JP6882996B2 - オキシステロールおよびそれらの使用の方法 - Google Patents

オキシステロールおよびそれらの使用の方法 Download PDF

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Publication number
JP6882996B2
JP6882996B2 JP2017568208A JP2017568208A JP6882996B2 JP 6882996 B2 JP6882996 B2 JP 6882996B2 JP 2017568208 A JP2017568208 A JP 2017568208A JP 2017568208 A JP2017568208 A JP 2017568208A JP 6882996 B2 JP6882996 B2 JP 6882996B2
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JP
Japan
Prior art keywords
independently
alkyl
compound
pharmaceutically acceptable
substituted
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JP2017568208A
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English (en)
Japanese (ja)
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JP2018519329A (ja
JP2018519329A5 (enExample
Inventor
フランセスコ ジー． サリトゥロ，
フランセスコ ジー． サリトゥロ，
アルバート ジーン ロビチャウド，
アルバート ジーン ロビチャウド，
ボテーラ， ガブリエル マルティネス
ボテーラ， ガブリエル マルティネス
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Sage Therapeutics, LLC
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Sage Therapeutics, LLC
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Publication date
Application filed by Sage Therapeutics, LLC filed Critical Sage Therapeutics, LLC
Publication of JP2018519329A publication Critical patent/JP2018519329A/ja
Publication of JP2018519329A5 publication Critical patent/JP2018519329A5/ja
Priority to JP2021001453A priority Critical patent/JP7410062B2/ja
Application granted granted Critical
Publication of JP6882996B2 publication Critical patent/JP6882996B2/ja
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017568208A 2015-07-06 2016-07-06 オキシステロールおよびそれらの使用の方法 Active JP6882996B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021001453A JP7410062B2 (ja) 2015-07-06 2021-01-07 オキシステロールおよびそれらの使用の方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189065P 2015-07-06 2015-07-06
US62/189,065 2015-07-06
PCT/US2016/041160 WO2017007832A1 (en) 2015-07-06 2016-07-06 Oxysterols and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021001453A Division JP7410062B2 (ja) 2015-07-06 2021-01-07 オキシステロールおよびそれらの使用の方法

Publications (3)

Publication Number Publication Date
JP2018519329A JP2018519329A (ja) 2018-07-19
JP2018519329A5 JP2018519329A5 (enExample) 2019-07-25
JP6882996B2 true JP6882996B2 (ja) 2021-06-02

Family

ID=57686058

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017568208A Active JP6882996B2 (ja) 2015-07-06 2016-07-06 オキシステロールおよびそれらの使用の方法
JP2021001453A Active JP7410062B2 (ja) 2015-07-06 2021-01-07 オキシステロールおよびそれらの使用の方法
JP2022107293A Active JP7478190B2 (ja) 2015-07-06 2022-07-01 オキシステロールおよびそれらの使用の方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021001453A Active JP7410062B2 (ja) 2015-07-06 2021-01-07 オキシステロールおよびそれらの使用の方法
JP2022107293A Active JP7478190B2 (ja) 2015-07-06 2022-07-01 オキシステロールおよびそれらの使用の方法

Country Status (8)

Country Link
US (4) US10696712B2 (enExample)
EP (2) EP3319610A4 (enExample)
JP (3) JP6882996B2 (enExample)
AU (2) AU2016289965B2 (enExample)
CA (1) CA2991311C (enExample)
HK (1) HK1255500A1 (enExample)
MA (1) MA42409A (enExample)
WO (1) WO2017007832A1 (enExample)

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CN107936076B (zh) 2011-09-08 2021-10-15 萨奇治疗股份有限公司 神经活性类固醇、组合物、及其用途
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US10259840B2 (en) 2014-06-18 2019-04-16 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP3204011A4 (en) * 2014-10-07 2018-06-20 Sage Therapeutics, Inc. Neuroactive compounds and methods of use thereof
US11117924B2 (en) * 2015-07-06 2021-09-14 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP6882996B2 (ja) 2015-07-06 2021-06-02 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびそれらの使用の方法
CA2991214C (en) 2015-07-06 2024-04-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MA44526A (fr) 2016-04-01 2021-06-02 Sage Therapeutics Inc Oxystérols et leurs méthodes d'utilisation
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MA45598B1 (fr) 2016-07-07 2021-09-30 Sage Therapeutics Inc Stéroles 24-hydroxylés substitués en position 11 pour le traitement des maladies liées au récepteur nmda
MA46351A (fr) 2016-09-30 2021-06-02 Sage Therapeutics Inc Oxystérols substitués en c7 et procédés en tant que modulateurs nmda
US11111266B2 (en) 2016-10-18 2021-09-07 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
RU2019115113A (ru) 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
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Also Published As

Publication number Publication date
US20250154192A1 (en) 2025-05-15
AU2016289965A1 (en) 2018-01-18
CA2991311A1 (en) 2017-01-12
EP4316591A2 (en) 2024-02-07
JP7410062B2 (ja) 2024-01-09
US20230047157A1 (en) 2023-02-16
JP2022130668A (ja) 2022-09-06
AU2021218227B2 (en) 2023-08-03
AU2021218227A1 (en) 2021-09-09
WO2017007832A1 (en) 2017-01-12
HK1255500A1 (zh) 2019-08-16
JP2018519329A (ja) 2018-07-19
NZ738582A (en) 2024-10-25
EP4316591A3 (en) 2024-04-24
JP2021063118A (ja) 2021-04-22
EP3319610A1 (en) 2018-05-16
JP7478190B2 (ja) 2024-05-02
MA42409A (fr) 2018-05-16
US20180201643A1 (en) 2018-07-19
CA2991311C (en) 2025-05-06
AU2016289965B2 (en) 2021-09-09
US10696712B2 (en) 2020-06-30
US20210101925A1 (en) 2021-04-08
EP3319610A4 (en) 2019-03-06

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