical compound Cc1ccc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c(cc(cc(cc2)Br)c2n2)c2OC)[s]1 PJSFBUYXIXJCIC-UHFFFAOYSA-N 0.000 description 1
- HMMNPJRRTFKRJZ-UHFFFAOYSA-N Cc1ccc(C(C(CCNC)(c2cc(OC)nc(OC)c2)O)c2cc3cc(Br)ccc3nc2OC)[s]1 Chemical compound Cc1ccc(C(C(CCNC)(c2cc(OC)nc(OC)c2)O)c2cc3cc(Br)ccc3nc2OC)[s]1 HMMNPJRRTFKRJZ-UHFFFAOYSA-N 0.000 description 1
- IZDJHINCBALCFL-UHFFFAOYSA-N Cc1cccc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c2cc3cc(Br)ccc3nc2OC)c1 Chemical compound Cc1cccc(C(C(CCN(C)C)(c2cc(OC)nc(OC)c2)O)c2cc3cc(Br)ccc3nc2OC)c1 IZDJHINCBALCFL-UHFFFAOYSA-N 0.000 description 1
- BZLIAEVSPAPOPT-UHFFFAOYSA-N ClCc1c(CCC2)c2ccc1 Chemical compound ClCc1c(CCC2)c2ccc1 BZLIAEVSPAPOPT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021138560A JP7453946B2 (ja) | 2016-03-07 | 2021-08-27 | 抗菌性化合物およびその使用 |
JP2023204901A JP2024028841A (ja) | 2016-03-07 | 2023-12-04 | 抗菌性化合物およびその使用 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662304661P | 2016-03-07 | 2016-03-07 | |
US62/304,661 | 2016-03-07 | ||
PCT/US2017/021031 WO2017155909A1 (fr) | 2016-03-07 | 2017-03-07 | Composés antibactériens et utilisations de ceux-ci |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021138560A Division JP7453946B2 (ja) | 2016-03-07 | 2021-08-27 | 抗菌性化合物およびその使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019507769A JP2019507769A (ja) | 2019-03-22 |
JP6997095B2 true JP6997095B2 (ja) | 2022-02-03 |
Family
ID=59790723
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018546705A Active JP6997095B2 (ja) | 2016-03-07 | 2017-03-07 | 抗菌性化合物およびその使用 |
JP2021138560A Active JP7453946B2 (ja) | 2016-03-07 | 2021-08-27 | 抗菌性化合物およびその使用 |
JP2023204901A Pending JP2024028841A (ja) | 2016-03-07 | 2023-12-04 | 抗菌性化合物およびその使用 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021138560A Active JP7453946B2 (ja) | 2016-03-07 | 2021-08-27 | 抗菌性化合物およびその使用 |
JP2023204901A Pending JP2024028841A (ja) | 2016-03-07 | 2023-12-04 | 抗菌性化合物およびその使用 |
Country Status (12)
Country | Link |
---|---|
US (2) | US10508097B2 (fr) |
EP (2) | EP4148053A1 (fr) |
JP (3) | JP6997095B2 (fr) |
KR (2) | KR102480410B1 (fr) |
CN (1) | CN109069514B (fr) |
AU (2) | AU2017229128B2 (fr) |
BR (3) | BR122023025283A2 (fr) |
CA (2) | CA3226824A1 (fr) |
EA (1) | EA201891644A1 (fr) |
ES (1) | ES2934785T3 (fr) |
WO (1) | WO2017155909A1 (fr) |
ZA (1) | ZA201805523B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109069514B (zh) * | 2016-03-07 | 2023-12-29 | 结核病药物开发全球联盟公司 | 抗菌化合物及其用途 |
CN108929310A (zh) * | 2018-06-29 | 2018-12-04 | 湖南华腾制药有限公司 | 一种二芳基喹啉衍生物的制备方法 |
CN108707138A (zh) * | 2018-06-29 | 2018-10-26 | 湖南华腾制药有限公司 | 一种二芳基喹啉衍生物的制备方法 |
CN108689998A (zh) * | 2018-06-29 | 2018-10-23 | 湖南华腾制药有限公司 | 一种二芳基喹啉衍生物的制备方法 |
CN108840857A (zh) * | 2018-07-10 | 2018-11-20 | 湖南华腾制药有限公司 | 一种喹啉衍生物的制备方法 |
WO2020047596A1 (fr) * | 2018-09-04 | 2020-03-12 | Monash University | Composés antibactériens et procédés d'utilisation |
CN109535068B (zh) * | 2018-12-26 | 2022-07-29 | 中国药科大学 | 吡啶取代查尔酮类化合物或其可药用的盐及其制备方法和用途 |
WO2021057190A1 (fr) * | 2019-09-29 | 2021-04-01 | 上海阳帆医药科技有限公司 | Composés quinoléine, leur procédé de préparation et utilisation associée |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006504658A (ja) | 2002-07-25 | 2006-02-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キノリン誘導体およびミコバクテリア抑制剤としてのそれらの使用 |
JP2006182755A (ja) | 2004-12-24 | 2006-07-13 | Janssen Pharmaceut Nv | 潜伏性結核の処置 |
JP2006342109A (ja) | 2005-06-09 | 2006-12-21 | Janssen Pharmaceut Nv | 抗バクテリア剤としてのキノリン誘導体 |
JP2008500992A (ja) | 2004-05-28 | 2008-01-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 薬剤耐性マイコバクテリア性疾患の処置のための置換キノリン誘導体の使用 |
JP2010511667A (ja) | 2006-12-06 | 2010-04-15 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗菌性キノリン誘導体 |
JP2010511669A5 (fr) | 2007-12-04 | 2010-11-18 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
SG162724A1 (en) * | 2005-05-25 | 2010-07-29 | Janssen Pharmaceutica Nv | Process for preparing <alpha s, beta r>-6-bromo-alpha-[2-<dimethylamino>ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol |
JO2837B1 (en) * | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
EP2195311B1 (fr) | 2007-08-17 | 2011-03-23 | Actelion Pharmaceuticals Ltd. | Derives de la pyridine an tant que modulateurs du recepteur s1p1/edg1 |
WO2009083553A1 (fr) | 2007-12-31 | 2009-07-09 | Rheoscience A/S | Composés azines en tant qu'activateurs de glucokinase |
US20110059948A1 (en) * | 2008-01-14 | 2011-03-10 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivatives as anti-mycobacterial agents |
UA103634C2 (en) | 2008-09-26 | 2013-11-11 | Берингер Ингельхайм Интернациональ Гмбх | Azaindazole compounds as ccr1 receptor antagonists |
JP5683489B2 (ja) | 2009-01-12 | 2015-03-11 | アレイ バイオファーマ、インコーポレイテッド | ピペリジン含有化合物およびその用途 |
WO2010100475A1 (fr) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Dérivés de l'acide hydroxamique en tant qu'agents contre des bactéries à gram négatif |
DK2841425T3 (en) * | 2012-04-27 | 2016-06-27 | Janssen Pharmaceutica Nv | ANTIBACTERIAL QUINOLIN DERIVATIVES |
US9572809B2 (en) * | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
US9878982B2 (en) | 2014-07-14 | 2018-01-30 | Cisen Pharmaceutical Co., Ltd. | Pyridine derivatives and anti-mycobacterial use thereof |
CN109069514B (zh) * | 2016-03-07 | 2023-12-29 | 结核病药物开发全球联盟公司 | 抗菌化合物及其用途 |
-
2017
- 2017-03-07 CN CN201780028310.6A patent/CN109069514B/zh active Active
- 2017-03-07 WO PCT/US2017/021031 patent/WO2017155909A1/fr active Application Filing
- 2017-03-07 BR BR122023025283A patent/BR122023025283A2/pt unknown
- 2017-03-07 AU AU2017229128A patent/AU2017229128B2/en active Active
- 2017-03-07 EP EP22202329.3A patent/EP4148053A1/fr active Pending
- 2017-03-07 BR BR112018067922-4A patent/BR112018067922B1/pt active IP Right Grant
- 2017-03-07 CA CA3226824A patent/CA3226824A1/fr active Pending
- 2017-03-07 CA CA3016068A patent/CA3016068C/fr active Active
- 2017-03-07 EP EP17763848.3A patent/EP3426255B1/fr active Active
- 2017-03-07 EA EA201891644A patent/EA201891644A1/ru unknown
- 2017-03-07 ES ES17763848T patent/ES2934785T3/es active Active
- 2017-03-07 KR KR1020227002071A patent/KR102480410B1/ko active IP Right Grant
- 2017-03-07 JP JP2018546705A patent/JP6997095B2/ja active Active
- 2017-03-07 KR KR1020187028857A patent/KR102355154B1/ko active IP Right Grant
- 2017-03-07 US US16/079,812 patent/US10508097B2/en active Active
- 2017-03-07 BR BR122021024097-3A patent/BR122021024097B1/pt active IP Right Grant
-
2018
- 2018-08-17 ZA ZA201805523A patent/ZA201805523B/en unknown
-
2019
- 2019-10-14 US US16/600,651 patent/US10981891B2/en active Active
-
2021
- 2021-08-27 JP JP2021138560A patent/JP7453946B2/ja active Active
-
2022
- 2022-06-10 AU AU2022204071A patent/AU2022204071B2/en active Active
-
2023
- 2023-12-04 JP JP2023204901A patent/JP2024028841A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006504658A (ja) | 2002-07-25 | 2006-02-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キノリン誘導体およびミコバクテリア抑制剤としてのそれらの使用 |
JP2008500992A (ja) | 2004-05-28 | 2008-01-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 薬剤耐性マイコバクテリア性疾患の処置のための置換キノリン誘導体の使用 |
JP2006182755A (ja) | 2004-12-24 | 2006-07-13 | Janssen Pharmaceut Nv | 潜伏性結核の処置 |
JP2006342109A (ja) | 2005-06-09 | 2006-12-21 | Janssen Pharmaceut Nv | 抗バクテリア剤としてのキノリン誘導体 |
JP2010511667A (ja) | 2006-12-06 | 2010-04-15 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗菌性キノリン誘導体 |
JP2010511669A5 (fr) | 2007-12-04 | 2010-11-18 |
Non-Patent Citations (2)
Title |
---|
BALEMANS, W. et al.,Novel antibiotics targeting respiratory ATP synthesis in Gram-positive pathogenic bacteria,Antimicrobial Agents and Chemotherapy,2012年,Vol. 56,pp. 4131-4139 |
NATALIE, M. et al.,Screening for phospholipidosis induced by central nervous drugs: Comparing the predictivity of an in vitro assay to high throughput in silico assays,Toxicology in Vitro,2010年,Vol. 24,pp. 1417-1425 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6997095B2 (ja) | 抗菌性化合物およびその使用 | |
JP6232429B2 (ja) | RORγT阻害剤としての3−シクロヘキセニルおよびシクロヘキシル置換インドールおよびインダゾール化合物およびそれらの使用 | |
KR20100058530A (ko) | 퀴놀론 유도체 | |
US20090326018A1 (en) | 2-Phenyl indene derivatives useful as estrogen receptor ligands | |
WO2017075341A1 (fr) | Dérivés d'imidazole fusionnés utilisés comme inhibiteurs d'ido/tdo | |
US8895565B2 (en) | Heterocyclic compound and use of the same | |
CZ281714B6 (cs) | Piperidylmethylsubstituované deriváty chromanu | |
CA2689985C (fr) | Derives de di(hetero)arylcyclohexane, leur preparation, leur utilisation et compositions pharmaceutiques les comprenant | |
JP2020500920A (ja) | 置換ピラゾロアゼピン−4−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 | |
TW201315469A (zh) | 菸鹼乙醯膽鹼受體之新正向異位調節子 | |
EA040011B1 (ru) | Антибактериальные соединения и их применение | |
JP2016537398A (ja) | 新規なチトクロムp450阻害剤及びこれらの使用方法 | |
EA007074B1 (ru) | 2-амино-6-(2,4,5-замещенный фенил)пиридины для применения в качестве ингибиторов синтазы оксида азота | |
JP2005060375A (ja) | 含酸素複素環化合物 | |
JPH10512552A (ja) | 4,4−(二置換)シクロヘキサン−1−オン二量体および関連化合物 | |
JP2002516601A (ja) | 4,4−(二置換)シクロヘキサン−1−オン単量体および関連化合物 | |
JP2005060376A (ja) | ピペリジン誘導体 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20181029 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20190522 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20190522 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191220 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201006 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210106 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20210205 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20210209 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210302 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210601 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210827 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20211116 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20211216 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6997095 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |