JP6931327B2 - Ｆｍｄｖ組換えワクチンおよびその使用 - Google Patents

Ｆｍｄｖ組換えワクチンおよびその使用 Download PDF

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JP6931327B2
JP6931327B2 JP2017516077A JP2017516077A JP6931327B2 JP 6931327 B2 JP6931327 B2 JP 6931327B2 JP 2017516077 A JP2017516077 A JP 2017516077A JP 2017516077 A JP2017516077 A JP 2017516077A JP 6931327 B2 JP6931327 B2 JP 6931327B2
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fmdv
antigen
vaccine
polypeptide
polynucleotide
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JP2017530124A (ja
JP2017530124A5 (enExample
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ジャン−クリストフ オードネ
ジャン−クリストフ オードネ
ザヒア アンナス−ジェバーラ
ザヒア アンナス−ジェバーラ
テショメ メバション
テショメ メバション
ユ−ウェイ チャン
ユ−ウェイ チャン
ジャスティン ワイドナー
ジャスティン ワイドナー
フレデリク レイナード
フレデリク レイナード
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ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド
ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/135—Foot- and mouth-disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017516077A 2014-09-23 2015-09-23 Ｆｍｄｖ組換えワクチンおよびその使用 Active JP6931327B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462054073P 2014-09-23 2014-09-23
US62/054,073 2014-09-23
PCT/US2015/051755 WO2016049209A1 (en) 2014-09-23 2015-09-23 Fmdv recombinant vaccines and uses thereof

Publications (3)

Publication Number Publication Date
JP2017530124A JP2017530124A (ja) 2017-10-12
JP2017530124A5 JP2017530124A5 (enExample) 2018-11-01
JP6931327B2 true JP6931327B2 (ja) 2021-09-01

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US (1) US10010605B2 (enExample)
EP (1) EP3197486A1 (enExample)
JP (1) JP6931327B2 (enExample)
KR (1) KR102526219B1 (enExample)
CN (1) CN107073100B (enExample)
AP (1) AP2017009834A0 (enExample)
AR (1) AR102006A1 (enExample)
AU (2) AU2015320673B2 (enExample)
CA (1) CA2962225A1 (enExample)
JO (1) JO3600B1 (enExample)
MA (1) MA40151B2 (enExample)
MX (1) MX388708B (enExample)
RU (1) RU2745373C2 (enExample)
TW (1) TWI733653B (enExample)
WO (1) WO2016049209A1 (enExample)
ZA (1) ZA201701851B (enExample)

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WO2017044890A1 (en) * 2015-09-10 2017-03-16 Academia Sinica Bird flu vaccine combination comprising virus-like particles and novel adjuvants
KR102153303B1 (ko) 2015-11-23 2020-09-09 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 Fmdv 및 e2 융합 단백질 및 이의 용도
TWI760322B (zh) 2016-01-29 2022-04-11 美商百靈佳殷格翰動物保健美國有限公司 重組腺病毒載體裝載之fmdv疫苗及其用途
US10172933B2 (en) * 2016-10-31 2019-01-08 The United States Of America, As Represented By The Secretary Of Agriculture Mosaic vaccines for serotype a foot-and-mouth disease virus
JP7083362B2 (ja) * 2017-07-12 2022-06-10 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド セネカウイルスａ免疫原性組成物およびその方法
CN108103034B (zh) * 2017-12-15 2022-06-24 云南农业大学动物医学院 同时表达A型、O型和Asia-1型口蹄疫病毒VP1基因重组腺病毒、构建方法及应用
CN108530522B (zh) * 2018-03-14 2021-09-17 中华人民共和国汕头海关 一种重组的OmpK多表位多肽、构建方法及其应用
CN110467654B (zh) * 2018-05-11 2022-08-09 普莱柯生物工程股份有限公司 口蹄疫病毒样颗粒抗原、其制备的疫苗组合物及其制备方法和应用
CN111233984B (zh) * 2018-11-29 2022-08-12 普莱柯生物工程股份有限公司 一种o型口蹄疫病毒样颗粒抗原、及其疫苗组合物、制备方法和应用
JP7303306B2 (ja) * 2019-01-15 2023-07-04 普莱柯生物工程股▲ふん▼有限公司 口蹄疫ウイルス様粒子抗原及びそのワクチン組成物並びに調製方法及び応用
WO2020263062A1 (ko) * 2019-06-28 2020-12-30 (주)플럼라인생명과학 구제역 바이러스 백신 조성물
CN116685687A (zh) * 2020-10-22 2023-09-01 英特维特国际股份有限公司 杆状病毒表达载体
EP4232082A1 (en) * 2020-10-22 2023-08-30 Intervet International B.V. Baculovirus expression vector
US12453767B2 (en) 2021-08-18 2025-10-28 The United States Of America, As Represented By The Secretary Of Agriculture Development of mosaic vaccines against foot and mouth disease virus serotype O
WO2023020737A1 (en) * 2021-08-20 2023-02-23 Intervet International B.V. Fmdv virus-like particle with stabilizing mutation
WO2023021168A1 (en) * 2021-08-20 2023-02-23 Intervet International B.V. Method of producing a foot and mouth disease virus virus-like particle
IL310905A (en) * 2021-08-20 2024-04-01 Intervet Int Bv A method for producing a virus-like particle for foot-and-mouth disease virus
CN117881424A (zh) * 2021-08-20 2024-04-12 珀布赖特研究所 具有双稳定突变的fmdv病毒样颗粒
KR102513632B1 (ko) * 2021-11-30 2023-03-28 주식회사 왓슨알앤디 구제역 바이러스 유사 입자를 생산하기 위한 백신 플랫폼
US12036318B2 (en) * 2022-02-16 2024-07-16 Chemical & Schutz High Performance Lubricants, S.A. De C.V. Self-emulsionable mineral oil as a vehicle in vaccines for poultry
CN120265316A (zh) 2022-11-23 2025-07-04 致优制药有限公司 用于生产口蹄疫病毒样颗粒或纳米颗粒的重组表达载体及利用其的疫苗组合物
JP2025538585A (ja) * 2022-11-23 2025-11-28 オプティファーム カンパニー リミテッド 口蹄疫ウィルス様粒子またはナノ粒子生産のための組換え発現ベクターおよびこれを用いたワクチン組成物
CN117210501B (zh) * 2023-09-13 2024-06-07 中国农业科学院兰州兽医研究所 口蹄疫病毒2b蛋白免疫抑制位点突变的重组口蹄疫病毒株的构建
CN117304277B (zh) * 2023-09-26 2024-03-08 中国农业科学院兰州兽医研究所 一种o型口蹄疫病毒vp4蛋白t细胞表位多肽及其应用
US20250134984A1 (en) * 2023-10-26 2025-05-01 The United States Of America, As Represented By The Secretary Of Agriculture Development of mosaic vaccines against foot and mouth disease virus serotype asia

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CA2962225A1 (en) 2016-03-31
AU2019210537A1 (en) 2019-08-15
AP2017009834A0 (en) 2017-03-31
US10010605B2 (en) 2018-07-03
CN107073100A (zh) 2017-08-18
KR102526219B1 (ko) 2023-04-26
JP2017530124A (ja) 2017-10-12
BR112017005833A8 (pt) 2023-02-14
AU2015320673A1 (en) 2017-05-11
RU2017113571A3 (enExample) 2019-04-22
RU2017113571A (ru) 2018-10-26
ZA201701851B (en) 2018-05-30
JO3600B1 (ar) 2020-07-05
AR102006A1 (es) 2017-01-25
TWI733653B (zh) 2021-07-21
AU2015320673B2 (en) 2019-05-02
BR112017005833A2 (pt) 2018-02-27
EP3197486A1 (en) 2017-08-02
MX388708B (es) 2025-03-20
US20160220659A1 (en) 2016-08-04
TW201625297A (zh) 2016-07-16
CN107073100B (zh) 2021-02-26
WO2016049209A1 (en) 2016-03-31
KR20170058430A (ko) 2017-05-26
MA40151A1 (fr) 2018-01-31
MA40151B2 (fr) 2022-12-30
RU2745373C2 (ru) 2021-03-24
MX2017003712A (es) 2017-06-28

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