JP6911033B2 - 極性非プロトン性溶媒を用いたｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法 - Google Patents

極性非プロトン性溶媒を用いたｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法 Download PDF

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JP6911033B2
JP6911033B2 JP2018534974A JP2018534974A JP6911033B2 JP 6911033 B2 JP6911033 B2 JP 6911033B2 JP 2018534974 A JP2018534974 A JP 2018534974A JP 2018534974 A JP2018534974 A JP 2018534974A JP 6911033 B2 JP6911033 B2 JP 6911033B2
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mixture
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isomer
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JP2019501923A (ja
Inventor
ビョン ヨン ウ，
ビョン ヨン ウ，
キ−フヮ イ，
キ−フヮ イ，
ジョン フヮ ノ，
ジョン フヮ ノ，
ジェ ホン パク，
ジェ ホン パク，
ミ ヨン パク，
ミ ヨン パク，
ヨン ホ パク，
ヨン ホ パク，
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Amorepacific Corp
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Amorepacific Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
JP2018534974A 2016-01-04 2016-12-28 極性非プロトン性溶媒を用いたｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法 Active JP6911033B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2016-0000212 2016-01-04
KR1020160000212A KR102565407B1 (ko) 2016-01-04 2016-01-04 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법
PCT/KR2016/015402 WO2017119666A1 (ko) 2016-01-04 2016-12-28 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법

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JP2019501923A JP2019501923A (ja) 2019-01-24
JP6911033B2 true JP6911033B2 (ja) 2021-07-28

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JP (1) JP6911033B2 (zh)
KR (1) KR102565407B1 (zh)
CN (1) CN108473418A (zh)
TW (1) TWI725098B (zh)
WO (1) WO2017119666A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102587297B1 (ko) * 2017-08-31 2023-10-12 (주)아모레퍼시픽 수면장애 예방 또는 치료용 조성물
KR102518632B1 (ko) * 2018-04-18 2023-04-06 (주)아모레퍼시픽 (r)-n-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 함유하는 약학 조성물
CN109608368B (zh) * 2018-10-24 2021-03-09 常州市阳光药业有限公司 N-[4-(1-氨基乙基)-2,6-二氟苯基]甲磺酰胺的合成及拆分方法
CN111925380A (zh) * 2019-05-13 2020-11-13 北京化工大学 引起手性选择性转变的组合共晶客体拆分剂及其应用

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US4968837A (en) * 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures
NL1004346C2 (nl) * 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US7301023B2 (en) * 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
JP2003226677A (ja) * 2002-02-01 2003-08-12 Sumitomo Pharmaceut Co Ltd 光学活性２−（１−アミノアルキル）アニリン類およびその光学活性な酒石酸類との塩、並びにそれらの製造方法
US20070185346A1 (en) 2006-02-03 2007-08-09 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
US20120088746A1 (en) * 2006-05-10 2012-04-12 Pfizer Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2007129188A1 (en) 2006-05-10 2007-11-15 Pfizer Japan Inc. Cyclopropanecarboxamide compound
EP1882687A1 (en) * 2006-07-27 2008-01-30 Amorepacific Corporation Heterocyclic compounds useful as vanilloid receptor antagonists and pharmaceutical compositions containing the same
JP5254228B2 (ja) * 2006-07-27 2013-08-07 株式會社アモーレパシフィック バニロイド受容体アンタゴニストとしての、新規化合物、その異性体またはその薬学的に許容される塩；並びにそれを含む医薬組成物
JP2011201778A (ja) 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd ｐ−置換アリールアセトアミドを有するヘテロシクリデン誘導体
CN101870660A (zh) * 2010-05-10 2010-10-27 青海省青海湖药业有限公司 一种L-(-)-盐酸麻黄碱和d-(+)-盐酸伪麻黄碱制备方法
CN104119240A (zh) * 2013-04-23 2014-10-29 中国人民解放军军事医学科学院毒物药物研究所 (S)-(-)-α-甲胺基苯丙酮的制备方法
US10479763B2 (en) * 2015-02-17 2019-11-19 Amorepacific Corporation Chiral resolution method of N-[4-(1-aminoethyl)-phenyl]-sulfonamide derivatives
KR20160101554A (ko) * 2015-02-17 2016-08-25 (주)아모레퍼시픽 N-[4-(1-아미노에틸)-페닐]-메탄술폰아미드 유도체의 카이랄 분할 방법

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Publication number Publication date
JP2019501923A (ja) 2019-01-24
WO2017119666A1 (ko) 2017-07-13
CN108473418A (zh) 2018-08-31
KR20170081315A (ko) 2017-07-12
TWI725098B (zh) 2021-04-21
TW201726585A (zh) 2017-08-01
KR102565407B1 (ko) 2023-08-10

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