KR102565407B1 - 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법 - Google Patents

극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법 Download PDF

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Publication number
KR102565407B1
KR102565407B1 KR1020160000212A KR20160000212A KR102565407B1 KR 102565407 B1 KR102565407 B1 KR 102565407B1 KR 1020160000212 A KR1020160000212 A KR 1020160000212A KR 20160000212 A KR20160000212 A KR 20160000212A KR 102565407 B1 KR102565407 B1 KR 102565407B1
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KR
South Korea
Prior art keywords
group
compound
formula
mixture
chiral auxiliary
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KR1020160000212A
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English (en)
Korean (ko)
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KR20170081315A (ko
Inventor
우병영
이기화
노종화
박제홍
박미영
박영호
Original Assignee
(주)아모레퍼시픽
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Priority to KR1020160000212A priority Critical patent/KR102565407B1/ko
Priority to TW105143494A priority patent/TWI725098B/zh
Priority to JP2018534974A priority patent/JP6911033B2/ja
Priority to CN201680077743.6A priority patent/CN108473418A/zh
Priority to PCT/KR2016/015402 priority patent/WO2017119666A1/ko
Publication of KR20170081315A publication Critical patent/KR20170081315A/ko
Application granted granted Critical
Publication of KR102565407B1 publication Critical patent/KR102565407B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
KR1020160000212A 2016-01-04 2016-01-04 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법 KR102565407B1 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020160000212A KR102565407B1 (ko) 2016-01-04 2016-01-04 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법
TW105143494A TWI725098B (zh) 2016-01-04 2016-12-28 藉由使用極性非質子性溶劑掌性解析n-[4-(1-胺基乙基)-苯基]-磺醯胺衍生物之方法
JP2018534974A JP6911033B2 (ja) 2016-01-04 2016-12-28 極性非プロトン性溶媒を用いたｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法
CN201680077743.6A CN108473418A (zh) 2016-01-04 2016-12-28 使用极性非质子溶剂的n-[4-(1-氨基乙基)苯基]磺酰胺衍生物的手性拆分方法
PCT/KR2016/015402 WO2017119666A1 (ko) 2016-01-04 2016-12-28 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020160000212A KR102565407B1 (ko) 2016-01-04 2016-01-04 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법

Publications (2)

Publication Number Publication Date
KR20170081315A KR20170081315A (ko) 2017-07-12
KR102565407B1 true KR102565407B1 (ko) 2023-08-10

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KR1020160000212A KR102565407B1 (ko) 2016-01-04 2016-01-04 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법

Country Status (5)

Country Link
JP (1) JP6911033B2 (zh)
KR (1) KR102565407B1 (zh)
CN (1) CN108473418A (zh)
TW (1) TWI725098B (zh)
WO (1) WO2017119666A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102587297B1 (ko) * 2017-08-31 2023-10-12 (주)아모레퍼시픽 수면장애 예방 또는 치료용 조성물
KR102518632B1 (ko) * 2018-04-18 2023-04-06 (주)아모레퍼시픽 (r)-n-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 함유하는 약학 조성물
CN109608368B (zh) * 2018-10-24 2021-03-09 常州市阳光药业有限公司 N-[4-(1-氨基乙基)-2,6-二氟苯基]甲磺酰胺的合成及拆分方法
CN111925380A (zh) * 2019-05-13 2020-11-13 北京化工大学 引起手性选择性转变的组合共晶客体拆分剂及其应用

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US20070185346A1 (en) 2006-02-03 2007-08-09 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
WO2007129188A1 (en) 2006-05-10 2007-11-15 Pfizer Japan Inc. Cyclopropanecarboxamide compound

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NL1004346C2 (nl) * 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US7301023B2 (en) * 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
JP2003226677A (ja) * 2002-02-01 2003-08-12 Sumitomo Pharmaceut Co Ltd 光学活性２−（１−アミノアルキル）アニリン類およびその光学活性な酒石酸類との塩、並びにそれらの製造方法
WO2007133637A2 (en) 2006-05-10 2007-11-22 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
CA2658925C (en) * 2006-07-27 2015-07-14 Amorepacific Corporation Novel sulfonylamino acrylamide derivatives, isomer thereof,or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
EP1882687A1 (en) * 2006-07-27 2008-01-30 Amorepacific Corporation Heterocyclic compounds useful as vanilloid receptor antagonists and pharmaceutical compositions containing the same
JP2011201778A (ja) 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd ｐ−置換アリールアセトアミドを有するヘテロシクリデン誘導体
CN101870660A (zh) * 2010-05-10 2010-10-27 青海省青海湖药业有限公司 一种L-(-)-盐酸麻黄碱和d-(+)-盐酸伪麻黄碱制备方法
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KR101791119B1 (ko) * 2015-02-17 2017-11-20 (주)아모레퍼시픽 N-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법
KR20160101554A (ko) * 2015-02-17 2016-08-25 (주)아모레퍼시픽 N-[4-(1-아미노에틸)-페닐]-메탄술폰아미드 유도체의 카이랄 분할 방법

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US20070185346A1 (en) 2006-02-03 2007-08-09 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
WO2007129188A1 (en) 2006-05-10 2007-11-15 Pfizer Japan Inc. Cyclopropanecarboxamide compound

Also Published As

Publication number Publication date
JP6911033B2 (ja) 2021-07-28
TW201726585A (zh) 2017-08-01
WO2017119666A1 (ko) 2017-07-13
JP2019501923A (ja) 2019-01-24
KR20170081315A (ko) 2017-07-12
TWI725098B (zh) 2021-04-21
CN108473418A (zh) 2018-08-31

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