TWI733653B - Fmdv重組疫苗及其用途 - Google Patents

Fmdv重組疫苗及其用途 Download PDF

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TWI733653B
TWI733653B TW104131548A TW104131548A TWI733653B TW I733653 B TWI733653 B TW I733653B TW 104131548 A TW104131548 A TW 104131548A TW 104131548 A TW104131548 A TW 104131548A TW I733653 B TWI733653 B TW I733653B
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fmdv
antigen
composition
vlp
vaccine
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TW104131548A
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TW201625297A (zh
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真 克利斯多夫 亞多納特
迪潔貝拉 札海 漢那斯
泰斯合 麥班遜
有為 蔣
賈斯汀 維德諾
費德里克 瑞那德
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美商百靈佳殷格翰動物保健美國有限公司
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    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW104131548A 2014-09-23 2015-09-23 Fmdv重組疫苗及其用途 TWI733653B (zh)

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US201462054073P 2014-09-23 2014-09-23
US62/054,073 2014-09-23

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TWI733653B true TWI733653B (zh) 2021-07-21

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KR (1) KR102526219B1 (enExample)
CN (1) CN107073100B (enExample)
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017044890A1 (en) * 2015-09-10 2017-03-16 Academia Sinica Bird flu vaccine combination comprising virus-like particles and novel adjuvants
KR102153303B1 (ko) 2015-11-23 2020-09-09 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 Fmdv 및 e2 융합 단백질 및 이의 용도
TWI760322B (zh) 2016-01-29 2022-04-11 美商百靈佳殷格翰動物保健美國有限公司 重組腺病毒載體裝載之fmdv疫苗及其用途
US10172933B2 (en) * 2016-10-31 2019-01-08 The United States Of America, As Represented By The Secretary Of Agriculture Mosaic vaccines for serotype a foot-and-mouth disease virus
JP7083362B2 (ja) * 2017-07-12 2022-06-10 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド セネカウイルスa免疫原性組成物およびその方法
CN108103034B (zh) * 2017-12-15 2022-06-24 云南农业大学动物医学院 同时表达A型、O型和Asia-1型口蹄疫病毒VP1基因重组腺病毒、构建方法及应用
CN108530522B (zh) * 2018-03-14 2021-09-17 中华人民共和国汕头海关 一种重组的OmpK多表位多肽、构建方法及其应用
CN110467654B (zh) * 2018-05-11 2022-08-09 普莱柯生物工程股份有限公司 口蹄疫病毒样颗粒抗原、其制备的疫苗组合物及其制备方法和应用
CN111233984B (zh) * 2018-11-29 2022-08-12 普莱柯生物工程股份有限公司 一种o型口蹄疫病毒样颗粒抗原、及其疫苗组合物、制备方法和应用
JP7303306B2 (ja) * 2019-01-15 2023-07-04 普莱柯生物工程股▲ふん▼有限公司 口蹄疫ウイルス様粒子抗原及びそのワクチン組成物並びに調製方法及び応用
WO2020263062A1 (ko) * 2019-06-28 2020-12-30 (주)플럼라인생명과학 구제역 바이러스 백신 조성물
CN116685687A (zh) * 2020-10-22 2023-09-01 英特维特国际股份有限公司 杆状病毒表达载体
EP4232082A1 (en) * 2020-10-22 2023-08-30 Intervet International B.V. Baculovirus expression vector
US12453767B2 (en) 2021-08-18 2025-10-28 The United States Of America, As Represented By The Secretary Of Agriculture Development of mosaic vaccines against foot and mouth disease virus serotype O
WO2023020737A1 (en) * 2021-08-20 2023-02-23 Intervet International B.V. Fmdv virus-like particle with stabilizing mutation
WO2023021168A1 (en) * 2021-08-20 2023-02-23 Intervet International B.V. Method of producing a foot and mouth disease virus virus-like particle
IL310905A (en) * 2021-08-20 2024-04-01 Intervet Int Bv A method for producing a virus-like particle for foot-and-mouth disease virus
CN117881424A (zh) * 2021-08-20 2024-04-12 珀布赖特研究所 具有双稳定突变的fmdv病毒样颗粒
KR102513632B1 (ko) * 2021-11-30 2023-03-28 주식회사 왓슨알앤디 구제역 바이러스 유사 입자를 생산하기 위한 백신 플랫폼
US12036318B2 (en) * 2022-02-16 2024-07-16 Chemical & Schutz High Performance Lubricants, S.A. De C.V. Self-emulsionable mineral oil as a vehicle in vaccines for poultry
CN120265316A (zh) 2022-11-23 2025-07-04 致优制药有限公司 用于生产口蹄疫病毒样颗粒或纳米颗粒的重组表达载体及利用其的疫苗组合物
JP2025538585A (ja) * 2022-11-23 2025-11-28 オプティファーム カンパニー リミテッド 口蹄疫ウィルス様粒子またはナノ粒子生産のための組換え発現ベクターおよびこれを用いたワクチン組成物
CN117210501B (zh) * 2023-09-13 2024-06-07 中国农业科学院兰州兽医研究所 口蹄疫病毒2b蛋白免疫抑制位点突变的重组口蹄疫病毒株的构建
CN117304277B (zh) * 2023-09-26 2024-03-08 中国农业科学院兰州兽医研究所 一种o型口蹄疫病毒vp4蛋白t细胞表位多肽及其应用
US20250134984A1 (en) * 2023-10-26 2025-05-01 The United States Of America, As Represented By The Secretary Of Agriculture Development of mosaic vaccines against foot and mouth disease virus serotype asia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1440296A (zh) * 2000-06-29 2003-09-03 梅瑞尔公司 抗口蹄疫疫苗
US20090253185A1 (en) * 2004-06-25 2009-10-08 Robert Nordgren Avipox recombinants expressing foot and mouth disease virus genes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA915593B (en) 1990-07-24 1993-03-31 Novagene Inc Herpesvirus-based viral vector which expresses a foot and mounth disease virus epitope on the surface of virus-infected cells and on the surface of virus particles,and vaccine against foot and mounth disease containing the same
BRPI0618441B8 (pt) 2005-11-10 2021-07-27 Genvec Inc vetor adenoviral
JP5309159B2 (ja) * 2008-01-09 2013-10-09 コングク ユニバーシティ インダストリアル コーオペレーション コーポレーション バキュロウイルスを利用したワクチン
CN101270155B (zh) * 2008-05-06 2011-04-27 中国农业科学院兰州兽医研究所 通过耐酸性改造在昆虫中组装口蹄疫病毒空衣壳的方法
GB0810710D0 (en) * 2008-06-11 2008-07-16 Animal Health Inst Vaccine
US9345759B2 (en) * 2010-03-12 2016-05-24 Merial, Inc. Bluetongue virus recombinant vaccines and uses thereof
SI3275892T1 (sl) * 2011-05-13 2020-06-30 Glaxosmithkline Biologicals S.A. Prefuzijski RSV F antigeni
GB201111183D0 (en) * 2011-06-30 2011-08-17 Animal Health Inst Peptide
IN2014KN02740A (enExample) * 2012-06-18 2015-05-08 Novartis Ag
US9738689B2 (en) * 2013-03-13 2017-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Prefusion RSV F proteins and their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1440296A (zh) * 2000-06-29 2003-09-03 梅瑞尔公司 抗口蹄疫疫苗
US20090253185A1 (en) * 2004-06-25 2009-10-08 Robert Nordgren Avipox recombinants expressing foot and mouth disease virus genes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Claudine Porta et al., "Efficient production of footand-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity", J Virol Methods. 2013 Feb;187(2):406-12. Epub 2012 Nov 19.
Claudine Porta et al., "Efficient production of footand-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity", J Virol Methods. 2013 Feb;187(2):406-12. Epub 2012 Nov 19. Mohana Subramanian B et al, "Development of foot-and-mouth disease virus (FMDV) serotype O virus-like-particles (VLPs) vaccine and evaluation of its potency", Antiviral Res. 2012 Dec;96(3):288-95. Epub 2012 Oct 6. *
Mohana Subramanian B et al, "Development of foot-and-mouth disease virus (FMDV) serotype O virus-like-particles (VLPs) vaccine and evaluation of its potency", Antiviral Res. 2012 Dec;96(3):288-95. Epub 2012 Oct 6.

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CA2962225A1 (en) 2016-03-31
AU2019210537A1 (en) 2019-08-15
AP2017009834A0 (en) 2017-03-31
US10010605B2 (en) 2018-07-03
CN107073100A (zh) 2017-08-18
KR102526219B1 (ko) 2023-04-26
JP2017530124A (ja) 2017-10-12
BR112017005833A8 (pt) 2023-02-14
AU2015320673A1 (en) 2017-05-11
RU2017113571A3 (enExample) 2019-04-22
JP6931327B2 (ja) 2021-09-01
RU2017113571A (ru) 2018-10-26
ZA201701851B (en) 2018-05-30
JO3600B1 (ar) 2020-07-05
AR102006A1 (es) 2017-01-25
AU2015320673B2 (en) 2019-05-02
BR112017005833A2 (pt) 2018-02-27
EP3197486A1 (en) 2017-08-02
MX388708B (es) 2025-03-20
US20160220659A1 (en) 2016-08-04
TW201625297A (zh) 2016-07-16
CN107073100B (zh) 2021-02-26
WO2016049209A1 (en) 2016-03-31
KR20170058430A (ko) 2017-05-26
MA40151A1 (fr) 2018-01-31
MA40151B2 (fr) 2022-12-30
RU2745373C2 (ru) 2021-03-24
MX2017003712A (es) 2017-06-28

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