JP6911062B2 - ベムラフェニブの新規な製造方法 - Google Patents
ベムラフェニブの新規な製造方法 Download PDFInfo
- Publication number
- JP6911062B2 JP6911062B2 JP2018568670A JP2018568670A JP6911062B2 JP 6911062 B2 JP6911062 B2 JP 6911062B2 JP 2018568670 A JP2018568670 A JP 2018568670A JP 2018568670 A JP2018568670 A JP 2018568670A JP 6911062 B2 JP6911062 B2 JP 6911062B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- production method
- equation
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(C=C1CCC1)C=C1CCCC1 Chemical compound *C(C=C1CCC1)C=C1CCCC1 0.000 description 3
- AIRHBAXIGSQPNX-UHFFFAOYSA-N Clc(cc1)ccc1-c1cnc2[nH]ccc2c1 Chemical compound Clc(cc1)ccc1-c1cnc2[nH]ccc2c1 AIRHBAXIGSQPNX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20165557 | 2016-07-01 | ||
| FI20165557 | 2016-07-01 | ||
| FI20165778 | 2016-10-12 | ||
| FI20165778 | 2016-10-12 | ||
| PCT/FI2017/000012 WO2018002415A1 (en) | 2016-07-01 | 2017-06-30 | New processes for the preparation of vemurafenib |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522662A JP2019522662A (ja) | 2019-08-15 |
| JP2019522662A5 JP2019522662A5 (enExample) | 2020-07-02 |
| JP6911062B2 true JP6911062B2 (ja) | 2021-07-28 |
Family
ID=59416718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568670A Expired - Fee Related JP6911062B2 (ja) | 2016-07-01 | 2017-06-30 | ベムラフェニブの新規な製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10407427B2 (enExample) |
| EP (1) | EP3478684B1 (enExample) |
| JP (1) | JP6911062B2 (enExample) |
| CA (1) | CA3029361A1 (enExample) |
| ES (1) | ES2802476T3 (enExample) |
| HR (1) | HRP20200821T1 (enExample) |
| HU (1) | HUE049682T2 (enExample) |
| PL (1) | PL3478684T3 (enExample) |
| RS (1) | RS60451B1 (enExample) |
| WO (1) | WO2018002415A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| DK3860598T3 (da) | 2018-10-03 | 2023-10-16 | Jyvaeskylaen Yliopisto | Vemurafenib og salte heraf til anvendelse til behandling af enterovirusinfektioner |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1303759B1 (it) * | 1998-11-17 | 2001-02-23 | Dompe Spa | Procedimento migliorato per la preparazione di acido 7-azaindolil-3-carbossilico. |
| PT1893612E (pt) | 2005-06-22 | 2011-11-21 | Plexxikon Inc | Derivados de pirrolo [2,3-b]piridina como inibidores de proteína quinase |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| US8779150B2 (en) | 2010-07-21 | 2014-07-15 | Hoffmann-La Roche Inc. | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
| EA028351B1 (ru) | 2013-03-14 | 2017-11-30 | Ратиофарм Гмбх | Твердые формы гидрохлорида вемурафениба |
| WO2015075749A1 (en) | 2013-11-22 | 2015-05-28 | Laurus Labs Private Limited | Novel processes for the preparation of vemurafenib |
| CZ2013943A3 (cs) | 2013-11-27 | 2015-06-03 | Zentiva, K.S. | Krystalické formy vemurafenibu |
| US10414764B2 (en) | 2014-11-29 | 2019-09-17 | Shilpa Medicare Limited | Substantially pure vemurafenib and its salts |
-
2017
- 2017-06-30 RS RS20200741A patent/RS60451B1/sr unknown
- 2017-06-30 PL PL17745368T patent/PL3478684T3/pl unknown
- 2017-06-30 US US16/313,597 patent/US10407427B2/en not_active Expired - Fee Related
- 2017-06-30 EP EP17745368.5A patent/EP3478684B1/en active Active
- 2017-06-30 ES ES17745368T patent/ES2802476T3/es active Active
- 2017-06-30 CA CA3029361A patent/CA3029361A1/en active Pending
- 2017-06-30 HR HRP20200821TT patent/HRP20200821T1/hr unknown
- 2017-06-30 HU HUE17745368A patent/HUE049682T2/hu unknown
- 2017-06-30 WO PCT/FI2017/000012 patent/WO2018002415A1/en not_active Ceased
- 2017-06-30 JP JP2018568670A patent/JP6911062B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUE049682T2 (hu) | 2020-10-28 |
| HRP20200821T1 (hr) | 2020-08-07 |
| US20190194197A1 (en) | 2019-06-27 |
| JP2019522662A (ja) | 2019-08-15 |
| RS60451B1 (sr) | 2020-07-31 |
| CA3029361A1 (en) | 2018-01-04 |
| US10407427B2 (en) | 2019-09-10 |
| ES2802476T3 (es) | 2021-01-19 |
| WO2018002415A1 (en) | 2018-01-04 |
| EP3478684B1 (en) | 2020-04-15 |
| PL3478684T3 (pl) | 2020-08-10 |
| EP3478684A1 (en) | 2019-05-08 |
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