JP6934722B2 - 中東呼吸器症候群−コロナウイルススパイクタンパク質に対するヒト抗体 - Google Patents

中東呼吸器症候群−コロナウイルススパイクタンパク質に対するヒト抗体 Download PDF

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JP6934722B2
JP6934722B2 JP2016567890A JP2016567890A JP6934722B2 JP 6934722 B2 JP6934722 B2 JP 6934722B2 JP 2016567890 A JP2016567890 A JP 2016567890A JP 2016567890 A JP2016567890 A JP 2016567890A JP 6934722 B2 JP6934722 B2 JP 6934722B2
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antibody
mers
cov
antigen
binding fragment
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JP2017524339A5 (OSRAM
JP2017524339A (ja
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クリストス・キラトゥス
ネイル・スタール
スマティ・シヴァパラシンガム
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Regeneron Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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JP2016567890A 2014-05-23 2015-05-20 中東呼吸器症候群−コロナウイルススパイクタンパク質に対するヒト抗体 Active JP6934722B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021092024A JP7297814B2 (ja) 2014-05-23 2021-06-01 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体
JP2023060532A JP7500812B2 (ja) 2014-05-23 2023-04-04 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体
JP2024090439A JP2024123027A (ja) 2014-05-23 2024-06-04 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462002233P 2014-05-23 2014-05-23
US62/002,233 2014-05-23
US201462004971P 2014-05-30 2014-05-30
US62/004,971 2014-05-30
US201462051717P 2014-09-17 2014-09-17
US62/051,717 2014-09-17
US201462072716P 2014-10-30 2014-10-30
US62/072,716 2014-10-30
PCT/US2015/031800 WO2015179535A1 (en) 2014-05-23 2015-05-20 Human antibodies to middle east respiratory syndrome -coronavirus spike protein

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JP2021092024A Division JP7297814B2 (ja) 2014-05-23 2021-06-01 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体

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JP2017524339A JP2017524339A (ja) 2017-08-31
JP2017524339A5 JP2017524339A5 (OSRAM) 2018-08-16
JP6934722B2 true JP6934722B2 (ja) 2021-09-15

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JP2016567890A Active JP6934722B2 (ja) 2014-05-23 2015-05-20 中東呼吸器症候群−コロナウイルススパイクタンパク質に対するヒト抗体
JP2021092024A Active JP7297814B2 (ja) 2014-05-23 2021-06-01 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体
JP2023060532A Active JP7500812B2 (ja) 2014-05-23 2023-04-04 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体
JP2024090439A Pending JP2024123027A (ja) 2014-05-23 2024-06-04 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体

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JP2021092024A Active JP7297814B2 (ja) 2014-05-23 2021-06-01 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体
JP2023060532A Active JP7500812B2 (ja) 2014-05-23 2023-04-04 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体
JP2024090439A Pending JP2024123027A (ja) 2014-05-23 2024-06-04 中東呼吸器症候群－コロナウイルススパイクタンパク質に対するヒト抗体

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US (3) US9718872B2 (OSRAM)
EP (1) EP3145539A1 (OSRAM)
JP (4) JP6934722B2 (OSRAM)
KR (1) KR102371300B1 (OSRAM)
CN (2) CN106414496B (OSRAM)
AU (1) AU2015264189B2 (OSRAM)
BR (1) BR112016025009B1 (OSRAM)
CA (1) CA2949438A1 (OSRAM)
CL (1) CL2016002934A1 (OSRAM)
EA (1) EA036023B1 (OSRAM)
IL (1) IL248392B2 (OSRAM)
JO (1) JO3701B1 (OSRAM)
MA (1) MA40688A (OSRAM)
MX (1) MX373581B (OSRAM)
MY (1) MY180741A (OSRAM)
PH (1) PH12016502064A1 (OSRAM)
SG (1) SG11201608567YA (OSRAM)
WO (1) WO2015179535A1 (OSRAM)
ZA (1) ZA201607047B (OSRAM)

Cited By (1)

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JP2021129594A (ja) * 2014-05-23 2021-09-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 中東呼吸器症候群−コロナウイルススパイクタンパク質に対するヒト抗体

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AR102198A1 (es) 2014-10-09 2017-02-08 Regeneron Pharma Proceso para reducir partículas subvisibles en una formulación farmacéutica
TWI797060B (zh) 2015-08-04 2023-04-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
CN106928326B (zh) * 2015-12-31 2019-12-24 中国科学院微生物研究所 一种基于二聚化的受体结合区亚单位的冠状病毒疫苗
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CN107298712B (zh) * 2016-04-14 2020-04-07 中国疾病预防控制中心病毒病预防控制所 全人源化抗中东呼吸综合征冠状病毒中和抗体
TW201815821A (zh) * 2016-07-18 2018-05-01 美商再生元醫藥公司 抗茲卡病毒抗體及使用方法
KR20230041834A (ko) 2016-08-16 2023-03-24 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
WO2018039499A1 (en) 2016-08-24 2018-03-01 Regeneron Pharmaceuticals, Inc. Host cell protein modification
AU2017350807B2 (en) 2016-10-25 2022-07-07 Regeneron Pharmaceuticals, Inc. Methods and systems for chromatography data analysis
KR20180058206A (ko) * 2016-11-23 2018-05-31 에스케이케미칼 주식회사 중동호흡기증후군 코로나바이러스 s 단백질 면역원 조성물 및 이의 제작 방법
KR102777514B1 (ko) 2017-01-19 2025-03-06 옴니에이비 오퍼레이션스, 인코포레이티드 다중 중쇄 면역글로불린 유전자좌를 갖는 트랜스제닉 설치류 기원의 인간 항체
CA3061236A1 (en) 2017-05-22 2018-11-29 F. Hoffmann-La Roche Ag Therapeutic compounds and compositions, and methods of use thereof
KR102782655B1 (ko) 2017-07-06 2025-03-14 리제너론 파마슈티칼스 인코포레이티드 당단백질을 만들기 위한 세포 배양 과정
KR101895228B1 (ko) 2017-08-23 2018-10-30 대한민국 중동호흡기증후군 코로나바이러스의 스파이크 단백질에 대한 단일클론항체 및 이의 용도
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